EP3784265A4 - THIOETHER PEPTIDE-AMYLIN CYCLIC RECEPTOR MODULATORS - Google Patents

THIOETHER PEPTIDE-AMYLIN CYCLIC RECEPTOR MODULATORS Download PDF

Info

Publication number: EP3784265A4
Authority: EP; European Patent Office
Prior art keywords: amylin; receptor modulators; thioether peptide; cyclic; cyclic receptor
Prior art date: 2018-04-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP19791705.7A

Other languages

German (de)

French (fr)

Other versions

EP3784265A2 (en

Inventor

Wenying Jian

Raymond Patch

Rui Zhang

Songmao ZHENG

Simon Hinke

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Janssen Pharmaceutica NV

Original Assignee

Janssen Pharmaceutica NV

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2018-04-25

Filing date

2019-04-17

Publication date

2022-06-22

2019-04-17 Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV

2021-03-03 Publication of EP3784265A2 publication Critical patent/EP3784265A2/en

2022-06-22 Publication of EP3784265A4 publication Critical patent/EP3784265A4/en

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Animal Behavior & Ethology (AREA)
Endocrinology (AREA)
Veterinary Medicine (AREA)
Zoology (AREA)
Public Health (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Cell Biology (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

EP19791705.7A 2018-04-25 2019-04-17 THIOETHER PEPTIDE-AMYLIN CYCLIC RECEPTOR MODULATORS Withdrawn EP3784265A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201862662492P	2018-04-25	2018-04-25
PCT/IB2019/053194 WO2019207427A2 (en)	2018-04-25	2019-04-17	Thioether cyclic peptide amylin receptor modulators

Publications (2)

Publication Number	Publication Date
EP3784265A2 EP3784265A2 (en)	2021-03-03
EP3784265A4 true EP3784265A4 (en)	2022-06-22

Family

ID=68293854

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP19791705.7A Withdrawn EP3784265A4 (en)	2018-04-25	2019-04-17	THIOETHER PEPTIDE-AMYLIN CYCLIC RECEPTOR MODULATORS

Country Status (5)

Country	Link
EP (1)	EP3784265A4 (en)
JP (1)	JP2021522231A (en)
CN (1)	CN112074289A (en)
CA (1)	CA3097812A1 (en)
WO (1)	WO2019207427A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA3204051A1 (en)	2021-01-20	2022-07-28	Brian Lian	Compositions and methods for the treatment of metabolic and liver disorders
WO2023044290A1 (en)	2021-09-15	2023-03-23	Viking Therapeutics, Inc.	Compositions and methods for the treatment of metabolic and liver disorders
CN114057862A (en) *	2021-12-14	2022-02-18	安徽省国平药业有限公司	Synthetic method of GLP-1(1-37) polypeptide
CN120040558A (en) *	2024-03-19	2025-05-27	深圳湾实验室	Polypeptides or analogues thereof and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1998050059A1 (en) *	1997-05-06	1998-11-12	Amylin Pharmaceuticals, Inc.	Method for preventing gastritis using amylin or amylin agonists
WO2005115437A2 (en) *	2004-05-20	2005-12-08	Amylin Pharmaceuticals, Inc.	Methods for affecting body composition
WO2016011208A1 (en) *	2014-07-17	2016-01-21	Protagonist Therapeutics, Inc.	Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5252435B2 (en) *	2006-03-15	2013-07-31	ノボ・ノルデイスク・エー／エス	Amylin derivatives
EP2036923A1 (en) *	2007-09-11	2009-03-18	Novo Nordisk A/S	Improved derivates of amylin
AU2010258898B8 (en) *	2009-06-08	2015-02-05	Amunix Operating Inc.	Glucose-regulating polypeptides and methods of making and using same
WO2011050008A2 (en) *	2009-10-19	2011-04-28	Amylin Pharmaceuticals, Inc.	Combination therapy comprising administration of an amylinomimetic and a pyy peptidomimetic for effecting weight loss and for treating obesity and related metabolic conditions and disorders
WO2011084808A2 (en) *	2009-12-21	2011-07-14	Amunix Operating Inc.	Bifunctional polypeptide compositions and methods for treatment of metabolic and cardiovascular diseases
JP2014516049A (en) *	2011-05-25	2014-07-07	アミリン・ファーマシューティカルズ，リミテッド・ライアビリティ・カンパニー	Amylin peptides and derivatives and uses thereof
WO2013059336A1 (en) *	2011-10-18	2013-04-25	Amylin Pharmaceuticals, Llc	Amylin-calcitonin chimeric peptides conjugated to duration enchancing moieties
US9683018B2 (en) *	2013-07-25	2017-06-20	Novartis Ag	Disulfide cyclic polypeptides for the treatment of heart failure
AR097701A1 (en) *	2013-09-19	2016-04-13	Zealand Pharma As	AMILINE ANALOGS
CA3003465A1 (en) *	2015-10-28	2017-05-04	Krishna Kumar	Novel polypeptides with improved proteolytic stability, and methods of preparing and using same

