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EP3487451B1 - Système indépendant de réparation de la valvule tricuspide - Google Patents

Système indépendant de réparation de la valvule tricuspide Download PDF

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Publication number
EP3487451B1
EP3487451B1 EP17831533.9A EP17831533A EP3487451B1 EP 3487451 B1 EP3487451 B1 EP 3487451B1 EP 17831533 A EP17831533 A EP 17831533A EP 3487451 B1 EP3487451 B1 EP 3487451B1
Authority
EP
European Patent Office
Prior art keywords
push
pull
push element
jaw
pin connected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP17831533.9A
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German (de)
English (en)
Other versions
EP3487451A1 (fr
EP3487451A4 (fr
Inventor
Sean A. Mcniven
Laura KALVASS
Benjamin L. Lee
Antonio N. GARCIA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Cardiovascular Systems Inc
Original Assignee
Abbott Cardiovascular Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Cardiovascular Systems Inc filed Critical Abbott Cardiovascular Systems Inc
Publication of EP3487451A1 publication Critical patent/EP3487451A1/fr
Publication of EP3487451A4 publication Critical patent/EP3487451A4/fr
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Publication of EP3487451B1 publication Critical patent/EP3487451B1/fr
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2454—Means for preventing inversion of the valve leaflets, e.g. chordae tendineae prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/246—Devices for obstructing a leak through a native valve in a closed condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2427—Devices for manipulating or deploying heart valves during implantation
    • A61F2/2436—Deployment by retracting a sheath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2466—Delivery devices therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008—Fixation appliances for connecting prostheses to the body

