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EP4161473A1 - Utilisation d'un composé contenant deux ou plusieurs groupes hydroxyle alcooliques ou groupes hydroxyle phénoliques en tant que régulateur du microbiome sur le cuir chevelu - Google Patents

Utilisation d'un composé contenant deux ou plusieurs groupes hydroxyle alcooliques ou groupes hydroxyle phénoliques en tant que régulateur du microbiome sur le cuir chevelu

Info

Publication number
EP4161473A1
EP4161473A1 EP20939406.3A EP20939406A EP4161473A1 EP 4161473 A1 EP4161473 A1 EP 4161473A1 EP 20939406 A EP20939406 A EP 20939406A EP 4161473 A1 EP4161473 A1 EP 4161473A1
Authority
EP
European Patent Office
Prior art keywords
scalp
glycol
compound
hydroxyl groups
microbiome regulator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP20939406.3A
Other languages
German (de)
English (en)
Other versions
EP4161473A4 (fr
Inventor
Yi Shi
Mengmeng Zhang
Xiaowei Chang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Henkel AG and Co KGaA
Original Assignee
Henkel AG and Co KGaA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henkel AG and Co KGaA filed Critical Henkel AG and Co KGaA
Publication of EP4161473A1 publication Critical patent/EP4161473A1/fr
Publication of EP4161473A4 publication Critical patent/EP4161473A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/006—Antidandruff preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/44—Staphylococcus
    • C12R2001/45—Staphylococcus epidermidis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Definitions

