EP3911350A4 - Formulations pharmaceutiques à base d'hormone adrénocorticotropique et leurs procédés de fabrication et d'utilisation - Google Patents

Formulations pharmaceutiques à base d'hormone adrénocorticotropique et leurs procédés de fabrication et d'utilisation Download PDF

Info

Publication number: EP3911350A4
Authority: EP; European Patent Office
Prior art keywords: fabricating; methods; pharmaceutical formulations; adrenocorticotropic hormone; based pharmaceutical
Prior art date: 2019-01-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP20741089.5A

Other languages

German (de)

English (en)

Other versions

EP3911350A1 (fr

Inventor

Dennis Elias Saadeh

Mark L. Baum

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Harrow IP LLC

Original Assignee

Harrow IP LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2019-01-17

Filing date

2020-01-14

Publication date

2022-12-14

2019-01-17 Priority claimed from US16/250,711 external-priority patent/US11338018B2/en

2020-01-14 Application filed by Harrow IP LLC filed Critical Harrow IP LLC

2021-11-24 Publication of EP3911350A1 publication Critical patent/EP3911350A1/fr

2022-12-14 Publication of EP3911350A4 publication Critical patent/EP3911350A4/fr

Status Withdrawn legal-status Critical Current

Links

239000000275 Adrenocorticotropic Hormone Substances 0.000 title 1
101800000414 Corticotropin Proteins 0.000 title 1
102100027467 Pro-opiomelanocortin Human genes 0.000 title 1
IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 title 1
229960000258 corticotropin Drugs 0.000 title 1
238000000034 method Methods 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- A61K38/35—Corticotropin [ACTH]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Inorganic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Dermatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

EP20741089.5A 2019-01-17 2020-01-14 Formulations pharmaceutiques à base d'hormone adrénocorticotropique et leurs procédés de fabrication et d'utilisation Withdrawn EP3911350A4 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US16/250,711 US11338018B2 (en)	2016-12-19	2019-01-17	Adrenocorticotropic hormone-based pharmaceutical formulations and methods for fabricating and using thereof
PCT/US2020/013543 WO2020150262A1 (fr)	2019-01-17	2020-01-14	Formulations pharmaceutiques à base d'hormone adrénocorticotropique et leurs procédés de fabrication et d'utilisation

Publications (2)

Publication Number	Publication Date
EP3911350A1 EP3911350A1 (fr)	2021-11-24
EP3911350A4 true EP3911350A4 (fr)	2022-12-14

Family

ID=71613567

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP20741089.5A Withdrawn EP3911350A4 (fr)	2019-01-17	2020-01-14	Formulations pharmaceutiques à base d'hormone adrénocorticotropique et leurs procédés de fabrication et d'utilisation

Country Status (2)

Country	Link
EP (1)	EP3911350A4 (fr)
WO (1)	WO2020150262A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US11338018B2 (en)	2016-12-19	2022-05-24	Harrow Ip, Llc	Adrenocorticotropic hormone-based pharmaceutical formulations and methods for fabricating and using thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2014130581A1 (fr) *	2013-02-20	2014-08-28	Questcor Pharmaceuticals, Inc.	Acth utile dans le traitement de la migraine et des céphalées
US20180169191A1 (en) *	2016-12-19	2018-06-21	Eton Pharmaceuticals, Inc.	Adrenocorticotropic hormone-based pharmaceutical formulations and methods for fabricating and using thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20090175821A1 (en) *	1999-05-17	2009-07-09	Bridon Dominique P	Modified therapeutic peptides with extended half-lives in vivo
WO2008049011A2 (fr) *	2006-10-18	2008-04-24	Research Development Foundation	Thérapies alpha-MSH destinées au traitement de maladies auto-immunes
WO2014153221A2 (fr) *	2013-03-14	2014-09-25	Questcor Pharmaceuticals, Inc.	Acth dans le traitement du syndrome de détresse respiratoire aiguë
GB201315335D0 (en) *	2013-08-29	2013-10-09	Of Singapore	Amino diacids containing peptide modifiers

2020
- 2020-01-14 WO PCT/US2020/013543 patent/WO2020150262A1/fr not_active Ceased
- 2020-01-14 EP EP20741089.5A patent/EP3911350A4/fr not_active Withdrawn

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2014130581A1 (fr) *	2013-02-20	2014-08-28	Questcor Pharmaceuticals, Inc.	Acth utile dans le traitement de la migraine et des céphalées
US20180169191A1 (en) *	2016-12-19	2018-06-21	Eton Pharmaceuticals, Inc.	Adrenocorticotropic hormone-based pharmaceutical formulations and methods for fabricating and using thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2020150262A1 *

Also Published As

Publication number	Publication date
WO2020150262A1 (fr)	2020-07-23
EP3911350A1 (fr)	2021-11-24

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HK40063684A (en)	2022-06-24	Adrenocorticotropic hormone-based pharmaceutical formulations and methods for fabricating and using thereof
EP3903782A4 (fr)	2022-10-05	Composition pharmaceutique
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EP3490578A4 (fr)	2020-02-26	Compositions pharmaceutiques à base de curcumine et procédés de fabrication associés
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HK40118631A (en)	2025-06-27	New pharmaceutical formulation
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HK40109859A (en)	2024-12-13	Pharmaceutical composition
HK40061251A (en)	2022-05-27	Pharmaceutical methods
EP4074313A4 (fr)	2024-01-03	Préparation pharmaceutique solide

Legal Events

Date	Code	Title	Description
2020-07-25	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2021-10-22	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2021-10-22	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2021-11-24	17P	Request for examination filed	Effective date: 20210729
2021-11-24	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2022-04-20	DAV	Request for validation of the european patent (deleted)
2022-04-20	DAX	Request for extension of the european patent (deleted)
2022-06-24	REG	Reference to a national code	Ref country code: HK Ref legal event code: DE Ref document number: 40063684 Country of ref document: HK
2022-11-08	REG	Reference to a national code	Ref country code: DE Ref legal event code: R079 Free format text: PREVIOUS MAIN CLASS: A61K0038000000 Ipc: A61K0009000000
2022-12-14	A4	Supplementary search report drawn up and despatched	Effective date: 20221114
2022-12-14	RIC1	Information provided on ipc code assigned before grant	Ipc: C12N 15/09 20060101ALI20221108BHEP Ipc: C07K 14/695 20060101ALI20221108BHEP Ipc: A61K 38/35 20060101ALI20221108BHEP Ipc: A61K 38/22 20060101ALI20221108BHEP Ipc: A61K 38/00 20060101ALI20221108BHEP Ipc: A61K 47/38 20060101ALI20221108BHEP Ipc: A61K 47/18 20170101ALI20221108BHEP Ipc: A61K 9/50 20060101ALI20221108BHEP Ipc: A61K 9/00 20060101AFI20221108BHEP
2023-10-20	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2023-11-22	18D	Application deemed to be withdrawn	Effective date: 20230613