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EP4580533A1 - Sonde et appareil d'électroporation - Google Patents

Sonde et appareil d'électroporation

Info

Publication number
EP4580533A1
EP4580533A1 EP23762520.7A EP23762520A EP4580533A1 EP 4580533 A1 EP4580533 A1 EP 4580533A1 EP 23762520 A EP23762520 A EP 23762520A EP 4580533 A1 EP4580533 A1 EP 4580533A1
Authority
EP
European Patent Office
Prior art keywords
electrode
probe
inner electrode
tissue
electroporation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP23762520.7A
Other languages
German (de)
English (en)
Inventor
Declan Soden
Colin Forde
Jason MCNAMARA
Cian KERRIGAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mirai Medical Ltd
Original Assignee
Mirai Medical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mirai Medical Ltd filed Critical Mirai Medical Ltd
Publication of EP4580533A1 publication Critical patent/EP4580533A1/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1477—Needle-like probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
    • A61B2018/00267—Expandable means emitting energy, e.g. by elements carried thereon having a basket shaped structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00273—Anchoring means for temporary attachment of a device to tissue
    • A61B2018/00291—Anchoring means for temporary attachment of a device to tissue using suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00613—Irreversible electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1405—Electrodes having a specific shape
    • A61B2018/142—Electrodes having a specific shape at least partly surrounding the target, e.g. concave, curved or in the form of a cave
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1405—Electrodes having a specific shape
    • A61B2018/1425—Needle

