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EP3873584A1 - Dispositif d'application extracorporelle ou intracorporelle sur ou dans un corps humain ou animal pour influencer et/ou détecter par des capteurs un milieu biologique local - Google Patents

Dispositif d'application extracorporelle ou intracorporelle sur ou dans un corps humain ou animal pour influencer et/ou détecter par des capteurs un milieu biologique local

Info

Publication number
EP3873584A1
EP3873584A1 EP19800948.2A EP19800948A EP3873584A1 EP 3873584 A1 EP3873584 A1 EP 3873584A1 EP 19800948 A EP19800948 A EP 19800948A EP 3873584 A1 EP3873584 A1 EP 3873584A1
Authority
EP
European Patent Office
Prior art keywords
electrode
support structure
electrode structure
unit
carrier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19800948.2A
Other languages
German (de)
English (en)
Inventor
Bernhard Wolf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Entwicklungsbuero Fuer Biotechnologie und Umwelttechnik GbR
Original Assignee
Entwicklungsbuero Fuer Biotechnologie und Umwelttechnik GbR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Entwicklungsbuero Fuer Biotechnologie und Umwelttechnik GbR filed Critical Entwicklungsbuero Fuer Biotechnologie und Umwelttechnik GbR
Publication of EP3873584A1 publication Critical patent/EP3873584A1/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/205—Applying electric currents by contact electrodes continuous direct currents for promoting a biological process
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14539—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring pH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/445—Evaluating skin irritation or skin trauma, e.g. rash, eczema, wound, bed sore
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683—Means for maintaining contact with the body
    • A61B5/6832—Means for maintaining contact with the body using adhesives
    • A61B5/6833—Adhesive patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/044—Shape of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448—Drug reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0492—Patch electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36002—Cancer treatment, e.g. tumour
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36135—Control systems using physiological parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A61N1/36153—Voltage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
    • G01N27/12—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluid; of a solid body in dependence upon reaction with a fluid, for detecting components in the fluid

