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EP4059427A1 - Dispositif pour écoulement suivi de sang - Google Patents

Dispositif pour écoulement suivi de sang Download PDF

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Publication number
EP4059427A1
EP4059427A1 EP22172551.8A EP22172551A EP4059427A1 EP 4059427 A1 EP4059427 A1 EP 4059427A1 EP 22172551 A EP22172551 A EP 22172551A EP 4059427 A1 EP4059427 A1 EP 4059427A1
Authority
EP
European Patent Office
Prior art keywords
blood
flow
container
attachment portion
housing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP22172551.8A
Other languages
German (de)
English (en)
Other versions
EP4059427B1 (fr
EP4059427C0 (fr
Inventor
Kishore K BOKKA SRINIVASA RAO
Jayeon IM
Milan Ivosevic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Priority to EP24164531.6A priority Critical patent/EP4364661A3/fr
Publication of EP4059427A1 publication Critical patent/EP4059427A1/fr
Application granted granted Critical
Publication of EP4059427B1 publication Critical patent/EP4059427B1/fr
Publication of EP4059427C0 publication Critical patent/EP4059427C0/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061—Means for enhancing collection
    • A61B5/150068—Means for enhancing collection by tissue compression, e.g. with specially designed surface of device contacting the skin area to be pierced
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150106—Means for reducing pain or discomfort applied before puncturing; desensitising the skin at the location where body is to be pierced
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150251—Collection chamber divided into at least two compartments, e.g. for division of samples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150259—Improved gripping, e.g. with high friction pattern or projections on the housing surface or an ergonometric shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150267—Modular design or construction, i.e. subunits are assembled separately before being joined together or the device comprises interchangeable or detachable modules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150343—Collection vessels for collecting blood samples from the skin surface, e.g. test tubes, cuvettes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
    • A61B5/150396—Specific tip design, e.g. for improved penetration characteristics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
    • A61B5/150404—Specific design of proximal end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150442—Blade-like piercing elements, e.g. blades, cutters, knives, for cutting the skin
    • A61B5/15045—Blade-like piercing elements, e.g. blades, cutters, knives, for cutting the skin comprising means for capillary action
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150442—Blade-like piercing elements, e.g. blades, cutters, knives, for cutting the skin
    • A61B5/150458—Specific blade design, e.g. for improved cutting and penetration characteristics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150748—Having means for aiding positioning of the piercing device at a location where the body is to be pierced
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150755—Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101—Details
    • A61B5/15103—Piercing procedure
    • A61B5/15105—Purely manual piercing, i.e. the user pierces the skin without the assistance of any driving means or driving devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15142—Devices intended for single use, i.e. disposable

Definitions

  • the present disclosure relates generally to devices adapted for use with biological fluids. More particularly, the present disclosure relates to devices for controlling the flow of blood.
  • Blood sampling is a common health care procedure involving the withdrawal of at least a drop of blood from a patient.
  • Blood samples are commonly taken from hospitalized, homecare, and emergency room patients either by finger stick, heel stick, or venipuncture. Once collected, blood samples may be analyzed to obtain medically useful information including chemical composition, hematology, or coagulation, for example.
  • Blood tests determine the physiological and biochemical states of the patient, such as disease, mineral content, drug effectiveness, and organ function. Blood tests may be performed in a clinical laboratory or at the point-of-care near the patient.
  • Lancet devices are used in the medical field for puncturing the skin of a patient to obtain a small sample of capillary blood from the patient.
  • Certain diseases such as diabetes, require that a patient's blood be tested on a regular basis to monitor, for example, the patient's blood sugar levels.
  • test kits such as cholesterol test kits, often require a small blood sample for analysis.
  • the blood collection procedure usually involves pricking a finger or other suitable body part in order to obtain the blood sample.
  • the amount of blood needed for such tests is relatively small and a small puncture wound or incision normally provides a sufficient amount of blood for these tests.
  • the blood Upon puncturing the skin of a patient using a lancet device, the blood will spread and remain on a surface of the finger.
  • the present disclosure provides a collection device which directs a flow of blood into a container and provides a controlled blood flow path that ensures blood flow from a collection site to a collection container.
  • the device for attached flow of blood of the present disclosure achieves this using three key technical elements to control the flow of blood in the desired manner.
  • First controlling and guiding a blood sample from a skin surface of a patient to a collection housing via a first flow directing attachment portion.
  • Second controlling and guiding the blood sample from a first end of a collection housing to a second end of the collection housing via capillary transfer.
  • Third controlling and guiding the blood sample from the second end of the collection housing into a collection cavity of a collection container via a second flow directing attachment portion.
  • a first flow directing attachment portion, a flow channel, a second flow directing attachment portion, and an interior wall surface of a container provide attachment portions to establish attached blood flow, for a first drop of blood and subsequent blood to follow, from the first end of the housing to a collection cavity of the container.
  • a device for attached flow of blood includes a housing defining a centerline and having a first end, a second end, and a flow channel having an inlet and an outlet, a portion of the flow channel offset from the centerline of the housing, and the flow channel having a first flow directing attachment portion adjacent the inlet and a second flow directing attachment portion adjacent the outlet; and a container removably connectable to the housing, the container defining a collection cavity and having an interior wall, wherein, with the container connected to the housing, the outlet of the flow channel is in fluid communication with the collection cavity of the container and the outlet of the flow channel is adjacent the interior wall of the container.
  • the first flow directing attachment portion provides a first fluid attachment point for blood to attach to for controlling the flow of blood from a skin surface to a portion of the housing.
  • the second flow directing attachment portion provides a second fluid attachment point for blood to attach to for controlling the flow of blood from a portion of the housing to the collection cavity of the container.
  • the first flow directing attachment portion, the flow channel, the second flow directing attachment portion, and the interior wall of the container provide attachment portions to establish attached blood flow, for a first drop of blood and subsequent blood to follow, from the first end of the housing to the collection cavity of the container.
  • the blood fluidly attaches to the first flow directing attachment portion and flows from the first flow directing attachment portion to the flow channel.
  • the blood is subsequently pulled through the flow channel to the second flow directing attachment portion via capillary action.
  • the blood fluidly attaches to the second flow directing attachment portion and the interior wall of the container to flow from the flow channel into the collection cavity of the container.
  • the first end of the housing includes a sloped wall surface, the first flow directing attachment portion extends from the sloped wall surface, and the sloped wall surface defines a flow channel entry.
  • the first flow directing attachment portion is an attachment pillar.
  • the first flow directing attachment portion comprises a plurality of attachment pillars.
  • the second flow directing attachment portion is an attachment lip.
  • the second flow directing attachment portion is an extended capillary tube portion.
  • the second flow directing attachment portion is an inward curved lip.
  • the second flow directing attachment portion is a planar cut lip.
  • the second flow directing attachment portion is an extended pillar structure.
  • the outlet of the flow channel extends beyond the second end of the housing.
  • a device for attached flow of blood includes a housing defining a centerline and having a first end, a second end, a hollow needle, and a flow channel having an inlet and an outlet, a portion of the flow channel offset from the centerline of the housing, the flow channel having a flow directing attachment portion adjacent the outlet, and the hollow needle between the first end of the housing and the flow channel; and a container removably connectable to the housing, the container defining a collection cavity and having an interior wall, wherein, with the container connected to the housing, the outlet of the flow channel is in fluid communication with the collection cavity of the container and the outlet of the flow channel is adjacent the interior wall of the container.
  • the flow directing attachment portion provides a fluid attachment point for blood to attach to for controlling the flow of blood from a portion of the housing to the collection cavity of the container.
  • the hollow needle, the flow channel, the flow directing attachment portion, and the interior wall of the container provide attachment portions to establish attached blood flow, for a first drop of blood and subsequent blood to follow, from the first end of the housing to the collection cavity of the container.
  • the blood fluidly attaches to a portion of the hollow needle and flows through the hollow needle to the flow channel.
