EP3463290A4 - HIV-1 REACTION CONTROL BY GENETIC EDITION STRATEGY - Google Patents

HIV-1 REACTION CONTROL BY GENETIC EDITION STRATEGY Download PDF

Info

Publication number: EP3463290A4
Authority: EP; European Patent Office
Prior art keywords: hiv; genetic; strategy; edition; reaction control
Prior art date: 2016-06-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP17810720.7A

Other languages

German (de)

French (fr)

Other versions

EP3463290A1 (en

Inventor

Kamel Khalili

Wenhui Hu

Rafal Kaminski

Thomas MALCOLM

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Temple Univ School of Medicine

Original Assignee

Temple Univ School of Medicine

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-06-03

Filing date

2017-05-26

Publication date

2019-10-30

2017-05-26 Application filed by Temple Univ School of Medicine filed Critical Temple Univ School of Medicine

2019-04-10 Publication of EP3463290A1 publication Critical patent/EP3463290A1/en

2019-10-30 Publication of EP3463290A4 publication Critical patent/EP3463290A4/en

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Zoology (AREA)
Virology (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Tropical Medicine & Parasitology (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Microbiology (AREA)
Communicable Diseases (AREA)
AIDS & HIV (AREA)
Chemical Kinetics & Catalysis (AREA)
Cell Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Developmental Biology & Embryology (AREA)
Immunology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

EP17810720.7A 2016-06-03 2017-05-26 HIV-1 REACTION CONTROL BY GENETIC EDITION STRATEGY Withdrawn EP3463290A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201662345549P	2016-06-03	2016-06-03
US201662394334P	2016-09-14	2016-09-14
PCT/US2017/034763 WO2017213896A1 (en)	2016-06-03	2017-05-26	Negative feedback regulation of hiv-1 by gene editing strategy

Publications (2)

Publication Number	Publication Date
EP3463290A1 EP3463290A1 (en)	2019-04-10
EP3463290A4 true EP3463290A4 (en)	2019-10-30

Family

ID=60578255

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP17810720.7A Withdrawn EP3463290A4 (en)	2016-06-03	2017-05-26	HIV-1 REACTION CONTROL BY GENETIC EDITION STRATEGY

Country Status (7)

Country	Link
EP (1)	EP3463290A4 (en)
JP (1)	JP2019517503A (en)
CN (1)	CN109640946A (en)
AU (1)	AU2017277810A1 (en)
CA (1)	CA3026332A1 (en)
RU (1)	RU2018144877A (en)
WO (1)	WO2017213896A1 (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP3613852A3 (en)	2011-07-22	2020-04-22	President and Fellows of Harvard College	Evaluation and improvement of nuclease cleavage specificity
US20150044192A1 (en)	2013-08-09	2015-02-12	President And Fellows Of Harvard College	Methods for identifying a target site of a cas9 nuclease
US9359599B2 (en)	2013-08-22	2016-06-07	President And Fellows Of Harvard College	Engineered transcription activator-like effector (TALE) domains and uses thereof
US9737604B2 (en)	2013-09-06	2017-08-22	President And Fellows Of Harvard College	Use of cationic lipids to deliver CAS9
US9228207B2 (en)	2013-09-06	2016-01-05	President And Fellows Of Harvard College	Switchable gRNAs comprising aptamers
US9388430B2 (en)	2013-09-06	2016-07-12	President And Fellows Of Harvard College	Cas9-recombinase fusion proteins and uses thereof
US11053481B2 (en)	2013-12-12	2021-07-06	President And Fellows Of Harvard College	Fusions of Cas9 domains and nucleic acid-editing domains
AU2015298571B2 (en)	2014-07-30	2020-09-03	President And Fellows Of Harvard College	Cas9 proteins including ligand-dependent inteins
US12043852B2 (en)	2015-10-23	2024-07-23	President And Fellows Of Harvard College	Evolved Cas9 proteins for gene editing
GB2568182A (en)	2016-08-03	2019-05-08	Harvard College	Adenosine nucleobase editors and uses thereof
WO2018031683A1 (en)	2016-08-09	2018-02-15	President And Fellows Of Harvard College	Programmable cas9-recombinase fusion proteins and uses thereof
US11542509B2 (en)	2016-08-24	2023-01-03	President And Fellows Of Harvard College	Incorporation of unnatural amino acids into proteins using base editing
GB2573062A (en)	2016-10-14	2019-10-23	Harvard College	AAV delivery of nucleobase editors
WO2018119359A1 (en)	2016-12-23	2018-06-28	President And Fellows Of Harvard College	Editing of ccr5 receptor gene to protect against hiv infection
WO2018165631A1 (en)	2017-03-09	2018-09-13	President And Fellows Of Harvard College	Cancer vaccine
US11898179B2 (en)	2017-03-09	2024-02-13	President And Fellows Of Harvard College	Suppression of pain by gene editing
CN110914310A (en)	2017-03-10	2020-03-24	哈佛大学的校长及成员们	Cytosine to guanine base editor
US11268082B2 (en)	2017-03-23	2022-03-08	President And Fellows Of Harvard College	Nucleobase editors comprising nucleic acid programmable DNA binding proteins
WO2018209320A1 (en)	2017-05-12	2018-11-15	President And Fellows Of Harvard College	Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
JP2020534795A (en)	2017-07-28	2020-12-03	プレジデントアンドフェローズオブハーバードカレッジ	Methods and Compositions for Evolving Base Editing Factors Using Phage-Supported Continuous Evolution (PACE)
WO2019139645A2 (en)	2017-08-30	2019-07-18	President And Fellows Of Harvard College	High efficiency base editors comprising gam
CA3082251A1 (en)	2017-10-16	2019-04-25	The Broad Institute, Inc.	Uses of adenosine base editors
US12406749B2 (en)	2017-12-15	2025-09-02	The Broad Institute, Inc.	Systems and methods for predicting repair outcomes in genetic engineering
US12157760B2 (en)	2018-05-23	2024-12-03	The Broad Institute, Inc.	Base editors and uses thereof
WO2020092453A1 (en)	2018-10-29	2020-05-07	The Broad Institute, Inc.	Nucleobase editors comprising geocas9 and uses thereof
US12351837B2 (en)	2019-01-23	2025-07-08	The Broad Institute, Inc.	Supernegatively charged proteins and uses thereof
WO2020160412A1 (en) *	2019-02-01	2020-08-06	Editas Medicine, Inc.	Crispr/cas-related methods and compositions targeting virus genomes
AU2020240109A1 (en)	2019-03-19	2021-09-30	President And Fellows Of Harvard College	Methods and compositions for editing nucleotide sequences
WO2020214842A1 (en)	2019-04-17	2020-10-22	The Broad Institute, Inc.	Adenine base editors with reduced off-target effects
US12435330B2 (en)	2019-10-10	2025-10-07	The Broad Institute, Inc.	Methods and compositions for prime editing RNA
BR112022022603A2 (en)	2020-05-08	2023-01-17	Broad Inst Inc	METHODS AND COMPOSITIONS FOR SIMULTANEOUS EDITING OF BOTH DUAL-STRANDED NUCLEOTIDE TARGET SEQUENCE STRAINS

