EP4349362A4 - Utilisation combinée d'ubénimex et d'inhibiteurs des points de contrôle immunitaires - Google Patents

Utilisation combinée d'ubénimex et d'inhibiteurs des points de contrôle immunitaires

Info

Publication number: EP4349362A4
Authority: EP; European Patent Office
Prior art keywords: ubenimex; immune checkpoint; combined use; checkpoint inhibitors; inhibitors
Prior art date: 2021-05-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

EP22811340.3A

Other languages

German (de)

English (en)

Other versions

EP4349362A1 (fr

Inventor

Naoko IGO

Daichi Nagai

Keiko Sekine

Michiko AIJIMA

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Nippon Kayaku Co Ltd

Original Assignee

Nippon Kayaku Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2021-05-28

Filing date

2022-05-25

Publication date

2025-05-14

2022-05-25 Application filed by Nippon Kayaku Co Ltd filed Critical Nippon Kayaku Co Ltd

2024-04-10 Publication of EP4349362A1 publication Critical patent/EP4349362A1/fr

2025-05-14 Publication of EP4349362A4 publication Critical patent/EP4349362A4/fr

Status Pending legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Mycology (AREA)
Microbiology (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EP22811340.3A 2021-05-28 2022-05-25 Utilisation combinée d'ubénimex et d'inhibiteurs des points de contrôle immunitaires Pending EP4349362A4 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2021089984		2021-05-28
PCT/JP2022/021320 WO2022250070A1 (fr)	2021-05-28	2022-05-25	Utilisation combinée d'ubénimex et d'inhibiteurs des points de contrôle immunitaires

Publications (2)

Publication Number	Publication Date
EP4349362A1 EP4349362A1 (fr)	2024-04-10
EP4349362A4 true EP4349362A4 (fr)	2025-05-14

Family

ID=84229856

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP22811340.3A Pending EP4349362A4 (fr)	2021-05-28	2022-05-25	Utilisation combinée d'ubénimex et d'inhibiteurs des points de contrôle immunitaires

Country Status (9)

Country	Link
US (1)	US20240082196A1 (fr)
EP (1)	EP4349362A4 (fr)
JP (1)	JPWO2022250070A1 (fr)
KR (1)	KR20240016267A (fr)
CN (1)	CN117412762A (fr)
AU (1)	AU2022280511A1 (fr)
CA (1)	CA3220025A1 (fr)
TW (1)	TW202313091A (fr)
WO (1)	WO2022250070A1 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2018112364A1 (fr) *	2016-12-16	2018-06-21	Evelo Biosciences, Inc.	Polythérapies pour le traitement d'un mélanome

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2439273B1 (fr)	2005-05-09	2019-02-27	Ono Pharmaceutical Co., Ltd.	Anticorps monoclonaux humains pour mort programmée 1 (PD-1) et procédés de traitement du cancer à l'aide d'anticorps anti-PD-1 seuls ou combinés à d'autres formulations immunothérapeutiques
MY203926A (en)	2016-02-24	2024-07-24	Childrens Hospital Of Eastern Ontario Res Institute Inc	Smc combination therapy for the treatment of cancer
CA3053226A1 (fr)	2017-03-31	2018-10-04	Boehringer Ingelheim International Gmbh	Polytherapie anticancereuse
WO2019122941A1 (fr)	2017-12-21	2019-06-27	Debiopharm International Sa	Polythérapie contre le cancer faisant intervenir un antagoniste d'iap et une molécule anti pd-1
EP3765085A1 (fr) *	2018-03-12	2021-01-20	Université de Paris	Utilisation de mimétiques de restriction calorique pour potentialiser la chimio-immunothérapie pour le traitement de cancers

2022
- 2022-05-25 EP EP22811340.3A patent/EP4349362A4/fr active Pending
- 2022-05-25 KR KR1020237040875A patent/KR20240016267A/ko active Pending
- 2022-05-25 JP JP2023523496A patent/JPWO2022250070A1/ja active Pending
- 2022-05-25 CN CN202280037979.2A patent/CN117412762A/zh active Pending
- 2022-05-25 CA CA3220025A patent/CA3220025A1/fr active Pending
- 2022-05-25 WO PCT/JP2022/021320 patent/WO2022250070A1/fr not_active Ceased
- 2022-05-25 AU AU2022280511A patent/AU2022280511A1/en active Pending
- 2022-05-27 TW TW111119886A patent/TW202313091A/zh unknown
2023
- 2023-11-27 US US18/519,225 patent/US20240082196A1/en active Pending

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2018112364A1 (fr) *	2016-12-16	2018-06-21	Evelo Biosciences, Inc.	Polythérapies pour le traitement d'un mélanome

