EP3226885A4 - Intermediates and processes to prepare micafungin - Google Patents

Intermediates and processes to prepare micafungin Download PDF

Info

Publication number: EP3226885A4
Authority: EP; European Patent Office
Prior art keywords: micafungin; intermediates; prepare; processes; prepare micafungin
Prior art date: 2014-10-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP15849490.6A

Other languages

German (de)

French (fr)

Other versions

EP3226885A2 (en

Inventor

Anand Vijaykumar MANTRI

Kumar HUCHANNA Yogish

Talluri Bhushaiah CHOWDARY

Gaurav Kulkarni

Ganga Ramu VASANTHAKUMAR

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Individual

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-10-07

Filing date

2015-10-07

Publication date

2018-07-18

2015-10-07 Application filed by Individual filed Critical Individual

2017-10-11 Publication of EP3226885A2 publication Critical patent/EP3226885A2/en

2018-07-18 Publication of EP3226885A4 publication Critical patent/EP3226885A4/en

Status Withdrawn legal-status Critical Current

Links

108010021062 Micafungin Proteins 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
PIEUQSKUWLMALL-YABMTYFHSA-N micafungin Chemical compound C1=CC(OCCCCC)=CC=C1C1=CC(C=2C=CC(=CC=2)C(=O)N[C@@H]2C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N3C[C@H](C)[C@H](O)[C@H]3C(=O)N[C@H](O)[C@H](O)C2)[C@H](O)CC(N)=O)[C@H](O)[C@@H](O)C=2C=C(OS(O)(=O)=O)C(O)=CC=2)[C@@H](C)O)=O)=NO1 PIEUQSKUWLMALL-YABMTYFHSA-N 0.000 title 1
229960002159 micafungin Drugs 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cephalosporin Compounds (AREA)

EP15849490.6A 2014-10-07 2015-10-07 Intermediates and processes to prepare micafungin Withdrawn EP3226885A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IN3174MU2014		2014-10-07
PCT/IN2015/000379 WO2016056023A2 (en)	2014-10-07	2015-10-07	Intermediates and processes to prepare micafungin

Publications (2)

Publication Number	Publication Date
EP3226885A2 EP3226885A2 (en)	2017-10-11
EP3226885A4 true EP3226885A4 (en)	2018-07-18

Family

ID=55653918

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP15849490.6A Withdrawn EP3226885A4 (en)	2014-10-07	2015-10-07	Intermediates and processes to prepare micafungin

Country Status (2)

Country	Link
EP (1)	EP3226885A4 (en)
WO (1)	WO2016056023A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN106866650A (en) *	2017-01-09	2017-06-20	博瑞生物医药泰兴市有限公司	A kind of synthesis of MFG and method of purification
WO2019138299A1 (en) *	2018-01-09	2019-07-18	Aurozymes	An improved process for the preparation of micafungin sodium
CN108752430B (en) *	2018-05-31	2022-02-18	杭州中美华东制药有限公司	Novel crystal form of micafungin sodium and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2013034670A1 (en) *	2011-09-09	2013-03-14	Sandoz Ag	Preparation of micafungin intermediates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT788511E (en) *	1994-10-07	2003-04-30	Fujisawa Pharmaceutical Co	CYCLE HEXAPEPTIDES WITH ANTIBIOTIC ACTIVITY
FR2794747B1 (en) *	1999-06-09	2004-04-16	Hoechst Marion Roussel Inc	NOVEL ECHINOCANDIN DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR APPLICATION AS ANTI-FUNGI
US7199248B2 (en) *	2002-08-08	2007-04-03	Astellas Pharma Inc.	Process

2015
- 2015-10-07 EP EP15849490.6A patent/EP3226885A4/en not_active Withdrawn
- 2015-10-07 WO PCT/IN2015/000379 patent/WO2016056023A2/en not_active Ceased

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2013034670A1 (en) *	2011-09-09	2013-03-14	Sandoz Ag	Preparation of micafungin intermediates

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ZBIGNIEW J. KAMINSKI: "Triazine-based condensing reagents", BIOPOLYMERS, vol. 55, no. 2, 1 January 2000 (2000-01-01), US, pages 140 - 164, XP055481702, ISSN: 0006-3525, DOI: 10.1002/1097-0282(2000)55:2<140::AID-BIP40>3.0.CO;2-B *

Also Published As

Publication number	Publication date
WO2016056023A2 (en)	2016-04-14
WO2016056023A3 (en)	2016-07-07
EP3226885A2 (en)	2017-10-11

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Legal Events

Date	Code	Title	Description
2017-09-08	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2017-10-11	17P	Request for examination filed	Effective date: 20170814
2017-10-11	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2017-10-11	AX	Request for extension of the european patent	Extension state: BA ME
2018-01-10	DAV	Request for validation of the european patent (deleted)
2018-01-10	DAX	Request for extension of the european patent (deleted)
2018-07-18	A4	Supplementary search report drawn up and despatched	Effective date: 20180619
2018-07-18	RIC1	Information provided on ipc code assigned before grant	Ipc: C07D 261/08 20060101AFI20180613BHEP Ipc: C07D 413/12 20060101ALI20180613BHEP Ipc: A61K 38/12 20060101ALI20180613BHEP
2019-10-23	17Q	First examination report despatched	Effective date: 20190924
2020-06-26	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2020-07-29	18D	Application deemed to be withdrawn	Effective date: 20200205