  • the blood is subsequently pulled through the flow channel to the flow directing attachment portion via capillary action.
  • the blood fluidly attaches to the flow directing attachment portion and the interior wall of the container to flow from the flow channel into the collection cavity of the container.
  • the housing includes a sloped wall surface between the hollow needle and the flow channel, and the sloped wall surface defines a flow channel entry.
  • the flow directing attachment portion is an attachment lip.
  • the flow directing attachment portion is an extended capillary tube portion.
  • the flow directing attachment portion is an inward curved lip.
  • the flow directing attachment portion is a planar cut lip.
  • the flow directing attachment portion is an extended pillar structure.
  • the outlet of the flow channel extends beyond the second end of the housing.
  • the device further includes a flow directing ring around the hollow needle.
  • the hollow needle includes a lancing blade.
  • a first drop of blood attaches to the lancing blade and flows through the hollow needle to the flow channel.
  • the device for attached flow of blood 10 of the present disclosure provides a controlled blood flow path that ensures attached blood flow from a collection site to a collection container.
  • the device for attached flow of blood 10 of the present disclosure achieves this using three key technical elements to control the flow of blood in the desired manner. First, controlling and guiding a blood sample from a skin surface of a patient to a collection housing via a first flow directing attachment portion. Second, controlling and guiding the blood sample from a first end of a collection housing to a second end of the collection housing via capillary transfer. Third, controlling and guiding the blood sample from the second end of the collection housing into a collection cavity of a collection container via a second flow directing attachment portion.
  • Figs. 1-10B illustrate an exemplary embodiment of a device for attached flow of blood of the present disclosure.
  • a device for attached flow of blood 10 of the present disclosure provides a controlled blood flow path that ensures attached blood flow from a collection site to a collection container.
  • the blood Upon puncturing the skin of a patient using a typical lancet device, the blood will spread and remain on a surface of the finger. Without controlling the blood and the flow of blood, the blood may remain on a surface of the finger and may not readily flow to a collection container.
  • a device for attached flow i.e., providing flow directing attachment portions for a blood sample to attach to for guiding and controlling the flow of the blood sample from a collection site to a collection container, of blood 10 generally includes a housing 12 and a collection container 14 that is removably connectable to the housing 12.
  • the container 14 defines a collection cavity 70 and includes an interior wall or interior wall surface 72.
  • the housing 12 defines a centerline CL and includes a first end 20, a second end 22, and a flow channel 24.
  • the flow channel 24 includes an inlet 26 and an outlet 28.
  • a portion of the flow channel 24, e.g., a middle portion 30, is offset from the centerline CL of the housing 12. This ensures that the outlet 28 of the flow channel 24 is adjacent to an interior wall surface 72 of the container 14, as described in more detail below.
  • the flow channel 24 also includes a first flow directing attachment portion 32 at the inlet 26 and a second flow directing attachment portion 34 at the outlet 28.
  • the outlet 28 of the flow channel 24 extends beyond the second end 22 of the housing 12 as shown in Figs. 1 and 2 .
  • the outlet 28 of the flow channel 24 is in fluid communication with the collection cavity 70 of the container 14 and the outlet 28 of the flow channel 24 is adjacent the interior wall surface 72 of the container 14.
  • the first end 20 of the housing 12 includes a sloped wall surface 36.
  • the sloped wall surface 36 provides physical structure, i.e., a wall surface, which allows the first flow directing attachment portion 32 to extend upwards from.
  • the first flow directing attachment portion 32 extends upwards from the sloped wall surface 36 to the inlet 26 of the housing 12.
  • the sloped wall surface 38 defines a flow channel entry 38.
  • the device for attached flow of blood 10 of the present disclosure provides a controlled blood flow path that ensures attached blood flow from a collection site to a collection container.
  • the device for attached flow of blood 10 of the present disclosure achieves this using three key technical elements to control the flow of blood in the desired manner. First, controlling and guiding a blood sample from a skin surface of a patient to a collection housing via a first flow directing attachment portion. Second, controlling and guiding the blood sample from a first end of a collection housing to a second end of the collection housing via capillary transfer. Third, controlling and guiding the blood sample from the second end of the collection housing into a collection cavity of a collection container via a second flow directing attachment portion.
  • the first flow directing attachment portion 32, the flow channel 24, the second flow directing attachment portion 34, and the interior wall surface 72 of the container 14 provide attachment portions to establish attached blood flow, for a first drop of blood 16 and subsequent blood 16 to follow, from the first end 20 of the housing 12 to a collection cavity 70 of the container 14.
  • the first key blood flow path element 40 involves directing the first drop of blood 16 away from a surface S of a finger F in a direction towards a collection container 14.
  • the first flow directing attachment portion 32 provides a pillar which the first drop of blood 16 attaches to and flows down and into the flow channel 24 of the housing 12 in a controlled manner.
  • a first drop of blood 16 attaches to the first flow directing attachment portion 32 and flows from the first flow directing attachment portion 32 to the flow channel 24.
  • the sloped wall surface 36 provides a downward attached flow path from the first flow directing attachment portion 32 to the flow channel 24 of the housing 12. After the first drop of blood 16 attaches to and flows down the first flow directing attachment portion 32, the subsequent blood 16 follows the attached blood flow path of the first drop of blood 16 from the first end 20 of the housing 12 to the collection cavity 70 of the container 14.
  • the second key blood flow path element 42 involves directing the blood 16 down the flow channel 24 to the second flow directing attachment portion 34 in a direction towards a collection container 14. For example, the first drop of blood 16, and subsequent blood 16, is pulled through the flow channel 24 to the second flow directing attachment portion 34 via capillary motion.
  • the flow channel 24 is a capillary flow channel.
  • the flow channel 24 is a capillary tube that uses capillary forces to pull the blood 16 down the flow channel 24 away from the surface S of the finger F.
  • the third key blood flow path element 44 involves directing the blood 16 from the flow channel 24 into the collection container 14.
  • the device 10 of the present disclosure ensures transition from the flow channel 24 to the container 14 via attached flow.
  • the blood 16 attaches to the second flow directing attachment portion 34 and the interior wall surface 72 of the container 14 to flow from the flow channel 24 into the collection cavity 70 of the container 14.
  • the third key blood flow path element 44 involving directing the blood 16 from the flow channel 24 into the collection container 14 is the reason that it is important that a portion of the flow channel 24, e.g., a middle portion 30, is offset from the centerline CL of the housing 12. This ensures that the outlet 28 of the flow channel 24, and the second flow directing attachment portion 34, is adjacent to an interior wall surface 72 of the container 14 to ensure the transition of the attached blood flow from the flow channel 24 to the container 14.
  • the blood 16 will only flow down and out the flow channel 24 into the container 14 if the blood 16 is able to find another portion to attach to.
  • the second flow directing attachment portion 34 and the interior wall surface 72 of the container 14 provide such attachment portions to control the blood 16 to the collection cavity 70 of the container 14 via attached blood flow.
  • the device 10 of the present disclosure establishes attached blood flow, for a first drop of blood 16 and subsequent blood 16 to follow, from the first end 20 of the housing 12 to a collection cavity 70 of the container 14.
  • the first flow directing attachment portion 32 may include a variety of different designs and structures as shown in Figs. 3-6 . Additional alternative designs and structures of the first flow directing attachment portion 32 are contemplated.
  • the first flow directing attachment portion 32 is an attachment pillar 50.
  • the attachment pillar 50 is a single pillar structure that may have a variable diameter and length.
  • the pillar 50 may include hydrophilic surface properties to attract the first drop of blood and establish a flow path to the second capillary section.
  • the pillar 50 may have a diameter of between 0.25 mm to 4 mm, and a length of between 2 mm and 20 mm.
  • the first flow directing attachment portion 32 is a plurality of attachment pillars 52.
  • the plurality of attachment pillars 52 may include pillars having different sizes and structures including a variety of different number of pillars.