Definitions

  • Such treatment is for treating/ablating tissue or tumours within body structures such as the oesophagus, stomach, colon and other Gastrointestinal areas particularly but the human body more generally including cutaneous disease.
  • the present invention is directed towards providing an improved electroporation probe and apparatus to address these problems.
  • the needle depth is adjustable relative to the elongate support. In some preferred examples, the outer electrode diameter/lateral dimension is adjustable.
  • the inner electrode is configured to penetrate tissue.
  • the inner electrode comprises a needle.
  • the inner electrode is mounted as an extension of the elongate support.
  • the elongate support comprises an endoscope.
  • the inner electrode is hollow for at least some of its length and is configured for delivery of a fluid to tissue being treated.
  • the needle has radial apertures for radial delivery of a fluid in addition to or instead of through a needle tip.
  • the outer electrode is deformable for engagement with a proximal facing surface of tissue being treated.
  • the outer electrode comprises an expanding body supporting or being integral with electrode elements.
  • the outer electrode comprises an expanding mesh.
  • the outer electrode comprises non-meshing wire elements
  • the outer electrode comprises an expanding body supporting discrete electrode elements at a distal end thereof, and optionally the elements are disc shaped.
  • the outer electrode diameter/lateral dimension is adjustable.
  • the elongate support is capable of being steered/positioned with respect to the outer electrode and the endoscope.
  • the outer and/or inner electrodes are steerable in relation to the elongate support.
  • the inner electrode is steerable either with the elongate support or relative to the elongate support.
  • the inner electrode includes an electrode element which is not needle-shaped but has a lateral dimension in the range of 1 mm to 10 mm to press distally against tissue being treated.
  • an electroporation apparatus comprising a probe of any example described herein and a pulse generator linked with said conductor for delivery of pulses to the electrodes.
  • the apparatus further comprises a pump for delivery of a fluid through the inner electrode.
  • Figs. 1(a), 1(b), and 1(c) are views showing use of an electroporation probe of the invention, having an expanding body made from an interwoven metal mesh, the use being in a potato for test purposes, this having a broadly similar set of characteristics to tissue to be treated, and in which Fig. 1(c) in particular illustrates the treated volume;
  • Fig. 1(d) is an image showing a section through a treated region of a potato in a test;
  • Fig. 1(e) is a computer generated simulation image illustrating applied voltage patterns for an probe with an outer electrode OE and an inner electrode IE;
  • Fig. 2 shows another probe before deployment, and Fig. 3 shows it with compression of the expanding body to illustrate the shape of the expanding body when not compressed on the distal side as it would be in use;
  • Fig. 4 shows an expanding body variant which has a shape with a distal part which is close to radial, to confer better contact between the expanding body and the tissue against which it is to be pushed;
  • Fig. 5 shows a different probe, in which there is not an interwoven mesh but instead a series of shape memory alloy wire loops which are arranged circumferentially similar to the petals of a flower, and which are heat-set to have the shape of an open flower when released from an overlayed sheath;
  • Fig. 6 is a set of perspective views showing alternative needle configurations for the inner electrode, some with radial pores/slots for flow of a treatment substance such as foam;
  • Fig. 7 is a diagrammatic side view of an alternative probe, in this case with disc-shaped electrode elements on the outer electrode, particularly suited for optimum contact with the proximal-facing surface of tissue being treated;
  • Fig. 8 is a diagrammatic side view of a further alternative probe, in this case with a mesh of electrode wires on the distal end of the mesh-shaped outer electrode or balloon;
  • Fig. 9 is a diagrammatic side view of a further alternative probe, in this case with circumferentially arranged non-meshing wires which are configured to extend radially inwardly and proximally at the distal end;
  • Fig. 10 is a diagrammatic side view of an alternative probe, in this case with an off-centre, asymmetric, expanding body which may be better suited for full tissue engagement when probes of this type are inserted into tissue at an angle due to geometric obstructions which would prevent their use perpendicular to the tissue to be treated;
  • Figs. 11, 12, and 13 are diagrammatic perspective views of alternative probes with directionality in articulation of the support rod and/or the needle electrode;
  • Figs. 16 and 17 are views of alternative probes having an inner electrode which is not configured to penetrate tissue, but rather to push against it,
  • Fig 18 (a) and 18 (b) illustrate two states of a probe of the invention, wherein the inner electrode is expandable and can expand to a lesser radial extent than the other electrode,
  • Figs. 19(a) to (f) inclusive show an alternative probe in which the inner electrode comprises an expanding mesh which is not configured to penetrate tissue, and in particular:
  • Fig. 19(a) is a side view when the probe is collapsed prior to deployment
  • Fig. 19(b) is a side view with the probe expanded
  • Fig. 19(d) is a diagrammatic side view showing the probe with the electrodes in contact with a tissue surface, showing how both of the electrodes push against the tissue surface to indent it rather than penetrate it and the region of treatment is illustrated,
  • Fig. 19(e) is an image of a prototype of the probe shown in Figs. 19(a) to (d), and Fig. 19(f) is an image showing this prototype when pressed against a hard surface to illustrate how it deforms upon contact with tissue.