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO2022250070A1 *
TOSHIYAMA REISHI ET AL: "Poly(ethylene glycol)-poly(lysine) block copolymer-ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells", ONCOGENE, NATURE PUBLISHING GROUP UK, LONDON, vol. 38, no. 2, 8 August 2018 (2018-08-08), pages 244 - 260, XP036668959, ISSN: 0950-9232, [retrieved on 20180808], DOI: 10.1038/S41388-018-0406-X *

Also Published As

Publication number	Publication date
TW202313091A (zh)	2023-04-01
AU2022280511A1 (en)	2023-12-14
WO2022250070A1 (fr)	2022-12-01
EP4349362A1 (fr)	2024-04-10
KR20240016267A (ko)	2024-02-06
CA3220025A1 (fr)	2022-12-01
CN117412762A (zh)	2024-01-16
US20240082196A1 (en)	2024-03-14
JPWO2022250070A1 (fr)	2022-12-01

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EP4143196A4 (fr)	2024-04-17	INHIBITEURS DE PI3K-a ET PROCÉDÉ D'UTILISATION DE CEUX-CI
SG11202107614PA (en)	2021-08-30	Pcsk9 inhibitors and methods of use thereof
SG11202107615TA (en)	2021-08-30	Pcsk9 inhibitors and methods of use thereof
EP3962479A4 (fr)	2023-06-07	Inhibiteurs de kcnt1 et procédés d'utilisation
IL312348A (en)	2024-06-01	HIF-2ALPHA inhibitors and methods of using it
IL287768A (en)	2022-01-01	kcnt1 inhibitors and methods of use
EP3969439A4 (fr)	2023-01-11	Inhibiteurs d'acss2 et leurs procédés d'utilisation
EP4370124A4 (fr)	2025-05-07	INHIBITEURS DE PI3Ka ET LEURS PROCÉDÉS D'UTILISATION
EP3986894A4 (fr)	2023-08-09	Inhibiteurs d'ectonucléotidases et leurs procédés d'utilisation
EP3959197A4 (fr)	2022-10-12	Inhibiteurs de papd5 et leurs procédés d'utilisation
EP4341254A4 (fr)	2025-04-09	Inhibiteurs et agents de dégradation de protéine pip4k
IL321357A (en)	2025-08-01	KIF18A inhibitors and their uses
IL299700A (en)	2023-03-01	KCNT1 inhibitors and methods of use
EP4329735A4 (fr)	2025-03-05	Inhibiteurs de kcnt1 et procédés d'utilisation
EP4349362A4 (fr)	2025-05-14	Utilisation combinée d'ubénimex et d'inhibiteurs des points de contrôle immunitaires
AU2021352981A9 (en)	2024-10-31	Anti-cd94 antibodies and methods of use thereof
EP4063366A4 (fr)	2023-12-20	Forme cristalline d'un inhibiteur de nucléoprotéine et son utilisation
EP3946300A4 (fr)	2023-01-18	Combinaisons d'inhibiteurs de transcription et d'inhibiteurs de point de contrôle immunitaire pour traiter une maladie
CA3281421A1 (fr)	2024-08-29	Combinaison d'anticorps d'activation de btn3a et d'inhibiteurs de point de contrôle immunitaire
HK40106484A (zh)	2024-09-06	HIF-2α抑制剂和其使用方法
HK40083370A (en)	2023-06-23	Tgfbeta inhibitors and use thereof
HK40119391A (zh)	2025-07-18	Pcsk9抑制剂及其使用方法
HK40119387A (zh)	2025-07-18	Pcsk9抑制剂及其使用方法
HK40119389A (zh)	2025-07-18	Pcsk9抑制剂及其使用方法
HK40120861A (zh)	2025-08-29	Pcsk9抑制剂及其使用方法

Legal Events

Date	Code	Title	Description
2022-12-02	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2024-03-08	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2024-03-08	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2024-04-10	17P	Request for examination filed	Effective date: 20231207
2024-04-10	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2024-09-04	DAV	Request for validation of the european patent (deleted)
2024-09-04	DAX	Request for extension of the european patent (deleted)
2025-04-08	REG	Reference to a national code	Ref country code: DE Ref legal event code: R079 Free format text: PREVIOUS MAIN CLASS: A61K0038050000 Ipc: A61K0031198000
2025-05-14	A4	Supplementary search report drawn up and despatched	Effective date: 20250411
2025-05-14	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 45/06 20060101ALI20250408BHEP Ipc: A61P 43/00 20060101ALI20250408BHEP Ipc: A61P 35/00 20060101ALI20250408BHEP Ipc: A61K 39/395 20060101ALI20250408BHEP Ipc: A61K 38/05 20060101ALI20250408BHEP Ipc: A61K 31/198 20060101AFI20250408BHEP