Definitions

  • Device for extra- or intracorporeal application to or in a human or animal body for influencing and / or sensory
  • the invention relates to a device for extra- or intracorporeal application to or in a human or animal body for influencing and / or sensory detection of a local biological environment.
  • a central research and therapy goal in the medical field of tumor therapy as well as wound therapy is the most targeted treatment of oneself in the body through uncontrolled proliferation, i.e. Cell division, multiplying and spreading tumor cells or cells from the wound area without or largely without an associated irritation of surrounding, healthy tissue areas as well as health burden of the patient to be treated.
  • tumor cells are able to maintain the intercellular milieu in their
  • the tumor cells to influence the immediate cellular environment by metabolically changing the pH value in such a way that the body's own phagocytes, which support the immune system, for example the so-called macrophages, in particular LAK cells, are naturally prevented from doing so by the tumor cells
  • the chemical or electrochemical milieu change takes place through a local acidification by overexpression or overactivation of the Na-H antiporter, typically up to a pH of 3.5, and the associated establishment of a pH gradient in the cellular environment around the Tumor cells.
  • the invention is based on the object of searching for suitable measures to eliminate or at least significantly weaken the pH gradient explained above, so that the barrier effect for the body's own cells, which is caused by tumor cells or is caused by malignant cells and is based on an acidified environmental environment, is reduced, is preferably completely eliminated.
  • the measures required for this should only be local, i.e. without significant impairment of adjacent tissue areas and in particular without a health hazard to the patient.
  • the device according to the solution can change or change the cell-specific polarity of the cell surface in the direction of more negative transmembrane potentials by means of a controlled and locally acting electrical voltage application.
  • the device according to the solution is also suitable for an extracorporeal device
  • Device designed in the manner of a plaster adhering to the skin surface and locally covering the wound site and, in the same way, is capable of the biological environment directly at the wound site in a wound healing process
  • the device according to the solution has a flat, biocompatible material with a support structure
  • Carrier structure surface on which an electrode structure is attached the at least two, each having a lateral distance from one another
  • Has electrode elements which are preferably elongated in the manner of unstructured or structured finger electrodes and which, together with the support structure surface, can locally limit the biological environment. Furthermore, an electronics unit is attached to the support structure, which makes electrical contact with the electrode structure and applies a predeterminable electrical voltage between the at least two electrode elements to form each as an electrode and counterelectrode.
  • the carrier substrate surface preferably has a means which directly or laterally adjoins the electrode structure and which is suitable for joining to a biological tissue surface.
  • the electrical voltage that can be applied to the electrode structure generates an electrical field between the electrode and the counterelectrode, which within a Extracellular fluid, which both intracorporeally surrounds a tumor cell tissue or extracorporeally emerges in the wound area of a skin wound and essentially consists of water and electrolytes, depending on the field strength selected, can trigger an electrolysis process through which oxygen is released.
  • the water fraction splits the water
  • Extracellular fluid from oxygen which is chemically reduced and in the case of tumor cell control contributes to the neutralization of the locally predominant acidic environment and at least reduces the risk of inflammation in the case of wound healing.
  • the oxygen generated in this way starts the complete implementation of glycolysis via intrinsic cellular sensors - predominantly by means of hypoxia-induced factor, or Hif for short - so that the metabolic end products of the cell can be led to H 2 O and CO 2 and the pH gradients balance out.
  • the electrode structure on the carrier substrate surface is in the form of a
  • Interdigital electrode structure formed, which is preferably applied to the support structure surface in the course of a printing process.
  • Interdigital electrode structure as well as the support structure itself depend primarily on the dimension and the spatial expression of the
  • the support structure surface can be flat or can take any free-form surfaces in order to ensure that the surface contact between the intra- or extracorporeal surface and the one provided with the interdigital electrode structure is as true to the contour as possible
  • highly flexible support structures are suitable for close surface contact between that applied to the support structure Manufacture electrode structure and the benign tissue areas.
  • the tissue areas to be treated are molded.
  • the free-form bodies obtained are coated on the surface with the highly flexible support structure.
  • the more or less concave spherical resection site is covered with a spherically shaped support structure in order to ensure the best possible fit between the electrode structure and the surrounding benign tissue
  • brain tumors play an important role in the delivery of electrical potentials to control metabolism.
  • the device according to the solution can be scaled almost arbitrarily, i.e. from the submillimeter range to large-scale dimensions that depend on the respective ergonomically predetermined conditions for the patient to be treated, such as, for example, extracorporeal skin surfaces to be treated.
  • the carrier structure is preferably designed in the manner of a fleece and preferably consists of a knitted fabric, braid or felt made of natural, synthetic or hollow fibers.
  • the carrier structure surface of the carrier structure preferably has at least one additional layering, which is either on the electrode structure and
  • Carrier structure surface is attached, biologically compatible, antiseptic, electrically non-conductive and can preferably contain at least one medicinal active ingredient.
  • This layer which is preferably a disposable article, serves as a removable wound dressing that can be discarded after use.
  • the thin layer in this case, designed as a wearing part, is preferably designed as a fleece with a corresponding porosity and suction force, but which at the same time is permeable to O 2 and / or is controlled or controlled via the field gradients
  • support structures which are customary in microsystems technology lend themselves in cases in which the device according to the solution, for example in the form of a microchip is dimensioned.
  • common wafer materials preferably silicon or ceramics, are suitable as the base material for the carrier structure.
  • the support structure as a body with a three-dimensional free-form surface, which can be produced, for example, by means of additive manufacturing processes.