Definitions

  • This invention relates to the repair of a tricuspid valve exhibiting valve regurgitation. More particularly, the invention relates to an apparatus suitable for a less invasive repair of a tricuspid heart valve.
  • the term "endovascular,” refers to procedure(s) of the present invention that are performed with interventional tools and supporting catheters and other equipment introduced to the heart chambers from the patient's arterial or venous vasculature remote from the heart.
  • the interventional tools and other equipment may be introduced percutaneously, i.e., through an access sheath, or may be introduced via a surgical cut down, and then advanced from the remote access site through the vasculature until they reach heart 14.
  • the methods and apparatus described herein generally do not require penetrations made directly through an exterior heart muscle, i.e., myocardium, although there may be some instances where penetrations will be made interior to the heart, e.g., through the interatrial septum to provide for a desired access route.
  • the atrioventricular valves are each located at a junction of the atria and their respective ventricles.
  • the atrioventricular valve extending between the right atrium 30 and the right ventricle 12 has three valve leaflets (cusps) and is referred to as the tricuspid or right atrioventricular valve 21.
  • the atrioventricular valve between the left atrium 32 and the left ventricle 10 is a bicuspid valve having only two leaflets or cusps 34 and is generally referred to as the mitral valve 20.
  • valve leaflets open during diastole when the heart atria fill with blood, allowing the blood to pass into the ventricle.
  • the valve leaflets are pushed together such that the free edges of the leaflets are closed against each other along a line of coaptation to prevent the back-flow of blood into the atria.
  • Back flow of blood or "regurgitation" through the mitral valve 20 is facilitated to be prevented when the leaflets 34 are closed, such that the mitral valve 20 functions as a "check valve” which prevents back-flow when pressure in the left ventricle 10 is higher than that in the left atrium 32.
  • the mitral valve leaflets 34 are attached to the surrounding heart structure along an annular region referred to as the valve annulus 40.
  • the free edges 36 of the leaflets 34 are secured to the lower portions of the left ventricle 10 through tendon-like tissue structures, known as chordae tendineae or chordae 42.
  • the chordae 42 are attached to the papillary muscles which extend upwardly from the lower portions of the left ventricle and interventricular septum 46.
  • the tricuspid valve is similar to the mitral valve, but it is more complex in that it has three leaflets, as described above.
  • Tricuspid valve prolapse i.e. degeneration of tricuspid valve leaflets, is the most common cause of tricuspid regurgitation in North America. Many cases of regurgitation can be repaired by modifications of the original valve in a procedure generally referred to as valvuloplasty. Valves that are heavily calcified or significantly compromised by disease may need to be replaced.
  • One approach suitable for mitral valve repair is to introduce instruments via a transcatheter procedure into the heart by direct introduction through a passageway through the wall of the heart.
  • Suitable gripping and fastening instruments have appropriate dimensions to fit through the cardiac catheter into the heart.
  • the methods typically include gripping the edges of the two leaflets of the mitral valve, and securing them together using clasping, stitching, or suturing techniques.
  • clasps such as the clasp of the MitraClip ® .
  • valve devices for replacement of mitral valves while preserving valvular and subvalvular mitral valve apparatus.
  • the valve device may be configured as a double orifice valve replacement device, and may include an anchoring and manifold assembly coupleable to a delivery catheter.
  • the invention is a system for repairing a tricuspid valve in a patient's heart, the system being positioned at a distal end of a catheter having a proximal end and a distal end and a bore extending between the proximal end and the distal end.
  • the system comprises an activation element, extending along the bore.
  • the activation element comprises a first push element and a first pull element slideable in relation to the first push element; a second push element and a second pull element slideable in relation to the second push element; and a third push element and a third pull element slideable in relation to the third push element.
  • the first push element, the second push element, and the third push element are independently slideable in relation to each other.
  • the system further comprises a first lower jaw being pin connected to the first pull element; a first strut being pin connected to the first push element and also being pin connected to the first jaw. It further comprises a second lower jaw being pin connected to the second pull element; and a second strut being pin connected to the second push element and also being pin connected to the second jaw. It further comprises a third lower jaw being pin connected to the third pull element; and a third strut being pin connected to the third push element and also being pin connected to the third jaw.
  • the first push element and the first pull element define a ratcheting means for preventing distal movement of the push element in relation to the pull element.
  • the system further included an elastic annulus that surrounds the activation element and which is positioned to apply a radially inward force on the ratcheting means.
  • the first push element defines a discontinuity surface means shaped for permitting separation of adjacent portions of the first push element.
  • the first pull element defines a discontinuity surface means shaped for permitting separation of adjacent portions of the first pull element.
  • the system further comprises a first upper jaw being connected to the first pull element by two pins that are spaced from each other. It further comprises a second upper jaw being connected to the first pull element by two pins that are spaced from each other. It further comprises a third upper jaw being connected to the first pull element by two pins that are spaced from each other.
  • the upper jaw defines gripping elements.
  • the first upper jaw is configured to assume a compressed radius condition during delivery, and an expanded radius condition during deployment.
  • a method, not forming part of the invention of repairing a tricuspid valve having a first leaflet, a second leaflet, and a third leaflet in a heart of a patient.
  • the method comprises inserting into the heart via transcatheter delivery a first set of opposing jaws, a second set of opposing jaws, and a third set of opposing jaws.
  • the first set of opposing jaws is operated, independently of the second set of opposing jaws and the third set of opposing jaws, to grasp the first leaflet.
  • the second set of opposing jaws is operated, independently of the first set of opposing jaws and the third set of opposing jaws, to grasp the second leaflet.
  • the third set of opposing jaws is operated, independently of the first set of opposing jaws and the second set of opposing jaws, to grasp the third leaflet.
  • the first set of opposing jaws may be locked in a fixed position. Locking the first set of jaws in a fixed position may include applying a tension force extending circumferentially around a catheter delivering the first set of opposing jaws, the second set of opposing jaws, and the third set of opposing jaws.
  • the first set of opposing jaws may be disconnected from a distal end of a delivery catheter. Disconnecting the first set of opposing jaws may include withdrawing proximally a sheath surrounding the delivery catheter. Operating the first set of jaws may include moving a lower jaw towards an upper jaw.
  • the invention is a system for repairing the tricuspid valve in the heart of a patient via a transcatheter procedure.
  • An objective of the system is to provide a mechanism that securely grips the three common points of meeting all three of the leaflets of a tricuspid valve simultaneously, at a central point where all three leaflets meet at the center of the valve.
  • the tricuspid valve is converted into a valve having three separate orifices instead of only one orifice.