  • the plurality of attachment pillars 52 provide multiple surfaces for the first drop of blood to establish a flow path without smearing to the side of the structure or pooling in an undesired location.
  • the multiple pillars 52 can also provide for additional capillary action due to the multiple capillary sections created between the individual pillar structures.
  • the plurality of attachment pillars 52 may include between 2 and 10 attachment pillars, such as between 5 and 10 attachment pillars.
  • the each pillar may have a diameter of between 0.25 mm to 4 mm, and a length of between 2 mm and 20 mm.
  • the first flow directing attachment portion 32 is a protruding structure 54.
  • the protruding structure 54 guides the attached flow of blood and may include different shapes, sizes, and structures.
  • the slanted structure provides a hydrophilic surface for the first drop of blood to attach to and be guided to the second capillary section.
  • the thickness of the slanted structure may be from about 0.25 to about 5 mm.
  • the first flow directing attachment portion 32 is a capillary groove portion 56.
  • the capillary groove portion 56 guides the attached flow of blood and may include different shapes, sizes, and number of grooves.
  • the pillar structure having grooves aids with higher capillary force due to the increased surface in the grooves thereby acting as capillary channels for the first drop of blood to be wicked from the finger and transferred to the second capillary channel.
  • the number of grooves provided may be between 1 and 20, and the diameter of each groove may be between 0.25 mm and 1 mm.
  • the second flow directing attachment portion 34 may include a variety of different designs and structures as shown in Figs. 7A-10B . Additional alternative designs and structures of the second flow directing attachment portion 34 are contemplated.
  • the second flow directing attachment portion 34 is an attachment lip 60.
  • the attachment lip 60 is a lip designed to establish attached blood flow into the collection cavity 70 of the container 14 as described above.
  • the attachment lip 60 provides a surface for the blood to expand and form a droplet to establish attachment to the collection cavity.
  • the second flow directing attachment portion 34 is an extended capillary tube portion 62.
  • the extended capillary tube portion may extend between 2 mm and 10 mm beyond the flow channel 24.
  • the extended capillary tube portion 62 may be spaces from the wall of the collection container a distance of less than 1 mm.
  • the second flow directing attachment portion 34 is an inward curved lip 64.
  • the inward curved lip structure aids in the attachment of the blood from a portion of the housing to the surface of the collection cavity.
  • the inward curved lip structure may extend beyond the flow channel 24 from about 0.5 to about 10 mm.
  • the second flow directing attachment portion 34 is a planar cut lip 66.
  • the planar cut lip 66 also aids in the formation of a blood droplet and the establishment of an attachment of blood to the surface of a collection cavity.
  • the planar cut lip may have an angle from about 10° to about 80°.
  • the second flow directing attachment portion 34 is an extended pillar structure 68.
  • the extended pillar structure may extend beyond the flow channel 24 a distance of from about 0.5 mm to about 10 mm.
  • a collection container 14 of the present disclosure is removably connectable to the housing 12.
  • the container 14 defines a collection cavity 70 and includes an interior wall or interior wall surface 72.
  • the outlet 28 of the flow channel 24 is in fluid communication with the collection cavity 70 of the container 14 and the outlet 28 of the flow channel 24 is adjacent the interior wall surface 72 of the container 14.
  • the inner diameter of the flow channel 24 may be from about 0.5 mm to about 2 mm.
  • the container 14 includes a removably connectable cap 74 and a tether element 76.
  • the cap 74 is removed when the container 14 is connected to the housing 12 as shown in Fig. 25A .
  • the tether element 76 ensures that the cap 74 still remains secured to a portion of the container 14 with the cap 74 disconnected from an open top end 78 of the container 14 as shown in Fig. 25B .
  • the container 14 is removed from the housing 12 and the cap 74 is connected to the container 14 to protectively seal the blood 16 within the container 14 as shown in Fig. 25C .
  • the container 14 includes a resealable septum 80.
  • a portion of the flow channel 24 pierces the septum 80 so that the flow channel 24 is in fluid communication with the collection cavity 70 of the container 14.
  • the septum 80 automatically reseals to the closed, sealed position to protectively seal the blood 16 within the container 14 as shown in Fig. 26B .
  • the container 14 includes a deformable dispensing portion 82.
  • a portion of the blood 16 may be dispensed from the container 14 by activation of the deformable portion 82.
  • the deformable portion 82 is transitionable between an initial position ( Figs. 27A-27B ) in which the blood 16 is contained within the collection cavity 70 and a deformed position ( Fig. 27C ) in which a portion of the blood 16 is expelled from the collection cavity 70 of the container 14.
  • the deformable portion 82 is squeezed to transition from the initial position ( Figs. 27A-27B ) to the deformed position ( Fig.
  • the blood 16 may be transferred to a device intended to analyze the sample, e.g., such as a point-of-care testing device, a cartridge tester, or a near patient testing device, while minimizing the exposure of the medical practitioner to the blood sample.
  • the container 14 also includes an end cap 84 to safely seal an exit portion 86 of the container 14. When a user is ready to expel a portion of blood 16 from the container 14, the end cap 84 is removed from the exit portion 86 of the container 14 before dispensing blood 16.
  • the container 14 includes an extension tube 88.
  • the extension tube 88 is compatible with analyzers and analyzing devices.
  • Figs. 17-24 illustrate another exemplary embodiment of a device for attached flow of blood of the present disclosure.
  • a device for attached flow of blood 100 of the present disclosure provides a controlled blood flow path that ensures attached blood flow from a collection site to a collection container.
  • the blood Upon puncturing the skin of a patient using a lancet device, the blood will spread and remain on a surface of the finger. Without controlling the blood and the flow of blood, the blood will remain on a surface of the finger and will not flow to a collection container.
  • a device for attached flow of blood 100 generally includes a housing 112 and a collection container 14 that is removably connectable to the housing 112.
  • the container 14 defines a collection cavity 70 and includes an interior wall or interior wall surface 72.
  • the same containers 14 that are compatible with the device 10 described above with reference to Figs. 1-10B are compatible with the device 100 described with reference to Figs. 17-24 .
  • the housing 112 defines a centerline CL and includes a first end 120, a second end 122, a hollow needle 123, and a flow channel 124.
  • the flow channel 24 includes an inlet 126 and an outlet 128.
  • a portion of the flow channel 124 e.g., a bottom portion 130, is offset from the centerline CL of the housing 112. This ensures that the outlet 128 of the flow channel 124 is adjacent to an interior wall surface 72 of the container 14, as described in more detail below.
  • the flow channel 124 also includes a flow directing attachment portion 134 at the outlet 128.
  • the outlet 128 of the flow channel 124 extends beyond the second end 122 of the housing 112 as shown in Fig. 17 .
  • the hollow needle 123 is between the first end 120 of the housing 112 and the flow channel 124.
  • the hollow needle 123 functions similar to the first flow directing attachment portion 32 described above with respect to device 10 shown in Figs. 1-10B .
  • the outlet 128 of the flow channel 124 is in fluid communication with the collection cavity 70 of the container 14 and the outlet 128 of the flow channel 124 is adjacent the interior wall surface 72 of the container 14.
  • the blood Upon puncturing the skin of a patient using a lancet device, the blood will spread and remain on a surface of the finger. Without controlling the blood and the flow of blood, the blood will remain on a surface of the finger and will not flow to a collection container.
  • the device for attached flow of blood 100 of the present disclosure provides a controlled blood flow path that ensures attached blood flow from a collection site to a collection container.
  • the device for attached flow of blood 100 of the present disclosure achieves this using three key technical elements to control the flow of blood in the desired manner.
  • the hollow needle 123, the flow channel 124, the flow directing attachment portion 134, and the interior wall surface 72 of the container 14 provide attachment portions to establish attached blood flow, for a first drop of blood 16 and subsequent blood 16 to follow, from the first end 120 of the housing 112 to the collection cavity 70 of the container 14.
  • the first key blood flow path element 140 involves directing the first drop of blood 16 away from the surface S of the finger F in a direction towards a collection container 14.