  • the present invention relates to a use of a compound containing two or more alcoholic hydroxyl groups or phenolic hydroxyl groups and three to sixteen carbon atoms per molecule, as a microbiome regulator for selectively inhibiting Cutibacterium acnes and Staphylococcus epidermidis on scalp; a method of screening a compound or mixture for a microbiome regulator on scalp; and a shampoo or scalp serum composition comprising the microbiome regulator.
  • scalp itchiness is the most common scalp discomfort among people. In particular, it is the top scalp concern of Chinese consumers.
  • the itchiness is associated with scalp diseases, dandruff, psoriasis, etc., and many of non-dandruff consumers also suffered scalp itchiness.
  • the traditional ways to relieve scalp itchiness is to inhibit histamine release, or numb sensorial channels, or reduce redness with actives.
  • the traditional solutions are partial solutions to cure single symptoms and can merely cure symptoms in a short period.
  • they cannot satisfy the needs of the consumers, who are longing for novel solutions not only curing symptoms in a short period, but also remedying scalp to improve scalp overall condition in a long period.
  • the inventors conducted a lot of experiments and an intensive study, and surprisingly obtained a compound containing two or more alcoholic hydroxyl groups or phenolic hydroxyl groups and three to sixteen carbon atoms per molecule, which can be used as a microbiome regulator for selectively inhibiting Cutibacterium acnes and Staphylococcus epidermidis on scalp.
  • the present invention provides a use of a compound containing two or more alcoholic hydroxyl groups or phenolic hydroxyl groups and three to sixteen carbon atoms per molecule, as a microbiome regulator for selectively inhibiting Cutibacterium acnes and Staphylococcus epidermidis on scalp.
  • the present invention also provides a method of screening a compound or mixture for a microbiome regulator on scalp, comprising:
  • the present invention provides a shampoo or scalp serum composition, comprising a microbiome regulator for selectively inhibiting Cutibacterium acnes and Staphylococcus epidermidis on scalp, which is a compound containing two or more alcoholic hydroxyl groups or phenolic hydroxyl groups and three to sixteen carbon atoms per molecule, or the mixture thereof.
  • the use and the shampoo or scalp serum composition according to the present invention not only cure symptoms in a short period but also remedy scalp to improve scalp overall condition in a long period. Moreover, by the method according to the present invention, the use and the shampoo or scalp serum which not only cure symptoms in a short period but also remedy scalp to improve scalp overall condition in a long period can be obtained.
  • microbiome regulator and “microbiome balancer” are interchangeable, and they both refer to a substance which can regulate the ecological communities of commensal bacteria on the scalp, up-regulating good bacteria and down-regulating bad ones, and then in consequence improve the scalp condition holistically, with moisturized barrier, soothed redness, and relieved scalp itch.
  • Minimum Inhibitory Concentration can be abbreviated to “MIC” ; and it refers to the minimum concentration of a chemical that will inhibit the growth of a microorganism, and is usually reported as ⁇ g/ml or mg/ml for a solid compound, and as percentage value for a liquid compound.
  • MIC Minimum Inhibitory Concentration
  • the “Minimum Inhibitory Concentration” in the present invention is measured according to the method as described in the Examples of the present description.
  • Minimum Inhibitory Concentration (Cutibacterium acnes) of the compound or mixture” and “Minimum Inhibitory Concentrations of the compound or mixture towards Cutibacterium acnes” are interchangeable, and they both refer to the minimum concentration of the compound or mixture that will inhibit the growth of Cutibacterium acnes.
  • Minimum Inhibitory Concentration (Staphylococcus epidermidis) of the compound or mixture” and “Minimum Inhibitory Concentrations of the compound or mixture towards Staphylococcus epidermidis” are interchangeable, and they both refer to the minimum concentration of the compound or mixture that will inhibit the growth of Staphylococcus epidermidis.
  • a compound containing two or more alcoholic hydroxyl groups or phenolic hydroxyl groups and three to sixteen carbon atoms per molecule can be used as a microbiome regulator for selectively inhibiting Cutibacterium acnes and Staphylococcus epidermidis on scalp.
  • the compound containing two or more alcoholic hydroxyl groups or phenolic hydroxyl groups and three to sixteen carbon atoms per molecule has a ratio of Minimum Inhibitory Concentration (Cutibacterium acnes) to Minimum Inhibitory Concentration (Staphylococcus epidermidis) ⁇ 1.
