EP3689870A4 - Médicament analgésique utilisant un médicament antagoniste du récepteur pac1 - Google Patents

Médicament analgésique utilisant un médicament antagoniste du récepteur pac1 Download PDF

Info

Publication number: EP3689870A4
Authority: EP; European Patent Office
Prior art keywords: drug; receptor antagonist; analgesic; pac1 receptor; pac1
Prior art date: 2017-09-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

EP18862130.4A

Other languages

German (de)

English (en)

Other versions

EP3689870B1 (fr

EP3689870A1 (fr

Inventor

Takashi Kurihara

Ichiro Takasaki

Naoki Toyooka

Hiroaki GOUDA

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Kagoshima University NUC

Showa University

Original Assignee

Kagoshima University NUC

Showa University

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-09-27

Filing date

2018-09-27

Publication date

2021-01-27

2018-09-27 Application filed by Kagoshima University NUC, Showa University filed Critical Kagoshima University NUC

2020-08-05 Publication of EP3689870A1 publication Critical patent/EP3689870A1/fr

2021-01-27 Publication of EP3689870A4 publication Critical patent/EP3689870A4/fr

2022-07-13 Application granted granted Critical

2022-07-13 Publication of EP3689870B1 publication Critical patent/EP3689870B1/fr

Status Active legal-status Critical Current

2038-09-27 Anticipated expiration legal-status Critical

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pain & Pain Management (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

EP18862130.4A 2017-09-27 2018-09-27 Médicament analgésique utilisant un médicament antagoniste du récepteur pac1 Active EP3689870B1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2017186447		2017-09-27
PCT/JP2018/035831 WO2019065794A1 (fr)	2017-09-27	2018-09-27	Médicament analgésique utilisant un médicament antagoniste du récepteur pac1

Publications (3)

Publication Number	Publication Date
EP3689870A1 EP3689870A1 (fr)	2020-08-05
EP3689870A4 true EP3689870A4 (fr)	2021-01-27
EP3689870B1 EP3689870B1 (fr)	2022-07-13

Family

ID=65901904

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP18862130.4A Active EP3689870B1 (fr)	2017-09-27	2018-09-27	Médicament analgésique utilisant un médicament antagoniste du récepteur pac1

Country Status (4)

Country	Link
US (1)	US11365194B2 (fr)
EP (1)	EP3689870B1 (fr)
JP (1)	JP7169592B2 (fr)
WO (1)	WO2019065794A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP3932490B1 (fr) *	2019-02-27	2025-04-02	Kagoshima University	Agent antiprurigineux utilisant un antagoniste du récepteur pac1
WO2021225161A1 (fr)	2020-05-08	2021-11-11	国立大学法人鹿児島大学	Médicament antidépresseur/anxiolytique utilisant un antagoniste du récepteur du pac1

Citations (1)

* Cited by examiner, † Cited by third party
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WO2017029202A1 (fr) *	2015-08-14	2017-02-23	Bergen Teknologioverføring As	Hyperphénylalaninémie et traitements de celle-ci

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EP1741713A3 (fr)	1999-12-15	2009-09-09	Bristol-Myers Squibb Company	Biphényl-sulfonamides comme antagonistes jumalées des récepteurs endothélines.
PE20050077A1 (es)	2002-09-20	2005-03-01	Hoffmann La Roche	Derivados de 4-pirrolidino-fenil-bencil-eter
CA2573848A1 (fr)	2004-07-12	2006-02-16	Phenomix Corporation	Composes cyano contraints
US20090099195A1 (en)	2007-05-08	2009-04-16	Astrazeneca Ab	Therapeutic Compounds 570
GB0910003D0 (en)	2009-06-11	2009-07-22	Univ Leuven Kath	Novel compounds for the treatment of neurodegenerative diseases
DE102010048374A1 (de)	2010-10-13	2012-04-19	Merck Patent Gmbh	Pyrrolidinone als MetAP-2 Inhibitoren
WO2015113990A1 (fr)	2014-01-30	2015-08-06	F. Hoffmann-La Roche Ag	Nouvelles dihydroquinolizinones pour le traitement et la prophylaxie d'une infection par le virus de l'hépatite b
JP2017186447A (ja)	2016-04-06	2017-10-12	コニカミノルタ株式会社	サーモクロミック性二酸化バナジウム含有粒子の製造方法及びサーモクロミック性二酸化バナジウム含有粒子分散液の製造方法