  • a first drop of blood 16 attaches to a portion of the hollow needle 123 and flows through the hollow needle 123 to the flow channel 124 in a controlled manner as shown in Fig. 17 .
  • the hollow needle 123 provides an attachment portion that functions similar to the first flow directing attachment portion 32 described above with respect to device 10 shown in Figs. 1-10B .
  • the device 100 of the present disclosure including a hollow needle 123 provides an advantage in that the hollow needle 123 can also be used to lance a skin surface S of a finger F to provide a source of blood 16. In such an embodiment, no separate lancet device is required.
  • the hollow needle 123 may include a lancing blade 151 that can be used to lance a skin surface S of a finger F to provide a source of blood 16.
  • the first end 120 of the housing 112 in communication with a source of blood 16, a first drop of blood 16, and subsequent blood 16, attaches to the lancing blade 151 and flows through the hollow needle 123 to the flow channel 124.
  • the subsequent blood 16 follows the attached blood flow path of the first drop of blood 16 from the first end 120 of the housing 112 to the collection cavity 70 of the container 14.
  • the second key blood flow path element 142 involves directing the blood 16 or pulling the blood 16 through the flow channel 124 to the flow directing attachment portion 134 via capillary motion.
  • the second key blood flow path element 142 involves directing the blood 16 or pulling the blood 16 through the hollow needle 123 and the flow channel 124 to the flow directing attachment portion 134 via capillary motion in a direction towards a collection container 14.
  • the first drop of blood 16, and subsequent blood 16 is pulled through the flow channel 124 to the flow directing attachment portion 134 via capillary motion.
  • the flow channel 124 is a capillary flow channel.
  • the flow channel 124 is a capillary tube that uses capillary forces to pull the blood 16 down the flow channel 124 away from the surface S of the finger F.
  • the housing 112 includes a sloped wall surface 136 between the hollow needle 123 and the flow channel 124.
  • the sloped wall surface 138 defines a flow channel entry 138.
  • the sloped wall surface 136 provides a downward attached flow path from the hollow needle 123 to the flow channel 124 of the housing 112.
  • the third key blood flow path element 144 involves directing the blood 16 from the flow channel 124 into the collection container 14.
  • the device 100 of the present disclosure ensures transition from the flow channel 124 to the container 14 via attached flow.
  • the blood 16 attaches to the flow directing attachment portion 134 and the interior wall surface 72 of the container 14 to flow from the flow channel 124 into the collection cavity 70 of the container 14.
  • the third key blood flow path element 144 involving directing the blood 16 from the flow channel 124 into the collection container 14 is the reason that it is important that a portion of the flow channel 124, e.g., a bottom portion 130, is offset from the centerline CL of the housing 112. This ensures that the outlet 128 of the flow channel 124, and the flow directing attachment portion 134, is adjacent to an interior wall surface 72 of the container 14 to ensure the transition of the attached blood flow from the flow channel 124 to the container 14.
  • the blood 16 will only flow down and out the flow channel 124 into the container 14 if the blood 16 is able to find another portion to attach to.
  • the flow directing attachment portion 134 and the interior wall surface 72 of the container 14 provide such attachment portions to control the blood 16 to the collection cavity 70 of the container 14 via attached blood flow.
  • the device 100 of the present disclosure establishes attached blood flow, for a first drop of blood 16 and subsequent blood 16 to follow, from the first end 120 of the housing 112 to a collection cavity 70 of the container 14.
  • a portion of the hollow needle 123 that provides an attachment portion for the flow of blood 16 functions similar to the first flow directing attachment portion 32 described above with respect to device 10 shown in Figs. 1-10B .
  • the hollow needle 123 may include a variety of different designs and structures as shown in Figs. 18-24 . Additional alternative designs and structures of the hollow needle 123 are contemplated.
  • the hollow needle 123 includes a bevel cut hollow needle.
  • the bevel of the needle may have a length of between 3 mm and 6 mm and the lumen inner diameter may be between 0.25 mm and 4 mm.
  • the hollow needle 123 may include a lancing blade 151 that can be used to lance a skin surface S of a finger F to provide a source of blood 16.
  • the hollow needle 123 includes a flow directing ring 155 around the hollow needle 123.
  • the flow directing ring 155 prevents blood 16 from flowing down the hollow needle 123 and ensures that the blood 16 flows through the hollow needle 123 to the flow channel 124.
  • Figs. 22-24 illustrate additional alternative designs and structures of the hollow needle 123.
  • the needle bevels serve as the additional first flow directed attachment sections, similar to the pillar structure portion 32 as described above with reference to Fig. 3 .
  • the flow directing attachment portion 134 may include a variety of different designs and structures as shown in Figs. 7A-10B . Additional alternative designs and structures of the flow directing attachment portion 134 are contemplated.
  • the flow directing attachment portion 134 of device 100 may include the same designs and structures as the second flow directing attachment portion 34 of device 10 as described above and as shown in Figs. 7A-10B .
  • a sample stabilizer 200 is positioned within a portion of flow channel 24, 124 such that a blood sample 16, as the blood sample 16 follows the controlled attached blood flow from a collection site to a collection container of the present disclosure, will pass through the sample stabilizer 200.
  • the blood sample 16 may be mixed with a sample stabilizer 200, such as an anticoagulant or other additive, provided within a portion of device 10, 100.
  • the sample stabilizer 200 can be an anticoagulant, or a substance designed to preserve a specific element within the blood such as, for example, RNA, protein analyte, or other element.
  • the sample stabilizer 200 includes a material 202 including pores 204 and a dry anticoagulant powder 206 that is within the pores 204 of the material 202.
  • the device 10, 100 may include a dry anticoagulant, such as Heparin or EDTA, deposited on or within a portion of the flow channel 24, 124.
  • the material 202 is an open cell foam that contains dry anticoagulant dispersed within the cells of the open cell foam to promote the effectiveness of the flow-through mixing and anticoagulant uptake.
  • the sample stabilizer 200 is the dry anticoagulant powder 206.
  • the open cell foam may be treated with an anticoagulant to form a dry anticoagulant powder 206 finely distributed throughout the pores 204 of the open cell foam.
  • an anticoagulant to form a dry anticoagulant powder 206 finely distributed throughout the pores 204 of the open cell foam.
  • the blood sample 16 flows through the flow channel 24, 124, the blood sample 16 passes through the open cell foam and is exposed to the anticoagulant powder 206 available throughout the internal pore structure of the open cell foam. In this manner, the blood sample 16 dissolves and mixes with the dry anticoagulant powder 206 while passing through the material 202 or open cell foam.
  • the open cell foam may be a soft deformable open cell foam that is inert to blood, for example, a melamine foam, such as Basotect ® foam commercially available from BASF, or may consist of a formaldehyde-melamine-sodium bisulfite copolymer.
  • the open cell foam may also be a flexible, hydrophilic open cell foam that is substantially resistant to heat and organic solvents.
  • the foam may include a sponge material.
  • the anticoagulant or other additive may be introduced into the open cell foam by soaking the foam in a liquid solution of the additive and water and subsequently evaporating the water forming a dry additive powder finely distributed throughout the internal structure of the foam.
  • Figs. 13-16 illustrate exemplary embodiments of a sample stabilizer 200 being including within a container 14.
  • anticoagulant lyophilized spheres 210 are provided within collection cavity 70 of container 14. As blood 16 follows the attached flow of the present disclosure into the container 14, the anticoagulant lyophilized spheres 210 dissolve within the blood 16 upon contact with the blood 16.
  • the sample stabilizer 200 includes a floating anticoagulant coated open cell foam material 220.
  • the sample stabilizer 200 includes a floating anticoagulant coated floating ball 230.
