EP3853353A4 - Ciml nk cells and methods therefor - Google Patents

Ciml nk cells and methods therefor Download PDF

Info

Publication number: EP3853353A4
Authority: EP; European Patent Office
Prior art keywords: ciml; cells; methods therefor; therefor; methods
Prior art date: 2019-07-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP19936806.9A

Other languages

German (de)

French (fr)

Other versions

EP3853353A1 (en

Inventor

Rohit Duggal

Ranjeet SINHA

Wenzhao Li

Jason ISAACSON

Patrick Soon-Shiong

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Immunitybio Inc

Original Assignee

Immunitybio Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2019-07-08

Filing date

2019-07-08

Publication date

2022-05-18

2019-07-08 Application filed by Immunitybio Inc filed Critical Immunitybio Inc

2021-07-28 Publication of EP3853353A1 publication Critical patent/EP3853353A1/en

2022-05-18 Publication of EP3853353A4 publication Critical patent/EP3853353A4/en

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2312—Interleukin-12 (IL-12)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2318—Interleukin-18 (IL-18)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Zoology (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Immunology (AREA)
Cell Biology (AREA)
Hematology (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Developmental Biology & Embryology (AREA)
Virology (AREA)

EP19936806.9A 2019-07-08 2019-07-08 Ciml nk cells and methods therefor Withdrawn EP3853353A4 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US2019/040889 WO2021006876A1 (en)	2019-07-08	2019-07-08	Ciml nk cells and methods therefor

Publications (2)

Publication Number	Publication Date
EP3853353A1 EP3853353A1 (en)	2021-07-28
EP3853353A4 true EP3853353A4 (en)	2022-05-18

Family

ID=74114922

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP19936806.9A Withdrawn EP3853353A4 (en)	2019-07-08	2019-07-08	Ciml nk cells and methods therefor

Country Status (9)

Country	Link
EP (1)	EP3853353A4 (en)
JP (1)	JP2022540267A (en)
KR (1)	KR20210079381A (en)
CN (1)	CN113195706A (en)
AU (1)	AU2019456438A1 (en)
CA (1)	CA3117134A1 (en)
IL (1)	IL283997A (en)
SG (1)	SG11202104256XA (en)
WO (1)	WO2021006876A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP4301846A4 (en) *	2021-03-03	2025-03-05	ImmunityBio, Inc.	HIGH POWER M-CENK CELLS AND PROCESSES
EP4370138A4 (en) *	2021-07-15	2025-08-06	Wugen Inc	EXPANSION OF NATURAL MEMORY KILLER CELLS
WO2025166096A1 (en) *	2024-02-01	2025-08-07	Inndura Therapeutics Inc.	Method of induction of immune cells into a memory-like state
CN119286778A (en) *	2024-12-09	2025-01-10	天津迈默睿生物技术有限公司	A method for preparing memory natural killer cells using peripheral blood mononuclear cells and application of memory natural killer cells

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2018165208A1 (en) *	2017-03-06	2018-09-13	Altor Bioscience Corporation	Il-15-based fusions to il-12 and il-18

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4275680B2 (en) *	2006-04-28	2009-06-10	裕照沼	Culture methods for lymphocyte activity / proliferation
PL3160498T3 (en) *	2014-06-30	2022-02-21	Altor Bioscience Corporation	Molecules based on IL-15 and methods of their application
CN105219713A (en) *	2015-11-20	2016-01-06	崔长友	For high proliferation power, the High Fragmentation power NK cell of tumour adoptive immunity
US10300089B2 (en) *	2016-11-08	2019-05-28	University Of Central Florida Research Foundation, Inc.	Methods for high scale therapeutic production of memory NK cells
AU2018226526B2 (en) *	2017-02-28	2025-03-13	Affimed Gmbh	Combination of an anti-CD16A antibody with a cytokine

2019
- 2019-07-08 CN CN201980082326.4A patent/CN113195706A/en active Pending
- 2019-07-08 AU AU2019456438A patent/AU2019456438A1/en not_active Abandoned
- 2019-07-08 WO PCT/US2019/040889 patent/WO2021006876A1/en not_active Ceased
- 2019-07-08 JP JP2021534175A patent/JP2022540267A/en not_active Withdrawn
- 2019-07-08 CA CA3117134A patent/CA3117134A1/en not_active Abandoned
- 2019-07-08 SG SG11202104256XA patent/SG11202104256XA/en unknown
- 2019-07-08 KR KR1020217018219A patent/KR20210079381A/en not_active Withdrawn
- 2019-07-08 EP EP19936806.9A patent/EP3853353A4/en not_active Withdrawn
2021
- 2021-06-14 IL IL283997A patent/IL283997A/en unknown

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2018165208A1 (en) *	2017-03-06	2018-09-13	Altor Bioscience Corporation	Il-15-based fusions to il-12 and il-18