  • the ratio of Minimum Inhibitory Concentration (Cutibacterium acnes) to Minimum Inhibitory Concentration (Staphylococcus epidermidis) is not more than 0.9, not more than 0.8, not more than 0.7, not more than 0.6, not more than 0.5, not more than 0.4, not more than 0.3, not more than 0.25, or not more than 0.20.
  • the ratio of Minimum Inhibitory Concentration (Cutibacterium acnes) to Minimum Inhibitory Concentration (Staphylococcus epidermidis) is at least 0.01, at least 0.02, or at least 0.025.
  • the ratio of Minimum Inhibitory Concentration (Cutibacterium acnes) to Minimum Inhibitory Concentration (Staphylococcus epidermidis) is in a range of 0.01 to 1, preferably 0.02 to 0.9, more preferably 0.025 to 0.5.
  • Minimum Inhibitory Concentration Cutibacterium acnes
  • Minimum Inhibitory Concentration Staphylococcus epidermidis
  • the ratio of Minimum Inhibitory Concentration (Cutibacterium acnes) to Minimum Inhibitory Concentration (Staphylococcus epidermidis) is less than 0.01, it will lead to an imbalance of the bacterium.
  • the compound containing two or more alcoholic hydroxyl groups or phenolic hydroxyl groups and three to sixteen carbon atoms per molecule contains two, three, four or five alcoholic hydroxyl groups or phenolic hydroxyl groups per molecule.
  • the compound contains two, three or four alcoholic hydroxyl groups or phenolic hydroxyl groups per molecule. More preferably, the compound contains two alcoholic hydroxyl groups or four phenolic hydroxyl groups per molecule.
  • the compound is selected from the group consisting of propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, caprylyl glycol, decylene glycol, dipropylene glycol, glycerin, ethylhexylglycerin and phloretin.
  • the compound is selected from the group consisting of pentylene glycol, hexylene glycol, caprylyl glycol, decylene glycol, ethylhexylglycerin and phloretin.
  • Examples of commercially available compound according to the present invention include, for example, SymClariol, which is decylene glycol available from Symrise Company; Caprylyl Glycol, which is available from Symrise Company; Pentylene Glycol, which is available from Symrise Company; EthylHexylGlycerin, which is available from Schülke & Mayr GmbH; and Phloretin, which is Phloretin available from Symrise Company.
  • a method of screening a compound or mixture for a microbiome regulator on scalp comprises:
  • a shampoo or scalp serum composition comprises a microbiome regulator for selectively inhibiting Cutibacterium acnes and Staphylococcus epidermidis on scalp, which is a compound containing two or more alcoholic hydroxyl groups or phenolic hydroxyl groups and three to sixteen carbon atoms per molecule, or the mixture thereof.
  • the mircobiome regulator is the compound containing two or more alcoholic hydroxyl groups or phenolic hydroxyl groups and three to sixteen carbon atoms per molecule as defined above, or the mixture thereof.
  • the amount of the microbiome regulator is at least 0.01 wt. %, at least 0.05%, at least 0.1 wt. %, at least 0.5%, or at least 1.0%.
  • the amount of the microbiome regulator is not more than 15.0 wt. %, not more than 14 wt. %, not more than 13 wt. %, not more than 12 wt. %, not more than 11 wt. %, or not more than 10 wt. %.
  • the amount of the microbiome regulator is within a range of 0.01 wt.
  • %to 15.0 wt. % preferably 0.5 wt. %to 13 wt. %, more preferably 1 wt. %to 10 wt. %, based on the total weight of the shampoo or scalp serum composition. If the amount of the microbiome regulator is less than 0.01 wt. %based on the total weight of the shampoo or scalp serum composition, the composition cannot effectively cure symptoms in a short period and remedy scalp to improve scalp overall condition in a long period. If the amount of the microbiome regulator is higher than 15.0 wt. %based on the total weight of the shampoo or scalp serum composition, the formulation will be not stable in a long term and the efficacy delivery of the microbiome regulator will be lower.
  • the microbiome regulator contains two alcoholic hydroxyl groups or four phenolic hydroxyl groups per molecule.
  • the microbiome regulator is selected from the group consisting of propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, caprylyl glycol, decylene glycol, dipropylene glycol, glycerin, ethylhexylglycerin and phloretin.
  • the microbiome regulator is selected from the group consisting of pentylene glycol, hexylene glycol, caprylyl glycol, decylene glycol, ethylhexylglycerin, glycerin and phloretin.
  • the microbiome regulator contains ethylhexylglycerin, decylene glycol and glycerin. More preferably, the microbiome regulator further contains 1, 2-hexanediol and/or propylene glycol.
  • the shampoo or scalp serum composition according to the present invention may be formulated to contain one or more additional components or additives besides those described above.
  • the shampoo composition may additionally comprise a solvent, a surfactant, a thickener, a hair conditioning agent and/or PH adjuster; and the scalp serum composition may additionally comprise a solvent, a thickener, a hair conditioning agent and/or PH adjuster.