  • arbitrarily shaped surface shapes for example spherical or cylindrical or the like, can be realized, which are adapted to patient-specific extra- or intracorporeal tissue shapes and thus produce ideal surface contact between the carrier substrate surface and a tissue area to be treated.
  • the finger electrode structure applied to the surface of the carrier structure preferably consists of a material which is a good metallic conductor, such as gold, silver, platinum or palladium, however alternative electrically conductive materials can also be used, such as graphene, graphene analogues or electrically conductive biocompatible polymers.
  • a means for joining to a biological tissue surface is provided on the support structure. This is preferably at least in some areas
  • the support structure surface with a biocompatible, adhesive layer, through which the support structure adheres to the biological tissue surface.
  • the electronics unit integrated in the support structure and electrically connected to the electrode structure serves for the controlled supply of the
  • Electrode structure with electrical voltage that can be specified precisely with regard to amount as well as time modulation.
  • the Electronics unit an electrical energy storage device in the form of a battery, a rechargeable battery or a capacitor, however it is possible to use the electrical
  • a further preferred embodiment provides a micropump unit with at least one attached to the support structure
  • Active substance reservoir the electronic unit being in signal exchange with the micropump unit such that the micropump unit can be activated for the metered delivery of at least one stored active substance into the area of the electrode structure.
  • the electronics unit attached to the support structure serves to control and activate the micropump unit which is formed separately from the support structure.
  • a gas reservoir or a gas generator in the form of a gas cell is attached directly or indirectly to the support structure and is designed and arranged in such a way that the gas reservoir or the gas cell by means of the electronics unit for the metered delivery of a stored or
  • the electrode structure applied to the support structure surface preferably has a large number of interdigital, alternating in each case and contactless interlocking, elongated electrode elements, each of which is electrically connected at the end in the form of a counter electrode and electrode.
  • At least one local electrode structure is attached or introduced along at least one finger-shaped electrode or counterelectrode
  • Length dimension in the longitudinal extension has a larger electrode surface than the elongated electrode element in the remaining area.
  • the at least one structure can be designed in the form of a bare electrode surface roughening.
  • the structure is preferably ring-shaped, spherical, zigzag or meandering and has a smooth or roughened shape
  • Electrode surface The local change in the surface geometry along at least one electrode element leads to a local change in the electrical field distribution between the electrode elements of the electrode structure, which is preferably in the form of an interdigital electrode structure, which results in
  • Oxygen formation by electrolysis affects.
  • the device according to the solution with suitable control of the electrode elements applied to the surface of the carrier structure, can be controlled by the device
  • Electronic unit also serve as a sensor device with which it is possible, for example, to adjust the pH and / or a certain gas content, for example.
  • Oxygen content within the biological environment bounded on one side by the carrier structure.
  • Device for the sensory detection of the local biological environment bounded on one side by the support structure provides at least one sensor element which serves at least two as an electrode and counterelectrode
  • Electrode elements contacted electrically locally. Iridium oxide, palladium oxide or aluminum oxide, the electrical properties of which are used as the sensor element
  • an electrical voltage of preferably about 650 mV is applied between the electrode elements.
  • Electronic unit can be specified, for example, sequentially
  • the device according to the solution can be used intracorporeally and also extracorporeally.
  • the device according to the solution can be designed as part of a plaster or in the form of a plaster in which the one that comes into direct contact with a wound site present on the skin surface
  • Surface area of the plaster corresponds to the explained support structure surface on which the electrode structure is attached, which is in contact with one inside the plaster, i.e. the electronic unit integrated in the support structure in the sense explained above.
  • the device according to the solution is particularly capable of
  • the plaster designed according to the solution can be supplemented with an integrally provided micropump unit or can be connected in a fluid-tight manner to a micropump unit designed separately from the plaster.
  • the carrier substrate surface on which the electrode structure is applied is hydrophilic formed, ie the preferably fleece-like carrier structure is able to absorb the extracellular liquid, in particular water, so that the electrode elements of the electrode structure are almost completely surrounded or wetted by liquid. In this way, oxygen production is efficiently supported in the course of electrolysis.
  • the carrier structure surface on which the electrode structure is attached consists of a hydrophobic material, for example of a polyether ether ketone, through which no liquid can penetrate into the material of the carrier structure and thus to the electronic unit, which it would otherwise have in the case explained above Sealing liquid accordingly applies.
  • the fluid preferably contains at least one medicinal active ingredient with a therapeutic target-promoting effect.
  • a further separate electrode structure is attached to the support structure in close proximity to the electrode structure, which serve as cleaning electrodes and / or as further functional electrodes , via which voltage potentials can be applied with predeterminable pulse shapes and pulse amplitudes, the electrical fields of which have a cleaning effect on the
  • Fig. 1 preferred, solution-based embodiment Fig. 2a, b representation of an intra- and extracorporeal purpose of
  • FIG. 5 alternative configuration of an electrode structure with local ones
  • Fig. 6 arrangement with a variety of solution devices on a common carrier.
  • Figure 1 shows a solution-based embodiment with a flat
  • trained support structure 1 preferably in the form of a fleece, consisting of a knitted fabric, braid or felt made of a natural, synthetic or flute fiber.
  • An electrode structure 3 in the form of a is on the support structure surface 2
  • Interdigital electrode structure attached, with longitudinally interlocking, finger-like electrodes 31 and counter electrodes 32.
  • the electrode structure 3 is electrically connected to an electronics unit 4 integrated in the support structure 1, which has at least one electrical energy source and one voltage potential Control unit which can be predetermined between electrodes 31 and counter electrodes 32 of the electrode structure 3.
  • the electronics unit 4 can be provided with a wireless interface, via which an electrical signal and / or energy exchange to an external signal or electrical energy source is possible.
  • Electrode structure 3 is on the way of a printing process
