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EP3457582A1 - Système de gestion de chaîne d'approvisionnement - Google Patents

Système de gestion de chaîne d'approvisionnement Download PDF

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Publication number
EP3457582A1
EP3457582A1 EP18193299.7A EP18193299A EP3457582A1 EP 3457582 A1 EP3457582 A1 EP 3457582A1 EP 18193299 A EP18193299 A EP 18193299A EP 3457582 A1 EP3457582 A1 EP 3457582A1
Authority
EP
European Patent Office
Prior art keywords
ingestible device
plates
capacitive
plate
power source
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP18193299.7A
Other languages
German (de)
English (en)
Other versions
EP3457582B1 (fr
Inventor
Mark J. Zdeblick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Proteus Digital Health Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proteus Digital Health Inc filed Critical Proteus Digital Health Inc
Priority to EP20167424.9A priority Critical patent/EP3694113A1/fr
Publication of EP3457582A1 publication Critical patent/EP3457582A1/fr
Application granted granted Critical
Publication of EP3457582B1 publication Critical patent/EP3457582B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
    • G06K17/00—Methods or arrangements for effecting co-operative working between equipments covered by two or more of main groups G06K1/00 - G06K15/00, e.g. automatic card files incorporating conveying and reading operations
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04B—TRANSMISSION
    • H04B5/00—Near-field transmission systems, e.g. inductive or capacitive transmission systems
    • H04B5/20—Near-field transmission systems, e.g. inductive or capacitive transmission systems characterised by the transmission technique; characterised by the transmission medium
    • H04B5/22—Capacitive coupling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/06—Devices, other than using radiation, for detecting or locating foreign bodies ; Determining position of diagnostic devices within or on the body of the patient
    • A61B5/061—Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
    • G06K7/00—Methods or arrangements for sensing record carriers, e.g. for reading patterns
    • G06K7/01—Details
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
    • G06K7/00—Methods or arrangements for sensing record carriers, e.g. for reading patterns
    • G06K7/08—Methods or arrangements for sensing record carriers, e.g. for reading patterns by means detecting the change of an electrostatic or magnetic field, e.g. by detecting change of capacitance between electrodes
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
    • G06Q10/00—Administration; Management
    • G06Q10/06—Resources, workflows, human or project management; Enterprise or organisation planning; Enterprise or organisation modelling
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
    • G06Q10/00—Administration; Management
    • G06Q10/08—Logistics, e.g. warehousing, loading or distribution; Inventory or stock management
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04B—TRANSMISSION
    • H04B5/00—Near-field transmission systems, e.g. inductive or capacitive transmission systems
    • H04B5/40—Near-field transmission systems, e.g. inductive or capacitive transmission systems characterised by components specially adapted for near-field transmission
    • H04B5/48—Transceivers
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04B—TRANSMISSION
    • H04B5/00—Near-field transmission systems, e.g. inductive or capacitive transmission systems
    • H04B5/70—Near-field transmission systems, e.g. inductive or capacitive transmission systems specially adapted for specific purposes
    • H04B5/77—Near-field transmission systems, e.g. inductive or capacitive transmission systems specially adapted for specific purposes for interrogation

