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EP3270081B1 - Systeme de transport et de stockage de medicaments - Google Patents

Systeme de transport et de stockage de medicaments Download PDF

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Publication number
EP3270081B1
EP3270081B1 EP16179091.0A EP16179091A EP3270081B1 EP 3270081 B1 EP3270081 B1 EP 3270081B1 EP 16179091 A EP16179091 A EP 16179091A EP 3270081 B1 EP3270081 B1 EP 3270081B1
Authority
EP
European Patent Office
Prior art keywords
cover
walls
fluid
container
lid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP16179091.0A
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German (de)
English (en)
Other versions
EP3270081A1 (fr
Inventor
Kai Bienert
Dirk Nehring
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Georg Utz Holding AG
Delta T Gesellschaft fur Medizintechnik Mbh
Original Assignee
Georg Utz Holding AG
Delta T Gesellschaft fur Medizintechnik Mbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georg Utz Holding AG, Delta T Gesellschaft fur Medizintechnik Mbh filed Critical Georg Utz Holding AG
Priority to EP16179091.0A priority Critical patent/EP3270081B1/fr
Publication of EP3270081A1 publication Critical patent/EP3270081A1/fr
Application granted granted Critical
Publication of EP3270081B1 publication Critical patent/EP3270081B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D3/00—Devices using other cold materials; Devices using cold-storage bodies
    • F25D3/02—Devices using other cold materials; Devices using cold-storage bodies using ice, e.g. ice-boxes
    • F25D3/06—Movable containers
    • F25D3/08—Movable containers portable, i.e. adapted to be carried personally
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D2303/00—Details of devices using other cold materials; Details of devices using cold-storage bodies
    • F25D2303/08—Devices using cold storage material, i.e. ice or other freezable liquid
    • F25D2303/083—Devices using cold storage material, i.e. ice or other freezable liquid using cold storage material disposed in closed wall forming part of a container for products to be cooled
    • F25D2303/0831—Devices using cold storage material, i.e. ice or other freezable liquid using cold storage material disposed in closed wall forming part of a container for products to be cooled the liquid is disposed in the space between the walls of the container
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D2303/00—Details of devices using other cold materials; Details of devices using cold-storage bodies
    • F25D2303/08—Devices using cold storage material, i.e. ice or other freezable liquid
    • F25D2303/084—Position of the cold storage material in relationship to a product to be cooled
    • F25D2303/0844—Position of the cold storage material in relationship to a product to be cooled above the product
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D2303/00—Details of devices using other cold materials; Details of devices using cold-storage bodies
    • F25D2303/08—Devices using cold storage material, i.e. ice or other freezable liquid
    • F25D2303/085—Compositions of cold storage materials