  • the three orifices are formed by leaflets that close more completely during the systole and therefore more effectively fulfill a function of a one way fluid valve which is to prevent regurgitation.
  • FIG. 3 shows an exemplary system 100 which is positioned at the distal end of a delivery catheter.
  • the system 100 extends along a central bore of the delivery catheter, and is configured to address problems found in the prior art.
  • the activation element includes six sub-elements configured to be slidably movable independently of each other and in relation to each other. There are three push elements 104a, 104b and 104c; and there are three pull elements 106a, 106b, and 106c. As may be seen in FIGS.
  • the three push elements and the three pull elements are oriented to be rotationally offset from each other at an interval of 120 degrees about a central axis of the catheter.
  • each push element is associated with one pull element, thus forming three pairs of push and pull elements namely - 104a and 106a; 104b and 106b; 104c and 106c.
  • the push and pull elements have the same orientation about the axis of the catheter.
  • the names "push” and "pull” for these elements are used herein merely for identification and differentiation purposes, because each element may push and it may also pull, as described more fully below, depending on the needs of the operating physician.
  • each pair of push and pull elements is configured so that, upon deployment within the heart of a patient, the push element may be slidingly moved both proximally and distally in relation to the pull element. This relative movement permits an advantageous movement of further elements in the system 100 which are now described.
  • each pull element 106a, 106b, 106c Attached to each pull element 106a, 106b, 106c is a lower jaw 108a, 108b, 108c respectively.
  • the lower jaw is attached to each pull element by a first pin 110a, 110b, 110c to allow the lower jaw to rotate vertically about the first pin.
  • pin 110c is not shown in the figures, but that it is the equivalent of pins 110a and 110b.
  • pin 110c is not shown in the figures, but that it is the equivalent of pins 110a and 110b.
  • each push element 104a, 104b, 104c Attached to each push element 104a, 104b, 104c is a strut 112a, 112b, 112c respectively.
  • Each strut is attached at a first end to each push element by a second pin 114a, 114b, 114c respectively, and at a second end is attached to each lower jaw by a third pin 116a, 116b, 116c. It will be appreciated that when a pull element is pulled proximally in relation to a push element, the lower jaw will be forced by the strut to rotate upwards towards the central axis of the catheter.
  • each pull element 106a, 106b, 106c is an upper jaw 118a.
  • Each upper jaw is fixed in relation to the activation element by two pins, namely a fourth pin 120a, 120b, 120c and the first pin 110a, 110b, 110c.
  • the upper jaw is shaped to be foldable in a delivery condition so that it extends parallel with the elongate axis of the activation element 102, where it may be contained inside a sliding outer sheath 103 ( FIGS. 3-4 ), but to extend outwardly at an angle to the elongate axis in a deployed condition, as seen in FIGS. 3-4 .
  • the upper jaw may be supplied with gripping elements 122 configured to enhance the capture of one of the leaves of the tricuspid valve when the lower jaw is rotated upwards, as will be described below.
  • each push element and each pull element are mating surfaces shaped to act as ratchet and pawl.
  • the pull element 106a, 106b, 106c may include a ratchet 124, namely a concave shape; the push element 104a, 104b, 104c may include a pawl 126, namely a convex element.
  • the ratchet on the pull element may be shaped with a sloping surface and a perpendicular surface, so that when the push element is slowly moved proximally in relation to the push element, the pawl falls into the ratchet and cannot slide back distally again, but it can advance further proximally.
  • This "catch" feature has functional significance in that it allows an operator to collect a single leaf of the tricuspid valve between the lower jaw 108a, 108b, 108c and the upper jaw 118a, 118b, 118c, and to squeeze the leaf between the two jaws.
  • the ratchet and pawl arrangement allows the leaf to be permanently captured without being released.
  • each one of the push elements includes a discontinuity 128a, 128b, 128c and each one of the pull elements includes a discontinuity 130a, 130b, 130c.
  • these discontinuities are discontinuous surfaces shaped so that, so long as the push elements and pull elements remain in axial alignment, the discontinuity may transmit both a compression force and a tension force along their lengths. It will be appreciated that, so long as the push elements and the pull elements remain under and are contained by the sheath 103, they will maintain axial alignment. However, when axial alignment is lost, then the shape of the discontinuities allows a separation of adjacent portions of the elements at the location of the discontinuity to occur.
  • This aspect has functional utility when the each of the three upper and lower jaws are successfully attached to the three leaves of the tricuspid valve.
  • Yet another element of the system 100 is an elastic annulus 130 which is positioned to surround all of the push elements 104a, 104b, 104c and pull elements 106a, 106b, 106c together, as seen in FIG 4-5 .
  • the elastic annulus 130 is positioned to surround these elements at the axial level of the ratchet and pawl, as seen in FIG. 4 .
  • the elastic annulus has the function of holding the push elements and pull elements together about the central axis of the activation element 102, yet at the same time allowing the ratchet system 100 to operate properly, by which the movement of the pawl in relation to the ratchet may force the push elements to part from the pull elements slightly, yet to snap back into contact with each other when the pawl is embedded within the ratchet. Even after the discontinuities 128a, 128b, 128c and 130a, 130b, 130c have been permitted to allow separation of adjacent portions of the push elements and pull elements, the elastic annulus 130 holds together the remaining structures supporting the upper jaws and lower jaws in their fixed positions, thus preventing these elements from simply falling apart.
  • Deployment of the system 100 may take the following steps.
  • the catheter is threaded into the right atrium of the heart of the patient according to known methodology until the system 100 contained in the distal end of the catheter is positioned directly above the tricuspid valve. (See for example, U.S. Patent 8,475,525 .)
  • the distal end is then advanced gently through the three leaflets of the tricuspid valve into the right ventricle. See FIG. 4 , where one leaflet 52 is shown in relation to the system.
  • the sheath 103 is withdrawn proximally by a short distance, sufficient to allow the upper jaw 118a to expand to its deployed configuration as seen in FIG. 4 .
  • the push member 104a is moved further proximally by an amount sufficient to engage the pawl 126a with the ratchet 124a. This action locks the first set of jaws onto the leaflet 52, after which the jaws may be further tightened, but they may not be loosened due to the action of the ratchet means.
  • the operator moves his attention to the second leaflet 54, and when that is captured and locked, the operator moves to the third leaflet 56.
  • the novel structure described permits the operator to approach each leaflet separately and independently for capture. The operator is not compelled to capture more than one leaf in a single action. Rather, individual attention may be brought to bear on each leaflet under visualization, thus permitting far greater focus and attention by the operator in overcoming problems in the prior art associated with capturing multiple leaves using one instrument in a single action.
  • the operator withdraws the sheath 103 proximally to expose the discontinuities 128a, 128b, 128c and 130a, 130b, 130c. Adjacent portions of the push elements and pull elements proximal and distal of the discontinuities are thus allowed to separate from each other.
  • the jaws are left behind in the heart, while the catheter and the balance of the system are withdrawn from the heart.

