EP3367785A4 - COMPOSITIONS AND METHODS FOR ASSISTING ORGAN ASSISTED BY A CHIMERIC EMBRYO - Google Patents

COMPOSITIONS AND METHODS FOR ASSISTING ORGAN ASSISTED BY A CHIMERIC EMBRYO Download PDF

Info

Publication number: EP3367785A4
Authority: EP; European Patent Office
Prior art keywords: assisting; assisted; organ; compositions; methods
Prior art date: 2015-10-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP16860830.5A

Other languages

German (de)

French (fr)

Other versions

EP3367785A2 (en

Inventor

Atsushi Asakura

Raj ARAVALLI

Maxim C. CHEERAN

James Dutton

Daniel J. GARRY

Mary G. GARRY

Melanie Graham

Ling Li

Walter Low

Angela Panoskaltsis-Mortari

Timothy O'brien

Clifford Steer

Jakub Tolar

Daniel F. Carlson

Scott C. Fahrenkrug

Naoko KOYANO-NAKAGAWA

Ann PARR

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of Minnesota Twin Cities

Recombinetics Inc

University of Minnesota System

Original Assignee

University of Minnesota Twin Cities

Recombinetics Inc

University of Minnesota System

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-10-27

Filing date

2016-10-27

Publication date

2019-08-14

2016-10-27 Application filed by University of Minnesota Twin Cities, Recombinetics Inc, University of Minnesota System filed Critical University of Minnesota Twin Cities

2018-09-05 Publication of EP3367785A2 publication Critical patent/EP3367785A2/en

2019-08-14 Publication of EP3367785A4 publication Critical patent/EP3367785A4/en

Status Withdrawn legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
- A01K2267/025—Animal producing cells or organs for transplantation

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Environmental Sciences (AREA)
Biotechnology (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Animal Husbandry (AREA)
Animal Behavior & Ethology (AREA)
Biodiversity & Conservation Biology (AREA)
Cell Biology (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Physics & Mathematics (AREA)
Mycology (AREA)
Veterinary Medicine (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Materials For Medical Uses (AREA)

EP16860830.5A 2015-10-27 2016-10-27 COMPOSITIONS AND METHODS FOR ASSISTING ORGAN ASSISTED BY A CHIMERIC EMBRYO Withdrawn EP3367785A4 (en)

Applications Claiming Priority (11)

Application Number	Priority Date	Filing Date	Title
US201562246929P	2015-10-27	2015-10-27
US201562246927P	2015-10-27	2015-10-27
US201562247117P	2015-10-27	2015-10-27
US201562247118P	2015-10-27	2015-10-27
US201562247096P	2015-10-27	2015-10-27
US201562246947P	2015-10-27	2015-10-27
US201562247092P	2015-10-27	2015-10-27
US201562246926P	2015-10-27	2015-10-27
US201562247115P	2015-10-27	2015-10-27
US201562247122P	2015-10-27	2015-10-27
PCT/US2016/059206 WO2017075276A2 (en)	2015-10-27	2016-10-27	Compositions and methods for chimeric embryo-assisted organ production

Publications (2)

Publication Number	Publication Date
EP3367785A2 EP3367785A2 (en)	2018-09-05
EP3367785A4 true EP3367785A4 (en)	2019-08-14

Family

ID=58631806

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP16860830.5A Withdrawn EP3367785A4 (en)	2015-10-27	2016-10-27	COMPOSITIONS AND METHODS FOR ASSISTING ORGAN ASSISTED BY A CHIMERIC EMBRYO

Country Status (7)

