[go: up one dir, main page]

EP3624810A4 - NANO-ACTIVATED ANTI-CANCER IMMUNOTHERAPY - Google Patents

NANO-ACTIVATED ANTI-CANCER IMMUNOTHERAPY Download PDF

Info

Publication number
EP3624810A4
EP3624810A4 EP18803111.6A EP18803111A EP3624810A4 EP 3624810 A4 EP3624810 A4 EP 3624810A4 EP 18803111 A EP18803111 A EP 18803111A EP 3624810 A4 EP3624810 A4 EP 3624810A4
Authority
EP
European Patent Office
Prior art keywords
nano
cancer immunotherapy
activated anti
activated
immunotherapy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP18803111.6A
Other languages
German (de)
French (fr)
Other versions
EP3624810A1 (en
Inventor
E. Andre NEL
Huan MENG
Jianqin LU
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
University of California Berkeley
University of California San Diego UCSD
Original Assignee
University of California
University of California Berkeley
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California, University of California Berkeley, University of California San Diego UCSD filed Critical University of California
Publication of EP3624810A1 publication Critical patent/EP3624810A1/en
Publication of EP3624810A4 publication Critical patent/EP3624810A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/34—Copper; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544—Phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • A61K47/551—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds one of the codrug's components being a vitamin, e.g. niacinamide, vitamin B3, cobalamin, vitamin B12, folate, vitamin A or retinoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5115—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Immunology (AREA)
  • Botany (AREA)
  • Biophysics (AREA)
  • Ceramic Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP18803111.6A 2017-05-18 2018-05-17 NANO-ACTIVATED ANTI-CANCER IMMUNOTHERAPY Pending EP3624810A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762507996P 2017-05-18 2017-05-18
US201862614325P 2018-01-05 2018-01-05
PCT/US2018/033265 WO2018213631A1 (en) 2017-05-18 2018-05-17 Nano-enabled immunotherapy in cancer

Publications (2)

Publication Number Publication Date
EP3624810A1 EP3624810A1 (en) 2020-03-25
EP3624810A4 true EP3624810A4 (en) 2021-02-17

Family

ID=64274728

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18803111.6A Pending EP3624810A4 (en) 2017-05-18 2018-05-17 NANO-ACTIVATED ANTI-CANCER IMMUNOTHERAPY

Country Status (4)