  • Fig 20 illustrates a probe without an inner electrode
  • Figs 21(a) to (e) inclusive show options for inner electrodes which may be provided, which facilitate secure temporary attachment of the probe to tissue.
  • an electroporation probe of the invention allows physicians to treat a variety of shapes of tumours within the body with an ability to: consistently successfully access the target, see the target lesion during or just before treatment, have good capability to manoeuvre, control the depth of treatment, and control the width of treatment.
  • an electroporation probe has an elongate support with conductors linked to an inner electrode and an outer electrode to engage tissue.
  • the inner electrode may be in the form of a needle to penetrate tissue on-axis, or it may just push against tissue.
  • the outer electrode engages tissue radially outwardly of the inner electrode, with a pressing action.
  • a large volume of tissue can be treated, in a manner which is very accurately located, in a conical pattern with an apex at the distal tip of the inner electrode (2 in Figs. 1(a) to 1(c)) and expanding proximally to the outer electrode (3 in Figs. 1(a) to 1(c)).
  • an electroporation probe 1 comprises an inner electrode provided by a leading needle 2, proximally of which there is an outer electrode provided by an expanding basket 3 with an exposed wire mesh forming an outer electrode, all mounted to a flexible rod 4.
  • a pulse generator is linked to drive the inner and outer electrodes 2 and 3, and there is an insulating sheath 11 around the rod 4 between the outer electrode 3 and the inner electrode 2.
  • the pulse generator linked to the conductors at the proximal end of the rod 4 may be of any suitable type, and an example is described in our published specification WO2021/043779 (Mirai Medical Ltd.), the contents of which are incorporated by reference.
  • the probe 1 is manoeuvred to the target site, and the user operates an actuator to unsheathe the needle 2 based on the depth of treatment required. This accounts for the shrouded portion between the needle electrode 2 and the expanding electrode 3 which will also contact tissue.
  • the user advances the probe with the needle 2 penetrating the tissue to the user-defined depth.
  • the user then actuates the expanding electrode body to its expanded state.
  • the outer electrode 3 is configured to contact tissue over an annular area around the axis of the inner electrode 2 and of the elongate support 4, and proximally of the distal end of the inner electrode.
  • the user interacts with the pulse generator to control pulses delivered to the needle 2 and to the mesh metal basket 3 (or nonmetal but with electrodes on its frame or body) pushed against the tissue front surface.
  • the sheath 4 There are separate conductors contained within the sheath 4, one for each of the needle 2 (inner electrode) and the basket 3 (outer electrode). Control of the needle 2 penetration depth allows the physician to treat lesions of a location, depth and spread they would not have been able to before.
  • the invention provides major advantages in utility, safety and speed over multi needle device designs.
  • the one needle may be more robust than those that likely would be chosen in a multi needle arrangement.
  • the outer electrode 3 allows the desired current carrying capacity and is able to conform to the shape of the surface of the tissue facing proximally.
  • the leading needle could be solid, hollow and/or tipped in such a manner as to allow delivery of chemotherapy or other treatment fluid to cause cell death or manage tissue impedance.
  • the fact that the needle can be both the centre (inner) electrode and also a conduit for delivery of the required substance means the substance is always in the correct location for the treatment, which may maximise efficacy.
  • the requirement not to use a secondary device for substance delivery potentially decreases procedural time and risk while enhancing procedure safety and accuracy.
  • ECT Electrochemotherapy
  • the procedure outcome is likely to be more efficacious due to the elimination of a time delay between intra- tumoural injection and subsequent electroporation as it is recommended that this take place as fast as possible as the injected agent will have less time to dissipate.
  • the elongate support includes a conduit for flow of fluid to the needle. This conduit runs parallel to the insulated power conductors delivering the pulses to the electrodes.
  • the probe may include a removable sheath for the expanding body.
  • an expanding body may be unsheathed from the proximal end in a manner well known in the art of balloons and stents; this would allow the physician to decide, for example, to unsheathe enough basket material such that the resulting basket has a certain diameter such as 20 mm: the amount unsheathed defining the basket resulting diameter and thus the spread of the electroporation experienced by the tissue.
  • the region 20 is generally conical, with an apex at the distal end (tip) of the inner electrode 2 and expanding proximally.
  • the probe produces an Irreversibly Electroporated region that demonstrates the electric field produced by this device is cone shaped, more specifically “Strawberry shaped”. Deployment of the central electrode to a shallower depth produces a field shape that could be described as ellipsoid.
  • the region demonstrating cell wall disturbance for the test shown is illustrated in Figs. 1(c) and 1(d) and is identified by the numeral 20.
  • Fig 1(d) demonstrates the irreversibly electroporated region generated in a potato using a prototype device to deliver eight 600 V unipolar square wave pulses at a rate of 10 Hz, the affected region in this example was estimated at 10 cubic centimetres however this is dependent on the tissue, the pulse type and quantity and the specific prototype dimensions but serves to demonstrate that relatively large volumes of tissue can be treated using a probe of the invention.