  • the container 14 includes an anticoagulant coated wall surface 240 and a mixing ball 242.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Molecular Biology (AREA)
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  • Dermatology (AREA)
  • Manufacturing & Machinery (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • External Artificial Organs (AREA)
  • Sampling And Sample Adjustment (AREA)
EP22172551.8A 2016-08-24 2017-08-23 Dispositif pour écoulement suivi de sang Active EP4059427B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP24164531.6A EP4364661A3 (fr) 2016-08-24 2017-08-23 Dispositif pour le flux sanguin attaché

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US201662378971P 2016-08-24 2016-08-24
EP17762279.2A EP3503807B1 (fr) 2016-08-24 2017-08-23 Dispositif pour écoulement de sang par raccordement
PCT/US2017/048147 WO2018039307A1 (fr) 2016-08-24 2017-08-23 Dispositif pour écoulement de sang par raccordement
EP20214283.2A EP3811865B1 (fr) 2016-08-24 2017-08-23 Dispositif pour écoulement suivi de sang

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EP17762279.2A Division EP3503807B1 (fr) 2016-08-24 2017-08-23 Dispositif pour écoulement de sang par raccordement

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EP4059427A1 true EP4059427A1 (fr) 2022-09-21
EP4059427B1 EP4059427B1 (fr) 2024-03-20
EP4059427C0 EP4059427C0 (fr) 2024-03-20

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EP20192101.2A Active EP3760122B1 (fr) 2016-08-24 2017-08-23 Dispositif de prélèvement d'un échantillon de sang
EP20214283.2A Active EP3811865B1 (fr) 2016-08-24 2017-08-23 Dispositif pour écoulement suivi de sang
EP22172551.8A Active EP4059427B1 (fr) 2016-08-24 2017-08-23 Dispositif pour écoulement suivi de sang
EP24164531.6A Pending EP4364661A3 (fr) 2016-08-24 2017-08-23 Dispositif pour le flux sanguin attaché
EP23167764.2A Pending EP4233722A3 (fr) 2016-08-24 2017-08-23 Dispositif pour obtenir un échantillon de sang
EP17762279.2A Active EP3503807B1 (fr) 2016-08-24 2017-08-23 Dispositif pour écoulement de sang par raccordement
EP17761172.0A Active EP3503806B1 (fr) 2016-08-24 2017-08-23 Dispositif de prélèvement d'un échantillon de sang

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EP24164531.6A Pending EP4364661A3 (fr) 2016-08-24 2017-08-23 Dispositif pour le flux sanguin attaché
EP23167764.2A Pending EP4233722A3 (fr) 2016-08-24 2017-08-23 Dispositif pour obtenir un échantillon de sang
EP17762279.2A Active EP3503807B1 (fr) 2016-08-24 2017-08-23 Dispositif pour écoulement de sang par raccordement
EP17761172.0A Active EP3503806B1 (fr) 2016-08-24 2017-08-23 Dispositif de prélèvement d'un échantillon de sang

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US (5) US11399755B2 (fr)
EP (7) EP3760122B1 (fr)
JP (8) JP7092747B2 (fr)
KR (4) KR102349711B1 (fr)
CN (4) CN109803581B (fr)
AU (4) AU2017315323B2 (fr)
BR (2) BR112019003638A2 (fr)
CA (2) CA3034843A1 (fr)
ES (4) ES2858340T3 (fr)
MX (4) MX2019002218A (fr)
PL (1) PL3503807T3 (fr)
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WO (2) WO2018039305A1 (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2408372B1 (fr) 2009-03-02 2019-01-09 Seventh Sense Biosystems, Inc. Dispositifs associés au prélèvement de sang
US20130158482A1 (en) 2010-07-26 2013-06-20 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
US20120039809A1 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
ES2565805T3 (es) 2010-11-09 2016-04-07 Seventh Sense Biosystems, Inc. Sistemas e interfaces para el muestreo de sangre
AU2012249683A1 (en) 2011-04-29 2013-11-14 Seventh Sense Biosystems, Inc. Devices and methods for collection and/or manipulation of blood spots or other bodily fluids
WO2019067567A1 (fr) * 2017-09-26 2019-04-04 Juno Diagnostics, Inc. Dispositifs, systèmes et procédés d'analyse de biomarqueur
US20190099117A1 (en) * 2017-10-02 2019-04-04 Reliant Immune Diagnostics, Inc Finger cuff having vibration mechanism for use in performing a finger prick
TWI833715B (zh) 2017-10-27 2024-03-01 美商奇諾診療公司 用於超低體積液體生物檢體之裝置、系統及方法
CA3095030A1 (fr) 2018-03-30 2019-10-03 Juno Diagnostics, Inc. Procedes, dispositifs et systemes bases sur l'apprentissage profond pour le depistage antenatal
JP6905953B2 (ja) * 2018-05-15 2021-07-21 富士フイルム株式会社 血液検体案内器具、及び血液検査キット
CN112437633A (zh) * 2018-05-25 2021-03-02 贝克顿·迪金森公司 带有振动模块的血液收集组件
AU2019334997B2 (en) * 2018-09-06 2025-03-20 Becton, Dickinson And Company Arterial blood gas collection system
WO2020167746A1 (fr) * 2019-02-14 2020-08-20 Becton, Dickinson And Company Collecteur capillaire à connexion rotative
BE1027338B1 (nl) * 2019-06-04 2021-01-14 Inst Of Tropical Medicine Vingerprikker-collector
JP7157711B2 (ja) * 2019-07-19 2022-10-20 株式会社日立ハイテク 採血装置
AU2020354484A1 (en) 2019-09-23 2022-05-19 Gateway Genomics, Llc Methods, compositions, and kits for determining the sex of a fetus
WO2021091380A1 (fr) * 2019-11-07 2021-05-14 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Dispositif de collecte de sang et procédé d'auto-collecte de sang par un utilisateur
JP2023527642A (ja) * 2020-03-31 2023-06-30 プレシヘルス エスアー 体液採取装置、およびその使用方法
GB202004718D0 (en) * 2020-03-31 2020-05-13 Osler Diagnostics Ltd Capillary blood sampling
WO2022043748A2 (fr) * 2020-08-23 2022-03-03 Preci Health Sa Dispositif d'échantillonnage de sang capillaire et procédé d'utilisation
GB2598334B (en) 2020-08-26 2022-11-30 Mowgli Innovations Ltd Finger receptacle and holding device
JP2024524404A (ja) * 2021-06-29 2024-07-05 ベクトン・ディキンソン・アンド・カンパニー 毛細血管採血装置
CN117794457A (zh) * 2021-06-29 2024-03-29 贝克顿·迪金森公司 毛细血管血液采集装置
WO2023278234A1 (fr) * 2021-06-29 2023-01-05 Becton, Dickinson And Company Dispositif de collecte de sang capillaire
WO2023278225A1 (fr) * 2021-06-29 2023-01-05 Becton, Dickinson And Company Dispositif de prélèvement de sang capillaire
MX2024000104A (es) 2021-06-29 2024-01-19 Becton Dickinson Co Dispositivo de extraccion de sangre capilar.
