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EP3380834A4 - Modification de cible pour le suivi et la détection - Google Patents

Modification de cible pour le suivi et la détection Download PDF

Info

Publication number
EP3380834A4
EP3380834A4 EP16869269.7A EP16869269A EP3380834A4 EP 3380834 A4 EP3380834 A4 EP 3380834A4 EP 16869269 A EP16869269 A EP 16869269A EP 3380834 A4 EP3380834 A4 EP 3380834A4
Authority
EP
European Patent Office
Prior art keywords
monitoring
detection
target modification
modification
target
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP16869269.7A
Other languages
German (de)
English (en)
Other versions
EP3380834A1 (fr
Inventor
Trevor J. MORIN
Daniel A. Heller
William B. Dunbar
Tyler SHROPSHIRE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ontera Inc
Original Assignee
Ontera Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ontera Inc filed Critical Ontera Inc
Publication of EP3380834A1 publication Critical patent/EP3380834A1/fr
Publication of EP3380834A4 publication Critical patent/EP3380834A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9453—Cardioregulators, e.g. antihypotensives, antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/631—Detection means characterised by use of a special device being a biochannel or pore
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8827—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving nucleic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
EP16869269.7A 2015-11-23 2016-11-23 Modification de cible pour le suivi et la détection Withdrawn EP3380834A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562259012P 2015-11-23 2015-11-23
PCT/US2016/063597 WO2017091724A1 (fr) 2015-11-23 2016-11-23 Modification de cible pour le suivi et la détection

Publications (2)

Publication Number Publication Date
EP3380834A1 EP3380834A1 (fr) 2018-10-03
EP3380834A4 true EP3380834A4 (fr) 2019-08-21

Family

ID=58764396

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16869269.7A Withdrawn EP3380834A4 (fr) 2015-11-23 2016-11-23 Modification de cible pour le suivi et la détection

Country Status (9)

Country Link
US (1) US20180328919A1 (fr)
EP (1) EP3380834A4 (fr)
JP (1) JP2018537673A (fr)
KR (1) KR20180085742A (fr)
CN (1) CN108474760A (fr)
CA (1) CA3005299A1 (fr)
HK (1) HK1256108A1 (fr)
MX (1) MX2018006146A (fr)
WO (1) WO2017091724A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7612659B2 (ja) * 2019-07-31 2025-01-14 エーエックスバイオ インコーポレイテッド 標的分子を評価するためのシステム及び方法
GB202007911D0 (en) * 2020-05-27 2020-07-08 Imperial College Innovations Ltd Analyte detection method
CN115112729B (zh) * 2022-07-04 2024-05-24 南京师范大学 基于镧基金属有机笼的固态纳米孔检测磷酸基分子的方法
CN118609666B (zh) * 2024-07-19 2024-11-26 中国疾病预防控制中心环境与健康相关产品安全所 环境污染物与健康效应的关联识别及机制解析方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010082860A1 (fr) * 2009-01-19 2010-07-22 Instituto De Biologia Experimental E Tecnologia (Ibet) Procédé et dispositif de détection, basée sur les nanopores, des interactions protéine/protéine dans des molécules uniques
WO2010111605A2 (fr) * 2009-03-27 2010-09-30 Nabsys, Inc. La présente invention concerne des dispositifs et des procédés d'analyse de biomolécules et des sondes liées à celles-ci
US20110250705A1 (en) * 2010-04-09 2011-10-13 International Business Machines Corporation Nanopore capture system
WO2012021149A1 (fr) * 2010-08-12 2012-02-16 Winters-Hilt Stephen N Procédés et systèmes de biodétection faisant appel à des nanopores
WO2012088339A2 (fr) * 2010-12-22 2012-06-28 Genia Technologies, Inc. Caractérisation de molécules individuelles d'adn, sur nanopores, à l'aide de ralentisseurs
WO2016126748A1 (fr) * 2015-02-02 2016-08-11 Two Pore Guys, Inc. Lieurs labiles pour détection de biomarqueurs
WO2016126746A1 (fr) * 2015-02-02 2016-08-11 Two Pore Guys, Inc. Détection de nanopores de polynucléotides cibles à partir de fond d'échantillon
WO2016145415A1 (fr) * 2015-03-11 2016-09-15 Two Pore Guys, Inc. Détection par nanopores de petites molécules par des analyses de concurrence