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
LEONG JEFFREY W ET AL: "Preactivation with IL-12, IL-15, and IL-18 Induces CD25 and a Functional High-Affinity IL-2 Receptor on Human Cytokine-Induced Memory-like Natural Killer Cells", BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, KLUGE CARDEN JENNINGS PUBLISHING, CHARLOTTESVILLE, VA, US, vol. 20, no. 4, 13 January 2014 (2014-01-13), pages 463 - 473, XP028636306, ISSN: 1083-8791, DOI: 10.1016/J.BBMT.2014.01.006 *
MEGAN A COOPER ET AL: "Cytokine-induced memory-like natural killer cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 106, no. 6, 10 February 2009 (2009-02-10), pages 1915 - 1919, XP002639517, ISSN: 0027-8424, [retrieved on 20090130], DOI: 10.1073/PNAS.0813192106 *
See also references of WO2021006876A1 *
ZHUANG LIHUI ET AL: "Activity of IL-12/15/18 primed natural killer cells against hepatocellular carcinoma", HEPATOLOGY INTERNATIONAL, SPRINGER INDIA, INDIA, vol. 13, no. 1, 22 November 2018 (2018-11-22), pages 75 - 83, XP036694504, ISSN: 1936-0533, [retrieved on 20181122], DOI: 10.1007/S12072-018-9909-3 *

Also Published As

Publication number	Publication date
EP3853353A1 (en)	2021-07-28
SG11202104256XA (en)	2021-05-28
KR20210079381A (en)	2021-06-29
CA3117134A1 (en)	2021-01-14
WO2021006876A1 (en)	2021-01-14
AU2019456438A1 (en)	2021-05-20
CN113195706A (en)	2021-07-30
IL283997A (en)	2021-07-29
JP2022540267A (en)	2022-09-15

Publication	Publication Date	Title
EP3591030A4 (en)	2020-03-25	Cell culture device and cell culture method
EP4038555A4 (en)	2023-10-25	Systems and methods for screening compounds in silico
EP3858064A4 (en)	2022-06-22	System and methods for enabling dl-edt
EP3739037A4 (en)	2021-10-06	Cell culturing method and device
EP3808856A4 (en)	2022-03-09	Undifferentiated cell detection method
EP3743121A4 (en)	2022-01-12	Cell culturing device and method
EP3943586A4 (en)	2022-05-04	Cell culture system and cell culture method
EP3853353A4 (en)	2022-05-18	Ciml nk cells and methods therefor
EP3836683A4 (en)	2022-01-05	Distribution unit, central unit, and method therefor
EP3826352A4 (en)	2021-09-15	Cell switching method, device and system
EP4024947A4 (en)	2022-08-10	Method and device for cell reselection
EP3962652A4 (en)	2023-01-18	Methods for encapsulating and assaying cells
EP3755051A4 (en)	2021-12-08	Cell processing method, device, and system
EP3438662A4 (en)	2020-01-22	Cell holding chip and screening method using cell holding chip
EP3858974A4 (en)	2022-06-29	Cell culture chip
EP4007586A4 (en)	2023-09-20	Cells for improved immunotherapy and uses thereof
EP3778992A4 (en)	2022-01-19	Electrolytic cell and electrolytic device
EP4023741A4 (en)	2023-11-08	Cell production device and cell production method
EP4039789A4 (en)	2023-10-04	Method for screening secretion-producing cells and kit for screening secretion-producing cells
EP3988637A4 (en)	2023-06-28	Cell dispensing device and cell dispensing method
EP3988636A4 (en)	2023-08-02	Cell culture device
EP3556842A4 (en)	2020-01-15	Cell culture apparatus and cell culture method
EP4059572A4 (en)	2024-01-17	Cell reprogramming method
EP4082613A4 (en)	2024-01-03	Cell group and method for acquiring same
EP4051777A4 (en)	2024-06-12	Methods and apparatus for cell culture wellplates

Legal Events

Date	Code	Title	Description
2021-01-18	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2021-06-25	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2021-06-25	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2021-07-28	17P	Request for examination filed	Effective date: 20210421
2021-07-28	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2022-02-23	RAP3	Party data changed (applicant data changed or rights of an application transferred)	Owner name: IMMUNITYBIO, INC.
2022-05-18	A4	Supplementary search report drawn up and despatched	Effective date: 20220414
2022-05-18	RIC1	Information provided on ipc code assigned before grant	Ipc: A61P 35/00 20060101ALI20220408BHEP Ipc: A61K 35/17 20150101ALI20220408BHEP Ipc: C12N 5/0783 20100101AFI20220408BHEP
2022-10-12	DAV	Request for validation of the european patent (deleted)
2022-10-12	DAX	Request for extension of the european patent (deleted)
2023-03-31	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2023-05-03	18D	Application deemed to be withdrawn	Effective date: 20221115