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EP4069868A4 - Méthodes de détection et d'analyse d'acide nucléique dans des exosomes dérivés de neurones - Google Patents

Méthodes de détection et d'analyse d'acide nucléique dans des exosomes dérivés de neurones Download PDF

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Publication number
EP4069868A4
EP4069868A4 EP20896246.4A EP20896246A EP4069868A4 EP 4069868 A4 EP4069868 A4 EP 4069868A4 EP 20896246 A EP20896246 A EP 20896246A EP 4069868 A4 EP4069868 A4 EP 4069868A4
Authority
EP
European Patent Office
Prior art keywords
neural
analysis
detection
methods
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20896246.4A
Other languages
German (de)
English (en)
Other versions
EP4069868A2 (fr
Inventor
Sandra Anne Banack
Rachael DUNLOP
Paul Alan Cox
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institute For Ethnomedicine dba Brain Chemistry Labs
Original Assignee
Institute For Ethnomedicine dba Brain Chemistry Labs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute For Ethnomedicine dba Brain Chemistry Labs filed Critical Institute For Ethnomedicine dba Brain Chemistry Labs
Publication of EP4069868A2 publication Critical patent/EP4069868A2/fr
Publication of EP4069868A4 publication Critical patent/EP4069868A4/fr
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/178Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP20896246.4A 2019-12-02 2020-12-02 Méthodes de détection et d'analyse d'acide nucléique dans des exosomes dérivés de neurones Pending EP4069868A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962942682P 2019-12-02 2019-12-02
US202063042469P 2020-06-22 2020-06-22
PCT/US2020/062936 WO2021113394A2 (fr) 2019-12-02 2020-12-02 Méthodes de détection et d'analyse d'acide nucléique dans des exosomes dérivés de neurones

Publications (2)

Publication Number Publication Date
EP4069868A2 EP4069868A2 (fr) 2022-10-12
EP4069868A4 true EP4069868A4 (fr) 2024-04-17

Family

ID=76091430

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20896246.4A Pending EP4069868A4 (fr) 2019-12-02 2020-12-02 Méthodes de détection et d'analyse d'acide nucléique dans des exosomes dérivés de neurones

Country Status (7)

Country Link
US (1) US20210164051A1 (fr)
EP (1) EP4069868A4 (fr)
JP (1) JP7734427B2 (fr)
AU (1) AU2020395776A1 (fr)
CA (1) CA3158712A1 (fr)
IL (1) IL293392A (fr)
WO (1) WO2021113394A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USD966445S1 (en) * 2019-02-13 2022-10-11 Global Sports Innovation LTD Sports training device
CA3222315A1 (fr) * 2021-06-15 2022-12-22 Thomas N. Chase Indices de diagnostic pour des affections neurodegeneratives
CN113466469B (zh) * 2021-07-07 2024-01-16 北京常友生物科技有限公司 自闭症检测的生物标志物、检测试剂盒及检测系统
CN116004618B (zh) * 2022-08-22 2025-05-06 集美大学 一种具有抗过敏活性的miRNA及其应用
JP7406059B1 (ja) * 2022-10-20 2023-12-27 防衛装備庁長官 急性ストレス評価用データの生成方法
CN117982667B (zh) * 2024-04-02 2024-06-21 四川省肿瘤医院 靶向TLR4-MD2/MyD88信号通路的递送系统、其制备方法及其应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016138287A1 (fr) * 2015-02-25 2016-09-01 Washington University Procédés pour détecter la maladie des motoneurones au moyen de micro-arn
US20180023142A1 (en) * 2011-10-11 2018-01-25 The Brigham And Women`S Hospital, Inc. Micrornas in neurodegenerative disorders
US20190249250A1 (en) * 2015-11-20 2019-08-15 Braindtech S.R.L. Microglia Microvesicles Contained MicroRNA-Based Methods For The Diagnosis, Prognosis And Treatment Monitoring Of Neurological, Neurodegenerative And Inflammation-Based Diseases
US20190361037A1 (en) * 2016-11-16 2019-11-28 Nanosomix, Inc. Quantification of subpopulations of exosomes and diagnosis of neurogenerative disorders
WO2020230133A1 (fr) * 2019-05-13 2020-11-19 Yeda Research And Development Co. Ltd. Biomarqueurs de micro-adn acellulaire pour le pronostic et le diagnostic de maladies neurodégénératives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6541049B2 (ja) * 2014-01-16 2019-07-10 国立大学法人北海道大学 筋萎縮性側索硬化症のバイオマーカー
JP2016198021A (ja) 2015-04-08 2016-12-01 国立大学法人北海道大学 筋萎縮性側索硬化症の検出を補助する方法及び治療剤
US20180356405A1 (en) * 2015-09-29 2018-12-13 Essenlix Corp. Method of Detecting an Analyte in a Sample
US11149313B2 (en) * 2016-03-21 2021-10-19 Diamir, Llc Methods of using miRNAs from bodily fluids for detection and differentiation of neurodegenerative diseases
JP7390285B2 (ja) * 2017-06-26 2023-12-01 ウニヴェルズィテート・フューア・ボーデンクルトゥーア・ウィーン 老化細胞を検出するための新規バイオマーカー

