EP3455337A4 - Systèmes et procédés pour l'enrichissement d'un échantillon en cellules cibles - Google Patents
Systèmes et procédés pour l'enrichissement d'un échantillon en cellules cibles Download PDFInfo
- Publication number
- EP3455337A4 EP3455337A4 EP16901116.0A EP16901116A EP3455337A4 EP 3455337 A4 EP3455337 A4 EP 3455337A4 EP 16901116 A EP16901116 A EP 16901116A EP 3455337 A4 EP3455337 A4 EP 3455337A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- sample
- systems
- methods
- target cells
- enriching target
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/56—Labware specially adapted for transferring fluids
- B01L3/567—Valves, taps or stop-cocks
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/04—Cell isolation or sorting
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0605—Metering of fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0621—Control of the sequence of chambers filled or emptied
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0652—Sorting or classification of particles or molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
- B01L2200/143—Quality control, feedback systems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/088—Channel loops
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0883—Serpentine channels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0622—Valves, specific forms thereof distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
- G01N2001/4083—Concentrating samples by other techniques involving separation of suspended solids sedimentation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Fluid Mechanics (AREA)
- Sustainable Development (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/SG2016/050205 WO2017192098A1 (fr) | 2016-05-04 | 2016-05-04 | Systèmes et procédés pour l'enrichissement d'un échantillon en cellules cibles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP3455337A1 EP3455337A1 (fr) | 2019-03-20 |
| EP3455337A4 true EP3455337A4 (fr) | 2020-01-01 |
Family
ID=60203155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP16901116.0A Withdrawn EP3455337A4 (fr) | 2016-05-04 | 2016-05-04 | Systèmes et procédés pour l'enrichissement d'un échantillon en cellules cibles |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11059042B2 (fr) |
| EP (1) | EP3455337A4 (fr) |
| JP (1) | JP6924210B2 (fr) |
| CN (1) | CN109072149B (fr) |
| AU (1) | AU2016405636B2 (fr) |
| SG (1) | SG11201809482TA (fr) |
| WO (1) | WO2017192098A1 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3455337A4 (fr) * | 2016-05-04 | 2020-01-01 | Biolidics Limited | Systèmes et procédés pour l'enrichissement d'un échantillon en cellules cibles |
| CN110951579A (zh) * | 2019-08-09 | 2020-04-03 | 上海乘黄纳米抗体科技有限公司 | 免疫磁珠分选容器、分选装置及分选系统 |
| US20220395831A1 (en) * | 2019-10-21 | 2022-12-15 | Nanyang Technological University | Direct and scalable isolation of circulating extracellular vesicles from whole blood using centrifugal forces |
| US20210237064A1 (en) | 2020-01-31 | 2021-08-05 | Astrin Biosciences, Inc. | Biological Fluid Filtration System |
| CN112903411B (zh) * | 2021-01-25 | 2023-02-03 | 东南大学 | 一种多模式生物粒子浓缩仪 |
| CN112958173B (zh) * | 2021-03-04 | 2023-01-10 | 深圳市美好创亿医疗科技股份有限公司 | 一种微流控试剂盒 |
| CN114806803A (zh) * | 2022-04-18 | 2022-07-29 | 广州万孚生物技术股份有限公司 | 细胞分选系统及其分选方法 |
| WO2024062903A1 (fr) * | 2022-09-21 | 2024-03-28 | キヤノン株式会社 | Dispositif à microcanaux, dispositif de séparation et procédé de séparation |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0901578A1 (fr) * | 1996-05-31 | 1999-03-17 | University of Washington | Microdistributeur de liquide sans clapet |
| EP1593968A2 (fr) * | 2004-05-06 | 2005-11-09 | Seiko Instruments Inc. | Dispositif, procédé et système d'analyse avec micropuces |
| US20110207621A1 (en) * | 2008-02-21 | 2011-08-25 | Avantra Biosciences Corporation | Assays Based on Liquid Flow over Arrays |
| WO2015002975A1 (fr) * | 2013-07-05 | 2015-01-08 | University Of Washington Through Its Center For Commercialization | Procédés, compositions et systèmes utilisables dans le cadre d'analyses microfluidiques |
| WO2015057159A1 (fr) * | 2013-10-16 | 2015-04-23 | Clearbridge Biomedics Pte Ltd | Trieur microfluidique pour détection et isolation de cellules |
| US20150226657A1 (en) * | 2014-02-13 | 2015-08-13 | Owl biomedical, Inc. | Microfluidic system with viscoelastic fluid |
