[go: up one dir, main page]

EP4436964A4 - Analogues de mdma pour moduler l'activité de sert, de dat et/ou de net - Google Patents

Analogues de mdma pour moduler l'activité de sert, de dat et/ou de net

Info

Publication number
EP4436964A4
EP4436964A4 EP22896885.5A EP22896885A EP4436964A4 EP 4436964 A4 EP4436964 A4 EP 4436964A4 EP 22896885 A EP22896885 A EP 22896885A EP 4436964 A4 EP4436964 A4 EP 4436964A4
Authority
EP
European Patent Office
Prior art keywords
mdma
sert
dat
analogues
modulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP22896885.5A
Other languages
German (de)
English (en)
Other versions
EP4436964A1 (fr
Inventor
Glenn Pullella
Michael Gandy
Adrian Scaffidi
Jasmine King
Matthew Piggott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Western Australia
Original Assignee
University of Western Australia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2021903836A external-priority patent/AU2021903836A0/en
Application filed by University of Western Australia filed Critical University of Western Australia
Publication of EP4436964A1 publication Critical patent/EP4436964A1/fr
Publication of EP4436964A4 publication Critical patent/EP4436964A4/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/54—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP22896885.5A 2021-11-26 2022-11-28 Analogues de mdma pour moduler l'activité de sert, de dat et/ou de net Pending EP4436964A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2021903836A AU2021903836A0 (en) 2021-11-26 Analogues
AU2022901261A AU2022901261A0 (en) 2022-05-12 Analogues
PCT/AU2022/051422 WO2023092195A1 (fr) 2021-11-26 2022-11-28 Analogues de mdma pour moduler l'activité de sert, de dat et/ou de net

Publications (2)

Publication Number Publication Date
EP4436964A1 EP4436964A1 (fr) 2024-10-02
EP4436964A4 true EP4436964A4 (fr) 2025-10-08

Family

ID=86538463

Family Applications (1)

Application Number Title Priority Date Filing Date
EP22896885.5A Pending EP4436964A4 (fr) 2021-11-26 2022-11-28 Analogues de mdma pour moduler l'activité de sert, de dat et/ou de net

Country Status (5)

Country Link
EP (1) EP4436964A4 (fr)
JP (1) JP2024544586A (fr)
AU (1) AU2022399234A1 (fr)
CA (1) CA3239040A1 (fr)
WO (1) WO2023092195A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018064465A1 (fr) 2016-09-29 2018-04-05 The Regents Of The University Of California Composés pour l'augmentation de la plasticité neuronale
WO2020176599A1 (fr) 2019-02-27 2020-09-03 The Regents Of The University Of California Azépino-indoles et autres hétérocycles pour traiter des troubles du cerveau
CA3239565A1 (fr) 2021-12-15 2023-06-22 Delix Therapeutics, Inc. Psychoplastogenes substitues par phenoxy et benzyloxy et leurs utilisations

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005051887A1 (fr) * 2003-11-26 2005-06-09 Japan Science And Technology Agency Methode de synthese d'allylamine asymetrique
WO2005063724A1 (fr) * 2003-12-23 2005-07-14 Basf Aktiengesellschaft Composes 1-(azolin-2-yl) amino-1,2-diphenylethane destines a la lutte contre les insectes, les arachnides et les nematodes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005051887A1 (fr) * 2003-11-26 2005-06-09 Japan Science And Technology Agency Methode de synthese d'allylamine asymetrique
WO2005063724A1 (fr) * 2003-12-23 2005-07-14 Basf Aktiengesellschaft Composes 1-(azolin-2-yl) amino-1,2-diphenylethane destines a la lutte contre les insectes, les arachnides et les nematodes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2023092195A1 *

Also Published As

Publication number Publication date
AU2022399234A1 (en) 2024-05-23
CA3239040A1 (fr) 2023-06-01
EP4436964A1 (fr) 2024-10-02
WO2023092195A1 (fr) 2023-06-01
JP2024544586A (ja) 2024-12-03

