[go: up one dir, main page]

EP4597105A3 - Methods and systems for the detection and removal of pathogens from blood - Google Patents

Methods and systems for the detection and removal of pathogens from blood

Info

Publication number
EP4597105A3
EP4597105A3 EP25181169.1A EP25181169A EP4597105A3 EP 4597105 A3 EP4597105 A3 EP 4597105A3 EP 25181169 A EP25181169 A EP 25181169A EP 4597105 A3 EP4597105 A3 EP 4597105A3
Authority
EP
European Patent Office
Prior art keywords
blood
systems
methods
pathogens
removal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP25181169.1A
Other languages
German (de)
French (fr)
Other versions
EP4597105A2 (en
Inventor
Robin VAN BRUGGEN
Astrid Elisabeth Visser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanquin Ip BV
Original Assignee
Sanquin Ip BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanquin Ip BV filed Critical Sanquin Ip BV
Publication of EP4597105A2 publication Critical patent/EP4597105A2/en
Publication of EP4597105A3 publication Critical patent/EP4597105A3/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
    • A61M1/3633—Blood component filters, e.g. leukocyte filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/362—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits changing physical properties of target cells by binding them to added particles to facilitate their subsequent separation from other cells, e.g. immunoaffinity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3672—Means preventing coagulation
    • A61M1/3675—Deactivation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/10—Enterobacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/554—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
    • G01N33/555—Red blood cell
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3623—Means for actively controlling temperature of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3672—Means preventing coagulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0429—Red blood cells; Erythrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/75—General characteristics of the apparatus with filters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/26—Infectious diseases, e.g. generalised sepsis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Dispersion Chemistry (AREA)

Abstract

The invention relates to methods and systems for removal of pathogens from blood or blood products. The invention further relates to methods and systems for treatment and diagnosis of infection in the blood and/or sepsis in a patient in need thereof.
EP25181169.1A 2015-01-26 2016-01-26 Methods and systems for the detection and removal of pathogens from blood Pending EP4597105A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15152486 2015-01-26
EP16714040.9A EP3250713B1 (en) 2015-01-26 2016-01-26 Methods and systems for the detection and removal of pathogens from blood
PCT/NL2016/050058 WO2016122316A2 (en) 2015-01-26 2016-01-26 Methods and systems for the detection and removal of pathogens from blood

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP16714040.9A Division-Into EP3250713B1 (en) 2015-01-26 2016-01-26 Methods and systems for the detection and removal of pathogens from blood
EP16714040.9A Division EP3250713B1 (en) 2015-01-26 2016-01-26 Methods and systems for the detection and removal of pathogens from blood

Publications (2)

Publication Number Publication Date
EP4597105A2 EP4597105A2 (en) 2025-08-06
EP4597105A3 true EP4597105A3 (en) 2025-10-22

Family

ID=52462801

Family Applications (2)

Application Number Title Priority Date Filing Date
EP16714040.9A Active EP3250713B1 (en) 2015-01-26 2016-01-26 Methods and systems for the detection and removal of pathogens from blood
EP25181169.1A Pending EP4597105A3 (en) 2015-01-26 2016-01-26 Methods and systems for the detection and removal of pathogens from blood

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP16714040.9A Active EP3250713B1 (en) 2015-01-26 2016-01-26 Methods and systems for the detection and removal of pathogens from blood

Country Status (6)

Country Link
US (2) US10994068B2 (en)
EP (2) EP3250713B1 (en)
AU (1) AU2016212815B2 (en)
SG (1) SG11201706096YA (en)
WO (1) WO2016122316A2 (en)
ZA (1) ZA201705297B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11908581B2 (en) 2018-04-10 2024-02-20 Hill-Rom Services, Inc. Patient risk assessment based on data from multiple sources in a healthcare facility
US11504071B2 (en) 2018-04-10 2022-11-22 Hill-Rom Services, Inc. Patient risk assessment based on data from multiple sources in a healthcare facility
EP3607978A1 (en) * 2018-08-06 2020-02-12 Pentracor GmbH Simplified regeneration of apheresis columns
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
US20220233756A1 (en) * 2019-05-17 2022-07-28 George A. Herzlinger Methods and systems for treating microbial disease
EP4037726A1 (en) * 2019-09-30 2022-08-10 hemotune AG Assembly for extracorporeal treatment of body fluids
US20230201440A1 (en) * 2020-05-08 2023-06-29 Innovative Cellular Therapeutics Holdings, Ltd. System and method for gene and/or cellular therapy
US20230310728A1 (en) * 2022-03-10 2023-10-05 Terumo Bct, Inc. Methods for providing automatic flow adjustments

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE452336B (en) * 1978-06-16 1987-11-23 Boehringer Mannheim Gmbh PROCEDURE FOR DISPOSAL OF DISEASE-BREATHING MICROORGANISMS WHICH ADSORBATED EXTRACORPORAL ON A SELECTIVE BINDING ADSORBENT
EP0894870B1 (en) 1995-08-17 2012-10-10 Myconostica Limited Extraction of fungal cells from clinical material
EP1455860B1 (en) 2001-12-10 2011-08-31 CaridianBCT, Inc. Method for the leukoreduction of red blood cells
US9199016B2 (en) 2009-10-12 2015-12-01 New Health Sciences, Inc. System for extended storage of red blood cells and methods of use
WO2012057029A1 (en) * 2010-10-25 2012-05-03 株式会社カネカ Novel leucocyte removal filter
EP2645854B1 (en) 2010-11-29 2017-10-18 New York Blood Center, Inc. Method of blood pooling and storage
CA2860158A1 (en) * 2011-01-07 2012-07-12 Somerset Group Enterprises, Inc. Modular extracorporeal systems and methods for treating blood-borne diseases
WO2012125470A1 (en) * 2011-03-11 2012-09-20 Fenwal, Inc. Membrane separation devices, systems and methods employing same and data management systems and methods

