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EP4008309A4 - BRUCIN GEL FORMULATION AND PROCESS OF PRODUCTION - Google Patents

BRUCIN GEL FORMULATION AND PROCESS OF PRODUCTION Download PDF

Info

Publication number
EP4008309A4
EP4008309A4 EP20850549.5A EP20850549A EP4008309A4 EP 4008309 A4 EP4008309 A4 EP 4008309A4 EP 20850549 A EP20850549 A EP 20850549A EP 4008309 A4 EP4008309 A4 EP 4008309A4
Authority
EP
European Patent Office
Prior art keywords
brucin
production
gel formulation
formulation
gel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20850549.5A
Other languages
German (de)
French (fr)
Other versions
EP4008309A1 (en
Inventor
Baoxian Zhang
Jie Hu
Zhenzhen Wu
Qian Zhao
Chunmei XUE
Wenhui Li
Ying Cao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Increasepharm Corp Ltd
Original Assignee
Beijing Increasepharm Corp Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Increasepharm Corp Ltd filed Critical Beijing Increasepharm Corp Ltd
Publication of EP4008309A1 publication Critical patent/EP4008309A1/en
Publication of EP4008309A4 publication Critical patent/EP4008309A4/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/475Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Rheumatology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP20850549.5A 2019-08-02 2020-07-31 BRUCIN GEL FORMULATION AND PROCESS OF PRODUCTION Pending EP4008309A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201910709653.XA CN112386565B (en) 2019-08-02 2019-08-02 Strychnine gel preparation and preparation method thereof
PCT/CN2020/106108 WO2021023099A1 (en) 2019-08-02 2020-07-31 Brucine gel formulation and preparation method therefor

Publications (2)

Publication Number Publication Date
EP4008309A1 EP4008309A1 (en) 2022-06-08
EP4008309A4 true EP4008309A4 (en) 2023-08-23

Family

ID=74503248

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20850549.5A Pending EP4008309A4 (en) 2019-08-02 2020-07-31 BRUCIN GEL FORMULATION AND PROCESS OF PRODUCTION

Country Status (6)

Country Link
US (1) US20220313683A1 (en)
EP (1) EP4008309A4 (en)
JP (1) JP2022542304A (en)
KR (1) KR20220042147A (en)
CN (1) CN112386565B (en)
WO (1) WO2021023099A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023551417A (en) * 2020-11-20 2023-12-08 セーリング ファーマシューティカル テクノロジー グループ カンパニー リミテッド Brusingel plaster, its manufacturing method and use
CN114931548A (en) * 2022-05-19 2022-08-23 季华实验室 Preparation method of gendarussa wine gel paste
CN115896237A (en) * 2022-12-19 2023-04-04 许奕鹏 Gel reagent, kit and rapid screening method for rapid screening of urease activity
CN115919754B (en) * 2023-01-06 2023-09-12 广州家安化妆品有限公司 Mucosal sterilizing gel for inactivating viruses and preparation method thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747021A (en) * 1997-01-10 1998-05-05 Mckenzie; Therman After shave treatment composition
US20100029765A1 (en) * 2008-07-30 2010-02-04 Ranbaxy Labortories Limited Topical aqueous composition comprising tretinoin
CN102008476B (en) * 2010-11-22 2015-01-07 南京中医药大学 Hydroxypropyl-beta-cyclodextrin inclusion of strychnine and preparation method thereof
HRP20201731T1 (en) * 2011-01-07 2020-12-25 Anji Pharma (Us) Llc CHEMOSENSORIC RECEPTOR LIGAND-BASED THERAPIES
KR20230129619A (en) * 2013-08-21 2023-09-08 베리카 파마슈티컬스 인크. Compositions, methods and systems for the treatment of cutaneous disorders
NZ738815A (en) * 2015-07-13 2019-10-25 Dr Reddy’s Laboratories Ltd Topical retinoid compositions

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
"Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Modification of the Stratum Corneum", 3 November 2015, SPRINGER, article DRAGICEVIC NINA ET AL: "Part 2 Chemical Penetration Enhancers in Penetration Enhancement; 2 Chemical Penetration Enhancers: Classification and Mode of Action", pages: 20 - 21, XP093133328 *
JUNLING WANG ET AL: "Preparation and pharmaceutical/pharmacodynamic evaluation of topical brucine-loaded liposomal hydrogel", JOURNAL OF MATERIALS SCIENCE: MATERIALS IN MEDICINE, KLUWER ACADEMIC PUBLISHERS, BO, vol. 20, no. 10, 21 May 2009 (2009-05-21), pages 2075 - 2084, XP019750145, ISSN: 1573-4838, DOI: 10.1007/S10856-009-3773-6 *
See also references of WO2021023099A1 *
VALENTA C ET AL: "The use of polymers for dermal and transdermal delivery", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL, vol. 58, no. 2, 1 September 2004 (2004-09-01), pages 279 - 289, XP004526312, ISSN: 0939-6411, DOI: 10.1016/J.EJPB.2004.02.017 *
WU PING ET AL: "A Novel Brucine Gel Transdermal Delivery System Designed for Anti-Inflammatory and Analgesic Activities", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 18, no. 4, 3 April 2017 (2017-04-03), pages 757, XP055780285, DOI: 10.3390/ijms18040757 *

Also Published As

Publication number Publication date
EP4008309A1 (en) 2022-06-08
CN112386565A (en) 2021-02-23
KR20220042147A (en) 2022-04-04
CN112386565B (en) 2024-09-13
US20220313683A1 (en) 2022-10-06
JP2022542304A (en) 2022-09-30
WO2021023099A1 (en) 2021-02-11

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