CN117580506A (zh) * 2021-06-29 2024-02-20 贝克顿·迪金森公司 毛细血管血液采集装置
CA3222424A1 (fr) * 2021-06-29 2023-01-05 Scott WENTZELL Kit de collecte de sang a dispositifs de collecte de sang de tailles multiples, et systemes et procedes de dimensionnement associes
CN117597069A (zh) * 2021-06-29 2024-02-23 贝克顿·迪金森公司 用于毛细血管采血的模拟装置
BR112023027415A2 (pt) * 2021-06-29 2024-03-12 Becton Dickinson Co Recipiente de amostra para coleta de sangue capilar
US20230122154A1 (en) * 2021-10-15 2023-04-20 Becton, Dickinson And Company Additive Mixing for Blood Sample Collection
US11957465B2 (en) 2022-08-23 2024-04-16 Reddrop Dx, Inc. Accelerated ergonomic collection of capillary blood
BE1030990B1 (nl) * 2022-10-25 2024-05-28 Inst Voor Tropische Geneeskunde Apparaat voor het nemen van bloedmonsters voor het verzamelen van een bloedmonster uit een vinger of teen
JP2025013307A (ja) 2023-07-13 2025-01-24 ベクトン・ディキンソン・アンド・カンパニー 小容量収集容器用収集付属品および関連するサンプル収集方法
WO2025064983A1 (fr) * 2023-09-21 2025-03-27 Becton, Dickinson And Company Manchon de piquage de doigt

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3623475A (en) * 1968-07-26 1971-11-30 Micromedic Systems Inc Blood collector device
GB2183159A (en) * 1985-11-19 1987-06-03 Sarstedt Kunststoff Blood collecting vessel
EP0224650A2 (fr) * 1985-11-29 1987-06-10 Becton, Dickinson and Company Dispositifs provoquant un écoulement pour récipients de faible contenance
EP1157660A1 (fr) * 2000-05-26 2001-11-28 Roche Diagnostics GmbH Système pour le prélèvement de fluides corporels
WO2002100254A2 (fr) * 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Procede et appareil pour un dispositif de lancement de lancette integre sur une cartouche de prelevement de sang
US20070083131A1 (en) * 2005-09-30 2007-04-12 Rosedale Medical, Inc. Catalysts for body fluid sample extraction
US20090259145A1 (en) * 2008-03-05 2009-10-15 Becton, Dickinson And Company Capillary Action Collection Device and Container Assembly
US20150351676A1 (en) * 2014-06-10 2015-12-10 Labatm, Inc. Automatic Blood Collection
WO2015191853A1 (fr) * 2014-06-13 2015-12-17 Siemens Healthcare Diagnostics Inc. Système de distribution d'échantillon

Family Cites Families (151)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2646799A (en) 1951-02-14 1953-07-28 Jr George W Jacoby Blood lancet
CH500707A (fr) * 1968-07-26 1970-12-31 Micromedic Systems Inc Dispositif pour effectuer une prise de sang percutanée et digitale
US3630191A (en) 1969-02-27 1971-12-28 Gilford Instr Labor Inc Apparatus and method for filling capillary tubing with fluids
CH538277A (fr) 1970-09-04 1973-06-30 Micromedic Systems Inc Dispositif pour prise de sang percutanée
US4024857A (en) 1974-12-23 1977-05-24 Becton, Dickinson And Company Micro blood collection device
SE7514611L (sv) * 1974-12-23 1976-06-24 Becton Dickinson Co Forfarande och anordning for mikroblodprovtagning
US4411163A (en) 1981-07-27 1983-10-25 American Hospital Supply Corporation Ventable sample collection device
US4397318A (en) 1981-08-10 1983-08-09 Becton Dickinson And Company Blood collector for microcollection container
US4620549A (en) 1985-01-25 1986-11-04 Becton, Dickinson And Company Blood collection assembly
US4646753A (en) 1985-06-11 1987-03-03 Becton, Dickinson And Company Blood collector for microcollection container
US4791938A (en) 1987-11-16 1988-12-20 Nanci Van Valkenburg Capillary blood collector and method
US5070886A (en) 1988-01-22 1991-12-10 Safety Diagnostice, Inc. Blood collection and testing means
US5014718A (en) 1988-01-22 1991-05-14 Safety Diagnostics, Inc. Blood collection and testing method
DE4000968C1 (en) * 1990-01-16 1991-06-20 Dieter 2090 Drage De Wendelborn Blood sampling apparatus - has blood observation chamber mounted in sampling vessel stopper
US5309924A (en) * 1992-04-29 1994-05-10 Peabody Alan M Spill-proof blood collection device
US5384096A (en) 1993-05-12 1995-01-24 Becton, Dickinson And Company Microcollection tube assembly
HU219921B (hu) 1993-10-20 2001-09-28 Ervin Lipscher Vérvételi eszköz, különösen ujjbegyből történő vérvételre
US5485856A (en) * 1994-04-22 1996-01-23 Buckland; Peter E. Hand immobilizing and positioning apparatus for x-ray examinations
JPH08317917A (ja) 1995-05-25 1996-12-03 Advance Co Ltd 採血装置
US5569223A (en) 1995-06-06 1996-10-29 Home Access Health Corporation Apparatus and method for enhancing blood flow to obtain a blood sample
US5709699A (en) 1995-09-01 1998-01-20 Biosafe Diagnostics Corporation Blood collection and testing device
US5662127A (en) 1996-01-17 1997-09-02 Bio-Plas, Inc. Self-contained blood withdrawal apparatus and method
US5714125A (en) * 1996-03-07 1998-02-03 Medical Safety Products, Inc. Device for collecting a blood sample from a plastic segment tube
EP1579814A3 (fr) 1996-05-17 2006-06-14 Roche Diagnostics Operations, Inc. Procedes et appareil de prelevement et d'analyse de liquide organique
US5857983A (en) 1996-05-17 1999-01-12 Mercury Diagnostics, Inc. Methods and apparatus for sampling body fluid
US5951492A (en) 1996-05-17 1999-09-14 Mercury Diagnostics, Inc. Methods and apparatus for sampling and analyzing body fluid
ES2121564B1 (es) 1996-05-17 2001-02-01 Mercury Diagnostics Inc Metodos y aparatos para extraer fluido corporal desde una incision.
US5951493A (en) 1997-05-16 1999-09-14 Mercury Diagnostics, Inc. Methods and apparatus for expressing body fluid from an incision
US20020010406A1 (en) 1996-05-17 2002-01-24 Douglas Joel S. Methods and apparatus for expressing body fluid from an incision
US6706000B2 (en) 1997-11-21 2004-03-16 Amira Medical Methods and apparatus for expressing body fluid from an incision
US6086545A (en) 1998-04-28 2000-07-11 Amira Medical Methods and apparatus for suctioning and pumping body fluid from an incision
JP4210782B2 (ja) 1999-10-13 2009-01-21 アークレイ株式会社 採血位置表示具
DE10026172A1 (de) 2000-05-26 2001-11-29 Roche Diagnostics Gmbh System zur Entnahme von Körperflüssigkeit
ES2378699T3 (es) 2000-06-09 2012-04-17 Diabetes Diagnostics, Inc. Caperuza para un dispositivo de punción
US6551267B1 (en) 2000-10-18 2003-04-22 Becton, Dickinson And Company Medical article having blood-contacting surface
CN101849829A (zh) 2001-01-12 2010-10-06 爱科来株式会社 穿刺装置
JP2002219115A (ja) * 2001-01-26 2002-08-06 Matsushita Electric Works Ltd 採血装置
US20040092843A1 (en) 2001-02-22 2004-05-13 Doron Kreiser Device and method for measuring fetal blood pH
US20020188223A1 (en) 2001-06-08 2002-12-12 Edward Perez Devices and methods for the expression of bodily fluids from an incision
JP2003070771A (ja) * 2001-09-07 2003-03-11 Omron Corp 生体情報測定器、生体情報測定システムおよび生体情報測定管理方法