Definitions

  • the invention relates to a system for transporting and storing medicines or other goods in specified temperature ranges, having the features of the preamble of claim 1.
  • the temperature range of 15°C to 25°C is prescribed for most medicines, namely the temperature range of the so-called Controlled Room Temperature (CRT), which is also specified in the so-called “Good Distribution Practice”. Medicines that require a cold chain are transported and stored at 2° to 8° C.
  • CRT Controlled Room Temperature
  • an insulating container which is formed from a heat-insulating cover and a heat-insulating receiving part which enclose an interior which is provided with at least one tempering element to maintain temperatures.
  • From the document DE 100 30 102 A1 is a system for transporting goods at constant temperatures, in particular for transporting blood and medical products, with a storage, protection and transport container made of two cells for perishable products.
  • the two cells are each provided with a double wall, which is filled on the inside with a liquid or solid latent heat accumulator and at the same time has an insulating effect, with the transport container being designed in such a way that two of the same cells can be connected via preferably several snaps on the long sides.
  • the document DE 695 12 750 T2 discloses an insulated storage/transport container with a lid, each with a double wall, which is filled internally with a liquid or solid latent heat accumulator to maintain a constant temperature.
  • a system according to the preamble of claim 1 is off FR1 161 997 A known.
  • U.S. 3,205,677 A further discloses a nestable container for cooling glasses having a taper of 10° to 30°.
  • the object of the invention is to create a system for the transport and storage of medicines or other goods in predetermined temperature ranges, with which the disadvantages of the prior art are overcome.
  • a system for the transport and storage of medicines or other goods in predetermined temperature ranges is provided with at least one container with an interior space open on one side in a lower part surrounded by walls and with a lid that fits the opening of the container, the structure of the walls of the container and of the lid in each case results in at least one hollow body which is filled with at least one material or fluid with a high heat or cold storage capacity.
  • the walls result in a trough-shaped lower part, each with a greater length and width on an open side facing the lid than on a closed bottom on the side facing away from the lid, in order to ensure "nesting" and thus a volume reduction of stacked containers for space-saving storage and transporting the containers when the interiors of the bases are empty, depending on the angles caused by the greater length and width on the open side than on the closed bottom, which in turn correlate with the thickness of the wall of the bases, a space saving of between 30 and 90% can be achieved compared to conventional cuboid insulated containers.
  • the drugs or other goods that are to be transported or stored at temperatures that are as constant as possible in predetermined temperature ranges can be transported and/or stored in the interior of the lower part.
  • the system of the present invention enables the Transport for CRT with a container consisting of a lid and base without separate pre-temperature control of the system for a specific summer or winter scenario, as long as transport and storage can take place in the range of 20 to 22°C.
  • a fluid with a high heat or cold storage capacity that is filled into the at least one hollow body is additionally packed in plastic sleeves made of polyethylene or polyethylene film to prevent mixing with another fluid with a high heat or cold storage capacity in this hollow body.
  • At least one separate outer container made of cover and receiving part is provided with a space adapted to the container with the lid for receiving the container with the lid.
  • This preferred embodiment of the invention enables protected and heat-insulated transport and storage at CRT of a container made of lid and base in the space of the separate outer container from which the container can be removed.
  • the insulation material is made of rigid polyurethane foam, extruded rigid polystyrene foam (XPS), expanded polystyrene (EPS), polypropylene foam (EPP), Neopor, glass fibre, aerogel, extruded polyethylene (XPE) or vacuum panels and/or or a combination of these insulating materials.
  • the at least one material or fluid with a high heat storage capacity is in contact with the inner wall of the lower part, the at least one material or fluid having its phase change from solid to liquid or liquid to solid close to the specified temperature range.
  • the at least one material or fluid contains paraffins, paraffin mixtures or saturated n-hydrocarbon of the empirical formula C n H 2n+2 with a phase change between 17 and 20° C. and/or salt hydrates with a phase change between 22 and 25°C.
  • the salt hydrate contains strontium chloride, calcium bromide and calcium chloride dihydrate and water or calcium chloride, ammonium chloride, potassium chloride, magnesium chloride, sodium chloride and water.
  • heat-storing fluid is in the at least one Hollow body packed in the wall using foil or additional plastic sleeves.
  • fluids packaged in foil or in additional plastic casings contain two separate salt hydrates with different phase changes or two paraffins or paraffin mixtures are separated by the foil or the additional plastic casing, in particular saturated n-hydrocarbon of the empirical formula C n H 2n+ 2 with a number of 14 to 22 carbon atoms.
  • the film or additional plastic sleeve separates the fluids in the at least one hollow body so that they do not mix with one another.
  • the lid of the container is also provided on the inside with insulating material made of rigid polyurethane foam, XPS, EPS, EPP, Neopor, glass fiber, aerogel, XPE or vacuum panels on the outer wall.
  • that part of the cover which faces the interior of the lower part when it is placed on is filled with at least one material or fluid with a high heat storage capacity.
  • the cover is filled with the same material or fluid in the same or different mixing ratios as the lower part.
  • the cover is tightly connected to the lower part by gluing or welding, so that no fluid can escape.