Country Link
EP (1) EP3624810A4 (en)
AU (1) AU2018269742B2 (en)
CA (1) CA3063932A1 (en)
WO (1) WO2018213631A1 (en)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9675561B2 (en) 2011-04-28 2017-06-13 President And Fellows Of Harvard College Injectable cryogel vaccine devices and methods of use thereof
EP3137105A4 (en) 2014-04-30 2017-12-27 President and Fellows of Harvard College Combination vaccine devices and methods of killing cancer cells
CN115487351A (en) 2016-02-06 2022-12-20 哈佛学院校长同事会 Remodel Blood Nest to rebuild immunity
FI3484448T3 (en) 2016-07-13 2025-06-16 Harvard College Antigen-presenting cell-mimetic scaffolds and methods for making and using the same
AU2017305345B2 (en) 2016-08-02 2024-09-05 President And Fellows Of Harvard College Biomaterials for modulating immune responses
US11433143B2 (en) 2017-05-18 2022-09-06 The Regents Of The University Of California Nano-enabled immunotherapy in cancer
WO2020061129A1 (en) 2018-09-19 2020-03-26 President And Fellows Of Harvard College Compositions and methods for labeling and modulation of cells in vitro and in vivo
WO2020072366A1 (en) * 2018-10-01 2020-04-09 The Regents Of The University Of California Methods for treating cancer with double stranded rna sensor activators and adoptive cell therapy
US12351653B1 (en) 2019-03-08 2025-07-08 Lisata Therapeutics, Inc. Pharmaceutical compositions comprising novel cyclic peptides
MX2021014758A (en) * 2019-05-30 2022-03-11 Univ Illinois PROCASPASE-3 ACTIVATION AND IMMUNOTHERAPY FOR THE TREATMENT OF CANCER.
CN110585131A (en) * 2019-09-20 2019-12-20 宁夏医科大学 Chemotherapy drug co-loaded 1-methyltryptophan immune prodrug micelle, preparation method and application thereof
WO2021061837A1 (en) * 2019-09-23 2021-04-01 President And Fellows Of Harvard College Biomaterial-based antigen free vaccine and the use thereof
CA3157508A1 (en) * 2019-10-14 2022-04-22 The Regents Of The University Of California Nano-enabled immunotherapy in cancer
KR20220100904A (en) * 2019-11-12 2022-07-18 남미 테라퓨틱스, 인크. Formulated and/or co-formulated liposome compositions containing IDO antagonist prodrugs useful for the treatment of cancer and methods thereof
CN111333653A (en) * 2019-12-16 2020-06-26 山东大学 A kind of ICD inducer-IDO inhibitor conjugate and preparation method and application
KR20220119085A (en) 2019-12-20 2022-08-26 남미 테라퓨틱스, 인크. Formulated and/or co-formulated liposome compositions containing toll-like receptor (“TLR”) agonist prodrugs useful for the treatment of cancer and methods thereof and methods thereof
CN111012919B (en) * 2019-12-23 2021-06-01 山东大学 Pegylated ICD inducer-IDO inhibitor nanoconjugate and preparation method and application
WO2021133037A1 (en) * 2019-12-26 2021-07-01 연세대학교 산학협력단 Pyrrolidine derivative, and pharmaceutical composition for preventing or treating beta-amyloid or tau protein-associated diseases containing same
WO2025058654A1 (en) 2020-02-19 2025-03-20 Nammi Therapeutics, Inc. Formulated and/or co-formulated liposome compositions containing tgfb antagonist prodrugs useful in the treatment of cancer and methods thereof
JP2023514324A (en) 2020-02-19 2023-04-05 ナミ セラピューティクス， インコーポレイテッド Formulated and/or co-formulated liposomal compositions containing TFGβ antagonist prodrugs useful in the treatment of cancer and methods thereof
CN111330004B (en) * 2020-03-04 2023-02-10 中国人民解放军军事科学院军事医学研究院 Application of molybdenum disulfide nanosheets in the preparation of dendritic cell function promoters
KR20230006540A (en) * 2020-05-04 2023-01-10 드럭센더 오스트레일리아 피티와이 리미티드 Methods of treating pancreatic cancer and other solid tumors
WO2022006083A1 (en) * 2020-06-30 2022-01-06 The Regents Of The University Of California Gsk3 inhibitor-loaded nano formulations as a cancer immunotherapeutic
WO2022010322A1 (en) * 2020-07-10 2022-01-13 (주)나디안바이오 Pharmaceutical composition for preventing or treating cancer comprising naphthoquinone-based compound and immune checkpoint inhibitor as active ingredients
