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EP4420781A4 - Puce microfluidique d'homogénéisation de concentration à base d'électro-mouillage et procédé d'homogénéisation de concentration - Google Patents

Puce microfluidique d'homogénéisation de concentration à base d'électro-mouillage et procédé d'homogénéisation de concentration

Info

Publication number
EP4420781A4
EP4420781A4 EP22882270.6A EP22882270A EP4420781A4 EP 4420781 A4 EP4420781 A4 EP 4420781A4 EP 22882270 A EP22882270 A EP 22882270A EP 4420781 A4 EP4420781 A4 EP 4420781A4
Authority
EP
European Patent Office
Prior art keywords
concentration homogenization
electrowetting
microfluidic chip
concentration
homogenization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP22882270.6A
Other languages
German (de)
English (en)
Other versions
EP4420781A1 (fr
Inventor
Liuqing Yang
Dongfeng Zhang
Yue Wu
Chao Wang
Cong Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Autobio Labtec Instruments Zhengzhou Co Ltd
Original Assignee
Autobio Labtec Instruments Zhengzhou Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Autobio Labtec Instruments Zhengzhou Co Ltd filed Critical Autobio Labtec Instruments Zhengzhou Co Ltd
Publication of EP4420781A1 publication Critical patent/EP4420781A1/fr
Publication of EP4420781A4 publication Critical patent/EP4420781A4/fr
Pending legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0694—Creating chemical gradients in a fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0427—Electrowetting

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
EP22882270.6A 2021-10-19 2022-05-09 Puce microfluidique d'homogénéisation de concentration à base d'électro-mouillage et procédé d'homogénéisation de concentration Pending EP4420781A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202111217576.XA CN113842962B (zh) 2021-10-19 2021-10-19 基于电润湿的浓度均一化微流控芯片及浓度均一化方法
PCT/CN2022/091636 WO2023065645A1 (fr) 2021-10-19 2022-05-09 Puce microfluidique d'homogénéisation de concentration à base d'électro-mouillage et procédé d'homogénéisation de concentration

Publications (2)

Publication Number Publication Date
EP4420781A1 EP4420781A1 (fr) 2024-08-28
EP4420781A4 true EP4420781A4 (fr) 2025-10-22

Family

ID=78978973

Family Applications (1)

Application Number Title Priority Date Filing Date
EP22882270.6A Pending EP4420781A4 (fr) 2021-10-19 2022-05-09 Puce microfluidique d'homogénéisation de concentration à base d'électro-mouillage et procédé d'homogénéisation de concentration

Country Status (3)

Country Link
EP (1) EP4420781A4 (fr)
CN (1) CN113842962B (fr)
WO (1) WO2023065645A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113842962B (zh) * 2021-10-19 2023-02-17 安图实验仪器(郑州)有限公司 基于电润湿的浓度均一化微流控芯片及浓度均一化方法
CN115283029B (zh) * 2022-08-01 2025-07-22 郑州安图生物工程股份有限公司 利于消除气泡的微流控芯片

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170073729A1 (en) * 2015-09-11 2017-03-16 lIIumina, Inc. Systems and methods for obtaining a droplet having a designated concentration of a substance-of-interest
US20190388894A1 (en) * 2018-06-21 2019-12-26 Sharp Life Science (Eu) Limited Ewod system and methods to increase dynamic range for digital nucleic acid amplification

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4251627B2 (ja) * 2003-09-19 2009-04-08 株式会社東芝 化学分析装置及びその分注方法
CN101194155B (zh) * 2005-04-09 2012-07-18 贝林格尔英格海姆米克罗帕茨有限责任公司 用于测试样品液的装置和方法
JP4969060B2 (ja) * 2005-06-08 2012-07-04 株式会社日立ハイテクノロジーズ 自動分析装置
EP2593228A4 (fr) * 2010-07-15 2016-07-13 Indian Statistical Inst Plan architectural pour dilution avec gaspillage réduit dans un laboratoire sur puce basé sur la technologie de microfluidique digitale
CN109321634A (zh) * 2017-07-26 2019-02-12 上海之江生物科技股份有限公司 核酸均一化方法及其试剂盒和应用
CN109971833B (zh) * 2017-12-28 2020-11-20 南京金斯瑞生物科技有限公司 快速均一化环状dna样本的方法
US20190329258A1 (en) * 2018-04-25 2019-10-31 Tecan Trading Ag Cartridge and electrowetting sample processing system with delivery zone
CN112881729B (zh) * 2021-01-15 2023-02-17 中山大学 一种药物浓度梯度产生和加样装置及其应用
CN113275052B (zh) * 2021-06-04 2023-01-24 北京京东方传感技术有限公司 微流控芯片
CN113252632B (zh) * 2021-06-25 2021-10-19 成都瀚辰光翼生物工程有限公司 样本浓度处理方法、装置、样本处理设备及可读存储介质
CN113842962B (zh) * 2021-10-19 2023-02-17 安图实验仪器(郑州)有限公司 基于电润湿的浓度均一化微流控芯片及浓度均一化方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170073729A1 (en) * 2015-09-11 2017-03-16 lIIumina, Inc. Systems and methods for obtaining a droplet having a designated concentration of a substance-of-interest
US20190388894A1 (en) * 2018-06-21 2019-12-26 Sharp Life Science (Eu) Limited Ewod system and methods to increase dynamic range for digital nucleic acid amplification

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2023065645A1 *

Also Published As

Publication number Publication date
EP4420781A1 (fr) 2024-08-28
WO2023065645A1 (fr) 2023-04-27
CN113842962A (zh) 2021-12-28
CN113842962B (zh) 2023-02-17

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