  • the lid is attached to the base with at least one hinge.
  • the walls 4 of the lower part 5 have a stable outer wall 7 made of polystyrene, polyethylene (PSPE) or PP, insulation material 8 made of PU with vacuum panels and an inner wall 9 made of PP that delimits the interior space 3 .
  • the lid 6 of the container 2 has a stable outer wall 7 made of PSPE or PP and is provided with insulating material made from vacuum panels. Both the cover 6 and the lower part 5 are manufactured as a thermoforming or injection-molded part.
  • the walls 4 of the lower part 5 and the structure of the lid 6 each result in hollow bodies which are filled towards the inner wall 9 with a salt hydrate and a paraffin as a material or fluid (not shown) with a high heat storage capacity in order to keep the temperature in the interior 3 in the range to stabilize between 20° and 22° C.
  • Different fluids with a high heat storage capacity are packed in plastic sleeves made of polyethylene or in polyethylene film (not shown) to avoid mixing in this hollow body.
  • two different paraffins or two different salt hydrates are each packed separately in one of two plastic casings.
  • the walls 4 result in a conical, trough-shaped base 5 from top to bottom, each with greater length and width on an open top side facing the lid 6 than on a closed bottom on the bottom side facing away from the lid 6, the transitions from the open Side to the closed bottom are each substantially linear to "nesting ability" or "nestability” and thus a volume reduction of stacked containers 2 to ensure space-saving storage and transport of the stacked containers 2 when interiors 3 of the bases 5 are empty.
  • the conicity of the trough-shaped lower part 5 depends on the respective thickness of the walls 4 so that it can be nested. Thicknesses of the walls 4 vary between 5 to 30 mm.
  • the lower part 5 has handles or recessed grips for carrying (not shown).
  • the lid 6 of the container 2 is attached to the lower part 5 with hinges (not shown) or the lower part 5 and lid 6 are tightly connected to one another by gluing or welding, so that no fluid can escape from the interior 3 .
  • the cover 6 can be sealed to the base 5 .
  • FIGS Figure 3a Corresponding features are given the reference symbols from FIGS Figures 1, 2 designated.
  • a liquid crystal display (LCD) thermometer, temperature measuring probe, temperature data logger is provided as a temperature measuring device 14 on the cover 6 and on the lower part 5, which can be read or transmit their data by radio.
  • the container 2 is equipped with a radio frequency identification (RFID) chip (not shown).
  • RFID radio frequency identification
  • FIGS Figures 1, 2 Corresponding features are given the reference symbols from FIGS Figures 1a - 3a designated.
  • Another system 1 for the transport and storage of medicines in predetermined temperature ranges is provided with the container 2 with an interior 3 in the lower part 5 surrounded by walls 4 and with the lid 6 lying on the lower part 5 in such a way that the inner space 3 of the Lower part 5 is closed to the outside.
  • a separate outer container 10 designed as a cuboid with a cover 11 and a receiving part 12 with a space 13 adapted to the container 2 with the lid 6 is provided for receiving the container 2 with the lid 6 .
  • the outer container 10 can be closed and sealed.
  • FIGS Fig. 1a - 2 Corresponding features are given the reference symbols from FIGS Fig. 1a - 2 designated.
  • the trough-shaped lower part 5 can be accommodated with the lid 6 in the outer container 10 and the outer container 10 can be closed and sealed with the cover 11 on the receiving part 12 .
  • FIGS Fig. 1a - 3 Corresponding features are given the reference symbols from FIGS Fig. 1a - 3 designated.
  • Yet another system 15 for the transport and storage of medicines contains the trough-shaped lower part 5 with the lid 6 of the container 2, which can be accommodated in an outer container 16 that can be nested.
  • the nestable outer container 16 has a nestable receiving part 17 with handles or handle recesses 18 for carrying.
  • a profiled cover 19 of the nestable outer container 16 with handles 20 lying opposite on the circumference can be attached to the nestable receiving part 17 by means of hinges 25 .
  • the profiled cover 19 can be closed on the nestable receiving part 17 by means of retaining devices 26 .
  • FIGS Fig. 1a - 5 Corresponding features are given the reference symbols from FIGS Fig. 1a - 5 designated.
  • the profiled cover 19 has a substantially rectangular outline with rounded corners and edges.
  • the profiled cover 19 has rigidity-increasing profiles 21 in its surface.
  • the nestable receiving part 17 has an essentially rectangular outline and is designed with a greater length and width on the open side facing the profiled cover 19 than on the closed bottom on the side facing away from the profiled cover 19 in order to "nestability" or nestability and thus ensuring a volume reduction of empty, stacked receiving parts 17 for space-saving storage and transport.
  • Broad sides 27 of the nestable receiving part 17 each have a bead 22 that increases the dimensional stability of the nestable receiving part 17 for improved engagement over the entire height.
  • a readable LCD 23 is provided as a temperature measuring device on a longitudinal side 28 of the nestable outer container 16 .
  • a lower part 5 can be accommodated with a cover 6 in the nestable receiving part 17 in such a way that the cover 19 can be closed on the receiving part 17 .
  • FIGS Fig. 1a - 7 Corresponding features are given the reference symbols from FIGS Fig. 1a - 7 designated.
  • a base 5 is stacked in an empty, open base 5 received in a receptacle 17 .
  • a larger inner length on the lid 6-facing, open, upper side of 423 mm with a smaller inner length on the lid 6-facing, closed, lower side of 319 mm and a larger inner width on the lid 6-facing, open, upper side of 285 mm with a smaller inner width on the closed lower side facing away from the cover 6 of 181 mm with an inner height of approx. 245 mm results in a preferred taper of 12° for the lower part 5.
  • the stacked lower part 5 reaches into the empty, open lower part 5 with a box dimension 30 between 50 and 165 mm and projects out of the empty, open lower part 5 with a stack dimension 31 between 225 and 110 mm.
  • the box size 30 is 128 mm and the stack size 31 is 147 mm.

