EP3720474A4 - Products and methods for assessing and increasing klotho protein levels - Google Patents
Products and methods for assessing and increasing klotho protein levels Download PDFInfo
- Publication number
- EP3720474A4 EP3720474A4 EP18885984.7A EP18885984A EP3720474A4 EP 3720474 A4 EP3720474 A4 EP 3720474A4 EP 18885984 A EP18885984 A EP 18885984A EP 3720474 A4 EP3720474 A4 EP 3720474A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- assessing
- products
- methods
- protein levels
- klotho protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01031—6-Phosphogluconolactonase (3.1.1.31)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01031—Beta-glucuronidase (3.2.1.31)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762595567P | 2017-12-06 | 2017-12-06 | |
| US201862666868P | 2018-05-04 | 2018-05-04 | |
| US201862692195P | 2018-06-29 | 2018-06-29 | |
| US16/208,552 US20190169593A1 (en) | 2016-06-02 | 2018-12-03 | Products and methods for assessing and increasing klotho protein levels |
| PCT/US2018/064333 WO2019113373A2 (en) | 2017-12-06 | 2018-12-06 | Products and methods for assessing and increasing klotho protein levels |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP3720474A2 EP3720474A2 (en) | 2020-10-14 |
| EP3720474A4 true EP3720474A4 (en) | 2021-12-29 |
Family
ID=66750330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP18885984.7A Pending EP3720474A4 (en) | 2017-12-06 | 2018-12-06 | Products and methods for assessing and increasing klotho protein levels |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP3720474A4 (en) |
| JP (2) | JP7290340B2 (en) |
| KR (1) | KR102831784B1 (en) |
| AU (2) | AU2018378802B2 (en) |
| CA (1) | CA3101100A1 (en) |
| WO (1) | WO2019113373A2 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020160617A1 (en) * | 2019-02-05 | 2020-08-13 | Helium 3 Biotech Pty Ltd | A membrane protein expression and distribution modulating composition and method of use thereof |
| CN111184728B (en) * | 2020-02-20 | 2023-04-04 | 上海市儿童医院 | Application of trehalose in nephrotic syndrome |
| CN112114075B (en) * | 2020-09-17 | 2022-12-09 | 哈尔滨珍宝制药有限公司 | Construction method and quality evaluation method of notopterygium root Shengshi Shang Zhiwen map |
| CN116211898A (en) * | 2020-11-26 | 2023-06-06 | 内蒙古伊利实业集团股份有限公司 | Bifidobacterium lactis BL-99 regulating sleep and its application |
| CN114441696A (en) * | 2021-12-22 | 2022-05-06 | 南京格亚医药科技有限公司 | A kind of detection method of eribulin mesylate key intermediate |
| KR102802882B1 (en) * | 2022-04-05 | 2025-05-08 | 한국과학기술연구원 | Dilution solution for measuring free steroid in blood and method for measuring steroid using the same |
| EP4434534A1 (en) | 2023-03-22 | 2024-09-25 | ADvantage Therapeutics, Inc. | Klotho mrna |
| WO2025205534A1 (en) * | 2024-03-25 | 2025-10-02 | 積水メディカル株式会社 | Immunoassay method, accuracy management method, standard sample, and immunoassay reagent |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090192087A1 (en) * | 2008-01-28 | 2009-07-30 | Novartis Ag | Methods and Compositions Using Klotho-FGF Fusion Polypeptides |
| WO2012018638A2 (en) * | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures |
| WO2016015162A1 (en) * | 2014-07-31 | 2016-02-04 | The Governing Council Of The University Of Toronto | ANTIBODIES WITH HIGH AFFINITY FOR αKLOTHO |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4313927A (en) * | 1979-10-19 | 1982-02-02 | Ames-Yissum Ltd. | Immunoassay method for detecting viral antibodies in whole blood samples |
| DE69127383T2 (en) * | 1990-01-19 | 1998-03-05 | Mina Ltd | Device and method for examining blood and for fingerprint identification |
| US20030109067A1 (en) * | 2001-12-06 | 2003-06-12 | Immunetech, Inc. | Homogeneous immunoassays for multiple allergens |
