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EP3564390A4 - METHOD OF DIAGNOSIS OF COLON TUMORS BY BACTERIAL METAGENOME ANALYSIS - Google Patents

METHOD OF DIAGNOSIS OF COLON TUMORS BY BACTERIAL METAGENOME ANALYSIS Download PDF

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Publication number
EP3564390A4
EP3564390A4 EP17887675.1A EP17887675A EP3564390A4 EP 3564390 A4 EP3564390 A4 EP 3564390A4 EP 17887675 A EP17887675 A EP 17887675A EP 3564390 A4 EP3564390 A4 EP 3564390A4
Authority
EP
European Patent Office
Prior art keywords
diagnosis
colon tumors
metagenome analysis
bacterial metagenome
bacterial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP17887675.1A
Other languages
German (de)
French (fr)
Other versions
EP3564390B1 (en
EP3564390A1 (en
EP3564390C0 (en
Inventor
Yoon-Keun Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MD Healthcare Inc
Original Assignee
MD Healthcare Inc
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Filing date
Publication date
Application filed by MD Healthcare Inc filed Critical MD Healthcare Inc
Priority claimed from PCT/KR2017/015557 external-priority patent/WO2018124735A1/en
Publication of EP3564390A1 publication Critical patent/EP3564390A1/en
Publication of EP3564390A4 publication Critical patent/EP3564390A4/en
Application granted granted Critical
Publication of EP3564390B1 publication Critical patent/EP3564390B1/en
Publication of EP3564390C0 publication Critical patent/EP3564390C0/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/6895—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2531/00—Reactions of nucleic acids characterised by
    • C12Q2531/10—Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
    • C12Q2531/113—PCR
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP17887675.1A 2016-12-28 2017-12-27 Method for diagnosing colon tumor via bacterial metagenomic analysis Active EP3564390B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20160181574 2016-12-28
KR1020170180144A KR101940426B1 (en) 2016-12-28 2017-12-26 Method for diagnosis of colon tumor using analysis of bacteria metagenome
PCT/KR2017/015557 WO2018124735A1 (en) 2016-12-28 2017-12-27 Method for diagnosing colon tumor via bacterial metagenomic analysis

Publications (4)

Publication Number Publication Date
EP3564390A1 EP3564390A1 (en) 2019-11-06
EP3564390A4 true EP3564390A4 (en) 2020-08-26
EP3564390B1 EP3564390B1 (en) 2023-11-29
EP3564390C0 EP3564390C0 (en) 2023-11-29

Family

ID=62921135

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17887675.1A Active EP3564390B1 (en) 2016-12-28 2017-12-27 Method for diagnosing colon tumor via bacterial metagenomic analysis

Country Status (5)

Country Link
US (1) US20190330687A1 (en)
EP (1) EP3564390B1 (en)
JP (1) JP6914552B2 (en)
KR (1) KR101940426B1 (en)
CN (1) CN110382720A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019139279A1 (en) * 2018-01-12 2019-07-18 주식회사 엠디헬스케어 Nanovesicles derived from morganella bacteria, and uses thereof
KR102095355B1 (en) 2018-01-12 2020-03-31 주식회사 엠디헬스케어 Nanovesicles derived from Morganella bacteria and Use thereof
KR102118198B1 (en) * 2018-02-28 2020-06-02 주식회사 엠디헬스케어 Nanovesicles derived from Rhizobium bacteria and Use thereof
WO2020122449A1 (en) * 2018-12-10 2020-06-18 주식회사 엠디헬스케어 Nano-vesicle derived from corynebacterium sp. bacteria and use thereof
KR102223406B1 (en) * 2018-12-10 2021-03-05 주식회사 엠디헬스케어 Nanovesicles derived from Corynebacterium bacteria and Use thereof
CN113631725A (en) * 2019-02-08 2021-11-09 得克萨斯州大学系统董事会 Isolation and detection of exosome-associated microbiome for diagnostic and therapeutic purposes
KR102308931B1 (en) * 2019-05-24 2021-10-06 주식회사 엠디헬스케어 Method for the diagnosis of colitis using analysis of qPCR
WO2021049834A1 (en) * 2019-09-10 2021-03-18 주식회사 엠디헬스케어 Method for diagnosing colorectal cancer on basis of metagenome and metabolite of extracellular vesicles
CN111254183B (en) * 2020-01-22 2023-09-05 中国科学院亚热带农业生态研究所 A Method for Evaluating Individual Protein Nutrition Status of Pigs
KR102542476B1 (en) 2020-06-22 2023-06-12 한국생명공학연구원 Composition for preventing or treating cancer comprising odoribacter splanchnicus or its cell-free supernatant as an effective component
KR102623834B1 (en) * 2020-07-13 2024-01-12 서울대학교병원 Composition for preventing or treating colon cancer in male through changes in gut microbiota comprising estrogen
KR102468788B1 (en) * 2020-08-25 2022-11-18 서울대학교병원 Composition for predicting or diagnosing irritable bowel syndrome comprising detection agent for microorganism
WO2022045730A1 (en) * 2020-08-25 2022-03-03 서울대학교병원 Composition for predicting or diagnosing irritable bowel syndrome, comprising microbial detection agent
KR102738021B1 (en) * 2020-10-20 2024-12-05 서울대학교병원 Composition for predicting or diagnosing the risk of inflammatory disease in animals comprising agent for detecting strain of the family Lachnospiraceae
CN114438162A (en) * 2022-01-26 2022-05-06 中山大学附属第一医院 A healthy urinary tract microecological map and its application in the field of genitourinary system health
EP4592405A1 (en) * 2024-01-26 2025-07-30 Servizo Galego de Saude Bacterial biomarkers for colorectal cancer diagnosis