  • Fig. 1(e) is a computer-generated simulation image illustrating applied voltage patterns for a probe with an outer electrode OE and an inner electrode IE.
  • the outer electrode OE has a washer-shaped configuration
  • the inner electrode IE has a needle configuration.
  • the electroporation field ranges from a value in the range of 2 kV/cm to 3 kV/cm around the inner electrode IE to a value in the range of 600 kV/cm to 1500 kV/cm close to the outer electrode OE.
  • the probe 1 preferably has a maximum diameter of less than 11 mm (a common endoscope diameter). It more preferably has a maximum diameter of less that 3.7 mm, which is a common endoscope instrument channel diameter. It may be less than 3.2 mm, less than 2.8 mm, or less than
  • I.8 mm which are other common endoscope instrument channel for smaller scopes.
  • the preferred shortest longitudinal length of the outer electrode when fully compressed is in the range of 0.5 mm to 20 mm.
  • the inner electrode can penetrate as far as required into tissue to be treated, whereas the outer electrode can surround the inner electrode, but be isolated from it by the sheath
  • Electroporation may be performed with desired voltages and other electrical parameters between the electrodes 2 and 3.
  • the probe may have different configurations to provide an inner electrode and an outer electrode.
  • the inner electrode is aligned with the longitudinal axis of the rod or catheter and the second electrode contacts tissue at a location radially spaced apart from the axis and in many cases contacts over an annular area around the axis, and proximally of the distal end of the inner electrode.
  • FIG. 2 there is shown a probe 21 before deployment, with a low profile being very small in the lateral/radial direction.
  • an outer electrode 23 has a narrow cylindrical shape before deployment, and there is a needle-shaped inner electrode 25 distally of the outer electrode.
  • a proximal rod 24 which contains the conductors linked to the electrodes, and an insulating sheath 22 distally of the outer electrode 23.
  • Fig. 3 shows it with axial compression of the expanding body 23 to illustrate the shape of the expanding body in its expanded state, this is its shape when not compressed on the distal side, by tissue with which it is interacting, as it would be in use.
  • the outer electrode has a pre-depl oyment diameter greater than that of the rod proximally of it.
  • the outer electrode, and potentially also the inner electrode are housed within a sheath pre-deployment, and they are exposed for use by retraction of the sheath.
  • Fig. 4 shows a probe 50 with an alternative outer electrode expanding body 53 which has a shape designed to potentially confer a greater surface area of contact between the outer electrode expanding body and the tissue against which it is pushed.
  • the distal end 55 is close to radial, conforming to within +/- 30° a plane which is normal to the longitudinal axis defined by the elongate support 54.
  • the expanded and unconstrained configuration of the expanding body has a large angle to normal at the distal end.
  • the inner electrode is indicated by the numeral 56 and is needle-shaped.
  • the expanding body may be configured to deform in any of a number of ways to provide effective electrode contact with the proximally facing tissue surface.
  • Fig. 5 shows a probe 100 with an outer electrode expanding body 103, a needle-shaped inner electrode 110, an insulating sheath 111 around the inner electrode 110 proximally of its tip, and a proximal support rod which houses electrode conductors and is linked to a user actuator.
  • the expanding body 103 has a series of shape memory alloy wire loops which are arranged circumferentially similar to the petals of a flower, and which are heat set to have the shape of an open flower when released from an overlayed sheath. Again, the configuration at the distal end of the expanding body will be close to normal when pressed against a surface around the needle 110, defining a much greater angle to the longitudinal axis than the proximal end 105.
  • the wire of the outer electrode 103 may be constructed of Nickel Titanium Alloy NiTi and shape set to be in their heat set form at a temperature just below human body temperature, thus ensuring that the NiTi demonstrates its super elastic capabilities and thus the petals are capable of being sheathed and unsheathed repeatably without undergoing plastic deformation and thus maintaining their intended deployed shape.
  • An advantage of this “Petal” design is that the clinician has additional scope for advancing the device further into the tissue which would, when correctly shaped, cause more of the wire loops to come into contact with the tumour surface thus enhancing the contact surface area. In one implementation this could be so implemented as to allow the user vary the diameter of the contact area also.
  • the probe 150 hollow with a tip, with radial holes at a higher density than in the probe 130.
  • the apertures may be smaller for lower viscosity liquids.
  • Fig. 7 shows an alternative probe, 200, in this case with an outer electrode comprising an array of disc-shaped electrodes 202 on a supporting expanding balloon body 201.
  • an outer electrode comprising an array of disc-shaped electrodes 202 on a supporting expanding balloon body 201.
  • a leading distal needle 210 forming the inner electrode, the proximal end of which is surrounded by an insulating sheath 211.
  • the drive provides a voltage in pulses between the inner electrode 210 and all of the outer electrode elements 202, the latter all being electrically connected together.
  • the electrode elements may be on an expanding mesh of insulated wire.
  • Fig. 8 shows a further alternative probe, 300, in this case with a mesh 302 of electrode wires on the distal end of a balloon expanding body 301, and a needle 310 and proximal sheath 311.