  • the solvent which can be used in the practice of the present invention can be any solvent conventionally used in the shampoo or scalp serum, and it is preferably Aqua.
  • the surfactants which can be used in the practice of the present invention include, but are not limited to:
  • Anionic surfactants for example, Acylated Amino Acids, such as Sodium Lauroyl Sarcosinate, and TEA-Cocoyl Glutamate; Carboxylic Acids &salts, such as Sodium Laureth-13 Carboxylate; Sulfonic Acid derivatives, such as Sodium Methyl Cocoyl Taurate, Sodium Cocoyl Isethionate, and Sodium C14-16 Olefin Sulfonate; Sulfuric Acid derivatives, such as Sodium Laureth Sulfate, and Ammonium Lauryl Sulfate;
  • Acylated Amino Acids such as Sodium Lauroyl Sarcosinate, and TEA-Cocoyl Glutamate
  • Carboxylic Acids &salts such as Sodium Laureth-13 Carboxylate
  • Sulfonic Acid derivatives such as Sodium Methyl Cocoyl Taurate, Sodium Cocoyl Isethionate, and Sodium C14-16 Olef
  • Nonionic surfactants for example, Alkyl Glucosides, such as Coco-Glucoside and Lauryl Glucoside; and Amine oxides, such as Lauramine Oxide;
  • Amphoteric surfactants for example, Alkyl amido Alkyl Amines, such as Sodium Lauroamphoacetate; and Alkyl Betaines, such as Cocamidopropyl betaine, Coco-betaine and coco-hydroxysultaine.
  • thickener which can be used for shampoo in the practice of the present invention include, but are not limited to PEG/PPG-120/10 Trimethylolpropane Trioleate, PEG-120 Methyl Glucose Dioleate, PEG-150 Distearate, PEG-150 Pentaerythrityl Tetrastearate, PEG-55 Propylene Glycol Oleate, PPG-2 Hydroxyethyl Cocamide, Laureth-2, Cocamide MEA and NaCl.
  • the PH adjuster which can be used in the practice of the present invention includes, but are not limited to citric acid, lactic acid, sodium hydroxide, and potassium hydroxide.
  • the shampoo or scalp serum composition according to the present invention can be made by any appropriate method.
  • the composition can be made by simply mixing all the components together.
  • the shampoo composition can be produced by a method comprising: heating water in a vessel; mixing the surfactants into the water; heating the mixture until the surfactants are fully dispersed; adding the thickener, hair conditioning agents, microbiome regulator and/or PH adjuster and/or other optional components with continuous stirring until all the components are fully dissolved; and cooling down the final mixture to room temperature.
  • the scalp serum composition can be produced by a method comprising: mixing the thickener, PH adjuster into water with continuous stirring until a homogeneous gel formed without flocs and lumps; adding hair conditioning agents, microbiome regulator and/or other optional components with continuous stirring until all the components are fully dispersed.
  • the shampoo or scalp serum composition can be in solid or liquid state.
  • the shampoo can be used in the form of viscous liquid.
  • the serum can be used in either gel form or liquid form.
  • the shampoo composition can be applied gently on wet hair, and then the hair is rinsed thoroughly.
  • the shampoo composition may be used as often as desired.
  • the scalp serum composition can be applied evenly over scalp, the scalp can be gently massaged for 2-3 minutes until the composition is fully absorbed, and there is no need to rinse or towel-wipe after use.
  • the scalp serum composition may be used whenever there are any discomforts on scalp.
  • the compound containing two or more alcoholic hydroxyl groups or phenolic hydroxyl groups and three to sixteen carbon atoms per molecule according to the present invention can be used as a microbiome regulator for selectively inhibiting Cutibacterium acnes and Staphylococcus epidermidis on scalp, and it can be used for not only curing symptoms in a short period but also remedying scalp to improve scalp overall condition in a long period
  • the compound containing two or more alcoholic hydroxyl groups or phenolic hydroxyl groups and three to sixteen carbon atoms per molecule can be obtained.
  • the shampoo or scalp serum composition according to the present invention can not only cure symptoms in a short period but also remedies scalp to improve scalp overall condition in a long period.
  • SymClariol which is decylene glycol, was manufactured by Symrise Company.
  • Caprylyl Glycol was manufactured by Symrise Company.
  • Pentylene Glycol was manufactured by Symrise Company.
  • Sensiva SC 50 which is EthylHexylGlycerin was manufactured by Schülke & Mayr GmbH.
  • Phloretin which is Phloretin, was manufactured by Symrise Company.
  • LIPACIDE C8G which is Capryloyl Glycine, was manufactured by Seppic Company.
  • Sphingony which is Sphinganine, was manufactured by Evonik Company.
  • BIOXYNE which is Quaternium-73, was manufactured by Sethic Company.
  • Phenoxyethanol was manufactured by BASF.
  • Propionibacterium acnes ATCC6919 was purchased from Shanghai Fuxiang Biotechnology Co., Ltd.