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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Combustion & Propulsion (AREA)
  • Physics & Mathematics (AREA)
  • Mechanical Engineering (AREA)
  • Thermal Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Packages (AREA)

Claims (14)

  1. Système (1, 15, 24) pour le transport et le stockage de médicaments dans des plages de température prédéterminées muni de - au moins un récipient (2) avec un espace intérieur (3) dans une partie basse (5) entouré de parois (4) et avec un couvercle (6), la structure des parois (4) de la partie basse (5) et du couvercle (6) aboutit à chaque fois à au moins un corps creux qui est rempli d'au moins un matériau ou fluide d'une capacité de stockage de chaleur élevée, et les parois (4) forment une partie inférieure en forme d'auge (5) avec une longueur et une largeur plus grandes au côté ouvert tourné vers un couvercle (6) que sur un fond fermé détourné du côté du couvercle (6), caractérisé en ce que les épaisseurs des parois (4) varient entre 5 à 30 mm, et les plus grandes longueurs et largeurs du côté supérieur ouvert tourné vers le couvercle (6) que du côté inférieur fermé côté opposé au couvercle (6) présentent des conicités entre 8° et 16°, ces conicités étant conditionnée par les épaisseurs des parois (4), afin de garantir la faculté d'emboîtement des conteneurs (2) empilés.
  2. Système (1, 15, 24) selon la revendication 1, caractérisé en ce que les plus grandes longueurs et largeurs du côté supérieur ouvert tourné vers le couvercle (6) que du côté inférieur fermé côté opposé au couvercle (6) présentent des conicités d'environ 12°, pour les parois (4) de la partie inférieure (5).
  3. Système (1, 15, 24) selon la revendication 1, caractérisé en ce qu'un fluide à haute capacité de stockage de chaleur ou de froid introduit dans le au moins un corps creux est en outre conditionné dans des manchons plastiques en polyéthylène ou en film de polyéthylène pour éviter le mélange avec un autre fluide.
  4. Système (1, 15) selon la revendication 1, caractérisé en ce qu'au moins un récipient extérieur séparé (10, 16) composé d'un couvercle (11, 18) et d'une partie réceptrice (12, 17) est équipé d'un couvercle (6) avec un espace adapté au récipient (2) avec le couvercle mis en place pour recevoir le récipient (2) avec le couvercle (6) est prévu.
  5. Système (1, 15, 24) selon la revendication 1, caractérisé en ce que les parois (4) de la partie inférieure (5) présentent une paroi extérieure stable (7), par ex. en polypropylène, matériau isolant (8), par ex. polyuréthane avec panneaux sous vide et une paroi intérieure (9), par ex. en polypropylène.
  6. Système (1, 15, 24) selon la revendication 5, caractérisé en ce que le matériau isolant (8) contient de la mousse rigide de polyuréthane, de la mousse rigide de polystyrène extrudé, du polystyrène expansé, de la mousse de polypropylène, du Neopor, de la fibre de verre, de l'aérogel, du polyéthylène extrudé ou des panneaux sous vide et/ou une combinaison de ces matériaux.
  7. Système (1, 15, 24) selon la revendication 1, caractérisé en ce que le au moins un matériau ou fluide à capacité de stockage de chaleur élevée est en contact avec la paroi interne (9) de la partie inférieure (5), le au moins un matériau ou le fluide change de phase de solide à liquide ou de liquide à solide près de l'une des plages de température spécifiées.
  8. Système (1, 15, 24) selon la revendication 1, caractérisé en ce que le au moins un matériau ou fluide contient des paraffines, des mélanges de paraffines ou des n-hydrocarbures saturés de formule moléculaire CnH2n+2 avec un changement de phase entre 17° et 20° C et/ou des hydrates de sel avec un changement de phase entre 22° et 25° C.
  9. Système (1, 15, 24) selon la revendication 8, caractérisé en ce que le sel hydraté contient du chlorure de strontium, du bromure de calcium et du chlorure de calcium dihydraté et de l'eau ou du chlorure de calcium, du chlorure d'ammonium, du chlorure de potassium, du chlorure de magnésium, du chlorure de sodium et de l'eau.
  10. Système (1, 15, 24) selon les revendications 7 à 9, caractérisé en ce que les fluides conditionnés dans des foils ou dans des manchons plastiques complémentaires contiennent deux hydrates salins distincts à changements de phase différents ou deux paraffines ou des mélanges de paraffines sont séparés par des foils ou des manchons plastiques complémentaires, en particulier un n-hydrocarbure saturé de formule moléculaire CnH2n+2 avec un nombre de 14 à 22 atomes de carbone.
  11. Système (1, 15, 24) selon la revendication 1, caractérisé en ce que le couvercle (6) du conteneur (2) est également pourvu d'un matériau isolant en mousse de polyuréthane rigide, XPS, EPS, EPP, Neopor, fibre de verre, aérogel, XPE ou panneaux sous vide.
  12. Système (1, 15, 24) selon la revendication 1, caractérisé en ce qu'une partie du corps creux du couvercle (6), qui fait face à l'intérieur (3) de la partie inférieure (5) lorsque le couvercle (6) est placé, est rempli d'au moins d'un matériau ou d'un fluide à haute capacité de stockage de chaleur.
  13. Système (1, 15, 24) selon la revendication 1, caractérisé en ce que le couvercle (6) est rempli du même matériau ou fluide dans des rapports de mélange identiques ou différents que la partie inférieure (5).
  14. Système (1, 15, 24) selon la revendication 1, caractérisé en ce que le couvercle (6) est fixé à la partie inférieure (5) par collage, soudure ou charnière.
EP16179091.0A 2016-07-12 2016-07-12 Systeme de transport et de stockage de medicaments Active EP3270081B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP16179091.0A EP3270081B1 (fr) 2016-07-12 2016-07-12 Systeme de transport et de stockage de medicaments

