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EP3745998A4 - Polymère antimicrobien destiné à être utilisé dans des implants ophtalmiques - Google Patents

Polymère antimicrobien destiné à être utilisé dans des implants ophtalmiques Download PDF

Info

Publication number
EP3745998A4
EP3745998A4 EP18903224.6A EP18903224A EP3745998A4 EP 3745998 A4 EP3745998 A4 EP 3745998A4 EP 18903224 A EP18903224 A EP 18903224A EP 3745998 A4 EP3745998 A4 EP 3745998A4
Authority
EP
European Patent Office
Prior art keywords
antimicrobial polymer
ophthalmic implants
ophthalmic
implants
antimicrobial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP18903224.6A
Other languages
German (de)
English (en)
Other versions
EP3745998A1 (fr
Inventor
Yichieh Shiuey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Keramed Inc
Original Assignee
Keramed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Keramed Inc filed Critical Keramed Inc
Publication of EP3745998A1 publication Critical patent/EP3745998A1/fr
Publication of EP3745998A4 publication Critical patent/EP3745998A4/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/142—Cornea, e.g. artificial corneae, keratoprostheses or corneal implants for repair of defective corneal tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F20/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
    • C08F20/02—Monocarboxylic acids having less than ten carbon atoms, Derivatives thereof
    • C08F20/10—Esters
    • C08F20/34—Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
    • G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
    • A61L2300/208—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Prostheses (AREA)
  • Eyeglasses (AREA)
EP18903224.6A 2018-01-31 2018-01-31 Polymère antimicrobien destiné à être utilisé dans des implants ophtalmiques Pending EP3745998A4 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2018/016257 WO2019152023A1 (fr) 2018-01-31 2018-01-31 Polymère antimicrobien destiné à être utilisé dans des implants ophtalmiques

Publications (2)

Publication Number Publication Date
EP3745998A1 EP3745998A1 (fr) 2020-12-09
EP3745998A4 true EP3745998A4 (fr) 2021-09-01

Family

ID=67478440

Family Applications (2)

Application Number Title Priority Date Filing Date
EP18903224.6A Pending EP3745998A4 (fr) 2018-01-31 2018-01-31 Polymère antimicrobien destiné à être utilisé dans des implants ophtalmiques
EP19780818.1A Active EP3850018B1 (fr) 2018-01-31 2019-02-14 Lentilles de contact antimicrobiennes

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP19780818.1A Active EP3850018B1 (fr) 2018-01-31 2019-02-14 Lentilles de contact antimicrobiennes

Country Status (5)

Country Link
US (1) US20210077249A1 (fr)
EP (2) EP3745998A4 (fr)
JP (2) JP7560865B2 (fr)
CN (2) CN111670020A (fr)
WO (2) WO2019152023A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4218554A (en) * 1978-10-11 1980-08-19 Foley William M Jr Process for preparing hydrogel contact lenses containing quaternary ammonium salts
EP0604369A1 (fr) * 1992-12-23 1994-06-29 Ciba-Geigy Ag Lentilles de contact empêchant les depôts
WO1998027896A1 (fr) * 1996-12-20 1998-07-02 Implemed, Inc. Lentilles intraoculaires a activite antimicrobienne
WO2008038721A1 (fr) * 2006-09-29 2008-04-03 Toray Industries, Inc. Lentille oculaire
EP3509593A1 (fr) * 2016-09-08 2019-07-17 Keramed, Inc. Polymère antimicrobien destiné à être utilisé dans des implants ophtalmiques