Country	Link
EP (1)	EP3367785A4 (en)
JP (1)	JP2019502400A (en)
KR (1)	KR20180100303A (en)
CN (1)	CN108697067A (en)
AU (1)	AU2016344152A1 (en)
CA (1)	CA3003652A1 (en)
WO (1)	WO2017075276A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2018506984A (en) *	2015-03-03	2018-03-15	リージェンツオブザユニバーシティオブミネソタ	ETV2 and its use
BR112017028608A2 (en)	2015-06-30	2018-09-04	Univ Minnesota	humanized heart muscle
CN108135943A (en)	2015-06-30	2018-06-08	明尼苏达大学校董会	The skeletal muscle of humanization
CN109414002A (en) *	2016-06-14	2019-03-01	里德尔再生医学研究所	Organ regeneration method using somatic cell nuclear transfer (SCNT) and blastocyst replenishment
WO2019033053A1 (en)	2017-08-11	2019-02-14	Recombinetics, Inc.	INDUCIBLE DISEASE MODELS, METHODS OF MAKING AND USING THEM IN TISSUE COMPLEMENTATION
CN109258575B (en) *	2018-12-10	2021-07-06	广东工业大学	A kind of incubation method of frog animal embryo
US11162079B2 (en)	2019-05-10	2021-11-02	The Regents Of The University Of California	Blood type O Rh-hypo-immunogenic pluripotent cells
JP2022532174A (en)	2019-05-10	2022-07-13	ザリージェンツオブザユニバーシティオブカリフォルニア	Modified pluripotent cells
US11859213B2 (en)	2019-05-16	2024-01-02	Regents Of The University Of Minnesota	Development of superior chimerism by hiPSC engineering and embryo aggregation
WO2020263880A1 (en) *	2019-06-26	2020-12-30	The Regents Of The University Of California	SIRPalpha-SILENCED NATURAL KILLER (NK) CELLS
US11576889B2 (en)	2019-09-23	2023-02-14	The Board Of Regents Of The University Of Texas System	Methods of identifying and treating patients with HIF-2 inhibitor resistance
CN116433652B (en) *	2023-05-11	2024-02-23	中南大学	Method, processor and device for determining pregnancy outcome of embryo transfer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20100122360A1 (en) *	2007-02-22	2010-05-13	The University Of Tokyo	Organ regeneration method utilizing blastocyst complementation

2016
- 2016-10-27 JP JP2018542691A patent/JP2019502400A/en active Pending
- 2016-10-27 EP EP16860830.5A patent/EP3367785A4/en not_active Withdrawn
- 2016-10-27 CA CA3003652A patent/CA3003652A1/en not_active Abandoned
- 2016-10-27 CN CN201680074878.7A patent/CN108697067A/en active Pending
- 2016-10-27 AU AU2016344152A patent/AU2016344152A1/en not_active Abandoned
- 2016-10-27 WO PCT/US2016/059206 patent/WO2017075276A2/en not_active Ceased
- 2016-10-27 KR KR1020187014498A patent/KR20180100303A/en not_active Withdrawn

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20100122360A1 (en) *	2007-02-22	2010-05-13	The University Of Tokyo	Organ regeneration method utilizing blastocyst complementation

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "Japan approves first human-animal embryo experiments", 26 July 2019 (2019-07-26), XP055643771, Retrieved from the Internet <URL:https://www.nature.com/articles/d41586-019-02275-3> [retrieved on 20191119] *
MADHUSUDANA GIRIJA SANAL: "Future of liver transplantation: Non-human primates for patient-specific organs from induced pluripotent stem cells", WORLD JOURNAL OF GASTROENTEROLOGY, vol. 17, no. 32, 2011, CN, pages 3684, XP055602899, ISSN: 1007-9327, DOI: 10.3748/wjg.v17.i32.3684 *
PREETHI SWAMINATHAN: "Human Stem Cell Complementation in PITX3 Null Porcine Blastocysts: Lens Development", December 2014 (2014-12-01), XP055493473, Retrieved from the Internet <URL:https://conservancy.umn.edu/bitstream/handle/11299/185108/Swaminathan_umn_0130M_15713.pdf?sequence=1> [retrieved on 20180718] *
XIANLONG WANG ET AL: "Efficient CRISPR/Cas9-mediated biallelic gene disruption and site-specific knockin after rapid selection of highly active sgRNAs in pigs", SCIENTIFIC REPORTS, vol. 5, no. 1, 21 August 2015 (2015-08-21), XP055551206, DOI: 10.1038/srep13348 *
YUYU NIU ET AL: "Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos", CELL, vol. 156, no. 4, February 2014 (2014-02-01), AMSTERDAM, NL, pages 836 - 843, XP055422516, ISSN: 0092-8674, DOI: 10.1016/j.cell.2014.01.027 *

