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EP4284911A4 - Capture à haut rendement de cellules foetales à partir d'échantillons maternels - Google Patents

Capture à haut rendement de cellules foetales à partir d'échantillons maternels

Info

Publication number
EP4284911A4
EP4284911A4 EP22746638.0A EP22746638A EP4284911A4 EP 4284911 A4 EP4284911 A4 EP 4284911A4 EP 22746638 A EP22746638 A EP 22746638A EP 4284911 A4 EP4284911 A4 EP 4284911A4
Authority
EP
European Patent Office
Prior art keywords
highly efficient
fetal cells
efficient detection
maternal samples
maternal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP22746638.0A
Other languages
German (de)
English (en)
Other versions
EP4284911A1 (fr
Inventor
Rolf Muller
Judy Muller-Cohn
Philip D. Buchanan
Jiri SONEK
Kulvinder Kaur
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BIOFLUIDICA Inc
Original Assignee
BIOFLUIDICA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BIOFLUIDICA Inc filed Critical BIOFLUIDICA Inc
Publication of EP4284911A1 publication Critical patent/EP4284911A1/fr
Publication of EP4284911A4 publication Critical patent/EP4284911A4/fr
Pending legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1011Control of the position or alignment of the transfer device
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N35/00069Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0631Purification arrangements, e.g. solid phase extraction [SPE]
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0627Sensor or part of a sensor is integrated
    • B01L2300/0636Integrated biosensor, microarrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883Serpentine channels
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/02Form or structure of the vessel
    • C12M23/16Microfluidic devices; Capillary tubes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02Separating microorganisms from the culture medium; Concentration of biomass
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099Characterised by type of test elements
    • G01N2035/00158Elements containing microarrays, i.e. "biochip"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027General features of the devices
    • G01N2035/103General features of the devices using disposable tips
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027General features of the devices
    • G01N2035/1034Transferring microquantities of liquid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
EP22746638.0A 2021-01-27 2022-01-27 Capture à haut rendement de cellules foetales à partir d'échantillons maternels Pending EP4284911A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163142288P 2021-01-27 2021-01-27
PCT/US2022/014168 WO2022165084A1 (fr) 2021-01-27 2022-01-27 Capture à haut rendement de cellules fœtales à partir d'échantillons maternels

Publications (2)

Publication Number Publication Date
EP4284911A1 EP4284911A1 (fr) 2023-12-06
EP4284911A4 true EP4284911A4 (fr) 2025-01-08

Family

ID=82654924

Family Applications (1)

Application Number Title Priority Date Filing Date
EP22746638.0A Pending EP4284911A4 (fr) 2021-01-27 2022-01-27 Capture à haut rendement de cellules foetales à partir d'échantillons maternels

Country Status (2)

Country Link
EP (1) EP4284911A4 (fr)
WO (1) WO2022165084A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4579214A1 (fr) * 2023-12-27 2025-07-02 Tecan Trading AG Séparation de particules avec dispositif d'automatisation de laboratoire

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120149014A1 (en) * 2009-04-21 2012-06-14 Genetic Technologies Limited Methods for obtaining fetal genetic material
US20150232936A1 (en) * 2006-06-14 2015-08-20 The General Hospital Corporation Rare Cell Analysis Using Sample Splitting And DNA Tags
US20170202211A1 (en) * 2014-06-10 2017-07-20 Biomatrica, Inc. Stabilization of Metabolically-Active Cells in a Blood Sample at Ambient Temperatures
US20180252698A1 (en) * 2008-05-16 2018-09-06 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Microfluidic Isolation of Tumor Cells or Other Rare Cells from Whole Blood or Other Liquids
US20200009562A1 (en) * 2018-07-06 2020-01-09 Lian LIU Methods and systems for cell-based non-invasive prenatal testing
US20200023351A1 (en) * 2017-04-20 2020-01-23 Biofluidica, Inc. Fluid-tight flow system to isolate biomarkers from a liquid sample

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2008013535A (es) * 2006-04-21 2008-10-29 Amgen Inc Agentes amortiguadores para formulaciones biofarmaceuticas.
EP2634268A3 (fr) 2009-01-07 2013-12-25 QuantiBact A/S Enrichissement et identification de cellules foetales dans le sang maternel et ligands pour une telle utilisation
WO2012062325A1 (fr) 2010-11-09 2012-05-18 Fbmc Aps Enrichissement et identification de cellules foetales dans le sang maternel et ligands pour ce faire
JP6404824B2 (ja) * 2012-11-09 2018-10-17 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 循環腫瘍細胞のインビトロでの捕捉および解析

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150232936A1 (en) * 2006-06-14 2015-08-20 The General Hospital Corporation Rare Cell Analysis Using Sample Splitting And DNA Tags
US20180252698A1 (en) * 2008-05-16 2018-09-06 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Microfluidic Isolation of Tumor Cells or Other Rare Cells from Whole Blood or Other Liquids
US20120149014A1 (en) * 2009-04-21 2012-06-14 Genetic Technologies Limited Methods for obtaining fetal genetic material
US20170202211A1 (en) * 2014-06-10 2017-07-20 Biomatrica, Inc. Stabilization of Metabolically-Active Cells in a Blood Sample at Ambient Temperatures
US20200023351A1 (en) * 2017-04-20 2020-01-23 Biofluidica, Inc. Fluid-tight flow system to isolate biomarkers from a liquid sample
US20200009562A1 (en) * 2018-07-06 2020-01-09 Lian LIU Methods and systems for cell-based non-invasive prenatal testing

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2022165084A1 *

Also Published As

Publication number Publication date
WO2022165084A1 (fr) 2022-08-04
EP4284911A1 (fr) 2023-12-06
WO2022165084A9 (fr) 2022-11-10

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