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  • Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)
  • Surgical Instruments (AREA)

Claims (7)

  1. Système pour réparer une valvule tricuspide dans le cœur d'un patient, le système étant positionné à une extrémité distale d'un cathéter ayant une extrémité proximale et une extrémité distale et un alésage s'étendant entre l'extrémité proximale et l'extrémité distale, le système comprenant :
    un élément d'activation (102) s'étendant le long de l'alésage, l'élément d'activation comprenant :
    un premier élément de poussée (104a) et un premier élément de traction (106a) pouvant coulisser par rapport au premier élément de poussée ;
    un deuxième élément de poussée (104b) et un deuxième élément de traction (106b) pouvant coulisser par rapport au deuxième élément de poussée ;
    un troisième élément de poussée (104c) et un troisième élément de traction (106c) pouvant coulisser par rapport au troisième élément de poussée ;
    le premier élément de poussée (104a), le deuxième élément de poussée (104b) et le troisième élément de poussée (104c) pouvant coulisser indépendamment les uns des autres ;
    une première mâchoire inférieure (108a) étant reliée par broche au premier élément de traction (106a) ;
    une première entretoise étant reliée par broche au premier élément de poussée (104a) et étant également reliée par broche à la première mâchoire ;
    une deuxième mâchoire inférieure (108b) étant reliée par broche au deuxième élément de traction (106b) ;
    une deuxième entretoise étant reliée par broche au deuxième élément de poussée (104b) et étant également reliée par broche à la deuxième mâchoire ;
    une troisième mâchoire inférieure (108c) étant reliée par broche au troisième élément de traction (106c) ;
    une troisième entretoise étant reliée par broche au troisième élément de poussée (104c) et étant également reliée par broche à la troisième mâchoire ;
    une première mâchoire supérieure (118a) étant reliée au premier élément de traction (106a) par deux broches (110a, 120a) qui sont espacées l'une de l'autre ;
    une deuxième mâchoire supérieure (118b) étant reliée au deuxième élément de traction (106b) par deux broches (110b, 120b) qui sont espacées l'une de l'autre ; et
    une troisième mâchoire supérieure (118c) étant reliée au troisième élément de traction (106c) par deux broches (110c, 120c) qui sont espacées l'une de l'autre.
  2. Système selon la revendication 1, le premier élément de poussée (104a) et le premier élément de traction (106a) définissant un moyen d'encliquetage pour empêcher le mouvement distal de l'élément de poussée par rapport à l'élément de traction.
  3. Système selon la revendication 2, comprenant en outre un anneau élastique (130) qui entoure l'élément d'activation (102) et qui est positionné pour appliquer une force radialement vers l'intérieur sur le moyen d'encliquetage.
  4. Système selon la revendication 1, le premier élément de poussée (104a) définissant un moyen de surface de discontinuité formé pour permettre la séparation de parties adjacentes du premier élément de poussée.
  5. Système selon la revendication 1, le premier élément de traction (106a) définissant un moyen de surface de discontinuité formé pour permettre la séparation de parties adjacentes du premier élément de traction.
  6. Système selon la revendication 1, la première mâchoire supérieure (118a) définissant des éléments de préhension (122).
  7. Système selon la revendication 1, la première mâchoire supérieure (118a) étant configurée pour prendre une condition de rayon comprimé pendant la pose, et une condition de rayon étendu pendant le déploiement.
EP17831533.9A 2016-07-20 2017-06-22 Système indépendant de réparation de la valvule tricuspide Active EP3487451B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15/215,387 US10478304B2 (en) 2016-07-20 2016-07-20 Independent system for tricuspid valve repair
PCT/US2017/038834 WO2018017279A1 (fr) 2016-07-20 2017-06-22 Système indépendant de réparation de la valvule tricuspide