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070054276A1 (en) * 2004-08-12 2007-03-08 Sampson Jeffrey R Polynucleotide analysis and methods of using nanopores
US20140335513A9 (en) * 2009-09-30 2014-11-13 Quantapore, Inc. Hybrid nanopore device with optical detection and methods of using same
WO2014071070A1 (fr) * 2012-11-01 2014-05-08 Pacific Biosciences Of California, Inc. Compositions et méthodes pour la sélection d'acides nucléiques
EP2994751B1 (fr) * 2013-05-06 2018-10-10 Two Pore Guys, Inc. Methode d'analyse pour des complexes de cibles biologiques avec un nanopore et protéine de fusion agent de liaison
EP3014264A4 (fr) * 2013-06-25 2016-11-16 Two Pore Guys Inc Quantification de biomarqueurs multiplexés par l'analyse de nanopores de complexes biomarqueur-polymère
EP3143165A4 (fr) * 2014-05-15 2018-05-16 Two Pore Guys, Inc. Stockage de données de structure et détection de cible dans un échantillon au moyen d'un nanopore

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010082860A1 (fr) * 2009-01-19 2010-07-22 Instituto De Biologia Experimental E Tecnologia (Ibet) Procédé et dispositif de détection, basée sur les nanopores, des interactions protéine/protéine dans des molécules uniques
WO2010111605A2 (fr) * 2009-03-27 2010-09-30 Nabsys, Inc. La présente invention concerne des dispositifs et des procédés d'analyse de biomolécules et des sondes liées à celles-ci
US20110250705A1 (en) * 2010-04-09 2011-10-13 International Business Machines Corporation Nanopore capture system
WO2012021149A1 (fr) * 2010-08-12 2012-02-16 Winters-Hilt Stephen N Procédés et systèmes de biodétection faisant appel à des nanopores
WO2012088339A2 (fr) * 2010-12-22 2012-06-28 Genia Technologies, Inc. Caractérisation de molécules individuelles d'adn, sur nanopores, à l'aide de ralentisseurs
WO2016126748A1 (fr) * 2015-02-02 2016-08-11 Two Pore Guys, Inc. Lieurs labiles pour détection de biomarqueurs
WO2016126746A1 (fr) * 2015-02-02 2016-08-11 Two Pore Guys, Inc. Détection de nanopores de polynucléotides cibles à partir de fond d'échantillon
WO2016145415A1 (fr) * 2015-03-11 2016-09-15 Two Pore Guys, Inc. Détection par nanopores de petites molécules par des analyses de concurrence

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
C. RAILLON ET AL: "Nanopore Detection of Single Molecule RNAP-DNA Transcription Complex", NANO LETTERS, vol. 12, no. 3, 2012, pages 1157 - 1164, XP055138698 *
See also references of WO2017091724A1 *
SHIV ACHARYA ET AL: "Research highlights: nanopore protein detection and analysis", LAB ON A CHIP, vol. 15, no. 17, 14 July 2015 (2015-07-14), pages 3424 - 3427, XP055575456 *

Also Published As

Publication number Publication date
WO2017091724A1 (fr) 2017-06-01
CA3005299A1 (fr) 2017-06-01
MX2018006146A (es) 2019-05-27
CN108474760A (zh) 2018-08-31
EP3380834A1 (fr) 2018-10-03
JP2018537673A (ja) 2018-12-20
KR20180085742A (ko) 2018-07-27
HK1256108A1 (zh) 2019-09-13
US20180328919A1 (en) 2018-11-15

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