2019
- 2019-04-17 WO PCT/IB2019/053194 patent/WO2019207427A2/en not_active Ceased
- 2019-04-17 CA CA3097812A patent/CA3097812A1/en active Pending
- 2019-04-17 JP JP2020558904A patent/JP2021522231A/en active Pending
- 2019-04-17 EP EP19791705.7A patent/EP3784265A4/en not_active Withdrawn
- 2019-04-17 CN CN201980027903.XA patent/CN112074289A/en active Pending

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1998050059A1 (en) *	1997-05-06	1998-11-12	Amylin Pharmaceuticals, Inc.	Method for preventing gastritis using amylin or amylin agonists
WO2005115437A2 (en) *	2004-05-20	2005-12-08	Amylin Pharmaceuticals, Inc.	Methods for affecting body composition
WO2016011208A1 (en) *	2014-07-17	2016-01-21	Protagonist Therapeutics, Inc.	Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MOLL G N ET AL: "A biological stabilization technology for peptide drugs: enzymatic introduction of thioether-bridges", DRUG DISCOVERY TODAY: TECHNOLOGIES, ELSEVIER, AMSTERDAM, NL, vol. 6, no. 1-4, January 2009 (2009-01-01), pages e13 - e18, XP027503974, ISSN: 1740-6749, [retrieved on 20090419], DOI: 10.1016/J.DDTEC.2009.03.001 *

Also Published As

Publication number	Publication date
EP3784265A2 (en)	2021-03-03
CA3097812A1 (en)	2019-10-31
WO2019207427A3 (en)	2020-01-02
JP2021522231A (en)	2021-08-30
WO2019207427A2 (en)	2019-10-31
CN112074289A (en)	2020-12-11

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DK3490986T3 (en)	2022-03-07	PIPERIDINE-CXCR7 RECEPTOR MODULATORS
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EP3852689A4 (en)	2021-11-24	OPERATIONAL PROCEDURE
DK3646748T3 (en)	2024-06-24	FASTENING DEVICE
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DK3729990T3 (en)	2025-05-26	FIXING DEVICE
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EP3580223A4 (en)	2021-01-06	BENZOTHIOPHENE EESTROGEN RECEPTOR MODULATORS
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PT3568609T (en)	2021-06-15	FIXING DEVICE
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EP3724220A4 (en)	2021-09-01	NKG2D DARIC RECEPTORS
EP3784265A4 (en)	2022-06-22	THIOETHER PEPTIDE-AMYLIN CYCLIC RECEPTOR MODULATORS
IL285074A (en)	2021-09-30	gpr35 modulators
EP3793748C0 (en)	2025-03-05	APPLICATOR
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EP3719381A4 (en)	2021-08-04	FILLING DEVICE

Legal Events

Date	Code	Title	Description
2019-11-02	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2021-01-29	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2021-01-29	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2021-03-03	17P	Request for examination filed	Effective date: 20201123
2021-03-03	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2021-03-03	AX	Request for extension of the european patent	Extension state: BA ME
2021-08-04	DAV	Request for validation of the european patent (deleted)
2021-08-04	DAX	Request for extension of the european patent (deleted)
2022-06-22	A4	Supplementary search report drawn up and despatched	Effective date: 20220520
2022-06-22	RIC1	Information provided on ipc code assigned before grant	Ipc: C07K 14/72 20060101ALI20220516BHEP Ipc: C07K 14/47 20060101ALI20220516BHEP Ipc: A61P 3/10 20060101ALI20220516BHEP Ipc: A61P 1/16 20060101ALI20220516BHEP Ipc: A61K 38/17 20060101AFI20220516BHEP
2023-04-28	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2023-05-31	18D	Application deemed to be withdrawn	Effective date: 20221220