Publications (3)

Publication Number Publication Date
EP3487451A1 EP3487451A1 (fr) 2019-05-29
EP3487451A4 EP3487451A4 (fr) 2020-03-11
EP3487451B1 true EP3487451B1 (fr) 2022-04-27

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EP17831533.9A Active EP3487451B1 (fr) 2016-07-20 2017-06-22 Système indépendant de réparation de la valvule tricuspide

Country Status (3)

Country Link
US (2) US10478304B2 (fr)
EP (1) EP3487451B1 (fr)
WO (1) WO2018017279A1 (fr)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11497602B2 (en) 2012-02-14 2022-11-15 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US11602429B2 (en) 2019-04-01 2023-03-14 Neovasc Tiara Inc. Controllably deployable prosthetic valve
US11617650B2 (en) 2012-05-30 2023-04-04 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US11737872B2 (en) 2018-11-08 2023-08-29 Neovasc Tiara Inc. Ventricular deployment of a transcatheter mitral valve prosthesis
US11779742B2 (en) 2019-05-20 2023-10-10 Neovasc Tiara Inc. Introducer with hemostasis mechanism
US11793640B2 (en) 2017-08-25 2023-10-24 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US11931254B2 (en) 2019-06-20 2024-03-19 Neovasc Tiara Inc. Low profile prosthetic mitral valve
US11998447B2 (en) 2019-03-08 2024-06-04 Neovasc Tiara Inc. Retrievable prosthesis delivery system
US12036117B2 (en) 2019-04-10 2024-07-16 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
US12053369B2 (en) 2011-11-23 2024-08-06 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US12109111B2 (en) 2015-12-15 2024-10-08 Neovasc Tiara Inc. Transseptal delivery system
US12193932B2 (en) 2016-01-29 2025-01-14 Neovasc Tiara Inc. Prosthetic valve for avoiding obstruction of outflow