Also Published As

Publication number	Publication date
KR20180100303A (en)	2018-09-10
CA3003652A1 (en)	2017-05-04
CN108697067A (en)	2018-10-23
JP2019502400A (en)	2019-01-31
WO2017075276A2 (en)	2017-05-04
EP3367785A2 (en)	2018-09-05
WO2017075276A3 (en)	2017-06-01
AU2016344152A1 (en)	2018-05-24

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2018-08-03	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
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2018-11-07	RIN1	Information on inventor provided before grant (corrected)	Inventor name: PANOSKALTSIS-MORTARI, ANGELA Inventor name: PARR, ANN Inventor name: ASAKURA, ATSUSHI Inventor name: KOYANO-NAKAGAWA, NAOKO Inventor name: O'BRIEN, TIMOTHY Inventor name: GARRY, MARY, G. Inventor name: DUTTON, JAMES Inventor name: CHEERAN, MAXIN Inventor name: CARLSON, DANIEL, F. Inventor name: LOW, WALTER Inventor name: FAHRENKRUG, SCOTT, C. Inventor name: GARRY, DANIEL, J. Inventor name: ARAVALLI, RAJ Inventor name: GRAHAM, MELANIE Inventor name: STEER, CLIFFORD Inventor name: LI, LING Inventor name: TOLAR, JAKUP
2019-01-30	DAV	Request for validation of the european patent (deleted)
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2019-04-17	RIN1	Information on inventor provided before grant (corrected)	Inventor name: CHEERAN, MAXIM C. Inventor name: PARR, ANN Inventor name: STEER, CLIFFORD Inventor name: TOLAR, JAKUB Inventor name: O'BRIEN, TIMOTHY Inventor name: GARRY, DANIEL, J. Inventor name: KOYANO-NAKAGAWA, NAOKO Inventor name: DUTTON, JAMES Inventor name: CARLSON, DANIEL, F. Inventor name: PANOSKALTSIS-MORTARI, ANGELA Inventor name: GARRY, MARY, G. Inventor name: LOW, WALTER Inventor name: ASAKURA, ATSUSHI Inventor name: ARAVALLI, RAJ Inventor name: LI, LING Inventor name: FAHRENKRUG, SCOTT, C. Inventor name: GRAHAM, MELANIE
2019-05-15	RIC1	Information provided on ipc code assigned before grant	Ipc: C12N 15/90 20060101ALI20190410BHEP Ipc: A01K 67/027 20060101AFI20190410BHEP Ipc: A01N 1/02 20060101ALI20190410BHEP Ipc: C12N 15/85 20060101ALI20190410BHEP Ipc: A61D 19/04 20060101ALI20190410BHEP
2019-08-14	A4	Supplementary search report drawn up and despatched	Effective date: 20190712
2019-08-14	RIC1	Information provided on ipc code assigned before grant	Ipc: C12N 15/85 20060101ALI20190708BHEP Ipc: A01K 67/027 20060101AFI20190708BHEP Ipc: C12N 15/90 20060101ALI20190708BHEP Ipc: A61D 19/04 20060101ALI20190708BHEP Ipc: A01N 1/02 20060101ALI20190708BHEP
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2020-10-21	RIN1	Information on inventor provided before grant (corrected)	Inventor name: O'BRIEN, TIMOTHY Inventor name: ARAVALLI, RAJ Inventor name: FAHRENKRUG, SCOTT, C. Inventor name: PANOSKALTSIS-MORTARI, ANGELA Inventor name: PARR, ANN Inventor name: KOYANO, NAOKO Inventor name: GARRY, MARY, G. Inventor name: GARRY, DANIEL, J. Inventor name: CHEERAN, MAXIM C. Inventor name: LI, LING Inventor name: ASAKURA, ATSUSHI Inventor name: LOW, WALTER Inventor name: GRAHAM, MELANIE Inventor name: DUTTON, JAMES Inventor name: CARLSON, DANIEL, F. Inventor name: STEER, CLIFFORD Inventor name: TOLAR, JAKUB
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