| DE102005003789A1 (en) * | 2005-01-19 | 2006-07-27 | Roche Diagnostics Gmbh | Test unit for one-time examinations of a body fluid |
| US7467065B2 (en) * | 2005-05-02 | 2008-12-16 | Home Diagnostics, Inc. | Computer interface for diagnostic meter |
| US7575876B2 (en) * | 2005-10-27 | 2009-08-18 | The University Of Washington | Biomarkers for neurodegenerative disorders |
| JP5201822B2 (en) * | 2006-12-11 | 2013-06-05 | アボット・ラボラトリーズ | Immunological assay for gastrin releasing peptide precursor |
| US10555963B2 (en) * | 2007-05-08 | 2020-02-11 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Klotho protein and related compounds for the treatment and diagnosis of cancer |
| BRPI0815416A2 (en) * | 2007-08-15 | 2014-10-21 | Amunix Inc | COMPOSITIONS AND METHODS FOR MODIFYING PROPERTIES OF BIOLOGICALLY ACTIVE POLYPEPTIDES |
| US8728744B2 (en) * | 2007-10-26 | 2014-05-20 | The Regents Of The University Of California | Salivary protein biomarkers for human oral cancer |
| WO2011050110A1 (en) * | 2009-10-20 | 2011-04-28 | Boston Microfluidics | Methods and systems to collect and prepare samples, to implement, initiate and perform assays, and to control and manage fluid flow |
| EP2512500A1 (en) * | 2009-12-16 | 2012-10-24 | Eli Lilly and Company | Therapeutic uses of soluble alpha-klotho |
| CN107209095A (en) * | 2014-11-28 | 2017-09-26 | 奇普凯尔公司 | Multiple pearl array is determined |
| EP3551212A4 (en) * | 2016-11-22 | 2020-11-04 | Klotho Therapeutics, Inc. | NOVEL RECOMBINANT KLOTHO PROTEINS AND COMPOSITIONS AND PROCESSES THEREOF |
-
2018
- 2018-12-06 CA CA3101100A patent/CA3101100A1/en active Pending
- 2018-12-06 AU AU2018378802A patent/AU2018378802B2/en active Active
- 2018-12-06 JP JP2020531132A patent/JP7290340B2/en active Active
- 2018-12-06 EP EP18885984.7A patent/EP3720474A4/en active Pending
- 2018-12-06 KR KR1020207019460A patent/KR102831784B1/en active Active
- 2018-12-06 WO PCT/US2018/064333 patent/WO2019113373A2/en not_active Ceased
-
2023
- 2023-05-25 JP JP2023086449A patent/JP2023113737A/en active Pending
-
2024
- 2024-11-08 AU AU2024259844A patent/AU2024259844A1/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090192087A1 (en) * | 2008-01-28 | 2009-07-30 | Novartis Ag | Methods and Compositions Using Klotho-FGF Fusion Polypeptides |
| WO2012018638A2 (en) * | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures |
| WO2016015162A1 (en) * | 2014-07-31 | 2016-02-04 | The Governing Council Of The University Of Toronto | ANTIBODIES WITH HIGH AFFINITY FOR αKLOTHO |
Non-Patent Citations (2)
| Title |
|---|
| MICHELLE SHARDELL ET AL: "Plasma Klotho and Frailty in Older Adults: Findings From the InCHIANTI Study", JOURNALS OF GERONTOLOGY, SERIES A, BIOLOGICAL SCIENCES ANDMEDICAL SCIENCES, vol. 00, 19 October 2017 (2017-10-19), US, pages 1 - 6, XP055521719, ISSN: 1079-5006, DOI: 10.1093/gerona/glx202 * |
| ROTONDI SILVERIO ET AL: "Soluble [alpha] -Klotho Serum Levels in Chronic Kidney Disease", INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, vol. 2015, 1 January 2015 (2015-01-01), US, pages 1 - 8, XP055832442, ISSN: 1687-8337, Retrieved from the Internet <URL:http://downloads.hindawi.com/journals/ije/2015/872193.pdf> [retrieved on 20210816], DOI: 10.1155/2015/872193 * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2018378802B2 (en) | 2024-08-15 |
| AU2018378802A1 (en) | 2020-07-23 |
| EP3720474A2 (en) | 2020-10-14 |
| WO2019113373A3 (en) | 2019-09-26 |
| CA3101100A1 (en) | 2019-06-13 |
| KR20200095538A (en) | 2020-08-10 |
| KR102831784B1 (en) | 2025-07-09 |
| JP2021508037A (en) | 2021-02-25 |
| AU2024259844A1 (en) | 2024-11-28 |
| JP7290340B2 (en) | 2023-06-13 |
| JP2023113737A (en) | 2023-08-16 |
| WO2019113373A2 (en) | 2019-06-13 |
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| RIC1 | Information provided on ipc code assigned before grant |
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