CA2461370A1 (fr) 2001-09-26 2003-05-15 F. Hoffmann-La Roche Ag Procede et appareil de prelevement de liquide organique
US20030212344A1 (en) * 2002-05-09 2003-11-13 Vadim Yuzhakov Physiological sample collection devices and methods of using the same
USD488588S1 (en) 2002-12-13 2004-04-13 James P. Murphy Finger accessory appliance
US20040127818A1 (en) 2002-12-27 2004-07-01 Roe Steven N. Precision depth control lancing tip
GB0301587D0 (en) 2003-01-23 2003-02-26 Epsom & St Helier Nhs Trust A lancet holding device
US8475395B2 (en) 2003-02-13 2013-07-02 Toru Nakayama Painless blood-collecting method
DE10315396A1 (de) 2003-04-04 2004-10-14 Lieblein, Martin, Dr. Vollautomatisches Blutzucker-Überwachungs-/ Warnsystem bei Hypo- und Hyperglyämie
USD488232S1 (en) 2003-06-30 2004-04-06 Nanma Ltd. Finger massager
DE10332283A1 (de) 2003-07-16 2005-02-03 Roche Diagnostics Gmbh System zur Entnahme von Körperflüssigkeit
DE10332488A1 (de) 2003-07-16 2005-02-24 Roche Diagnostics Gmbh Analysegerät und Analyseverfahren für Körperflüssigkeiten
JP2005094425A (ja) 2003-09-18 2005-04-07 Fuji Xerox Co Ltd リモートコントロール装置
JP4762341B2 (ja) 2003-10-29 2011-08-31 アークレイ株式会社 穿刺装置
JP4484669B2 (ja) * 2003-10-29 2010-06-16 アークレイ株式会社 穿刺装置
JP4621850B2 (ja) 2003-10-29 2011-01-26 アークレイ株式会社 搾液具および穿刺装置
GB2409411A (en) * 2003-12-22 2005-06-29 William Thomas Dennis Bates Blood collection system
US8398567B2 (en) * 2004-02-06 2013-03-19 Bayer Healthcare Llc Method and apparatus for measuring an analyte in a body fluid
US7201723B2 (en) 2004-03-25 2007-04-10 Roche Diagnostics Operations, Inc. Pulsating expression cap
US20050215923A1 (en) 2004-03-26 2005-09-29 Wiegel Christopher D Fingertip conforming fluid expression cap
CA2562215A1 (fr) 2004-04-10 2005-10-20 F. Hoffmann-La Roche Ag Procede et systeme de prelevement de liquides corporels
US20050234491A1 (en) 2004-04-16 2005-10-20 Allen John J Method for lancing a dermal tissue target site employing a dermal tissue lancing device with a tiltable cap
US20050234486A1 (en) 2004-04-16 2005-10-20 Allen John J Apparatus for extracting bodily fluid
US20050234488A1 (en) 2004-04-16 2005-10-20 John Allen Saddle-contoured cap for a dermal tissue lancing device
US9380975B2 (en) 2004-05-07 2016-07-05 Becton, Dickinson And Company Contact activated lancet device
US7322942B2 (en) 2004-05-07 2008-01-29 Roche Diagnostics Operations, Inc. Integrated disposable for automatic or manual blood dosing
DE102004024970A1 (de) 2004-05-21 2005-12-08 Roche Diagnostics Gmbh Vorrichtung und Verfahren zur Positionierung eines Körperteils
US7384402B2 (en) 2004-06-10 2008-06-10 Roche Diagnostics Operations, Inc. Expression pad
US20050277849A1 (en) 2004-06-10 2005-12-15 Daniel Wong Vacuum sample expression device
JP3926811B2 (ja) 2004-08-03 2007-06-06 株式会社ヒポクラテス 定量採血具
US20070060842A1 (en) 2005-08-29 2007-03-15 Manuel Alvarez-Icaza Lancing cap kit applied pressure sensing cap
US20070073187A1 (en) 2005-09-26 2007-03-29 Anne Thomson Analyte monitoring system with a device for promoting bodily fluid expression from a target site
US20070093863A1 (en) 2005-10-20 2007-04-26 Pugh Jerry T Cap for a dermal tissue lancing device
US20070093864A1 (en) 2005-10-20 2007-04-26 Pugh Jerry T Method for lancing a dermal tissue target site
JP4874623B2 (ja) 2005-10-20 2012-02-15 積水化学工業株式会社 採血ホルダー
EP1785090A1 (fr) 2005-11-10 2007-05-16 F.Hoffmann-La Roche Ag Lancette et système pour la détection de la peau
US20070112281A1 (en) 2005-11-17 2007-05-17 Olson Lorin P Cap with revolving body for a dermal tissue lancing device
EP1961381A4 (fr) 2005-12-01 2011-04-13 Arkray Inc Dispositif a capteur/lancette integres et procede de prelevement de fluide sanguin l'utilisant
JP4999372B2 (ja) * 2006-06-30 2012-08-15 株式会社サカエ 液体採取具
CN101500476A (zh) 2006-07-06 2009-08-05 雷比德克斯有限公司 综合血液取样和检验设备及其使用方法
JP2008022988A (ja) * 2006-07-19 2008-02-07 Ritsumeikan 採血装置
US8372015B2 (en) * 2006-08-28 2013-02-12 Intuity Medical, Inc. Body fluid sampling device with pivotable catalyst member
JP2008099991A (ja) 2006-10-20 2008-05-01 Olympus Corp 採血装置
EP1929948A1 (fr) 2006-12-08 2008-06-11 Roche Diagnostics GmbH Dispositif de perçage
USD576277S1 (en) 2007-03-30 2008-09-02 T.A.G. Medical Products A Limited Partnership. Finger mounting surgical instrument with spatula retractor
USD582037S1 (en) 2007-03-30 2008-12-02 Ethicon Endo-Surgery, Inc. Finger mounted specialty grasper
USD569514S1 (en) 2007-03-30 2008-05-20 Ethicon Endo-Surgery, Inc. Finger mounted locking forceps
EP1982653A1 (fr) 2007-04-18 2008-10-22 Roche Diagnostics GmbH Appareil de perçage et appareil d'analyse
US20110092854A1 (en) 2009-10-20 2011-04-21 Uwe Kraemer Instruments and system for producing a sample of a body fluid and for analysis thereof
US7591791B2 (en) 2007-06-21 2009-09-22 Inverness Medical Switzerland Gmbh Diagnostic thimble
JP4625062B2 (ja) 2007-08-31 2011-02-02 テルモ株式会社 補助具
TW200918021A (en) 2007-10-26 2009-05-01 Delta Electronics Inc Bleeding apparatus
TW200918022A (en) 2007-10-26 2009-05-01 Delta Electronics Inc Bleeding apparatus
JP2011508872A (ja) 2007-12-10 2011-03-17 バイエル・ヘルスケア・エルエルシー 一体型の流体分析対象物測定システム
WO2009081405A2 (fr) 2007-12-25 2009-07-02 Rapidx Ltd. Dispositifs et procédés de prélèvement de sang provoquant une douleur réduite
US10631771B2 (en) 2008-01-07 2020-04-28 Morteza Naghavi Methods and apparatus for blood sampling
US7766846B2 (en) 2008-01-28 2010-08-03 Roche Diagnostics Operations, Inc. Rapid blood expression and sampling
US20090198152A1 (en) * 2008-02-02 2009-08-06 Stanley Kim Finger tip tourniquet
JP5162602B2 (ja) 2008-02-21 2013-03-13 テルモ株式会社 針穿刺痛低減機構付き穿刺具および針穿刺痛低減器具
WO2009111622A2 (fr) 2008-03-05 2009-09-11 Becton, Dickinson And Company Bouchon perforable comoulé et son procédé de fabrication
FR2929135A1 (fr) * 2008-03-31 2009-10-02 Commissariat Energie Atomique Dispositif d'aliquotage et de dispense d'un liquide
JP4388597B1 (ja) 2008-05-09 2009-12-24 パナソニック株式会社 皮膚切開器具
EP2293719B1 (fr) 2008-05-30 2015-09-09 Intuity Medical, Inc. Dispositif de prélèvement de liquide organique et interface de site de prélèvement
CA3095014A1 (fr) 2008-06-06 2009-12-10 Intuity Medical, Inc. Dispositif de mesure et mode de fonctionnement
US20100022916A1 (en) 2008-07-24 2010-01-28 Javanbakhsh Esfandiari Method and Apparatus for Collecting and Preparing Biological Samples for Testing
EP2181651A1 (fr) 2008-10-29 2010-05-05 Roche Diagnostics GmbH Instrument et système pour produire un échantillon d'un corps liquide et analyse correspondante