  • Carrier structure surface 2 of the carrier structure 1 applied.
  • alternative metallic deposition methods known to those skilled in the art can also be used to produce the electrode structure 3.
  • a main application of the device according to the solution relates to
  • the support structure surface 2 of the carrier substrate 1 is preferably joined as permanently as possible to the surface 5 of the tumor tissue by means of a biocompatible adhesive 7.
  • the support structure surface 2 closes with the
  • Tumor tissue 6 a volume 8 in which, as in the rest of the intracorporeal area, extracellular fluid is contained, which determines a local biological environment.
  • an electrical voltage of at least 1 V, preferably greater than 1.1 V, is applied to the electrode structure 3 by means of the electronics unit 4, the extracellular fluid near the electrode structure 3 is electrolyzed and an associated oxygen release occurs.
  • the electrodes 31 of the electrode structure 3 see local oxygen generation
  • structures of this type can also take on other electrode shapes that enlarge the electrode surface.
  • the device according to the solution is also suitable for extracorporeal application for the purpose of supporting wound healing. In the same way, the
  • carrier structure 1 preferably in the form of a plaster, can be attached to the skin surface 10 by means of a biologically compatible adhesive adhesive 7, on which there is a wound 11 which is preferably seamlessly covered by the carrier structure 1.
  • wound healing is achieved through the local generation of oxygen with the aid of the voltage-loaded electrode arrangement 3 by means of electrolysis between the skin surface 10 and
  • Support structure surface 2 enclosed extracellular fluid 12 supports.
  • a gas reservoir 13 preferably in the form of a gas cell, from which controlled gas, preferably oxygen, can be released via the support structure surface 2, preferably in the region of the electrode structure 3.
  • a micropump unit 14 with at least one
  • the active substance stored within the active substance reservoir is suitable for the respective intended use and the desired therapeutic goal, and is to be dispensed via the carrier structure surface 2, preferably in the area of the electrode arrangement 3.
  • a large number of no, bubble-like, fluid reservoirs can be arranged distributed on the support structure in the region of the electrode structure, the individual envelopes of which are provided by a high electrical force which can be applied briefly to the electrode structure
  • an alternative development of the device provides the provision of so-called sensor elements 14, which are each arranged in a contacting manner between the electrodes 31 and counter electrodes 32 and are used, for example, for the purpose of oxygen detection or pH value determination.
  • the sensor elements 15 preferably consist of iridium oxide, palladium oxide or aluminum oxide.
  • FIG. 3 illustrates an embodiment for the design of the device as a plaster, which has adhesive strips 16 on at least two sides, on the surface of which the biologically compatible adhesive adhesive 7 is applied.
  • FIG. 4 shows a further development of the embodiment illustrated in FIG. 1
  • a further layer 17 is applied to the support structure surface 2 of the support structure 1, which can be made hydrophilic or hydrophobic depending on the application.
  • the additional layer 17 can also be designed in the form of a barrier membrane which is water-repellent but gas-permeable. Suitable materials are, for example, polyether ether ketone, hydrogels or Goretex®.
  • FIG. 5 shows a preferred design for the configuration of the electrode elements 31, 32 of an electrode structure 3, with which the generation of oxygen is particularly effective.
  • the elongate finger-shaped electrodes 31 have web-like extensions 3T oriented transversely to their longitudinal extension, which end at a spherical or plate-shaped extension 31 ′′ and open into bulges 32 ′′, each of which is attached along the counter electrodes 32.
  • FIG. 6 shows an arrangement A which comprises a large number of devices V in an array-like arrangement pattern, all of which are connected to one another via a data bus transmission system 18, in which a central computing and control unit 19, which is preferably chip-based, is also formed is integrated.
  • the devices V see detailed view in FIG. 6, each have an electrode structure 3, comprising at least one electrode 31 and a counter electrode 32, and one
  • the central computing unit 19 communicates with the electronic units 4 contained in the devices V jointly or separately, a flatly homogeneous or heterogeneously controllable one
  • the individual devices V present in the data bus network can be designed to be multifunctionally expanded in the manner explained above, for example by supplementing them with at least one sensor, for example for detecting the pFI value, 0 2 content or the like.
  • the therapeutic influence of the arrangement A on a tissue area to be treated can be carried out in a surface-specific manner, ie depending on the healing or intracorporeal milieu, which can be detected by means of surface resolution, selected devices V or a group of selected devices V can be activated in the arrangement A, For example, for the purpose of a local electrolysis process or the local one Release of a medium by means of a gas cell or a micropump unit, which is connected to an active substance reservoir.
  • all devices V are each on one
  • Carrier structure 1 applied, for example on a chip, which in turn is applied on a carrier T on which the devices V have a fixed spatial
  • the individual chips or devices 1 linked via the data bus transmission system 18 can have a very small or larger area.
  • the chip-based central computing and control unit 19 can be applied on a ceramic or on a fleece as a carrier 1 ', on or in which the individual chips or devices V are embedded.
  • the data bus transmission system 18 is wired, i.e. the devices V are electrically connected to one another and to the central computing and control unit 19 via electrical lines applied or integrated on or in the carrier.
  • the electrical connection pattern illustrated in FIG. 6 is only to be understood as representative of a large number of possible circuit topologies.
  • the electronic units 4 of the individual devices V have electrical energy sources, for example in the form of at least one interface for wireless transmission of electrical energy or in the form of a battery or rechargeable batteries or the like.
  • electrical energy sources for example in the form of at least one interface for wireless transmission of electrical energy or in the form of a battery or rechargeable batteries or the like.
  • the signal transmission within the data bus transmission system 18 by means of the electrically conductive liquid environment surrounding the entire arrangement A, for example lymph or
  • the same biocompatible materials that are also suitable for the support structures 1, as explained above, are suitable for the material formation of the support 1 '.
  • the electrode structure 3 and at least the electronics unit 4 of each device V can be applied directly to the carrier T of the arrangement A.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
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  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Materials For Medical Uses (AREA)
  • Electrotherapy Devices (AREA)