| WO2016010861A1 (fr) * | 2014-07-14 | 2016-01-21 | President And Fellows Of Harvard College | Systèmes et procédés pour une performance améliorée de systèmes fluidiques et microfluidiques |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007084392A2 (fr) * | 2006-01-13 | 2007-07-26 | Micronics, Inc. | Soupapes a actionnement electromagnetique a utiliser dans des structures microfluidiques |
| JP5062658B2 (ja) | 2006-07-28 | 2012-10-31 | 東京エレクトロン株式会社 | 導波管内の定在波測定部および定在波測定方法、電磁波利用装置、プラズマ処理装置およびプラズマ処理方法 |
| JP2010151777A (ja) | 2008-11-19 | 2010-07-08 | Sony Corp | 微小粒子解析装置、微小粒子解析用マイクロチップ及び微小粒子解析方法 |
| ES2672366T3 (es) * | 2009-03-17 | 2018-06-14 | Menarini Silicon Biosystems S.P.A. | Dispositivo microfluídico para el aislamiento de celdas |
| JP2010226978A (ja) * | 2009-03-26 | 2010-10-14 | Mitsui Eng & Shipbuild Co Ltd | セルソータ |
| BRPI1106097A2 (pt) | 2010-01-24 | 2017-06-27 | Inst Chemy Fizycznej Polskiej Akademi Nauk | sistema e método para produção e manipulação automazitada de misturas liquidas |
| US20140087412A1 (en) | 2011-04-20 | 2014-03-27 | 4Dx Pty Ltd | Method and Device for Application of Fluid Forces to Cells |
| JP2015524674A (ja) * | 2012-08-17 | 2015-08-27 | ユニバーシティ オブ セントラル フロリダ リサーチ ファウンデーション,インコーポレイテッド | 哺乳動物系の機能的なインビトロ細胞モデルについての方法、システム、および組成物 |
| CN105682802B (zh) * | 2013-05-27 | 2018-03-16 | 星阵私人有限公司 | 一种微流控装置及控制其流体流动的方法 |
| US9863865B2 (en) * | 2013-10-01 | 2018-01-09 | Owl biomedical, Inc. | Cell sorting system using electromagnetic solenoid |
| SG2013078050A (en) * | 2013-10-16 | 2015-05-28 | Clearbridge Biomedics Pte Ltd | An interface for packaging a microfluidic device |
| US9360164B2 (en) * | 2013-12-12 | 2016-06-07 | Owl biomedical, Inc. | Particle manipulation system with stay-wet algorithm |
| WO2015200857A1 (fr) * | 2014-06-27 | 2015-12-30 | The Regents Of The University Of California | Appareil et procédé pour analyse sans marqueur de cellules rares provenant de fluides corporels |
| CN104195028B (zh) * | 2014-08-05 | 2017-07-25 | 深圳先进技术研究院 | 用于对特异性细胞进行筛选的微流控芯片及细胞筛选方法 |
| EP3455337A4 (fr) * | 2016-05-04 | 2020-01-01 | Biolidics Limited | Systèmes et procédés pour l'enrichissement d'un échantillon en cellules cibles |
-
2016
- 2016-05-04 EP EP16901116.0A patent/EP3455337A4/fr not_active Withdrawn
- 2016-05-04 CN CN201680085349.7A patent/CN109072149B/zh active Active
- 2016-05-04 US US16/098,025 patent/US11059042B2/en not_active Expired - Fee Related
- 2016-05-04 SG SG11201809482TA patent/SG11201809482TA/en unknown
- 2016-05-04 AU AU2016405636A patent/AU2016405636B2/en not_active Ceased
- 2016-05-04 WO PCT/SG2016/050205 patent/WO2017192098A1/fr not_active Ceased
- 2016-05-04 JP JP2018557005A patent/JP6924210B2/ja active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0901578A1 (fr) * | 1996-05-31 | 1999-03-17 | University of Washington | Microdistributeur de liquide sans clapet |
| EP0901578B1 (fr) * | 1996-05-31 | 2002-01-02 | University of Washington | Microdistributeur de liquide sans clapet e methode |
| EP1593968A2 (fr) * | 2004-05-06 | 2005-11-09 | Seiko Instruments Inc. | Dispositif, procédé et système d'analyse avec micropuces |
| US20110207621A1 (en) * | 2008-02-21 | 2011-08-25 | Avantra Biosciences Corporation | Assays Based on Liquid Flow over Arrays |
| WO2015002975A1 (fr) * | 2013-07-05 | 2015-01-08 | University Of Washington Through Its Center For Commercialization | Procédés, compositions et systèmes utilisables dans le cadre d'analyses microfluidiques |
| WO2015057159A1 (fr) * | 2013-10-16 | 2015-04-23 | Clearbridge Biomedics Pte Ltd | Trieur microfluidique pour détection et isolation de cellules |
| US20150226657A1 (en) * | 2014-02-13 | 2015-08-13 | Owl biomedical, Inc. | Microfluidic system with viscoelastic fluid |
| WO2016010861A1 (fr) * | 2014-07-14 | 2016-01-21 | President And Fellows Of Harvard College | Systèmes et procédés pour une performance améliorée de systèmes fluidiques et microfluidiques |
Non-Patent Citations (1)
| Title |
|---|
| See also references of WO2017192098A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US11059042B2 (en) | 2021-07-13 |
| CN109072149B (zh) | 2022-02-18 |
| JP6924210B2 (ja) | 2021-08-25 |
| AU2016405636B2 (en) | 2019-12-05 |
| US20190151847A1 (en) | 2019-05-23 |
| AU2016405636A1 (en) | 2018-11-15 |
| CN109072149A (zh) | 2018-12-21 |
| JP2019515678A (ja) | 2019-06-13 |
| EP3455337A1 (fr) | 2019-03-20 |
| SG11201809482TA (en) | 2018-11-29 |
| WO2017192098A1 (fr) | 2017-11-09 |
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