US8956307B2 (en) 2009-07-01 2015-02-17 Kawasumi Laboratories, Inc. Blood collection set, sampling holder, and needlestick-preventive needle cover
JP6297777B2 (ja) 2009-07-30 2018-03-20 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 鞍状のチップを有する穿刺装置
JP2011078518A (ja) 2009-10-06 2011-04-21 Panasonic Corp 血液検査装置
US8647357B2 (en) 2011-02-05 2014-02-11 Birch Narrows Development Llc Lancet device with flexible cover
RU2580295C2 (ru) 2011-06-08 2016-04-10 Бектон, Дикинсон Энд Компани Безопасный шприц с убирающейся иглой для взятия пробы крови
ES2560405T3 (es) * 2011-09-22 2016-02-18 Sanofi-Aventis Deutschland Gmbh Obtención de una muestra de sangre
US20130211289A1 (en) 2012-01-25 2013-08-15 Tasso, Inc. Handheld Device for Drawing, Collecting, and Analyzing Bodily Fluid
BR302012006435S1 (pt) 2012-06-15 2014-06-03 Rml Engineering Ltd Configuração aplicada em recipiente
EP2874942B1 (fr) 2012-07-23 2018-09-05 Tasso, Inc. Procédés et dispositifs associés à des canaux microfluidiques ouverts
EP2882341B1 (fr) 2012-08-09 2019-03-06 Emory University Trousses et procédés pour la détermination du taux ou des taux physiologiques et/ou de la plage ou des plages d'hémoglobine et/ou d'un état de maladie
US9427184B2 (en) 2012-09-06 2016-08-30 Theranos, Inc. Systems, devices, and methods for bodily fluid sample collection
WO2014063344A1 (fr) 2012-10-26 2014-05-01 Zhang Jianming Dispositif intégral de prélèvement de sang sous vide avec manchon de protection de pointe d'aiguille
RU2570750C2 (ru) 2012-11-20 2015-12-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Набор для получения, хранения и транспортировки сухих образцов крови для последующего проведения лабораторного анализа
US9681834B2 (en) 2013-03-05 2017-06-20 Carolyn Consulting, LLC Finger guide for testing blood glucose and associated methods
USD732684S1 (en) 2013-03-25 2015-06-23 Sysmex Corporation Container for analyzer
US9517026B2 (en) * 2013-04-15 2016-12-13 Becton, Dickinson And Company Biological fluid collection device and biological fluid separation and testing system
KR101851188B1 (ko) 2013-09-05 2018-04-24 가부시키가이샤 미야비 체액채취기, 체액용기, 및 체액채취장치
TW201513832A (zh) 2013-10-11 2015-04-16 Ysp Co Ltd 採血裝置及其採血針與採血筆
US9556027B2 (en) 2013-12-02 2017-01-31 Praxair Technology, Inc. Method and system for producing hydrogen using an oxygen transport membrane based reforming system with secondary reforming
USD757267S1 (en) 2013-12-02 2016-05-24 Sterilance Medical (Suzhou) Inc. Lancet protective cap with two cup-shape openings
CA157667S (en) 2014-03-31 2015-04-30 Htl Strefa Spólka Akcyjna Lancet device
JP6424014B2 (ja) * 2014-05-27 2018-11-14 株式会社テクノメデイカ 指先駆血具
EP3151965B1 (fr) 2014-06-04 2021-02-24 Edan Instruments, Inc. Prélèvement d'échantillons et dispositifs d'analyse
US10779757B2 (en) 2014-08-01 2020-09-22 Tasso, Inc. Devices, systems and methods for gravity-enhanced microfluidic collection, handling and transferring of fluids
USD800333S1 (en) 2014-09-23 2017-10-17 Critical Care Diagnostics, Inc. Blood test kit
US10722163B2 (en) 2015-03-31 2020-07-28 Labrador Diagnostics Llc Methods, devices, systems, and kits for automated blood collection by fingerstick
CN204683616U (zh) * 2015-04-21 2015-10-07 中国人民解放军第四军医大学 一种用于血糖计的安全采血针
USD868268S1 (en) 2015-05-26 2019-11-26 Serenity Sayre Finger splint
JP6558971B2 (ja) 2015-06-17 2019-08-14 株式会社日立ハイテクノロジーズ 採血装置
US10371606B2 (en) 2015-07-21 2019-08-06 Theraos IP Company, LLC Bodily fluid sample collection and transport
USD856148S1 (en) 2016-05-05 2019-08-13 Csp Technologies, Inc. Container for sampling
US10136848B2 (en) 2016-05-20 2018-11-27 Winnoz Technology, Inc. Device and system of blood collection, and method thereof
JP6735161B2 (ja) 2016-06-21 2020-08-05 株式会社日立ハイテク 採血装置および採血装置の作動方法
WO2018160523A1 (fr) 2017-03-01 2018-09-07 Fenwal, Inc. Support de tube d'échantillon et système et procédé l'utilisant
US10928411B2 (en) 2017-04-21 2021-02-23 2Pi-Sigma Corporation Automated medical sample collection and testing
US11103163B2 (en) 2017-04-21 2021-08-31 2Pi-Sigma Corporation Test cartridge and lancet for automated medical sample collection and testing
US11202593B2 (en) 2017-04-21 2021-12-21 2Pi-Sigma Corp. Adjustable lancet and test cartridge for automated medical sample collection and testing
WO2018218341A1 (fr) 2017-05-29 2018-12-06 Autograph Biosciences, Inc. Système et procédé de collecte et de conservation d'échantillons de sang pour imagerie ultérieure indépendante des anticorps
US20190015030A1 (en) 2017-07-12 2019-01-17 Michael James Barker System, method and apparatus to facilitate drawing blood and extracting other bodily fluids
US20190099117A1 (en) 2017-10-02 2019-04-04 Reliant Immune Diagnostics, Inc Finger cuff having vibration mechanism for use in performing a finger prick
USD882113S1 (en) 2017-11-30 2020-04-21 Biotix, Inc. Fluid handling tube
US11154657B2 (en) 2017-12-15 2021-10-26 Arkray, Inc. Method of and apparatus for performing intravenous drip injection
USD881410S1 (en) 2018-01-19 2020-04-14 Biotix, Inc. Fluid handling tube
JP6905953B2 (ja) 2018-05-15 2021-07-21 富士フイルム株式会社 血液検体案内器具、及び血液検査キット
US11132878B2 (en) 2018-06-01 2021-09-28 Elizabeth Whitaker Fingertip medical vibratory device
JP2021536571A (ja) 2018-08-28 2021-12-27 ロシュ・ダイアグノスティクス・ヘマトロジー・インコーポレイテッドRoche Diagnostics Hematology, Inc. 条線を有する試験管およびこれを用いる流体移送方法
US10610142B1 (en) 2019-03-20 2020-04-07 Paulus Holdings Limited Vibrating tourniquet and methods of collecting blood using same

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3623475A (en) * 1968-07-26 1971-11-30 Micromedic Systems Inc Blood collector device
GB2183159A (en) * 1985-11-19 1987-06-03 Sarstedt Kunststoff Blood collecting vessel
EP0224650A2 (fr) * 1985-11-29 1987-06-10 Becton, Dickinson and Company Dispositifs provoquant un écoulement pour récipients de faible contenance
EP1157660A1 (fr) * 2000-05-26 2001-11-28 Roche Diagnostics GmbH Système pour le prélèvement de fluides corporels
WO2002100254A2 (fr) * 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Procede et appareil pour un dispositif de lancement de lancette integre sur une cartouche de prelevement de sang
US20070083131A1 (en) * 2005-09-30 2007-04-12 Rosedale Medical, Inc. Catalysts for body fluid sample extraction
US20090259145A1 (en) * 2008-03-05 2009-10-15 Becton, Dickinson And Company Capillary Action Collection Device and Container Assembly
US20150351676A1 (en) * 2014-06-10 2015-12-10 Labatm, Inc. Automatic Blood Collection
WO2015191853A1 (fr) * 2014-06-13 2015-12-17 Siemens Healthcare Diagnostics Inc. Système de distribution d'échantillon

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