2018
- 2018-09-27 JP JP2019545596A patent/JP7169592B2/ja active Active
- 2018-09-27 EP EP18862130.4A patent/EP3689870B1/fr active Active
- 2018-09-27 US US16/650,133 patent/US11365194B2/en active Active
- 2018-09-27 WO PCT/JP2018/035831 patent/WO2019065794A1/fr not_active Ceased

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2017029202A1 (fr) *	2015-08-14	2017-02-23	Bergen Teknologioverføring As	Hyperphénylalaninémie et traitements de celle-ci

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ICHIRO TAKASAKI ET AL: "In Silico Screening Identified Novel Small-molecule Antagonists of PAC1 Receptor", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 365, no. 1, 23 January 2018 (2018-01-23), US, pages 1 - 8, XP055734734, ISSN: 0022-3565, DOI: 10.1124/jpet.117.245415 *
NAGASHIMA ET AL: "2P-045: Development of small molecule antagonists for PAC1 receptor aimed at drug discovery of novel analgesics -1", ABSTRACTS OF SYMPOSIUM ON MEDICINAL CHEMISTRY; LECTURE ABSTRACTS OF THE 35TH MEDICINAL CHEMISTRY SYMPOSIUM, COMMITTEE FOR MEDICINAL CHEMISTRY SYMPOSIUM, EDITED BY GROUP EXECUTIVE COMMITTEE ANNUAL PHARMACEUTICAL SCIENCES PHARMACEUTICAL SOCIETY OF JAPA, vol. 35, 4 October 2017 (2017-10-04), pages 229, XP009519579, ISSN: 0919-214X *
OHGASHI ET AL: "1P-054: Development of small molecule antagonists for PAC1 receptor aimed at drug discovery of novel analgesics -2", ABSTRACTS OF SYMPOSIUM ON MEDICINAL CHEMISTRY; LECTURE ABSTRACTS OF THE 35TH MEDICINAL CHEMISTRY SYMPOSIUM, COMMITTEE FOR MEDICINAL CHEMISTRY SYMPOSIUM, EDITED BY GROUP EXECUTIVE COMMITTEE ANNUAL PHARMACEUTICAL SCIENCES PHARMACEUTICAL SOCIETY OF JAPA, 4 October 2017 (2017-10-04), pages 116, XP009519580, ISSN: 0919-214X *
See also references of WO2019065794A1 *

Also Published As

Publication number	Publication date
WO2019065794A1 (fr)	2019-04-04
EP3689870B1 (fr)	2022-07-13
JPWO2019065794A1 (ja)	2020-10-22
EP3689870A1 (fr)	2020-08-05
US11365194B2 (en)	2022-06-21
US20210188841A1 (en)	2021-06-24
JP7169592B2 (ja)	2022-11-11

Publication	Publication Date	Title
FR22C1021I2 (fr)	2023-04-14	Régime posologique pour ponesimod, un agoniste du récepteur s1p1 sélectif
DK3302641T3 (da)	2024-01-22	Hørbar indikator til en lægemiddeladministrationsanordning
CY2022011I2 (el)	2022-07-22	Δοσολογικο σχημα για την πονεσιμοδη, εναν επιλεκτικο αγωνιστη του υποδοχεα s1p1
DK3329217T3 (da)	2023-08-21	Sensoranordning til en lægemiddeladministrationsanordning
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IL268718B (en)	2021-04-29	Opioid receptor modulator dosage formulations
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DK3334721T3 (da)	2021-06-28	Cgrp-receptorantagonister
EP3689870A4 (fr)	2021-01-27	Médicament analgésique utilisant un médicament antagoniste du récepteur pac1
FR3017733B1 (fr)	2017-08-25	Transaction securisee utilisant un dispositif mobile
EP3473274A4 (fr)	2020-03-11	Plateforme composite anticorps-médicament utilisant un anticorps bispécifique
DK3247429T3 (da)	2019-08-19	Indretning til en lægemiddeladministrationsanordning
HUE042368T2 (hu)	2019-06-28	Progeszteronreceptor-antagonista dózisformája
DK3068469T3 (da)	2019-05-06	Indretning til en lægemiddeladministrationsanordning og lægemiddeladministrationsanordning
EP3697393A4 (fr)	2021-10-13	Formes posologiques pharmaceutiques
DK3277278T3 (da)	2020-04-06	Kombinationsdoseringsform af en my-opioid receptorantagonist og et opioid
EP3932490A4 (fr)	2022-11-16	Agent antiprurigineux utilisant un antagoniste du récepteur pac1

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