  • Fig. 9 shows a further alternative probe, 400, in which the outer electrode comprises a number of separate wire loops 403.
  • the loops 403 are circumferentially arranged around the longitudinal axis, formed from a laser cut shape memory alloy tube or assembly of shape memory wires, which are configured to extend radially inwardly and proximally at the distal end.
  • FIG. 10 is a diagrammatic side view of an alternative probe, 500, in this case with an off-centre, asymmetric, expanding body 501 which may be better suited for full tissue engagement when probes of this type are inserted into tissue at an angle due to geometric obstructions which would prevent their use perpendicular to the tissue to be treated.
  • a probe 750 in this case having a dish-shaped outer electrode 752 and an elongate and bent inner electrode 751 to allow access to a particular location within tissue.
  • the rod which supports the electrodes is in use steered by the clinician so that the inner electrode penetrates the tissue in the desired direction.
  • the outer electrode is dish shaped, as the electrodes 702 and 752 are expandable, they are preferably of shape memory material.
  • Fig. 13 shows a probe 800 within a steerable endoscope 801, and a dish-shaped outer electrode 802 which extends distally and radially when employed for optimum contact with the tissue proximally facing surface, and a needle 804.
  • the head formed by the electrodes 802 and 804 is hinged to the device’s elongate body to allow versatile manipulation.
  • Fig. 14 shows a probe 900 with an elongate support 901, an outer electrode formed by non-meshing wires 902, and a needle 903 with apertures along its length providing the inner electrode.
  • Fig. 15 shows a probe 1000 with an elongate support 1001, and an outer electrode 1002 formed by non-meshing wires 1004 supporting flexible wires extending circumferentially, and a needle with apertures along its length providing the inner electrode.
  • Figs. 16 and 17 show a probe 1100 with an elongate support 1101 and an outer electrode formed by non-meshing wires 1102
  • an inner electrode 1103 comprises an elongate rod 1104 terminating at its distal end with a frusto-conical shaped element 1103 which does not pierce tissue but rather presses against it. There is placement of the inner electrode 1103 against the tissue to be treated with the force as required to ensure good electrode-tissue contact.
  • Figs. 18(a) and (b) illustrate two states of a probe 1200 of the invention in which the inner electrode is expandable and can expand to a lesser extent than the outer electrode.
  • the outer electrode 1201 is an expanding mesh of conductive wires for engaging tissue in an annular region around the longitudinal axis.
  • the inner electrode 1204 may/may not have a needle tip for penetrating tissue to a limited extent.
  • the inner electrode is an expanding mesh to increase the surface area contact with the tissue without tissue penetration within the annular region defined by the distally facing part of the outer electrode 1201. Benefits of this arrangement are to provide a sufficient electrical field by maximising tissue contact area whilst avoiding tissue penetration.
  • a probe 1250 has a support 1252 with an outer electrode 1251 having an expanding mesh which is dish-shaped when expanded to present an annular mesh to facing tissue.
  • an inner electrode comprising an expanding mesh which is smaller in radial dimension than the outer electrode 1251 and is generally ball shaped.
  • the inner electrode 1254 in use, presses tissue distally to a great er extent than the outer electrode 1251, providing a dish-shaped treatment region 1270.
  • Figs. 19(e) and (f) show this probe in the form of a prototype pressed against a hard surface for illustrative purposes.
  • the inner electrode comprises an expanding mesh
  • it may have any of the features described above for the outer electrode, though having a smaller radial dimension.
  • it may have discrete electrode elements mounted to a wire mesh or it may have non-contacting wire loops in a petal-shaped arrangement.
  • Figs. 20 and 21 illustrate variations of elements of the probe of this invention which facilitate secure temporary attachment of the probe to the tissue.
  • Fig. 20 shows a probe with a rod 1301 and an expanding mesh outer electrode 1302 with meshed wires 1303 and a distal insulating sleeve 1304.
  • the inner electrode may be any of those illustrated in Figs. 1 (a) to (e) inclusive, as follows, each operated by a proximal actuator at the proximal end of the elongate support 1301.
  • a clamping element 1310 with a pair of jaws for closing over tissue on the longitudinal axis. In use this can be used to clamp onto the centre of target tissue ensuring maintenance of position during delivery of pulses.
  • a screw 1320 In use this can be used, via controlled rotation of the centre element, to grip the centre of target tissue ensuring maintenance of position during delivery of pulses.
  • a suction cup 1330 to form a vacuum. In use this can be used to grip via suction the centre of target tissue ensuring maintenance of position during delivery of pulses.
  • a partially shrouded shape set element 1340 which when expanded, increases surface contact area with tissue and facilitates maintenance of position during delivery of pulses via suction applied through the gaps present in its body.
  • Fig. 21(e) a hook, which when revealed forms a hooking engagement with tissue.
  • the probe of the invention has in many embodiments an elongate support with electrical conductors extending from a proximal end to a distal end, the support supporting at least two electroporation electrodes connected to at least two conductors and being mounted to engage tissue.
  • an inner electrode which is substantially on the longitudinal axis, or bent off it to some extent, and in many examples, it is suited to penetrate tissue, or press against tissue in the distal direction to the desired depth, or to grip tissue (Figs. 20 and 21).