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU546039B2 (en) * 1982-05-08 1985-08-08 Menicon Co., Ltd Oxygen permeable hard contact lens
EP0537774B1 (fr) * 1991-10-18 1998-01-07 Kuraray Co., Ltd. Composition antimicrobienne polymérisable, le polymère et article fabriqué à partir de ce polymère
JP3357094B2 (ja) * 1991-10-18 2002-12-16 株式会社クラレ 抗菌性重合性組成物、それより得られるポリマーおよび用品
US5409731A (en) * 1992-10-08 1995-04-25 Tomei Sangyo Kabushiki Kaisha Method for imparting a hydrophilic nature to a contact lens
TW243455B (fr) * 1993-02-09 1995-03-21 Ciba Geigy
JPH06337378A (ja) * 1993-05-31 1994-12-06 Hoya Corp 抗菌性ハイドロゲルおよびそれを含む抗菌性ソフトコンタクトレンズ
WO1995002617A1 (fr) * 1993-07-14 1995-01-26 Nippon Chemical Industrial Co., Ltd. Polymere antimicrobien, lentille de contact et produits d'entretien de lentilles de contact
US5760100B1 (en) * 1994-09-06 2000-11-14 Ciba Vision Corp Extended wear ophthalmic lens
TW393498B (en) * 1995-04-04 2000-06-11 Novartis Ag The preparation and use of Polysiloxane-comprising perfluoroalkyl ethers
AUPN354595A0 (en) * 1995-06-14 1995-07-06 Ciba-Geigy Ag Novel materials
RU2089198C1 (ru) * 1995-11-30 1997-09-10 Межотраслевой научно-технический комплекс "Микрохирургия глаза" Способ получения биоматериала для использования в офтальмологии
US20030007993A1 (en) * 2000-03-01 2003-01-09 Mark Wilcox biomedical devices with antimicrobial cationic peptide and protein coatings
AUPQ765200A0 (en) * 2000-05-19 2000-06-15 Oversby Pty Ltd Intraocular lens implants
JP4822609B2 (ja) * 2000-05-22 2011-11-24 クラレメディカル株式会社 抗菌性組成物
CN1177002C (zh) * 2000-05-22 2004-11-24 可乐丽股份有限公司 抗菌性组合物
DE10114247A1 (de) * 2001-03-22 2002-10-10 Heraeus Kulzer Gmbh & Co Kg Antibiotikum-/Antibiotika-Polymer-Kombination
DE602004021248D1 (de) * 2003-04-03 2009-07-09 Seed Co Ltd Kontaktlinsen mit der fähigkeit einer andauernden medikamentenfreigabe und schutzlösungen dafür
GB2404920A (en) * 2003-08-12 2005-02-16 Johnson & Johnson Medical Ltd Antimicrobial polymer
GB0322640D0 (en) * 2003-09-26 2003-10-29 1800 Contacts Process
US8343473B2 (en) * 2005-08-24 2013-01-01 Purdue Research Foundation Hydrophilized antimicrobial polymers
US7759408B2 (en) * 2005-12-21 2010-07-20 Bausch & Lomb Incorporated Silicon-containing monomers end-capped with polymerizable cationic hydrophilic groups
US20080081070A1 (en) * 2006-09-15 2008-04-03 Auriga Laboratories, Inc. Pharmaceutical formulation with enhanced solubility for the delivery of corticosteroids
JP5128308B2 (ja) * 2008-02-20 2013-01-23 Ｈｏｙａ株式会社 眼内レンズ製造方法
AU2013207646B2 (en) * 2008-06-25 2014-10-30 Baxter Healthcare Sa Antimicrobial resins
KR20110030696A (ko) * 2008-07-15 2011-03-23 알콘, 인코퍼레이티드 토릭 옵틱 및 확장된 초점 심도를 갖는 조절성 ｉｏｌ
CA2789943A1 (fr) * 2009-03-05 2010-09-10 Robert R. Birge Retines artificielles a base de proteine
EP2453293B1 (fr) * 2009-07-08 2014-01-08 Menicon Co., Ltd. Lentille ophtalmique
EP3427693B1 (fr) * 2010-09-30 2020-06-24 KeraMed, Inc. Cornée artificielle déformable de manière réversible
GB201314455D0 (en) * 2013-08-13 2013-09-25 Contamac Ltd Monomers for use in a polymerizable composition and high refractive index polymer for opthalmic applications
CN104193890B (zh) 2014-08-20 2017-02-15 海昌隐形眼镜有限公司 一种基于交联共聚的抗菌角膜接触镜制备方法
EP3389721A4 (fr) * 2015-12-18 2019-08-28 Commonwealth Scientific and Industrial Research Organisation Composite polymère pour la libération contrôlée d'un agent
WO2018232025A1 (fr) 2017-06-16 2018-12-20 Yichieh Shiuey Copolymère inhibant la croissance cellulaire destiné à être utilisé dans des implants ophtalmiques

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4218554A (en) * 1978-10-11 1980-08-19 Foley William M Jr Process for preparing hydrogel contact lenses containing quaternary ammonium salts
EP0604369A1 (fr) * 1992-12-23 1994-06-29 Ciba-Geigy Ag Lentilles de contact empêchant les depôts
WO1998027896A1 (fr) * 1996-12-20 1998-07-02 Implemed, Inc. Lentilles intraoculaires a activite antimicrobienne
WO2008038721A1 (fr) * 2006-09-29 2008-04-03 Toray Industries, Inc. Lentille oculaire
EP3509593A1 (fr) * 2016-09-08 2019-07-17 Keramed, Inc. Polymère antimicrobien destiné à être utilisé dans des implants ophtalmiques

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2019152023A1 *

Also Published As

Publication number Publication date
WO2019152023A1 (fr) 2019-08-08
EP3850018C0 (fr) 2023-08-23
EP3850018B1 (fr) 2023-08-23
CN111836839A (zh) 2020-10-27
US20210077249A1 (en) 2021-03-18
EP3850018A4 (fr) 2021-11-17
JP7560865B2 (ja) 2024-10-03
EP3850018A1 (fr) 2021-07-21
EP3745998A1 (fr) 2020-12-09
JP2021513107A (ja) 2021-05-20
WO2019194903A1 (fr) 2019-10-10
CN111670020A (zh) 2020-09-15
JP2021516075A (ja) 2021-07-01
JP7408153B2 (ja) 2024-01-05

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