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "Microscopic Procedures for Diagnosing Malaria", 8 June 2007 (2007-06-08), XP055274013, Retrieved from the Internet <URL:http://www.cdc.gov/mmwr/preview/mmwrhtml/ss5606a3.htm> [retrieved on 20160520] *
CARDO LISA J ET AL: "Removal of Plasmodium falciparum-infected red blood cells from whole blood by leukoreduction filters", TRANSFUSION, AMERICAN ASSOCIATION OF BLOOD BANKS, BETHESDA, MD, US, vol. 49, no. 2, 1 February 2009 (2009-02-01), pages 337 - 346, XP002567071, ISSN: 0041-1132, [retrieved on 20081112], DOI: 10.1111/J.1537-2995.2008.01974.X *
H. HARTMANN ET AL: "Rapid Identification of Staphylococcus aureus in Blood Cultures by a Combination of Fluorescence In Situ Hybridization Using Peptide Nucleic Acid Probes and Flow Cytometry", JOURNAL OF CLINICAL MICROBIOLOGY, vol. 43, no. 9, 1 September 2005 (2005-09-01), US, pages 4855 - 4857, XP055296834, ISSN: 0095-1137, DOI: 10.1128/JCM.43.9.4855-4857.2005 *
HAYK MINASYAN: "Erythrocyte and blood antibacterial defense", EUROPEAN JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY, vol. 4, no. 2, 1 June 2014 (2014-06-01), pages 138 - 143, XP055274019, ISSN: 2062-509X, DOI: 10.1556/EuJMI.4.2014.2.7 *
J.-M. HAMENT ET AL: "Pneumococcal immune adherence to human erythrocytes", EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, vol. 33, no. 2, 1 February 2003 (2003-02-01), GB, pages 169 - 175, XP055277113, ISSN: 0014-2972, DOI: 10.1046/j.1365-2362.2002.01109.x *
MASAYA YAMAGUCHI ET AL: "Streptococcus pneumoniae Invades Erythrocytes and Utilizes Them to Evade Human Innate Immunity", PLOS ONE, vol. 8, no. 10, 23 October 2013 (2013-10-23), US, pages e77282, XP055296830, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0077282 *

Also Published As

Publication number Publication date
WO2016122316A3 (en) 2016-10-27
WO2016122316A2 (en) 2016-08-04
EP3250713B1 (en) 2025-07-09
EP4597105A2 (en) 2025-08-06
SG11201706096YA (en) 2017-08-30
EP3250713A2 (en) 2017-12-06
CA2974913A1 (en) 2016-08-04
US20210353843A1 (en) 2021-11-18
EP3250713C0 (en) 2025-07-09
AU2016212815B2 (en) 2022-03-03
US20180264186A1 (en) 2018-09-20
AU2016212815A1 (en) 2017-08-17
WO2016122316A8 (en) 2016-09-01
US10994068B2 (en) 2021-05-04
ZA201705297B (en) 2023-01-25

Similar Documents

Publication Publication Date Title
EP4597105A3 (en) Methods and systems for the detection and removal of pathogens from blood
MX2024009339A (en) Methods for diagnosis of bacterial and viral infections.
EP3544483A4 (en) System and method for medical condition diagnosis, treatment and prognosis determination
EP3194373A4 (en) Diagnostic system and process for rapid bacterial infection diagnosis
IL256256A (en) System and method for extracorporeal blood treatment
HUE056608T2 (en) Trispecific and / or trivalent binding proteins for the prevention or treatment of HIV infection
WO2015153889A3 (en) Materials and methods for the treatment of latent viral infection
EP3115014A4 (en) Endoscope treatment system and endoscopic treatment tool
EP3294108A4 (en) Method and system for steam sterilization of endoscopes
EP4056208C0 (en) SYSTEMS FOR THE TREATMENT OF BLOOD
EP3238761A4 (en) Blood treatment system
EP3275393A4 (en) Medical observation device, surgical observation device, and medical observation system
MA40535A (en) Hsp90-targeted inflammation and infection imaging and therapy
EP3242954A4 (en) Diagnosis and treatment of incipient diabetes
PL3125969T3 (en) Extracorporeal blood treatment alarm docking
EP3337828C0 (en) Anti-PCSK9 inhibitory antibodies for the treatment of patients with hyperlipidemia undergoing lipoprotein apheresis
EP2978449A4 (en) Compositions and methods for the treatment or prevention of human immunodeficiency virus infection
WO2013150126A3 (en) Method for treating blood, blood products and organs
EP3167830A4 (en) Locking plate system for treatment of fracture of distal radius
PL3183003T3 (en) Methods for prevention and/or treatment of infection
WO2016086153A3 (en) Use of hsp90 inhibitors for the treatment of hiv infections and aids
EP3632365A4 (en) MEDICAL OBSERVATION DEVICE, PROCESSING METHOD AND MEDICAL OBSERVATION SYSTEM
EP3278717A4 (en) Signal processing device and medical observation system
AU2016272910B2 (en) Testing of a medical fluid treatment system
EP3263010A4 (en) Over-tube for endoscope, and medical system

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20250605

AC Divisional application: reference to earlier application

Ref document number: 3250713

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Free format text: PREVIOUS MAIN CLASS: G01N0033500000

Ipc: C12Q0001680000

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

RIC1 Information provided on ipc code assigned before grant

Ipc: C12Q 1/68 20180101AFI20250917BHEP

Ipc: A61M 1/36 20060101ALI20250917BHEP

Ipc: G01N 33/50 20060101ALI20250917BHEP