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2015126927A2 (en) *	2014-02-18	2015-08-27	Duke University	Compositions for the inactivation of virus replication and methods of making and using the same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI105105B (en) *	1998-02-27	2000-06-15	Finnish Immunotechnology Ltd O	A self-replicating DNA vector for immunization against HIV
US6576422B1 (en) *	2000-10-17	2003-06-10	Rohm And Haas Company	Method for identifying products employing gene expression
JP4772045B2 (en) *	2004-07-16	2011-09-14	アメリカ合衆国	Vaccine against AIDS containing CMV / R nucleic acid construct
EP1942192A1 (en) *	2007-01-08	2008-07-09	Heinrich-Pette-Institut für experimentelle Virologie und Immunologie	Use of a tailored recombinase for the treatment of retroviral infections
KR102479178B1 (en) *	2012-12-06	2022-12-19	시그마-알드리치 컴퍼니., 엘엘씨	Crispr-based genome modification and regulation
US9925248B2 (en) *	2013-08-29	2018-03-27	Temple University Of The Commonwealth System Of Higher Education	Methods and compositions for RNA-guided treatment of HIV infection
US20180334732A1 (en) *	2014-11-25	2018-11-22	Drexel University	Compositions and methods for hiv quasi-species excision from hiv-1-infected patients
MA41382A (en) *	2015-03-20	2017-11-28	Univ Temple	GENE EDITING BASED ON THE TAT-INDUCED CRISPR / ENDONUCLEASE SYSTEM

2017
- 2017-05-26 JP JP2018562997A patent/JP2019517503A/en active Pending
- 2017-05-26 EP EP17810720.7A patent/EP3463290A4/en not_active Withdrawn
- 2017-05-26 CN CN201780048467.5A patent/CN109640946A/en active Pending
- 2017-05-26 AU AU2017277810A patent/AU2017277810A1/en not_active Abandoned
- 2017-05-26 RU RU2018144877A patent/RU2018144877A/en not_active Application Discontinuation
- 2017-05-26 WO PCT/US2017/034763 patent/WO2017213896A1/en not_active Ceased
- 2017-05-26 CA CA3026332A patent/CA3026332A1/en not_active Abandoned

