EP3810627A4 - BIVALIRUNDIN SYNTHESIS METHOD - Google Patents

BIVALIRUNDIN SYNTHESIS METHOD Download PDF

Info

Publication number: EP3810627A4
Authority: EP; European Patent Office
Prior art keywords: bivalirundin; synthesis method; synthesis; bivalirundin synthesis
Prior art date: 2018-06-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP18923472.7A

Other languages

German (de)

French (fr)

Other versions

EP3810627A1 (en

Inventor

Ivan Di BONAVENTURA

Runze HE

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Shanghai Space Peptides Pharmaceutical Co Ltd

Original Assignee

Shanghai Space Peptides Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2018-06-19

Filing date

2018-06-19

Publication date

2022-03-09

2018-06-19 Application filed by Shanghai Space Peptides Pharmaceutical Co Ltd filed Critical Shanghai Space Peptides Pharmaceutical Co Ltd

2021-04-28 Publication of EP3810627A1 publication Critical patent/EP3810627A1/en

2022-03-09 Publication of EP3810627A4 publication Critical patent/EP3810627A4/en

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Tropical Medicine & Parasitology (AREA)
Gastroenterology & Hepatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

EP18923472.7A 2018-06-19 2018-06-19 BIVALIRUNDIN SYNTHESIS METHOD Withdrawn EP3810627A4 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/CN2018/091752 WO2019241903A1 (en)	2018-06-19	2018-06-19	Synthetic method of bivalirundin

Publications (2)

Publication Number	Publication Date
EP3810627A1 EP3810627A1 (en)	2021-04-28
EP3810627A4 true EP3810627A4 (en)	2022-03-09

Family

ID=68982571

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP18923472.7A Withdrawn EP3810627A4 (en)	2018-06-19	2018-06-19	BIVALIRUNDIN SYNTHESIS METHOD

Country Status (3)

Country	Link
EP (1)	EP3810627A4 (en)
CN (1)	CN112424216A (en)
WO (1)	WO2019241903A1 (en)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007033383A2 (en) *	2005-09-14	2007-03-22	Novetide, Ltd.	Process for production of bivalirudin
US20090062511A1 (en) *	2007-09-05	2009-03-05	Raghavendracharyulu Venkata Palle	Process for the preparation of bivalirudin and its pharmaceutical compositions
WO2010117725A2 (en) *	2009-04-06	2010-10-14	Novetide, Ltd.	Production of peptides containing poly-gly sequences using fmoc chemistry
US20100292436A1 (en) *	2009-05-15	2010-11-18	Shanghai Ambiopharm, Inc.	Method for producing bivalirudin
CN103374054A (en) *	2012-04-28	2013-10-30	上海第一生化药业有限公司	One-step method based solid-phase polypeptide synthesis method
US20140187745A1 (en) *	2011-06-23	2014-07-03	Chengdu Shengnuo Tech Co., Ltd.	Method for preparing bivalirudin
CN103242431B (en) *	2013-05-20	2015-05-13	齐鲁制药有限公司	Preparation method of bivalirudin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN101033249B (en) *	2006-03-10	2011-05-11	周逸明	Preparation method of synthesizing bivalirudin from solid phase polypeptide
CN102532274B (en) *	2012-02-13	2014-04-23	成都圣诺生物制药有限公司	Method for preparing bivalirudin
CN103319570A (en) *	2013-05-30	2013-09-25	深圳翰宇药业股份有限公司	Preparation method of bivalirudin
WO2017070512A1 (en) *	2015-10-23	2017-04-27	Cem Corporation	Improvements in solid phase peptide synthesis

2018
- 2018-06-19 CN CN201880094571.2A patent/CN112424216A/en active Pending
- 2018-06-19 EP EP18923472.7A patent/EP3810627A4/en not_active Withdrawn
- 2018-06-19 WO PCT/CN2018/091752 patent/WO2019241903A1/en not_active Ceased