Abstract

L'invention concerne un dispositif d'application extracorporelle ou intracorporelle sur ou dans un corps humain ou animal destiné à influencer et/ou détecter par des capteurs un milieu biologique local, ledit dispositif comprenant une structure de support plan pourvue d'un matériau biocompatible et une surface de structure de support sur laquelle une structure d'électrode est placée qui comporte au moins deux éléments d'électrode espacés latéralement l'un de l'autre, qui permet de limiter localement le milieu biologique conjointement avec la surface de structure de support, ainsi qu'une unité électronique disposée sur ou dans la structure de support et venant en contact électrique avec la structure d'électrode et appliquant une tension électrique spécifiable entre les au moins deux éléments d'électrode pour former respectivement une électrode et une contre-électrode.
EP19800948.2A 2018-10-31 2019-10-30 Dispositif d'application extracorporelle ou intracorporelle sur ou dans un corps humain ou animal pour influencer et/ou détecter par des capteurs un milieu biologique local Pending EP3873584A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102018218686.3A DE102018218686A1 (de) 2018-10-31 2018-10-31 Vorrichtung zur extra- oder intrakorporalen Applikation an oder in einem menschlichen oder tierischen Körper zur Beeinflussung und/oder sensorischen Erfassung eines lokalen biologischen Milieus
PCT/EP2019/079649 WO2020089290A1 (fr) 2018-10-31 2019-10-30 Dispositif d'application extracorporelle ou intracorporelle sur ou dans un corps humain ou animal pour influencer et/ou détecter par des capteurs un milieu biologique local

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EP3873584A1 true EP3873584A1 (fr) 2021-09-08

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EP (1) EP3873584A1 (fr)
DE (1) DE102018218686A1 (fr)
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Citations (2)

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US20110295241A1 (en) * 2009-02-03 2011-12-01 Babak Ziaie Method and apparatus for improving local hypoxicity for enhanced therapy
US20160296269A1 (en) * 2013-11-14 2016-10-13 Rm2 Technology Llc Methods, systems, and apparatuses for tissue ablation using electrolysis and permeabilization

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US8734421B2 (en) * 2003-06-30 2014-05-27 Johnson & Johnson Consumer Companies, Inc. Methods of treating pores on the skin with electricity
US20140046240A1 (en) * 2012-08-07 2014-02-13 Stmicroelectronics International N.V. Electronic assembly for iontophoresis transdermal drug delivery and device thereof
US20180326201A1 (en) * 2015-12-07 2018-11-15 Vomaris Innovations, Inc. Iontophoresis devices and methods of use
EP3257550B1 (fr) * 2016-06-16 2018-11-21 Nokia Technologies Oy Appareil configuré pour permettre un flux de courant à travers la peau d'un utilisateur

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US20110295241A1 (en) * 2009-02-03 2011-12-01 Babak Ziaie Method and apparatus for improving local hypoxicity for enhanced therapy
US20160296269A1 (en) * 2013-11-14 2016-10-13 Rm2 Technology Llc Methods, systems, and apparatuses for tissue ablation using electrolysis and permeabilization

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Title
See also references of WO2020089290A1 *
WOLF B ET AL: "POTENTIAL OF MICROSENSOR-BASED FEEDBACK BIOACTUATORS FOR BIOPHYSICAL CANCER TREATMENT", BIOSENSORS AND BIOELECTRONICS, ELSEVIER SCIENCE LTD, UK, AMSTERDAM , NL, vol. 12, no. 4, 1 January 1997 (1997-01-01), pages 301 - 309, XP000869780, ISSN: 0956-5663, DOI: 10.1016/S0956-5663(96)00071-1 *

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WO2020089290A1 (fr) 2020-05-07
DE102018218686A1 (de) 2020-04-30

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