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2015126927A2 (en) *	2014-02-18	2015-08-27	Duke University	Compositions for the inactivation of virus replication and methods of making and using the same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO2017213896A1 *
VICKERS T ET AL: "Inhibition of HIV-LTR gene expression by oligonucleotides targeted to the TAR element", NUCLEIC ACIDS RESEARCH, INFORMATION RETRIEVAL LTD, vol. 19, no. 12, 1 January 1991 (1991-01-01), pages 3359 - 3368, XP002979384, ISSN: 0305-1048 *

Also Published As

Publication number	Publication date
WO2017213896A1 (en)	2017-12-14
CA3026332A1 (en)	2017-12-14
JP2019517503A (en)	2019-06-24
AU2017277810A2 (en)	2019-01-03
RU2018144877A (en)	2020-07-09
EP3463290A1 (en)	2019-04-10
CN109640946A (en)	2019-04-16
AU2017277810A1 (en)	2018-12-06

Publication	Publication Date	Title
EP3463290A4 (en)	2019-10-30	HIV-1 REACTION CONTROL BY GENETIC EDITION STRATEGY
EP3302575A4 (en)	2019-01-16	GENOME EDITION VECTORS
EP3517644A4 (en)	2020-02-26	GALVANISED STEEL
EP3517643A4 (en)	2020-03-04	GALVANISED STEEL
EP3374878A4 (en)	2019-06-26	COLLABORATIVE CREATION OF DOCUMENT BY A PLURALITY OF DISTINCT TEAMS
EP3387571A4 (en)	2019-03-20	IMPROVEMENT OF MICROBIAL STRAINS BY A GENOMIC HTP ENGINEERING PLATFORM
EP3426774A4 (en)	2019-08-14	IMAGING MEDIATED BY A TRANSPOSASE OF THE ACCESSIBLE GENOME
EP3464996A4 (en)	2020-01-15	WIDE ANGLE DIRECTIONAL IMAGING BACKLIGHTS
EP3407953A4 (en)	2020-03-18	OXYGEN MASKS
EP3430853A4 (en)	2019-03-27	MECHANISMS FOR MULTI-STAGE MULTI-STAGE COOPERATIVE MULTIPOINT TECHNOLOGY
EP3304188A4 (en)	2019-02-27	DIRECTIONALLY WIDE IMAGING IMAGING BACKLIGHTS
MA42924A (en)	2018-08-01	OPTIMIZED VARIANTS OF ANTI-VEGF ANTIBODIES
PT3411478T (en)	2022-09-13	OPTIMIZED FACTOR VIII GENES
DK3368678T3 (en)	2021-09-13	GENETIC CONSTRUCT
EP3421070A4 (en)	2019-03-27	OXYGEN CONCENTRATOR
EP3423599A4 (en)	2020-01-08	AUTOMATED NESTED AMPLIFICATION BY RECOMBINASE POLYMERASE
EP3385571A4 (en)	2019-08-07	TRAINING MECHANISM AT TWO DEGREES OF FREEDOM
EP3515506A4 (en)	2020-04-29	DUX4 SILENCING BY RECOMBINANT GENE EDITING COMPLEXES
EP3302790A4 (en)	2019-01-16	HDN HIGH-SELECTIVITY HYDROTREATMENT CATALYST
IL261311B (en)	2020-09-30	Vector validation instruction
EP3512460A4 (en)	2020-04-29	BLOOD VESSELS OBTAINED BY ENGINEERING
PT3532921T (en)	2021-03-30	VECTOR COMPARISON INSTRUCTION FOR COMBATING FLOATING WITH SELECTABLE OPTIONS
EP3460088A4 (en)	2020-03-11	GALVANISED STEEL
EP3280445A4 (en)	2019-05-15	GENE THERAPY TO PREVENT REACTIONS TO ALLERGENS
MA44212A (en)	2018-12-26	Sustained-release pregabalin

Legal Events

Date	Code	Title	Description
2017-12-16	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2019-03-08	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2019-03-08	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2019-04-10	17P	Request for examination filed	Effective date: 20181228
2019-04-10	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2019-04-10	AX	Request for extension of the european patent	Extension state: BA ME
2019-09-11	DAV	Request for validation of the european patent (deleted)
2019-09-11	DAX	Request for extension of the european patent (deleted)
2019-10-30	A4	Supplementary search report drawn up and despatched	Effective date: 20190930
2019-10-30	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 35/12 20150101ALI20190924BHEP Ipc: C12N 7/00 20060101ALI20190924BHEP Ipc: A61K 48/00 20060101ALI20190924BHEP Ipc: A61K 9/00 20060101AFI20190924BHEP Ipc: A61K 45/06 20060101ALI20190924BHEP Ipc: C12N 9/22 20060101ALI20190924BHEP
2020-06-05	REG	Reference to a national code	Ref country code: HK Ref legal event code: DE Ref document number: 40007490 Country of ref document: HK
2022-03-25	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2022-04-27	18D	Application deemed to be withdrawn	Effective date: 20211201