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8052592B2 (en) * 2005-09-27 2011-11-08 Evalve, Inc. Methods and devices for tissue grasping and assessment
WO2006037073A2 (fr) * 2004-09-27 2006-04-06 Evalve, Inc. Procédés et dispositifs de saisie et d'évaluation de tissus
US8652202B2 (en) 2008-08-22 2014-02-18 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
US10517719B2 (en) 2008-12-22 2019-12-31 Valtech Cardio, Ltd. Implantation of repair devices in the heart
US9968452B2 (en) 2009-05-04 2018-05-15 Valtech Cardio, Ltd. Annuloplasty ring delivery cathethers
US8449599B2 (en) 2009-12-04 2013-05-28 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
EP3345573B1 (fr) 2011-06-23 2020-01-29 Valtech Cardio, Ltd. Élément de fermeture à utiliser avec une structure d'annuloplastie
US8945177B2 (en) 2011-09-13 2015-02-03 Abbott Cardiovascular Systems Inc. Gripper pusher mechanism for tissue apposition systems
US9011468B2 (en) 2011-09-13 2015-04-21 Abbott Cardiovascular Systems Inc. Independent gripper
US9439763B2 (en) 2013-02-04 2016-09-13 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US10105221B2 (en) 2013-03-07 2018-10-23 Cedars-Sinai Medical Center Method and apparatus for percutaneous delivery and deployment of a cardiovascular prosthesis
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US9622863B2 (en) 2013-11-22 2017-04-18 Edwards Lifesciences Corporation Aortic insufficiency repair device and method
US10799359B2 (en) 2014-09-10 2020-10-13 Cedars-Sinai Medical Center Method and apparatus for percutaneous delivery and deployment of a cardiac valve prosthesis
US10758265B2 (en) 2014-11-14 2020-09-01 Cedars-Sinai Medical Center Cardiovascular access and device delivery system
EP3226810A4 (fr) 2014-12-04 2018-08-15 Edwards Lifesciences Corporation Pince percutanée pour réparation d'une valvule cardiaque
EP4512372A3 (fr) 2015-05-14 2025-05-14 Edwards Lifesciences Corporation Dispositifs d'étanchéité de valvule cardiaque et dispositifs de pose associés
EP3324855B1 (fr) 2015-07-23 2024-03-20 Cedars-Sinai Medical Center Dispositif pour fixer les feuillets de valve cardiaque
US10799675B2 (en) 2016-03-21 2020-10-13 Edwards Lifesciences Corporation Cam controlled multi-direction steerable handles
US10799676B2 (en) 2016-03-21 2020-10-13 Edwards Lifesciences Corporation Multi-direction steerable handles for steering catheters
US10799677B2 (en) 2016-03-21 2020-10-13 Edwards Lifesciences Corporation Multi-direction steerable handles for steering catheters
US11219746B2 (en) 2016-03-21 2022-01-11 Edwards Lifesciences Corporation Multi-direction steerable handles for steering catheters
US10835714B2 (en) 2016-03-21 2020-11-17 Edwards Lifesciences Corporation Multi-direction steerable handles for steering catheters
US11963712B2 (en) 2016-06-20 2024-04-23 Evalve, Inc. Transapical removal device
US10973638B2 (en) 2016-07-07 2021-04-13 Edwards Lifesciences Corporation Device and method for treating vascular insufficiency
US10653862B2 (en) 2016-11-07 2020-05-19 Edwards Lifesciences Corporation Apparatus for the introduction and manipulation of multiple telescoping catheters
US10398553B2 (en) * 2016-11-11 2019-09-03 Evalve, Inc. Opposing disk device for grasping cardiac valve tissue
CN109996581B (zh) 2016-11-21 2021-10-15 内奥瓦斯克迪亚拉公司 用于快速收回经导管心脏瓣膜递送系统的方法和系统
US10905554B2 (en) 2017-01-05 2021-02-02 Edwards Lifesciences Corporation Heart valve coaptation device
WO2018140535A1 (fr) * 2017-01-25 2018-08-02 Cedars-Sinai Medical Center Dispositif pour la fixation de feuillets valvulaires cardiaques
US11224511B2 (en) 2017-04-18 2022-01-18 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
CN115990075A (zh) * 2017-04-18 2023-04-21 爱德华兹生命科学公司 心脏瓣膜密封装置及其递送装置
US10799312B2 (en) 2017-04-28 2020-10-13 Edwards Lifesciences Corporation Medical device stabilizing apparatus and method of use
US10959846B2 (en) 2017-05-10 2021-03-30 Edwards Lifesciences Corporation Mitral valve spacer device
US11051940B2 (en) 2017-09-07 2021-07-06 Edwards Lifesciences Corporation Prosthetic spacer device for heart valve
US11065117B2 (en) 2017-09-08 2021-07-20 Edwards Lifesciences Corporation Axisymmetric adjustable device for treating mitral regurgitation
US11110251B2 (en) 2017-09-19 2021-09-07 Edwards Lifesciences Corporation Multi-direction steerable handles for steering catheters
EP3697318B1 (fr) * 2017-10-20 2024-08-14 Edwards Lifesciences Corporation Fusion localisée de valves natives à l'aide d'un adhésif activé
US10076415B1 (en) 2018-01-09 2018-09-18 Edwards Lifesciences Corporation Native valve repair devices and procedures
PL3964175T3 (pl) 2018-01-09 2025-02-24 Edwards Lifesciences Corporation Urządzenia do naprawy zastawek naturalnych
US10238493B1 (en) 2018-01-09 2019-03-26 Edwards Lifesciences Corporation Native valve repair devices and procedures
US10136993B1 (en) 2018-01-09 2018-11-27 Edwards Lifesciences Corporation Native valve repair devices and procedures
US10973639B2 (en) 2018-01-09 2021-04-13 Edwards Lifesciences Corporation Native valve repair devices and procedures
US10159570B1 (en) 2018-01-09 2018-12-25 Edwards Lifesciences Corporation Native valve repair devices and procedures
US10245144B1 (en) 2018-01-09 2019-04-02 Edwards Lifesciences Corporation Native valve repair devices and procedures
US10507109B2 (en) 2018-01-09 2019-12-17 Edwards Lifesciences Corporation Native valve repair devices and procedures
US10105222B1 (en) 2018-01-09 2018-10-23 Edwards Lifesciences Corporation Native valve repair devices and procedures
US10123873B1 (en) 2018-01-09 2018-11-13 Edwards Lifesciences Corporation Native valve repair devices and procedures
US10231837B1 (en) 2018-01-09 2019-03-19 Edwards Lifesciences Corporation Native valve repair devices and procedures
US10111751B1 (en) 2018-01-09 2018-10-30 Edwards Lifesciences Corporation Native valve repair devices and procedures
US10568740B2 (en) * 2018-01-15 2020-02-25 Vdyne, Llc Device and method to plicate the tricuspid valve
US11389297B2 (en) 2018-04-12 2022-07-19 Edwards Lifesciences Corporation Mitral valve spacer device
US11207181B2 (en) 2018-04-18 2021-12-28 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US10945844B2 (en) 2018-10-10 2021-03-16 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
SG11202105160XA (en) 2018-11-20 2021-06-29 Edwards Lifesciences Corp Deployment tools and methods for delivering a device to a native heart valve
AU2019384540B2 (en) 2018-11-21 2025-01-02 Edwards Lifesciences Corporation Heart valve sealing devices, delivery devices therefor, and retrieval devices
CA3120859A1 (fr) 2018-11-29 2020-06-04 Edwards Lifesciences Corporation Methode et appareil de catheterisation
CN114173680B (zh) * 2019-01-08 2025-05-06 纽约哥伦比亚大学董事会 用于心脏瓣膜修复的系统和方法
CR20210427A (es) 2019-02-14 2022-03-30 Edwards Lifesciences Corp Dispositivos de sellado de válvulas cardíacas y dispositivos de suministro para los mismos
CA3131522A1 (fr) 2019-02-25 2020-09-03 Edwards Lifesciences Corporation Dispositifs d'etancheite de valvule cardiaque
US11534303B2 (en) 2020-04-09 2022-12-27 Evalve, Inc. Devices and systems for accessing and repairing a heart valve
EP3998993A1 (fr) 2019-07-15 2022-05-25 Evalve, Inc. Mécanismes de fixation et de libération d'actionneur d'élément proximal
CA3147583C (fr) 2019-07-15 2025-06-10 Evalve Inc Procédés d'actionnement d'élément proximal indépendant
EP3998994A1 (fr) 2019-07-15 2022-05-25 Evalve, Inc. Clip large à ailes non déformables
CN112386368B (zh) * 2019-08-13 2025-01-17 杭州德晋医疗科技有限公司 可调式瓣膜夹合器及瓣膜夹合系统
CN112472363B (zh) * 2019-09-12 2025-01-17 杭州德晋医疗科技有限公司 防滑脱的瓣膜夹合器及瓣膜夹合系统
US11707228B2 (en) 2019-09-26 2023-07-25 Evalve, Inc. Systems and methods for intra-procedural cardiac pressure monitoring
EP4041136A1 (fr) 2019-10-11 2022-08-17 Evalve, Inc. Pince de réparation pour épaisseur de tissu variable
WO2021092107A1 (fr) 2019-11-06 2021-05-14 Evalve, Inc. Stabilisateur pour système médical de pose
EP4292546B1 (fr) 2019-11-08 2025-04-23 Evalve, Inc. Système de pose de dispositif médical avec système de verrouillage
WO2021097089A1 (fr) 2019-11-14 2021-05-20 Evalve, Inc. Kit avec aide à la coaptation et système de fixation et procédés de réparation de valve
WO2021097124A1 (fr) 2019-11-14 2021-05-20 Evalve, Inc. Ensemble cathéter avec aide à la coaptation et procédés de réparation de valve
US12109115B2 (en) 2019-12-18 2024-10-08 Evalve, Inc. Wide clip with deformable width
WO2022081328A1 (fr) 2020-10-15 2022-04-21 Evalve, Inc. Ensembles distaux sollicités avec mécanisme de verrouillage
US12138169B2 (en) 2021-04-30 2024-11-12 Evalve, Inc. Fixation device having a flexure portion
CN115300181B (zh) * 2021-05-06 2025-08-12 杭州德晋医疗科技有限公司 具有稳定夹合力的三尖瓣瓣膜修复装置及系统
US11992199B2 (en) * 2022-09-30 2024-05-28 Shanghai ConFlow MedTech Co., Ltd. Valve leaflet obstruction repair clip and repair system thereof
CN117918999B (zh) * 2022-10-17 2025-08-05 江苏臻亿医疗科技有限公司 瓣膜夹合器械及瓣膜修复系统
CN117982268A (zh) * 2022-11-03 2024-05-07 杭州德晋医疗科技有限公司 贴合稳定的瓣膜夹合装置及瓣膜夹合系统
EP4618905A1 (fr) * 2022-11-18 2025-09-24 Evalve, Inc. Dispositif de fixation à éléments d'extension symétriques
USD1071198S1 (en) 2023-06-28 2025-04-15 Edwards Lifesciences Corporation Cradle