Definitions

  • the present invention is related to methods and systems for using electronic devices to track products. More specifically, the present disclosure includes a methods, devices, and system for tracking medical inventory from source to consumer.
  • the invention includes capacitive plates which probe a variety of products, resulting in indications of product validity or invalidity. In this manner, various supply chain or other pursuits may be accomplished.
  • the products include, for example, IV bags, syringes, ingestible event markers (IEMs) and similar devices, as disclosed and described in PCT application serial no. PCT/US2006/016370 published as WO/2006/116718 ; PCT application serial no. PCT/US2007/082563 published as WO/2008/052136 ; PCT application serial no. PCT/US2007/024225 published as WO/2008/063626 ; PCT application serial no. PCT/US2007/022257 published as WO/2008/066617 ; PCT application serial no. PCT/US2008/052845 published as WO/2008/095183 ; PCT application serial no.
  • Such products may typically be designed to include conductive materials/components.
  • the use of capacitive coupling to probe the product's conductive materials and components by the capacitive plates may indicate the presence of the correct configuration of conductive components of the product.
  • failure to communicatively couple when probed may indicate product nonconformance, e.g., one or more conductive materials is absent, incorrectly configured, etc.
  • a device 10a inside a pharmaceutical product 12a such as a pill or tablet, which is completely packaged up and tested via a probe, as discussed in detail below.
  • the device 10a may be located within the product 12a or secured to the surface of the product 12a, as contemplated within the scope of the present invention.
  • the device 10a includes a control module for communication and a memory for storing information, such as identity. The probing of the device 10a is performed to ensure, for example, that the device 10a is still functioning.
  • the probing uses a capacitive coupling approach where there is capacitive coupling of a first probing capacitive plate 20a to a first metal or material 14a on one side of the device 10a and a second probing capacitive plate 30a to a second metal or material 16a on another side of the device 10a.
  • the plate 20a is electrically insulated from the plate 30a even though the insulation is not specifically shown.
  • Various ways to probe using capacitive coupling may be accomplished, e.g., metal, metal pads, etc. In accordance with one aspect of the present invention, for example, there is capacitive coupling between material 14a and capacitive plate 20a and material 16a and capacitive plate 30a.
  • the plates 20a and 30a are probes that can communicate with the device 10a through capacitive coupling.
  • the plates 20a and 30a are electrically connected to a system (not shown) that can receive the information from the plates 20a and 30a as well as process the information.
  • the product may be coated with non-conducting material.
  • the device 10 may be an ingestible event marker (IEM) with a unique identity that can be read using capacitive coupling pre-ingenstion and communicated using transconduction post-consumption.
  • IEM ingestible event marker
  • Various aspects of an IEM are disclosed in US Patent Application 12/564,017 titled COMMUNICATION SYSTEM WITH PARTIAL POWER SOURCE filed on September 21, 2009, the entire disclosure of which is incorporated herein by reference.
  • a device 10b is shown as part of a product 12b in accordance with one aspect of the present invention.
  • the device 10b includes a first material 14b and a second material 16b deposited on the surface of the device 10b for forming a capacitive connection.
  • the materials 14b and 16b are in communication with the control module of the device 10b.
  • Probes 20b and 30b are capacitively coupled to materials 14b and 16b, respectively.
  • materials 14b and 16b are capacitively coupled to the probes 20b and 30b.
  • information associated with the device 10b that is stored in the memory of the device 10b can be encoded by a control module of the device 10b and communicated to the probes using capacitive coupling.
  • a device 10c is shown secured to a product 12c in accordance with the present invention.
  • the device 10c includes a first material 14c and a second material 16c deposited around the perimeter of a skirt 18c of the device 10c with at least a portion of the materials 14c and 16c being deposited on the skirt 18c.
  • the materials 14c and 16c are coupled to the control module of the device 10c to allow for communication through capacitive coupling from the control module of the device 10c to allow the identity of the device 10c to be communicated to a system through the probes 20c and 30c.
  • the materials 14c and 16c are conductive inks, such as an ingestible graphite or carbon based ink or paste.
  • Probes 20c and 30c are powered by an AC source and when brought close to the materials 14c and 16c, the probes 20c and 30c can communicate with the device 10c using capacitive coupling through the materials 14c and 16c, respectively.
  • probes 22c and 32c are positioned proximal to the material 14c and 16c at different locations to allow for alternative positioning of the device 10c or to provide for probing of the device from an alternative direction.
  • the materials 14c and 16c can be used to pass information between the device 10c and the system connected to the probes 20c and 30c through capacitive coupling.