  • Staphylococcus epidermidis ATCC12228 was purchased from the mall North Natronian Biotechnology Co., Ltd.
  • the solid medium was prepared after being cooled to about 60 °C and poured into a clean sterilization plate.
  • the amount of liquid added was about 1/4-1/3 of the anaerobic bottle. Fully purged with nitrogen to remove oxygen and sterilized at 115 °C as preparation.
  • Cutibacterium acnes (cultured for 3 ⁇ 5 days, anaerobically) with a sterile syringe, transferred it to a culture flask containing 1/3 volume of ground beef in fresh broth, and kept anaerobic at 37 °C. After 3 to 5 days of culture, it could be passaged or used for subsequent experiments.
  • the antibacterial activity of the test substance against Cutibacterium acnes was evaluated by the micro-broth dilution method recommended by the American Association of Clinical and Laboratory Standards (see Dej-Adisai S, Meechai I, Puripattanavong J, Kummee S. Antityrosinase and antimicrobial activities from Thai medicinal plants. Arch Pharm Res, 2014, 37 (4) : 473-483; and Guo M, Lu Y, Yang J, Zhao X, Lu Y. Inhibitory effects of Schisandra chinensis extract on acne-related inflammation and UVB-induced photoageing. Pharmaceutical Biology, 2016, 54 (12) : 2987-2994) to determine the minimum inhibitory concentration (MIC) of the test substance against Cutibacterium acnes.
  • MIC minimum inhibitory concentration
  • the lyophilized powder was taken out from the refrigerator, resuscitated according to the species instructions, and cultured at 105 rpm with a constant temperature of 37 °C. After 1-2 days of culture, transferred a small amount of bacterial liquid to fresh liquid medium. Generally cultured for 3 generations after resuscitation, it could be used for subsequent experiments.
  • the solid powder sample to be tested was first dissolved in DMSO (completely dissolved) , and then filtered through a 0.22 ⁇ M microporous membrane. Diluted twice with the corresponding culture solution, and the appropriate concentration was prepared according to the supplier's recommended amount (DMSO is less than 1%) .
  • the insoluble sample was directly diluted with a medium to prepare a suspension, and the liquid sample was diluted with a medium by volume concentration.
  • the sample solution needed to be prepared right before use. This process needed to be performed aseptically in a clean bench.
  • the 96-well plate was sealed with a parafilm, wrapped in a fresh-keeping bag, and cultured at 37 °C, 105 rpm for 24 h, and the OD value at 530 nm was measured by a microplate reader.
  • the positive drug is: penicillin.
  • Three sets of parallel experiments were conducted. The minimum inhibitory concentration (MIC) was defined as the lowest concentration of the test substance at which bacterial growth was completely inhibited.
  • the direct values of Minimum Inhibitory Concentration (Cutibacterium acnes) and Minimum Inhibitory Concentration (Staphylococcus epidermidis) of all the tested samples were obtained. Then, the calculated values of ( (Minimum Inhibitory Concentration (Cutibacterium acnes) /Minimum Inhibitory Concentration (Staphylococcus epidermidis) ) of all the tested samples were obtained. If the calculated value of a sample is less than 1, the sample is suitable as a microbiome regulator on scalp; whereas if the calculated value of a sample is equal to or higher than 1, the sample is not suitable as a microbiome regulator.
  • the compound containing two or more alcoholic hydroxyl groups or phenolic hydroxyl groups and three to sixteen carbon atoms per molecule can be used as a microbiome regulator for selectively inhibiting Cutibacterium acnes and Staphylococcus epidermidis on scalp.
  • the compounds of Inventive Examples 1-5 can be used as microbiome regulator for selectively inhibiting Cutibacterium acnes and Staphylococcus epidermidis on scalp
  • the compounds of Comparative Examples 1-6 which contain one hydroxyl group, eighteen carbon atoms, no hydroxyl group, one hydroxyl group, no hydroxyl group and twenty-three carbon atoms, and one hydroxyl group per molecule, respectively
  • the compounds of Comparative Examples 1-6 which contain one hydroxyl group, eighteen carbon atoms, no hydroxyl group, one hydroxyl group, no hydroxyl group and twenty-three carbon atoms, and one hydroxyl group per molecule, respectively
  • composition of Example 1 10 subjects were shampooed with the composition of Example 1 every the other day, that is three times shampoos in total. For each shampooing, the composition of Example 1 was applied twice, 6g of each application.
  • Example 2 which is a leave-on serum, it was applied on blow-dried scalp of another 10 subjects after washing, 4 g each subject. During the course, the composition of Example 2 was also applied three times in total.
  • compositions according to the present invention not only cure scalp itchiness &redness to the subject in this short period but also remedy scalp with improved scalp moisture and reduced inflammation securing a healthy scalp condition in a long run.