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180023142A1 (en) * 2011-10-11 2018-01-25 The Brigham And Women`S Hospital, Inc. Micrornas in neurodegenerative disorders
WO2016138287A1 (fr) * 2015-02-25 2016-09-01 Washington University Procédés pour détecter la maladie des motoneurones au moyen de micro-arn
US20190249250A1 (en) * 2015-11-20 2019-08-15 Braindtech S.R.L. Microglia Microvesicles Contained MicroRNA-Based Methods For The Diagnosis, Prognosis And Treatment Monitoring Of Neurological, Neurodegenerative And Inflammation-Based Diseases
US20190361037A1 (en) * 2016-11-16 2019-11-28 Nanosomix, Inc. Quantification of subpopulations of exosomes and diagnosis of neurogenerative disorders
WO2020230133A1 (fr) * 2019-05-13 2020-11-19 Yeda Research And Development Co. Ltd. Biomarqueurs de micro-adn acellulaire pour le pronostic et le diagnostic de maladies neurodégénératives

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BANACK SANDRA ANNE ET AL: "An miRNA fingerprint using neural-enriched extracellular vesicles from blood plasma: towards a biomarker for amyotrophic lateral sclerosis/motor neuron disease", vol. 10, no. 6, 24 June 2020 (2020-06-24), XP093096835, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333885/pdf/rsob-10-200116.pdf> DOI: 10.1098/rsob.200116 *
BASAK INDRANIL ET AL: "microRNAs as neuroregulators, biomarkers and therapeutic agents in neurodegenerative diseases", CMLS CELLULAR AND MOLECULAR LIFE SCIENCES, BIRKHAUSER VERLAG, HEIDELBERG, DE, vol. 73, no. 4, 25 November 2015 (2015-11-25), pages 811 - 827, XP035616688, ISSN: 1420-682X, [retrieved on 20151125], DOI: 10.1007/S00018-015-2093-X *
CAGGIU ELISA ET AL: "Differential expression of miRNA 155 and miRNA 146a in Parkinson's disease patients", ENEUROLOGICALSCI, vol. 13, 14 September 2018 (2018-09-14), pages 1 - 4, XP055934499, ISSN: 2405-6502, DOI: 10.1016/j.ensci.2018.09.002 *
KATSU MASATAKA ET AL: "MicroRNA expression profiles of neuron-derived extracellular vesicles in plasma from patients with amyotrophic lateral sclerosis", NEUROSCIENCE LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 708, 4 June 2019 (2019-06-04), XP085799833, ISSN: 0304-3940, [retrieved on 20190604], DOI: 10.1016/J.NEULET.2019.03.048 *
RICCI CLAUDIA ET AL: "MicroRNAs as Biomarkers in Amyotrophic Lateral Sclerosis", CELLS, vol. 7, no. 11, 20 November 2018 (2018-11-20), pages 219, XP055943572, DOI: 10.3390/cells7110219 *
SADLON ANG�LIQUE ET AL: "miRNAs Identify Shared Pathways in Alzheimer's and Parkinson's Diseases", TRENDS IN MOLECULAR MEDICINE, ELSEVIER CURRENT TRENDS, GB, vol. 25, no. 8, 17 June 2019 (2019-06-17), pages 662 - 672, XP085749558, ISSN: 1471-4914, [retrieved on 20190617], DOI: 10.1016/J.MOLMED.2019.05.006 *
V VISWABHARAN ET AL: "miRNAs as biomarkers of neurodegenerative disorders", BIOMARKERS IN MEDICINE, vol. 11, no. 2, 26 January 2017 (2017-01-26), UK, pages 151 - 157, XP055522146, ISSN: 1752-0363, DOI: https://doi.org/10.2217/bmm-2016-0242 *

Also Published As

Publication number Publication date
WO2021113394A2 (fr) 2021-06-10
US20210164051A1 (en) 2021-06-03
IL293392A (en) 2022-07-01
EP4069868A2 (fr) 2022-10-12
JP2023510083A (ja) 2023-03-13
AU2020395776A1 (en) 2022-06-23
CA3158712A1 (fr) 2021-06-10
WO2021113394A3 (fr) 2021-10-28
JP7734427B2 (ja) 2025-09-05

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