  • a conducting material 14d is deposited on the surface of a material 19a that is associated with the device 10d.
  • the material 19a and the material 19b of the device 10d are dissimilar materials and form a partial power source for the device 10d.
  • the material 19a maybe CuCI and the material 19b may be Mg.
  • the device 10d also includes transistors at connection 19c that is capable of electrically connected the composite 14d to V-high or the material 19b, which is at the same potential as V-low.
  • the device 10d includes a composite material 16d that is physically associated with the device 10d and rests on top of an oxide layer 17d.
  • the material 16d may be gold-plated CuCI.
  • probes or plates similar to those shown in Figs. 1A-1C and powered by an oscillating or AC voltage source, are brought close to the device 10d there is capacitive coupling between the composite 14d and the composite 16d and the probes.
  • the voltage source isolates, the energy transferred to the material 14d and the material 16d varies accordingly and is stored on the device 10d. As the voltage source is reduce to zero or quiet, then the device 10d switches from receiving energy to sending energy to the probes using capacitive coupling.
  • the transistors 19c are used to connect and disconnect the material 14d between the material 19b (which represents V-low) and V-high. As the material 14d changes energy levels from V-high to V-low, information can be transferred to the probes. Thus, during a portion of the cycle when the power is off or quiet (as shown in Fig. 2C ), the device 10d is able to transfer energy to the probes, which energy includes information about the device 10d. Hence, using capacitive coupling, information may be communicated between the device 10d and the system connected to the probes near the device 10d.
  • the inner conductive probe or plate 20e is surrounded by the insulating material 25e, which is surrounded by the outer conductive probe or plate 30e.
  • the device 10e is shown as part of a pharmaceutical product 12e.
  • the device 10e includes a conducting material or ink 15e deposited on the side opposite the co-axial probe.
  • the probe 20e Is positioned over the center of the device 10e and the probe 30e is positioned above the outer edges of the device 10e and proximal to the material 15e.
  • the power source is isolating, energy is transferred from the co-axial probe to the device 10e and as the power source is shut-off or quiet, then energy is transferred from the device 10e to the system connected to the co-axial probe.
  • a voltage source e.g., an AC voltage or other isolating or alternating source 40 runs at a high frequency, e.g., 1 MHz, etc.
  • the voltage source is connected to the probes or plates.
  • the device 10 includes a control module 50 and bonding pads 52 to which the materials (for example, materials 14 and 16 of Fig. 1A ) are coupled.
  • a diode 54 such as a Schottky diode or other type of diode that creates an internal supply voltage
  • a switch 56 with some impedance that is turned on and off which changes the impedance of the device 10.
  • the variation in the impedance is used to communicate information about the identity of the device 10.
  • the change in impedance allows for the information associated with the device 10 to be encoded and sent to a system through the probes using capacity coupling, as represented by the capacitors 58 and 60.
  • the information is captured by the system connected to the probes represented by the capacitors and read as Vout through the sampling amplifier across the impedance labeled R-sample.
  • the oscillation signal contains information and the isolating signal can be encoded into, for example, a 1 MHz signal or similar frequency, e.g., 500 KHz, as may be dependent on the degree of capacitive coupling.
  • the voltage of the source 40 will be determined by how much capacitive coupling is achieved between the capacitive plate or probe 20 and 30 of Fig. 1 and the materials 14 and 16 thereof. Thus, at a high frequency that represents, perhaps, 5 volts, the capacitive value between the probe, such as probe 20 or 30, and the material is represented by the capacitors 58 and 60.
  • a diode bridge is shown that is a circuit representation of the interaction between the plates 20 and 30 and the materials 14 and 16 of the device 10.
  • the isolating voltage present at the plates 20 and 30 results in an energy transfer in the form of high voltage and a low voltage for the device 10.
  • the device 10 includes a control module as part of the processor or logic unit.
  • the logic unit may be a processor, a microprocessor, a multi-module device or any form of integrated circuit.
  • the logic unit is in communication with the conductive materials 14 and 16 and the plates 20 and 30 (labeled "PLATE 1" and "PLATE 2"). As the plates 20 and 30 are powered with an AC source, the logic unit stores energy and later uses that energy to send information.
  • the power cycle is shown with an active period and a quiet period and the transfer cycle of the device 10 is shown as the transfer window.
  • the duration of the active period energy is transferred from the power source to the device 10.
  • the energy stored by the device 10 is used to transfer energy from the device 10 to the system connected to the probes.