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007033383A2 (en) *	2005-09-14	2007-03-22	Novetide, Ltd.	Process for production of bivalirudin
US20090062511A1 (en) *	2007-09-05	2009-03-05	Raghavendracharyulu Venkata Palle	Process for the preparation of bivalirudin and its pharmaceutical compositions
WO2010117725A2 (en) *	2009-04-06	2010-10-14	Novetide, Ltd.	Production of peptides containing poly-gly sequences using fmoc chemistry
US20100292436A1 (en) *	2009-05-15	2010-11-18	Shanghai Ambiopharm, Inc.	Method for producing bivalirudin
US20140187745A1 (en) *	2011-06-23	2014-07-03	Chengdu Shengnuo Tech Co., Ltd.	Method for preparing bivalirudin
CN103374054A (en) *	2012-04-28	2013-10-30	上海第一生化药业有限公司	One-step method based solid-phase polypeptide synthesis method
CN103242431B (en) *	2013-05-20	2015-05-13	齐鲁制药有限公司	Preparation method of bivalirudin

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2019241903A1 *

Also Published As

Publication number	Publication date
WO2019241903A1 (en)	2019-12-26
CN112424216A (en)	2021-02-26
EP3810627A1 (en)	2021-04-28

Publication	Publication Date	Title
PT3873883T (en)	2023-03-24	SYNTHESIS METHOD
EP3778621A4 (en)	2021-06-30	PEPTIDIC SYNTHESIS PROCESS
EP3398952A4 (en)	2019-08-14	PROCESS FOR THE SYNTHESIS OF RUXOLITINIB
EP3392266A4 (en)	2019-08-14	PROCESS FOR THE SYNTHESIS OF LINACLOTIDE
DK3728585T3 (en)	2022-05-23	Novel methods for making oligonucleotides
EP3766984A4 (en)	2021-05-12	DETERMINATION PROCESS
PL3665173T3 (en)	2025-08-18	A new method for the synthesis of amanitins
EP3822259A4 (en)	2021-08-25	VALSARTAN SYNTHESIS PROCESS
EP3613404A4 (en)	2021-03-03	FILM PRODUCTION PROCESS
EP3398957A4 (en)	2019-08-14	PROCESS FOR SYNTHESIZING ETTEAL ALLOYDE
EP3845523A4 (en)	2021-07-07	CARIPRAZINE SYNTHESIS PROCESS
EP3470546A4 (en)	2019-05-08	FILM FORMATION METHOD
EP3953503C0 (en)	2025-09-24	ELECTROPOLISING PROCESS
EP3674394A4 (en)	2021-05-26	PRIMARY CULTURE PROCESS
EP3854908A4 (en)	2021-09-01	FILM FORMATION PROCESS
EP4081687A4 (en)	2023-01-18	CONSTRUCTION PROCESS
EP3395813A4 (en)	2019-06-05	VORICONAZOLE INTERMEDIATE AND METHOD FOR SYNTHESIZING VORICONAZOLE
EP3626804A4 (en)	2020-05-27	RAFFINAT-2 PURIFICATION PROCESS
EP3361237A4 (en)	2019-09-04	TOMOGRAPHY METHOD
EP3423402A4 (en)	2019-10-30	PROCESS FOR THE SYNTHESIS OF NANODIAMANTS
EP3747582A4 (en)	2021-11-17	BRAZING PROCESS
EP3704551A4 (en)	2021-08-18	DISTRIBUTED PRODUCTION PROCESS
EP3514522A4 (en)	2019-11-06	MEASURING METHOD
EP3504817C0 (en)	2023-06-07	FREQUENCY CHANNEL SELECTION METHOD
EP3820169A4 (en)	2021-12-22	PARAMETER CONFIGURATION PROCESS

Legal Events

Date	Code	Title	Description
2019-12-27	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2021-03-26	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2021-03-26	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2021-04-28	17P	Request for examination filed	Effective date: 20210115
2021-04-28	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2021-04-28	AX	Request for extension of the european patent	Extension state: BA ME
2021-09-22	DAV	Request for validation of the european patent (deleted)
2021-09-22	DAX	Request for extension of the european patent (deleted)
2022-03-09	A4	Supplementary search report drawn up and despatched	Effective date: 20220203
2022-03-09	RIC1	Information provided on ipc code assigned before grant	Ipc: C07K 1/04 20060101ALI20220128BHEP Ipc: C07K 1/06 20060101ALI20220128BHEP Ipc: C07K 7/08 20060101AFI20220128BHEP
2023-01-20	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2023-02-22	18D	Application deemed to be withdrawn	Effective date: 20220906