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Abstract

L'invention concerne une utilisation d'un composé contenant deux ou plusieurs groupes hydroxyle alcooliques ou groupes hydroxyle phénoliques et trois à seize atomes de carbone par molécule, en tant que régulateur du microbiome pour inhiber sélectivement Cutibacterium acnes et Staphylococcus epidermidis sur le cuir chevelu. L'invention concerne une méthode de criblage d'un composé ou d'un mélange pour un régulateur du microbiome sur le cuir chevelu, comprenant les étapes consistant à : tester des Concentrations Minimales Inhibitrices du composé ou du mélange envers Cutibacterium acnes et Staphylococcus epidermidis, respectivement; obtenir des valeurs directes de Concentration Minimale Inhibitrice (Cutibacterium acnes) et de Concentration Minimale Inhibitrice (Staphylococcus epidermidis) du composé ou du mélange, respectivement; obtenir une valeur calculée de ( (Concentration Minimale Inhibitrice (Cutibacterium acnes) / Concentration Minimale Inhibitrice (Staphylococcus epidermidis) ) du composé ou du mélange à partir des valeurs directes ci-dessus; et déterminer que le composé ou le mélange est approprié en tant que régulateur du microbiome sur le cuir chevelu, si la valeur calculée est <1; ou alors que le composé ou que le mélange n'est pas approprié en tant que régulateur du microbiome sur le cuir chevelu, si la valeur calculée est > = 1. L'invention concerne une composition de shampooing ou de sérum de cuir chevelu, comprenant un régulateur du microbiome pour inhiber sélectivement Cutibacterium acnes et Staphylococcus epidermidis sur le cuir chevelu, qui est un composé contenant deux ou plusieurs groupes hydroxyle alcooliques ou groupes hydroxyle phénoliques et trois à seize atomes de carbone par molécule, ou le mélange de ceux-ci.
EP20939406.3A 2020-06-05 2020-06-05 Utilisation d'un composé contenant deux ou plusieurs groupes hydroxyle alcooliques ou groupes hydroxyle phénoliques en tant que régulateur du microbiome sur le cuir chevelu Withdrawn EP4161473A4 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2020/094505 WO2021243669A1 (fr) 2020-06-05 2020-06-05 Utilisation d'un composé contenant deux ou plusieurs groupes hydroxyle alcooliques ou groupes hydroxyle phénoliques en tant que régulateur du microbiome sur le cuir chevelu

Publications (2)

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EP4161473A1 true EP4161473A1 (fr) 2023-04-12
EP4161473A4 EP4161473A4 (fr) 2024-01-24

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WO (1) WO2021243669A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
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WO2024007235A1 (fr) * 2022-07-07 2024-01-11 Henkel Ag & Co. Kgaa Méthode pour déterminer si un cuir chevelu démange ou non, et méthode de traitement de la démangeaison du cuir chevelu
CN115969752B (zh) * 2023-01-19 2024-03-01 广州环亚化妆品科技股份有限公司 无患子发酵物在调节皮肤微生态平衡中的应用
WO2024212124A1 (fr) * 2023-04-12 2024-10-17 Henkel Ag & Co. Kgaa Composition pour améliorer la santé du cuir chevelu, et procédé pour améliorer la santé du cuir chevelu l'utilisant

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1363499A (en) * 1997-10-23 1999-05-10 Pharmaprint, Inc. Pharmaceutical grade echinacea
EP2807925A1 (fr) * 2013-05-26 2014-12-03 Symrise AG Compositions antimcrobielles
CN103494713B (zh) * 2013-10-16 2015-05-06 广东轻工职业技术学院 一种具有防腐功效的组合物及在化妆品中的应用
CN103767884B (zh) * 2014-01-02 2016-08-17 北京桑普生物化学技术有限公司 一种天然植物防腐剂组合物
CN103936606B (zh) * 2014-04-03 2015-03-25 陕西师范大学 一种水溶性根皮素衍生物及其制备方法
EP4450128A3 (fr) * 2016-10-11 2024-11-06 Symrise AG Compositions antimicrobiennes
CN108888541A (zh) * 2018-06-29 2018-11-27 广州昕生医学材料有限公司 一种皮肤护理组合物及其制备方法

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