  • information associated with the device can be transferred from the device 10 through the probes 20 and 30 to the system connected to the probes.
  • the information sent from the device 10 to the system of the probes 20 and 30 during the quiet phase is based on the information stored in memory of the device. Thus, even though there is a "1" shown during the transfer window or quiet stage of the power source, the information transferred during the quiet stage or phase of the power source may be a "0".
  • 1A-1C will result in significant current going through which may be detected with, for example, by a sampling amplifier as shown in Fig. 2 .
  • the output is through a sampling amplifier which is essentially looking at the current going through the loop and the modulation of that current caused by the control module 50.
  • the capacitive coupling may be used with devices that are DC source devices, which are modified for interoperability, e.g., a device having a rectifier in place to provide a stable voltage on the chip, the impedance of which may be modulated.
  • the capacitive plates/probes and the system connected thereto for receiving information may be integrated or otherwise associated with various structural components and other devices, e.g., a tubular structure 60 as shown in Fig. 3A having capacitive plates 20 and 30.
  • a tubular structure 60 as shown in Fig. 3A having capacitive plates 20 and 30.
  • one or more pharmaceuticals having an IEM or similar device 10 may be introduced into the structure.
  • the device 10 may be introduced manually or automatically via automated means. As the device travels through the structure 60, the device 10 is probed by the capacitive plates 20 and 30 in the tube 60.
  • other devices and/or components may be associated.
  • a programmable device may be communicatively associated with the capacitive coupling device to receive and/or transmit data and/or information derived by the capacitive coupling device.
  • the capacitive coupling system can communicate, e.g., wireless, wired, etc., to a database with a display device for further storage, display, manipulation, etc. In this manner, an individual datum, data, large volumes of data, etc., may be processed for various purposes.
  • One such purpose may be, for example, to track pharmaceuticals in a supply chain application, e.g., during a manufacturing process such as a tablet pressing or other process, during a pharmacy verification process, during a pharmacy prescription process, etc.
  • Various processes may be complementary, incorporated, etc.
  • One such example is validation through reading the number. If it is valid, e.g., readable, the tablet is accepted. If not, the tablet is rejected.
  • a user or care provider can probe the product, which can be a pill or tablet in accordance with one aspect of the present invention, with the device 10 associated therewith and determine if the pill is authentic or a counterfeit product.
  • a pill having a device 10 is shown with a coating 74 that is non-conductive or fairly impervious coating and the pill itself comprises a non-conductive medicine powder.
  • a region 72 e.g., a cone-shaped region, as shown, comprises a conductive material 70, e.g., small particles or grains of conductive material intermixed with other pharmaceutical material(s), excipient(s), placebo material(s), etc., such that the region 72 is converted into a conductive region.
  • conductive material 70 e.g., small particles or grains of conductive material intermixed with other pharmaceutical material(s), excipient(s), placebo material(s), etc.
  • graphite and other conductive materials may be used, e.g., one part in ten, five parts in ten, etc. such that the region 72 is conductive.
  • the particles of the conductive material 70 in the region 72 may be shorted together.
  • the conductive material 70 may include various materials and form factors, as well as combinations thereof, e.g., variously sized particles, wires, metal films, threads, etc.
  • the scope of the present invention is not limited by the type or shape of the conductive material 70 used in the region 72.
  • the conductive material 70 may be integrated or formed via a variety of methods and proportions.
  • the device 10 is embedded or otherwise mechanically associated with a "doughnut-shaped" powder and the hole formed therein is filled or otherwise associated with the conductive particles, etc., to form the conductive region.
  • the size, area, volume, locations or other parameters of the conductive regions may vary to the extent the functionality described herein may be carried out.
  • capacitive plates or probes 80 and 82 are coupled to a system for collecting the data.
  • Probes 80 and 82 are used to probe the device 10 through capacitive coupling to the materials 84 and 86, respectively.
  • An impedance feedback system may be used to drive them fairly close to one another and once the current gets to a certain amount to use that to gauge the distance. Using a high enough impedance, this system may be useful in a variety of applications, e.g., a manufacturing environment to validate that the device 10 is present, is operating correctly etc.
  • a close proximity between the capacitive coupling probes/plates and the device 10 may facilitate, promote, etc., privacy aspects.
  • certain related devices may include, for example, a circuit with a Schottky diode in parallel with a CMOS transistor that is timed to be opened and closed, opened up, etc. Other circuit designs and modifications are possible.

