EP4180445A4 - Composé glycoside triterpénoïde pentacyclique, son procédé de préparation et son utilisation - Google Patents

Composé glycoside triterpénoïde pentacyclique, son procédé de préparation et son utilisation Download PDF

Info

Publication number: EP4180445A4
Authority: EP; European Patent Office
Prior art keywords: preparation; method therefor; glycoside compound; pentacyclic triterpenoid; triterpenoid glycoside
Prior art date: 2020-07-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP21838780.1A

Other languages

German (de)

English (en)

Other versions

EP4180445A1 (fr

Inventor

Hong Liu

Jiang Wang

Yichu LIU

Changyue YU

Yibing Wang

Hualiang Jiang

Kaixian Chen

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Shanghai Institute of Materia Medica of CAS

Original Assignee

Shanghai Institute of Materia Medica of CAS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2020-07-07

Filing date

2021-07-05

Publication date

2024-10-02

2021-07-05 Application filed by Shanghai Institute of Materia Medica of CAS filed Critical Shanghai Institute of Materia Medica of CAS

2023-05-17 Publication of EP4180445A1 publication Critical patent/EP4180445A1/fr

2024-10-02 Publication of EP4180445A4 publication Critical patent/EP4180445A4/fr

Status Withdrawn legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Virology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Obesity (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Child & Adolescent Psychology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Steroid Compounds (AREA)

EP21838780.1A 2020-07-07 2021-07-05 Composé glycoside triterpénoïde pentacyclique, son procédé de préparation et son utilisation Withdrawn EP4180445A4 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CN202010647960		2020-07-07
PCT/CN2021/104599 WO2022007765A1 (fr)	2020-07-07	2021-07-05	Composé glycoside triterpénoïde pentacyclique, son procédé de préparation et son utilisation

Publications (2)

Publication Number	Publication Date
EP4180445A1 EP4180445A1 (fr)	2023-05-17
EP4180445A4 true EP4180445A4 (fr)	2024-10-02

Family

ID=79187545

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP21838780.1A Withdrawn EP4180445A4 (fr)	2020-07-07	2021-07-05	Composé glycoside triterpénoïde pentacyclique, son procédé de préparation et son utilisation

Country Status (8)

Country	Link
US (1)	US20240262860A1 (fr)
EP (1)	EP4180445A4 (fr)
JP (2)	JP2023533557A (fr)
KR (1)	KR20230043878A (fr)
CN (1)	CN113896757B (fr)
AU (1)	AU2021304754B2 (fr)
CA (1)	CA3185288A1 (fr)
WO (1)	WO2022007765A1 (fr)

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WO2015135474A1 (fr) *	2014-03-14	2015-09-17	中国科学院上海药物研究所	Composé triterpénique pentacyclique et son utilisation dans la préparation d'un médicament pour le traitement de la maladie d'alzheimer
WO2016086453A1 (fr) *	2014-12-04	2016-06-09	中国药科大学	Inhibiteur de la protéine de transfert des esters de cholestérol de type terpénoïde pentacyclique, composition pharmaceutique et son utilisation
US20200163983A1 (en) *	2017-07-13	2020-05-28	East China University Of Science And Technology	Saponin compound targeting pd-1 and application thereof

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2021
- 2021-07-05 WO PCT/CN2021/104599 patent/WO2022007765A1/fr not_active Ceased
- 2021-07-05 CN CN202110758853.1A patent/CN113896757B/zh active Active
- 2021-07-05 KR KR1020237004426A patent/KR20230043878A/ko active Pending
- 2021-07-05 JP JP2023501493A patent/JP2023533557A/ja active Pending
- 2021-07-05 CA CA3185288A patent/CA3185288A1/fr active Pending
- 2021-07-05 EP EP21838780.1A patent/EP4180445A4/fr not_active Withdrawn
- 2021-07-05 US US18/014,932 patent/US20240262860A1/en active Pending
- 2021-07-05 AU AU2021304754A patent/AU2021304754B2/en active Active
2025
- 2025-07-08 JP JP2025114951A patent/JP2025165936A/ja active Pending

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WO2015135474A1 (fr) *	2014-03-14	2015-09-17	中国科学院上海药物研究所	Composé triterpénique pentacyclique et son utilisation dans la préparation d'un médicament pour le traitement de la maladie d'alzheimer
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See also references of WO2022007765A1 *

Also Published As

Publication number	Publication date
CA3185288A1 (fr)	2022-01-13
JP2025165936A (ja)	2025-11-05
CN113896757B (zh)	2024-12-06
US20240262860A1 (en)	2024-08-08
CN113896757A (zh)	2022-01-07
KR20230043878A (ko)	2023-03-31
WO2022007765A1 (fr)	2022-01-13
EP4180445A1 (fr)	2023-05-17
AU2021304754B2 (en)	2024-07-25
JP2023533557A (ja)	2023-08-03
AU2021304754A1 (en)	2023-02-16

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