US20230338363A1 (en) * 2020-08-07 2023-10-26 The Regents Of The University Of California Combination chemo-immunotherapy for pancreatic cancer using the immunogenic effects of an irinotecan silicasome nanocarrier plus anti-pd-1
AU2021340521A1 (en) 2020-09-10 2023-05-25 Nammi Therapeutics, Inc. Formulated and/or co-formulated liposome compositions containing pd-1 antagonist prodrugs useful in the treatment of cancer and methods thereof
US20230398077A1 (en) * 2020-10-30 2023-12-14 The Regents Of The University Of California Silicasome nanocarrier for metal-based drug delivery
AU2021392036A1 (en) * 2020-12-01 2023-05-11 The Regents Of The University Of California Method of sensitizing cancers to immunotherapy using immunomodulatory agents
JP2024510613A (en) 2021-03-18 2024-03-08 ナミ セラピューティクス， インコーポレイテッド Formulated and/or co-formulated liposomal compositions containing A2aR antagonist prodrugs useful in the treatment of cancer and methods thereof
CN113332450B (en) * 2021-05-11 2023-08-04 铜仁学院 Preparation method and application method of zinc oxide nanoparticles of ocular drug delivery system
CN113353939B (en) * 2021-05-25 2023-09-08 中国科学院上海硅酸盐研究所 Band gap adjustable and degradability controllable two-dimensional hydrosilylene nano material and preparation method and application thereof
CN114890385B (en) * 2021-07-01 2023-09-08 中国科学院上海硅酸盐研究所 An efficient antioxidant two-dimensional hydrogen germanene nanosheet and its preparation method and application
CN118265543A (en) 2021-11-18 2024-06-28 纳米医疗有限公司 Formulated and/or co-formulated nanocarrier compositions containing immunogenic cell death (ICD) inducing prodrugs useful for treating cancer and methods thereof
AU2023232077A1 (en) 2022-03-10 2024-10-10 Nammi Therapeutics, Inc. Formulated and/or co-formulated lipid nanocarriers compositions containing toll-like receptor ("tlr") agonist prodrugs useful in the treatment of cancer and methods thereof
WO2023172300A1 (en) * 2022-03-10 2023-09-14 The Regents Of The University Of California A drug nanocarrier system to deliver a combination of tlr agonists and/or a lipoxin plus immunogenic cell death inducing chemotherapeutic agents for cancer immunotherapy
US20250205170A1 (en) * 2022-03-23 2025-06-26 You First Services, Inc. Delmopinol and delmopinol salt containing nanoparticles and uses thereof
CN114748414B (en) * 2022-04-20 2024-05-31 中国医学科学院生物医学工程研究所 Sodium alginate hydrogel composite system loaded with chemotherapeutic drugs and nanoparticles together and preparation method and application thereof
CN115708874B (en) * 2022-12-08 2024-10-29 广州中医药大学(广州中医药研究院) Matrine-loaded PEGylated two-dimensional boron alkene nanosheet as well as preparation method and application thereof
CN116492452A (en) * 2023-04-17 2023-07-28 同济大学 Syrosingopine/LOD co-loaded nano-enzyme, and preparation method and application thereof
CN116327979B (en) * 2023-05-25 2023-08-01 西南石油大学 Transition metal-based mesoporous nano catalytic medicine, preparation method and application
WO2025081013A1 (en) * 2023-10-12 2025-04-17 Hdt Bio Corp. Junction opener protein and nanoparticle compositions and uses thereof
CN117860778A (en) * 2024-01-02 2024-04-12 中国人民解放军总医院第一医学中心 Iron monoatomic supported graphene oxide drug, preparation method and application
CN118903048B (en) * 2024-07-23 2025-09-23 中南大学 A neutrophil membrane-coated metal coordination nanoparticle drug and its construction method and application
CN118976102B (en) * 2024-08-02 2025-03-04 哈尔滨工业大学 A method for preparing a high molecular polymer nanozyme for regulating tumor immunosuppressive microenvironment
CN119405602B (en) * 2024-11-04 2025-09-30 安徽医科大学 A composite micelle co-loaded with an immune checkpoint blocker and its preparation method and application
CN119318701B (en) * 2024-12-18 2025-03-21 山东大学 A hydrogel-based personalized tumor vaccine and its preparation method and application