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  • Engineering & Computer Science (AREA)
  • Business, Economics & Management (AREA)
  • Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Economics (AREA)
  • Entrepreneurship & Innovation (AREA)
  • Strategic Management (AREA)
  • Human Resources & Organizations (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Signal Processing (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Quality & Reliability (AREA)
  • General Business, Economics & Management (AREA)
  • Tourism & Hospitality (AREA)
  • Operations Research (AREA)
  • Development Economics (AREA)
  • Marketing (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Educational Administration (AREA)
  • Game Theory and Decision Science (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Pathology (AREA)
  • Human Computer Interaction (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Near-Field Transmission Systems (AREA)
  • Control Of Conveyors (AREA)
  • Power Sources (AREA)
EP18193299.7A 2009-11-04 2010-11-04 Système de gestion de chaîne d'approvisionnement Active EP3457582B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP20167424.9A EP3694113A1 (fr) 2009-11-04 2010-11-04 Système pour la gestion de chaîne d'approvisionnement

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25818209P 2009-11-04 2009-11-04
PCT/US2010/055522 WO2011057024A2 (fr) 2009-11-04 2010-11-04 Système pour la gestion de chaîne d'approvisionnement
EP10829125.3A EP2497054B1 (fr) 2009-11-04 2010-11-04 Système pour la gestion de chaîne d'approvisionnement

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP10829125.3A Division EP2497054B1 (fr) 2009-11-04 2010-11-04 Système pour la gestion de chaîne d'approvisionnement

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP20167424.9A Division-Into EP3694113A1 (fr) 2009-11-04 2010-11-04 Système pour la gestion de chaîne d'approvisionnement
EP20167424.9A Division EP3694113A1 (fr) 2009-11-04 2010-11-04 Système pour la gestion de chaîne d'approvisionnement

Publications (2)

Publication Number Publication Date
EP3457582A1 true EP3457582A1 (fr) 2019-03-20
EP3457582B1 EP3457582B1 (fr) 2020-09-30

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ID=43970768

Family Applications (3)

Application Number Title Priority Date Filing Date
EP10829125.3A Active EP2497054B1 (fr) 2009-11-04 2010-11-04 Système pour la gestion de chaîne d'approvisionnement
EP18193299.7A Active EP3457582B1 (fr) 2009-11-04 2010-11-04 Système de gestion de chaîne d'approvisionnement
EP20167424.9A Withdrawn EP3694113A1 (fr) 2009-11-04 2010-11-04 Système pour la gestion de chaîne d'approvisionnement

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP10829125.3A Active EP2497054B1 (fr) 2009-11-04 2010-11-04 Système pour la gestion de chaîne d'approvisionnement

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP20167424.9A Withdrawn EP3694113A1 (fr) 2009-11-04 2010-11-04 Système pour la gestion de chaîne d'approvisionnement

Country Status (20)

Country Link
US (5) US8868453B2 (fr)
EP (3) EP2497054B1 (fr)
JP (2) JP5697678B2 (fr)
KR (6) KR101845059B1 (fr)
CN (1) CN102667834B (fr)
AU (1) AU2010315128B2 (fr)
BR (1) BR112012010672B1 (fr)
CA (3) CA2980571C (fr)
CL (1) CL2012001174A1 (fr)
DK (1) DK2497054T3 (fr)
ES (1) ES2697510T3 (fr)
IL (4) IL219606A (fr)
MA (1) MA33727B1 (fr)
MY (1) MY154613A (fr)
PE (1) PE20130018A1 (fr)
SG (2) SG10202102470UA (fr)
TN (1) TN2012000199A1 (fr)
TW (1) TWI517050B (fr)
WO (1) WO2011057024A2 (fr)
ZA (1) ZA201203319B (fr)