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2955232A1 (en) * 2014-06-12 2015-12-16 Peer Bork Method for diagnosing adenomas and/or colorectal cancer (CRC) based on analyzing the gut microbiome
WO2016085356A1 (en) * 2014-11-28 2016-06-02 Anagenix Ip Limited Gold kiwifruit compositions and methods of preparation and use therefor
WO2017062625A1 (en) * 2015-10-06 2017-04-13 Regents Of The University Of Minnesota Method to detect colon cancer by means of the microbiome
WO2019004668A1 (en) * 2017-06-30 2019-01-03 주식회사 엠디헬스케어 Nanovesicle derived from proteus genus bacteria, and use thereof
EP3647437A1 (en) * 2017-06-30 2020-05-06 MD Healthcare Inc. Nanovesicle derived from proteus genus bacteria, and use thereof

Family Cites Families (8)

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WO2011027956A2 (en) * 2009-09-04 2011-03-10 주식회사이언메딕스 Extracellular vesicles derived from gram-positive bacteria, and disease model using same
CA2789494C (en) * 2010-02-10 2021-08-17 The Regents Of The University Of California Salivary biomarkers for lung cancer detection
US20130121968A1 (en) 2011-10-03 2013-05-16 Atossa Genetics, Inc. Methods of combining metagenome and the metatranscriptome in multiplex profiles
KR101798176B1 (en) * 2014-12-16 2017-11-15 주식회사 엠디헬스케어 Method for identification of causative bacteria of bacterial infectious diseases using bacteria-derived nanovesicles
KR101726488B1 (en) * 2015-02-23 2017-04-13 이화여자대학교 산학협력단 Composition for the treatment of pregnancy-related diseases comprising the extracellular vesicles derived from Bacillus spp.
KR20160110232A (en) * 2015-03-11 2016-09-21 주식회사 엠디헬스케어 Composition for Prevention or Treatment of Inflammatory disease Comprising Extracellular Vesicles Derived from Lactic acid bacteria
CN105132518B (en) * 2015-09-30 2018-08-10 上海锐翌生物科技有限公司 Large intestine carcinoma marker and its application
CN105296590B (en) * 2015-09-30 2019-04-19 上海锐翌生物科技有限公司 Colorectal cancer markers and their applications

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2955232A1 (en) * 2014-06-12 2015-12-16 Peer Bork Method for diagnosing adenomas and/or colorectal cancer (CRC) based on analyzing the gut microbiome
WO2016085356A1 (en) * 2014-11-28 2016-06-02 Anagenix Ip Limited Gold kiwifruit compositions and methods of preparation and use therefor
WO2017062625A1 (en) * 2015-10-06 2017-04-13 Regents Of The University Of Minnesota Method to detect colon cancer by means of the microbiome
WO2019004668A1 (en) * 2017-06-30 2019-01-03 주식회사 엠디헬스케어 Nanovesicle derived from proteus genus bacteria, and use thereof
EP3647437A1 (en) * 2017-06-30 2020-05-06 MD Healthcare Inc. Nanovesicle derived from proteus genus bacteria, and use thereof

Non-Patent Citations (2)

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Title
BARTENEVA NATASHA S ET AL: "Extracellular vesicles in gastrointestinal cancer in conjunction with microbiota: On the border of Kingdoms", BBA - REVIEWS ON CANCER, vol. 1868, no. 2, 29 June 2017 (2017-06-29), pages 372 - 393, XP085255158, ISSN: 0304-419X, DOI: 10.1016/J.BBCAN.2017.06.005 *
J. P. ZACKULAR ET AL: "The Human Gut Microbiome as a Screening Tool for Colorectal Cancer", CANCER PREVENTION RESEARCH, vol. 7, no. 11, 7 August 2014 (2014-08-07), United States, pages 1112 - 1121, XP055333767, ISSN: 1940-6207, DOI: 10.1158/1940-6207.CAPR-14-0129 *

Also Published As

Publication number Publication date
US20190330687A1 (en) 2019-10-31
KR20180077070A (en) 2018-07-06
EP3564390B1 (en) 2023-11-29
EP3564390A1 (en) 2019-11-06
JP2020503864A (en) 2020-02-06
CN110382720A (en) 2019-10-25
JP6914552B2 (en) 2021-08-04
EP3564390C0 (en) 2023-11-29
KR101940426B1 (en) 2019-01-18

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