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6165183A (en) 1998-07-15 2000-12-26 St. Jude Medical, Inc. Mitral and tricuspid valve repair
US6752813B2 (en) 1999-04-09 2004-06-22 Evalve, Inc. Methods and devices for capturing and fixing leaflets in valve repair
US8216256B2 (en) * 1999-04-09 2012-07-10 Evalve, Inc. Detachment mechanism for implantable fixation devices
US7563267B2 (en) 1999-04-09 2009-07-21 Evalve, Inc. Fixation device and methods for engaging tissue
US6626930B1 (en) 1999-10-21 2003-09-30 Edwards Lifesciences Corporation Minimally invasive mitral valve repair method and apparatus
CA2597066C (fr) 2005-02-07 2014-04-15 Evalve, Inc. Procedes, systemes et dispositifs pour reparer une valvule cardiaque
EP3042615B1 (fr) 2009-09-15 2024-12-04 Evalve, Inc. Systèmes et dispositifs de réparation de valvule cardiaque
US20120179184A1 (en) * 2009-09-15 2012-07-12 Boris Orlov Heart valve remodeling
US9662205B2 (en) 2012-08-02 2017-05-30 St. Jude Medical, Cardiology Division, Inc. Apparatus and method for heart valve repair
US10390943B2 (en) * 2014-03-17 2019-08-27 Evalve, Inc. Double orifice device for transcatheter mitral valve replacement
US9572666B2 (en) * 2014-03-17 2017-02-21 Evalve, Inc. Mitral valve fixation device removal devices and methods
US9750605B2 (en) * 2014-10-23 2017-09-05 Caisson Interventional, LLC Systems and methods for heart valve therapy
US10188392B2 (en) 2014-12-19 2019-01-29 Abbott Cardiovascular Systems, Inc. Grasping for tissue repair