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110159017A1 (en) * 2008-04-11 2011-06-30 Ludwig Institute For Cancer Research Ltd. Trytophan catabolism in cancer treatment and diagnosis
WO2017023667A1 (en) * 2015-07-31 2017-02-09 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Immunostimulatory nanocarrier
WO2018140826A1 (en) * 2017-01-27 2018-08-02 The Methodist Hospital Core/shell structure platform for immunotherapy
WO2019173391A1 (en) * 2018-03-06 2019-09-12 Rita Elena Serda A high capacity platform for immunogenic cancer cell death

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10828255B2 (en) * 2013-03-05 2020-11-10 The Regents Of The University Of California Lipid bilayer coated mesoporous silica nanoparticles with a high loading capacity for one or more anticancer agents
WO2017201528A1 (en) * 2016-05-20 2017-11-23 The University Of Chicago Nanoparticles for chemotherapy, targeted therapy, photodynamic therapy, immunotherapy, and any combination thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110159017A1 (en) * 2008-04-11 2011-06-30 Ludwig Institute For Cancer Research Ltd. Trytophan catabolism in cancer treatment and diagnosis
WO2017023667A1 (en) * 2015-07-31 2017-02-09 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Immunostimulatory nanocarrier
WO2018140826A1 (en) * 2017-01-27 2018-08-02 The Methodist Hospital Core/shell structure platform for immunotherapy
WO2019173391A1 (en) * 2018-03-06 2019-09-12 Rita Elena Serda A high capacity platform for immunogenic cancer cell death

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANU PURI ET AL: "Lipid-Based Nanoparticles as Pharmaceutical Drug Carriers: From Concepts to Clinic", PUBMED CENTRAL (PMC) AUTHOR MANUSCRIPT - HHS PUBLIC ACCESS, 14 June 2010 (2010-06-14), pages 1 - 48, XP055580417, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885142/> [retrieved on 20190412] *
JING-JING SUN ET AL: "Programmable co-delivery of the immune checkpoint inhibitor NLG919 and chemotherapeutic doxorubicin via a redox-responsive immunostimulatory polymeric prodrug carrier", ACTA PHARMACOLOGICA SINICA, vol. 38, no. 6, 8 May 2017 (2017-05-08), GB, pages 823 - 834, XP055580410, ISSN: 1671-4083, DOI: 10.1038/aps.2017.44 *
See also references of WO2018213631A1 *

Also Published As

Publication number Publication date
WO2018213631A1 (en) 2018-11-22
CA3063932A1 (en) 2018-11-12
AU2018269742A1 (en) 2019-12-05
AU2018269742B2 (en) 2024-01-11
EP3624810A1 (en) 2020-03-25

Similar Documents

Publication Publication Date Title
EP3624810A4 (en) NANO-ACTIVATED ANTI-CANCER IMMUNOTHERAPY
DK3344654T3 (en) ANTI-LAG-3 ANTIBODIES
SI3354729T1 (en) ANTI-GARP ANTIBODIES
EP3563835A4 (en) NOVEL EXOSOME-BASED ANTI-CANCER AGENT
EP3285633A4 (en) ORIENTABLE MICRO-ENDOSCOPE
DK3234128T3 (en) SEQUENCE CONTROLS
HUE060878T2 (en) Anti-transthyretin antibodies
DK3350218T3 (en) POLYOMAVIRUS-NEUTRALIZING ANTIBODIES
DK3250593T3 (en) ANTI-TRANSTHYRETIN ANTIBODIES
SMT202400518T1 (en) ANTI-CANCER COMPOSITIONS
IL256099A (en) antibody
LT3226842T (en) ANTI - CANCER COMPOSITIONS
DK3452507T3 (en) TAU IMMUNOTHERAPY
LT3226843T (en) ANTI - CANCER COMPOSITIONS
LT4268843T (en) IMPROVED ANTIBODIES AGAINST IL-6
MA45090A (en) ANTI-CANCER COMPOSITIONS
DK3228312T3 (en) IMMUNE REGULATOR
EP3558317A4 (en) COMBINATION CHEMOTHERAPY
EP3310915A4 (en) TUMOR IMMUNOTHERAPY
EP3551665A4 (en) CYSTEIN PEPTID-ACTIVATED ANTIBODIES
DK3571208T3 (en) IMMUNE PROTEASOMINHIBITORS
EP3728590C0 (en) NOVEL THIOPHOSPHORAMIDITES
EP3675891A4 (en) ANTI-CANCER POLYTHERAPY
LT3178931T (en) ANTI-ORAI1 ANTIBODIES
LT3126391T (en) HPA-1A ANTIBODIES

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20191119

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Free format text: PREVIOUS MAIN CLASS: A61K0031711500

Ipc: A61K0047500000

A4 Supplementary search report drawn up and despatched

Effective date: 20210118

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 31/7115 20060101ALI20210112BHEP

Ipc: A61K 47/69 20170101ALI20210112BHEP

Ipc: A61K 31/7125 20060101ALI20210112BHEP

Ipc: A61K 47/50 20170101AFI20210112BHEP

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230524