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16179091.0A EP3270081B1 (fr) 2016-07-12 2016-07-12 Systeme de transport et de stockage de medicaments

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EP3270081A1 EP3270081A1 (fr) 2018-01-17
EP3270081B1 true EP3270081B1 (fr) 2023-06-07

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1161997A (fr) * 1956-12-06 1958-09-08 Procédé et dispositif pour refroidir et maintenir au frais des substances solides ou liquides
US3205677A (en) * 1962-12-17 1965-09-14 Arthur M Stoner Portable device for cooling drinking glasses and the like and their contents
DE202011100097U1 (de) * 2011-05-02 2011-06-27 Optipack GmbH, 86850 Stapelbarer Verpackungsbehälter

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4528439A (en) * 1982-10-29 1985-07-09 Standard Oil Company Portable thermally insulated case
EP0718212B2 (fr) 1994-12-20 2004-09-15 Joseph N. Villa Récipient isolé de stockage/transport pour maintenir une température constante
DE10030102C2 (de) 2000-06-19 2003-05-15 Delta T Ges Fuer Medizintechni System zum Transport von Gütern bei gleichbleibenden Temperaturen
US6761041B2 (en) * 2002-09-06 2004-07-13 Henry Roth Thermal energy storage system
DE202006017869U1 (de) 2006-11-23 2007-03-15 delta T Gesellschaft für Medizintechnik mbH Isolierbehälter mit Temperierelementen
DE102008032531A1 (de) 2008-07-10 2010-01-21 Delta T Gmbh Temperierelement und Verfahren zum Betrieb eines Isolierbehälters
US8640487B2 (en) * 2009-07-08 2014-02-04 Adan Francisco Chapa Refreezable container
JP5402416B2 (ja) * 2009-09-02 2014-01-29 玉井化成株式会社 定温保管容器及び輸送方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1161997A (fr) * 1956-12-06 1958-09-08 Procédé et dispositif pour refroidir et maintenir au frais des substances solides ou liquides
US3205677A (en) * 1962-12-17 1965-09-14 Arthur M Stoner Portable device for cooling drinking glasses and the like and their contents
DE202011100097U1 (de) * 2011-05-02 2011-06-27 Optipack GmbH, 86850 Stapelbarer Verpackungsbehälter

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