EP3919049C0 - COMBINATIONS OF RAPAMYCIN AND METFORMIN FOR THE TREATMENT OF JOINT AND SKIN DISEASES - Google Patents

COMBINATIONS OF RAPAMYCIN AND METFORMIN FOR THE TREATMENT OF JOINT AND SKIN DISEASES

Info

Publication number: EP3919049C0
Authority: EP; European Patent Office
Prior art keywords: metformin; rapamycin; combinations; joint; treatment
Prior art date: 2015-11-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

EP21187553.9A

Other languages

German (de)

French (fr)

Other versions

EP3919049A1 (en

EP3919049B1 (en

Inventor

Jeffrey M Melin

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Individual

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-11-24

Filing date

2016-11-18

Publication date

2025-04-23

2016-11-18 Application filed by Individual filed Critical Individual

2021-12-08 Publication of EP3919049A1 publication Critical patent/EP3919049A1/en

2025-04-23 Application granted granted Critical

2025-04-23 Publication of EP3919049B1 publication Critical patent/EP3919049B1/en

2025-04-23 Publication of EP3919049C0 publication Critical patent/EP3919049C0/en

Status Active legal-status Critical Current

2036-11-18 Anticipated expiration legal-status Critical

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Dermatology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

EP21187553.9A 2015-11-24 2016-11-18 Combinations of rapamycin and metformin for the treatment of joint and skin diseases Active EP3919049B1 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US201562259384P	2015-11-24	2015-11-24
US201662318302P	2016-04-05	2016-04-05
US15/241,312 US10765665B2 (en)	2015-11-24	2016-08-19	Composition comprising combination of rapamycin and an activator of AMP kinase and use thereof for treating diseases
PCT/US2016/062656 WO2017091454A1 (en)	2015-11-24	2016-11-18	Combinations of rapamycin and metformin for the treatment of joint and skin diseases
EP16805683.6A EP3380075B1 (en)	2015-11-24	2016-11-18	Combinations of rapamycin and metformin for the treatment of joint and skin diseases

Related Parent Applications (2)

Application Number	Title	Priority Date	Filing Date
EP16805683.6A Division EP3380075B1 (en)	2015-11-24	2016-11-18	Combinations of rapamycin and metformin for the treatment of joint and skin diseases
EP16805683.6A Division-Into EP3380075B1 (en)	2015-11-24	2016-11-18	Combinations of rapamycin and metformin for the treatment of joint and skin diseases

Publications (3)

Publication Number	Publication Date
EP3919049A1 EP3919049A1 (en)	2021-12-08
EP3919049B1 EP3919049B1 (en)	2025-04-23
EP3919049C0 true EP3919049C0 (en)	2025-04-23

Family

ID=58720381

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
EP21187553.9A Active EP3919049B1 (en)	2015-11-24	2016-11-18	Combinations of rapamycin and metformin for the treatment of joint and skin diseases
EP16805683.6A Active EP3380075B1 (en)	2015-11-24	2016-11-18	Combinations of rapamycin and metformin for the treatment of joint and skin diseases

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
EP16805683.6A Active EP3380075B1 (en)	2015-11-24	2016-11-18	Combinations of rapamycin and metformin for the treatment of joint and skin diseases

Country Status (6)

Country	Link
US (6)	US10765665B2 (en)
EP (2)	EP3919049B1 (en)
JP (3)	JP7152015B2 (en)
AU (2)	AU2016361326B2 (en)
CA (1)	CA3006294C (en)
WO (1)	WO2017091454A1 (en)

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US11969445B2 (en)	2013-12-20	2024-04-30	Seed Health, Inc.	Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH
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2016
- 2016-08-19 US US15/241,312 patent/US10765665B2/en active Active
- 2016-11-18 EP EP21187553.9A patent/EP3919049B1/en active Active
- 2016-11-18 WO PCT/US2016/062656 patent/WO2017091454A1/en not_active Ceased
- 2016-11-18 AU AU2016361326A patent/AU2016361326B2/en active Active
- 2016-11-18 JP JP2018527959A patent/JP7152015B2/en active Active
- 2016-11-18 CA CA3006294A patent/CA3006294C/en active Active
- 2016-11-18 EP EP16805683.6A patent/EP3380075B1/en active Active
2017
- 2017-12-01 US US15/828,926 patent/US10925862B2/en active Active
2018
- 2018-07-19 US US16/040,160 patent/US10952994B2/en active Active
2020
- 2020-07-16 US US16/931,133 patent/US11141409B2/en active Active
2021
- 2021-08-03 US US17/392,516 patent/US11890274B2/en active Active
2022
- 2022-07-20 JP JP2022115787A patent/JP2022153502A/en active Pending
- 2022-11-10 AU AU2022268363A patent/AU2022268363B2/en active Active
2023
- 2023-12-22 US US18/394,155 patent/US12409170B2/en active Active
2024
- 2024-04-18 JP JP2024067519A patent/JP2024096967A/en active Pending

Also Published As

Publication number	Publication date
EP3380075A1 (en)	2018-10-03
US20240261269A1 (en)	2024-08-08
AU2016361326A1 (en)	2018-06-14
CA3006294A1 (en)	2017-06-01
JP7152015B2 (en)	2022-10-12
US11890274B2 (en)	2024-02-06
AU2022268363B2 (en)	2025-03-06
US20180153864A1 (en)	2018-06-07
US20190000815A1 (en)	2019-01-03
JP2022153502A (en)	2022-10-12
CA3006294C (en)	2024-01-16
US11141409B2 (en)	2021-10-12
AU2022268363A1 (en)	2022-12-15
EP3919049A1 (en)	2021-12-08
EP3919049B1 (en)	2025-04-23
US10765665B2 (en)	2020-09-08
JP2024096967A (en)	2024-07-17
US10952994B2 (en)	2021-03-23
US20200345703A1 (en)	2020-11-05
US10925862B2 (en)	2021-02-23
JP2018535244A (en)	2018-11-29
US12409170B2 (en)	2025-09-09
US20210361630A1 (en)	2021-11-25
EP3380075B1 (en)	2023-05-03
AU2016361326B2 (en)	2022-08-11
WO2017091454A1 (en)	2017-06-01
US20170143682A1 (en)	2017-05-25

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