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12053369B2 (en) 2011-11-23 2024-08-06 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US11497602B2 (en) 2012-02-14 2022-11-15 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US12138159B2 (en) 2012-02-14 2024-11-12 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US11617650B2 (en) 2012-05-30 2023-04-04 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US12109111B2 (en) 2015-12-15 2024-10-08 Neovasc Tiara Inc. Transseptal delivery system
US12193932B2 (en) 2016-01-29 2025-01-14 Neovasc Tiara Inc. Prosthetic valve for avoiding obstruction of outflow
US11793640B2 (en) 2017-08-25 2023-10-24 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US11737872B2 (en) 2018-11-08 2023-08-29 Neovasc Tiara Inc. Ventricular deployment of a transcatheter mitral valve prosthesis
US11998447B2 (en) 2019-03-08 2024-06-04 Neovasc Tiara Inc. Retrievable prosthesis delivery system
US11602429B2 (en) 2019-04-01 2023-03-14 Neovasc Tiara Inc. Controllably deployable prosthetic valve
US12036117B2 (en) 2019-04-10 2024-07-16 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
US11779742B2 (en) 2019-05-20 2023-10-10 Neovasc Tiara Inc. Introducer with hemostasis mechanism
US11931254B2 (en) 2019-06-20 2024-03-19 Neovasc Tiara Inc. Low profile prosthetic mitral valve

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US20180021134A1 (en) 2018-01-25
US11304807B2 (en) 2022-04-19
EP3487451A1 (fr) 2019-05-29
WO2018017279A1 (fr) 2018-01-25
US10478304B2 (en) 2019-11-19
EP3487451A4 (fr) 2020-03-11
US20200078173A1 (en) 2020-03-12

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