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  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plasma & Fusion (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Otolaryngology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
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  • Surgical Instruments (AREA)

Abstract

Une sonde d'électroporation a un support allongé (2) avec des conducteurs reliés à une électrode interne (2) et une électrode externe (3) pour venir en prise avec un tissu. L'électrode interne peut se présenter sous la forme d'une aiguille (3) pour pénétrer dans le tissu sur l'axe, ou elle peut juste pousser contre le tissu (1103, 1254). L'électrode externe vient en prise avec un tissu radialement vers l'extérieur de l'électrode interne, avec une action de pression. Un grand volume (20) de tissu peut être traité, de manière très précisément localisée, selon un motif conique avec un sommet au niveau de la pointe distale de l'électrode interne (2) et se dilatant de manière proximale par rapport à l'électrode externe (3).
EP23762520.7A 2022-09-02 2023-09-01 Sonde et appareil d'électroporation Pending EP4580533A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP22193699 2022-09-02
PCT/EP2023/073999 WO2024047215A1 (fr) 2022-09-02 2023-09-01 Sonde et appareil d'électroporation

Publications (1)

Publication Number Publication Date
EP4580533A1 true EP4580533A1 (fr) 2025-07-09

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EP23762520.7A Pending EP4580533A1 (fr) 2022-09-02 2023-09-01 Sonde et appareil d'électroporation

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Country Link
EP (1) EP4580533A1 (fr)
WO (1) WO2024047215A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4593740A2 (fr) * 2022-09-30 2025-08-06 Alpfa Medical, Inc. Appareil et procédés d'ablation de tissu
WO2025213017A1 (fr) * 2024-04-04 2025-10-09 Alpfa Medical, Inc. Appareils et systèmes de cathéter pour thérapie par ablation par champ électrique pulsé

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WO2009036459A1 (fr) * 2007-09-14 2009-03-19 Lazure Technologies, Llc Sonde à plusieurs dents et traitement par actionnement de dents opposées
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