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* Cited by examiner, † Cited by third party
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US8718193B2 (en) 2006-11-20 2014-05-06 Proteus Digital Health, Inc. Active signal processing personal health signal receivers
MY165368A (en) 2007-02-01 2018-03-21 Proteus Digital Health Inc Ingestible event marker systems
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US8115618B2 (en) 2007-05-24 2012-02-14 Proteus Biomedical, Inc. RFID antenna for in-body device
FI2192946T3 (fi) 2007-09-25 2022-11-30 Elimistön sisäinen laite, jossa on virtuaalinen dipolisignaalinvahvistus
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MY172060A (en) 2008-07-08 2019-11-13 Proteus Digital Health Inc Ingestible event marker data framework
WO2010080843A2 (fr) 2009-01-06 2010-07-15 Proteus Biomedical, Inc. Rétroaction biologique liée à l'ingestion et méthode de traitement médical personnalisée et système
TWI517050B (zh) 2009-11-04 2016-01-11 普羅托斯數位健康公司 供應鏈管理之系統
TWI557672B (zh) 2010-05-19 2016-11-11 波提亞斯數位康健公司 用於從製造商跟蹤藥物直到患者之電腦系統及電腦實施之方法、用於確認將藥物給予患者的設備及方法、患者介面裝置
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US20130129869A1 (en) 2011-11-23 2013-05-23 Hooman Hafezi Compositions comprising a shelf-life stability component
EP3968263A1 (fr) 2013-06-04 2022-03-16 Otsuka Pharmaceutical Co., Ltd. Système, appareil et procédés de collecte de données et d'évaluation des résultats
US10084880B2 (en) 2013-11-04 2018-09-25 Proteus Digital Health, Inc. Social media networking based on physiologic information
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ZA201203319B (en) 2015-11-25
EP2497054A4 (fr) 2014-12-03
MY154613A (en) 2015-07-15
AU2010315128B2 (en) 2016-11-17
CN102667834B (zh) 2016-08-31
EP2497054B1 (fr) 2018-09-12
KR20180035940A (ko) 2018-04-06
AU2010315128A1 (en) 2012-05-31
IL268511A (en) 2019-09-26
KR102002406B1 (ko) 2019-07-23
EP3457582B1 (fr) 2020-09-30
US20150171924A1 (en) 2015-06-18
CN102667834A (zh) 2012-09-12
US20170215761A1 (en) 2017-08-03
US9941931B2 (en) 2018-04-10
IL219606A0 (en) 2012-07-31
KR20200105538A (ko) 2020-09-07
JP5697678B2 (ja) 2015-04-08
CA2980571A1 (fr) 2011-05-12
DK2497054T3 (en) 2018-12-17
IL277105B (en) 2022-02-01
SG10202102470UA (en) 2021-04-29
BR112012010672A2 (pt) 2016-04-12
TWI517050B (zh) 2016-01-11
IL219606A (en) 2017-03-30
SG10201500851VA (en) 2015-04-29
BR112012010672B1 (pt) 2020-10-13
US20120220838A1 (en) 2012-08-30
KR20190089075A (ko) 2019-07-29
TN2012000199A1 (en) 2013-12-12
ES2697510T3 (es) 2019-01-24
JP2015133125A (ja) 2015-07-23
JP6005776B2 (ja) 2016-10-12
IL268511B (en) 2020-09-30
EP3694113A1 (fr) 2020-08-12
TW201140457A (en) 2011-11-16
KR20170081725A (ko) 2017-07-12
KR20190017062A (ko) 2019-02-19
CA3051659C (fr) 2022-03-08
PE20130018A1 (es) 2013-01-28
CA2780361A1 (fr) 2011-05-12
KR101845059B1 (ko) 2018-04-04
WO2011057024A2 (fr) 2011-05-12
US20190341967A1 (en) 2019-11-07
IL251223B (en) 2019-08-29
US11251834B2 (en) 2022-02-15
CA2980571C (fr) 2019-09-24
IL251223A0 (en) 2017-05-29
CL2012001174A1 (es) 2012-10-05
KR101948119B1 (ko) 2019-02-15
CA2780361C (fr) 2017-12-12
EP2497054A2 (fr) 2012-09-12
IL277105A (en) 2020-10-29
US11870508B2 (en) 2024-01-09
WO2011057024A3 (fr) 2011-08-18
US20220311474A1 (en) 2022-09-29
US10305544B2 (en) 2019-05-28
CA3051659A1 (fr) 2011-05-12
US8868453B2 (en) 2014-10-21
KR101754803B1 (ko) 2017-07-07
MA33727B1 (fr) 2012-11-01
KR102150605B1 (ko) 2020-09-02
KR20120102651A (ko) 2012-09-18
JP2013510374A (ja) 2013-03-21

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