Similar Documents

Publication Publication Date Title
EP4436964A4 (fr) Analogues de mdma pour moduler l'activité de sert, de dat et/ou de net
EP4009725A4 (fr) Procédé de mise à jour d'informations de faisceau et appareil de communication
EP3880685C0 (fr) Inhibiteurs d'arg1 et/ou d'arg2
EP4068130A4 (fr) Système de partage de données, procédé de partage de données et programme de partage de données
DE102022120616A8 (de) Selbstheilung von Rechenzentren
EP3912623C0 (fr) Pd-0184264 pour le traitement des infections à coronavirus et/ou d'une tempête de cytokines de la covid-19
EP4163847C0 (fr) Détermination d'une ou plusieurs caractéristiques ainsi que simulation de trafic pour un environnement pouvant être mis à l'échelle automatiquement
EP3701391A4 (fr) Système et procédé pour actualiser des données dans une chaîne de blocs
EP3921445C0 (fr) Détection d'un cancer, d'un tissu cancéreux d'origine et/ou d'un type de cellule cancéreuse
EP3967321A4 (fr) Utilisation de cyclo-his-pro (chp) pour prévenir, améliorer ou traiter la fibrose
EP3987420A4 (fr) Procédé pour empêcher une attaque d'accès au niveau racine et plate-forme de sécurité et de conformité de sla mesurables
EP4271255A4 (fr) Dispositifs et procédés de patch ecg ambulatoire
EP4239928A4 (fr) Procédé de configuration, d'activation et de désactivation de duplication pdcp et terminal
EP3768402A4 (fr) Vérification d'inondation de données et performance améliorée de processus de jeu
EP4206896C0 (fr) Identification de bits aléatoires dans des paquets de données de commande
EP4024115A4 (fr) Dispositif de traitement d'informations chirurgicales, procédé de traitement d'informations chirurgicales et programme de traitement d'informations chirurgicales
EP3933037C0 (fr) Criblage, identification et expression optimisée de la chondrosulfatase
EP3582702A4 (fr) Systèmes, méthodes et dispositifs d'élimination de thrombus et/ou de plaque molle
EP4147137A4 (fr) Génération et modification de contenu à l'aide de structures de données
EP4362027A4 (fr) Appareil d'exploration, système et programme informatique pour explorer des informations de marqueur moléculaire ou d'activité physiologique dans un tissu se rapportant à une distribution ou à une activité physiologique de matériau en cours d'exploration
EP3764917A4 (fr) Dispositifs pour guider des procédures de traitement et/ou d'ablation de tissu
PL4077317T3 (pl) Tienylooksazolony i analogi
EP3855449A4 (fr) Procédé d'échantillonnage de données biométriques et appareil de gestion d'échantillonnage associé
EP3920692A4 (fr) Système de surveillance d'insectes et de créatures
EP4473478A4 (fr) Systèmes et procédés favorisant la croissance, la santé ou la résilience du corail

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20240624

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Free format text: PREVIOUS MAIN CLASS: C07D0413060000

Ipc: C07D0317580000

A4 Supplementary search report drawn up and despatched

Effective date: 20250905

RIC1 Information provided on ipc code assigned before grant

Ipc: C07D 317/58 20060101AFI20250901BHEP

Ipc: C07D 317/60 20060101ALI20250901BHEP

Ipc: C07D 405/06 20060101ALI20250901BHEP

Ipc: C07D 413/06 20060101ALI20250901BHEP

Ipc: C07D 407/06 20060101ALI20250901BHEP

Ipc: C07D 407/12 20060101ALI20250901BHEP

Ipc: C07D 409/06 20060101ALI20250901BHEP

Ipc: A61P 25/00 20060101ALI20250901BHEP

Ipc: A61K 31/36 20060101ALI20250901BHEP

Ipc: A61K 31/38 20060101ALI20250901BHEP

Ipc: A61K 31/381 20060101ALI20250901BHEP

Ipc: A61K 31/4025 20060101ALI20250901BHEP

Ipc: A61K 31/4192 20060101ALI20250901BHEP

Ipc: A61K 31/422 20060101ALI20250901BHEP

Ipc: A61K 31/443 20060101ALI20250901BHEP

Ipc: A61K 31/5377 20060101ALI20250901BHEP