EP4162030A4 - LIVE ATTENUATED STRAINS OF FOOT-AND-MOUTH DISEASE MODIFIED BY DEOPTIMISATION AND USES THEREOF - Google Patents

LIVE ATTENUATED STRAINS OF FOOT-AND-MOUTH DISEASE MODIFIED BY DEOPTIMISATION AND USES THEREOF Download PDF

Info

Publication number: EP4162030A4
Authority: EP; European Patent Office
Prior art keywords: deoptimisation; foot; mouth disease; live attenuated; attenuated strains
Prior art date: 2020-05-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP21813459.1A

Other languages

German (de)

French (fr)

Other versions

EP4162030A1 (en

Inventor

Teresa B. De Los Santos

Aida E. Rieder

Fayna C. DIAZ-SAN SEGUNDO

Anna KLOC

John R. Coleman

Steffen Mueller

Gisselle N. MEDINA

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

US Department of Agriculture USDA

Codagenix Inc

Original Assignee

US Department of Agriculture USDA

Codagenix Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2020-05-27

Filing date

2021-05-26

Publication date

2024-07-24

2021-05-26 Application filed by US Department of Agriculture USDA, Codagenix Inc filed Critical US Department of Agriculture USDA

2021-05-26 Priority claimed from PCT/US2021/034282 external-priority patent/WO2021242879A1/en

2023-04-12 Publication of EP4162030A1 publication Critical patent/EP4162030A1/en

2024-07-24 Publication of EP4162030A4 publication Critical patent/EP4162030A4/en

Status Withdrawn legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/125—Picornaviridae, e.g. calicivirus
- A61K39/135—Foot- and mouth-disease virus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
- C12N2770/32121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
- C12N2770/32134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Virology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Microbiology (AREA)
Zoology (AREA)
Pharmacology & Pharmacy (AREA)
Immunology (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Mycology (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

EP21813459.1A 2020-05-27 2021-05-26 LIVE ATTENUATED STRAINS OF FOOT-AND-MOUTH DISEASE MODIFIED BY DEOPTIMISATION AND USES THEREOF Withdrawn EP4162030A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US202063030431P	2020-05-27	2020-05-27
PCT/US2021/034282 WO2021242879A1 (en)	2020-05-27	2021-05-26	Live attenuated strains of foot and mouth disease modified by deoptimization and uses thereof

Publications (2)

Publication Number	Publication Date
EP4162030A1 EP4162030A1 (en)	2023-04-12
EP4162030A4 true EP4162030A4 (en)	2024-07-24

Family

ID=85463132

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP21813459.1A Withdrawn EP4162030A4 (en)	2020-05-27	2021-05-26	LIVE ATTENUATED STRAINS OF FOOT-AND-MOUTH DISEASE MODIFIED BY DEOPTIMISATION AND USES THEREOF

Country Status (2)

Country	Link
EP (1)	EP4162030A4 (en)
CN (1)	CN116249708A (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9180179B1 (en) *	2010-07-01	2015-11-10	The United States Of America, As Represented By The Secretary Of Agriculture	Development of a marker foot and mouth disease virus vaccine candidate that is attenuated in the natural host
US20170067030A1 (en) *	2007-03-30	2017-03-09	The Research Foundation For The State University Of New York	Attenuated viruses useful for vaccines

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP3312272B1 (en) *	2004-10-08	2019-08-28	The Government of The United States of America as represented by The Secretary of The Department of Health and Human Services	Modulation of replicative fitness by using less frequently used synonymous codons
CN104826098B (en) *	2015-05-14	2017-08-29	中国农业科学院兰州兽医研究所	A kind of A types aftosa marker vaccine and its construction method

2021
- 2021-05-26 CN CN202180061079.7A patent/CN116249708A/en active Pending
- 2021-05-26 EP EP21813459.1A patent/EP4162030A4/en not_active Withdrawn

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20170067030A1 (en) *	2007-03-30	2017-03-09	The Research Foundation For The State University Of New York	Attenuated viruses useful for vaccines
US9180179B1 (en) *	2010-07-01	2015-11-10	The United States Of America, As Represented By The Secretary Of Agriculture	Development of a marker foot and mouth disease virus vaccine candidate that is attenuated in the natural host

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
C. CARRILLO ET AL: "Comparative Genomics of Foot-and-Mouth Disease Virus", JOURNAL OF VIROLOGY, vol. 79, no. 10, 27 April 2005 (2005-04-27), pages 6487 - 6504, XP055120718, ISSN: 0022-538X, DOI: 10.1128/JVI.79.10.6487-6504.2005 *
DIAZ-SAN SEGUNDO FAYNA ET AL: "Foot-and-mouth disease vaccines", VETERINARY MICROBIOLOGY, ELSEVIER BV, NL, vol. 206, 19 December 2016 (2016-12-19), pages 102 - 112, XP085115673, ISSN: 0378-1135, DOI: 10.1016/J.VETMIC.2016.12.018 *
DIAZ-SAN SEGUNDO FAYNA ET AL: "Use of Synonymous Deoptimization to Derive Modified Live Attenuated Strains of Foot and Mouth Disease Virus", FRONTIERS IN MICROBIOLOGY, vol. 11, 21 January 2021 (2021-01-21), Lausanne, XP093174242, ISSN: 1664-302X, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861043/pdf/fmicb-11-610286.pdf> DOI: 10.3389/fmicb.2020.610286 *
LE NOUËN CYRIL ET AL: "Attenuation of Human Respiratory Viruses by Synonymous Genome Recoding", FRONTIERS IN IMMUNOLOGY, vol. 10, 4 June 2019 (2019-06-04), Lausanne, CH, XP093174278, ISSN: 1664-3224, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558635/pdf/fimmu-10-01250.pdf> DOI: 10.3389/fimmu.2019.01250 *
MARTIN D ET AL: "Rational Design of Attenuated FMDV Vaccines By Elevation of -CpG-and -UpA-Dinucleotide Frequencies", 1 January 2018 (2018-01-01), pages 1 - 22, XP093174293, Retrieved from the Internet <URL:https://www.fao.org/fileadmin/user_upload/eufmd_new/docs/Meeting_documents/Open_Session_2018/8.A.2_-_Ryan.pdf> *
See also references of WO2021242879A1 *

Also Published As

Publication number	Publication date
EP4162030A1 (en)	2023-04-12
CN116249708A (en)	2023-06-09

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Legal Events

Date	Code	Title	Description
2021-12-03	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2023-03-10	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2023-03-10	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2023-04-12	17P	Request for examination filed	Effective date: 20230102
2023-04-12	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2023-08-30	DAV	Request for validation of the european patent (deleted)
2023-08-30	DAX	Request for extension of the european patent (deleted)
2024-07-24	A4	Supplementary search report drawn up and despatched	Effective date: 20240625
2024-07-24	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 39/00 20060101ALI20240619BHEP Ipc: A61P 31/12 20060101ALI20240619BHEP Ipc: A61K 39/135 20060101ALI20240619BHEP Ipc: C07K 14/005 20060101ALI20240619BHEP Ipc: C12N 7/00 20060101AFI20240619BHEP
2025-03-28	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2025-04-30	18D	Application deemed to be withdrawn	Effective date: 20241203