EP3247403A1 - Cellobiose contenue dans des compositions à consommer ou à prendre par voie orale - Google Patents
Cellobiose contenue dans des compositions à consommer ou à prendre par voie oraleInfo
- Publication number
- EP3247403A1 EP3247403A1 EP16701354.9A EP16701354A EP3247403A1 EP 3247403 A1 EP3247403 A1 EP 3247403A1 EP 16701354 A EP16701354 A EP 16701354A EP 3247403 A1 EP3247403 A1 EP 3247403A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- weight
- composition
- cellobiose
- ingredient
- content
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- GUBGYTABKSRVRQ-CUHNMECISA-N D-Cellobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-CUHNMECISA-N 0.000 title claims abstract description 294
- 239000000203 mixture Substances 0.000 title claims abstract description 288
- 230000037406 food intake Effects 0.000 title claims abstract description 7
- 239000004615 ingredient Substances 0.000 claims abstract description 119
- 239000003765 sweetening agent Substances 0.000 claims abstract description 119
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 94
- 239000003814 drug Substances 0.000 claims abstract description 72
- 229940079593 drug Drugs 0.000 claims abstract description 38
- 239000007787 solid Substances 0.000 claims abstract description 38
- 235000021092 sugar substitutes Nutrition 0.000 claims abstract description 25
- 235000015097 nutrients Nutrition 0.000 claims abstract description 12
- 208000005223 Alkalosis Diseases 0.000 claims description 92
- 238000002360 preparation method Methods 0.000 claims description 83
- 239000000796 flavoring agent Substances 0.000 claims description 61
- 238000000034 method Methods 0.000 claims description 53
- 239000002245 particle Substances 0.000 claims description 52
- 239000003826 tablet Substances 0.000 claims description 29
- -1 flow regulators Substances 0.000 claims description 27
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 24
- 239000003795 chemical substances by application Substances 0.000 claims description 23
- 239000003925 fat Substances 0.000 claims description 22
- 235000019197 fats Nutrition 0.000 claims description 21
- 230000008569 process Effects 0.000 claims description 21
- 239000000126 substance Substances 0.000 claims description 20
- 239000002253 acid Substances 0.000 claims description 18
- 239000007938 effervescent tablet Substances 0.000 claims description 16
- 150000001720 carbohydrates Chemical class 0.000 claims description 15
- FYGDTMLNYKFZSV-ZWSAEMDYSA-N cellotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](OC(O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-ZWSAEMDYSA-N 0.000 claims description 15
- 229940124531 pharmaceutical excipient Drugs 0.000 claims description 14
- 230000003647 oxidation Effects 0.000 claims description 13
- 238000007254 oxidation reaction Methods 0.000 claims description 13
- OCIBBXPLUVYKCH-FYTDUCIRSA-N beta-D-cellohexaose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3[C@H](O[C@@H](O[C@@H]4[C@H](O[C@@H](O[C@@H]5[C@H](O[C@@H](O)[C@H](O)[C@H]5O)CO)[C@H](O)[C@H]4O)CO)[C@H](O)[C@H]3O)CO)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O OCIBBXPLUVYKCH-FYTDUCIRSA-N 0.000 claims description 12
- 235000014633 carbohydrates Nutrition 0.000 claims description 12
- OCIBBXPLUVYKCH-UHFFFAOYSA-N cellopentanose Natural products OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(OC2C(OC(OC3C(OC(OC4C(OC(OC5C(OC(O)C(O)C5O)CO)C(O)C4O)CO)C(O)C3O)CO)C(O)C2O)CO)C(O)C1O OCIBBXPLUVYKCH-UHFFFAOYSA-N 0.000 claims description 12
- FTNIPWXXIGNQQF-XHCCAYEESA-N cellopentaose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3[C@H](O[C@@H](O[C@@H]4[C@H](OC(O)[C@H](O)[C@H]4O)CO)[C@H](O)[C@H]3O)CO)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FTNIPWXXIGNQQF-XHCCAYEESA-N 0.000 claims description 12
- 239000003349 gelling agent Substances 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 11
- 241000196324 Embryophyta Species 0.000 claims description 10
- 229920002472 Starch Polymers 0.000 claims description 10
- 239000007884 disintegrant Substances 0.000 claims description 10
- 150000004676 glycans Chemical class 0.000 claims description 10
- 229920001282 polysaccharide Polymers 0.000 claims description 10
- 239000005017 polysaccharide Substances 0.000 claims description 10
- 235000019698 starch Nutrition 0.000 claims description 10
- LUEWUZLMQUOBSB-ZLBHSGTGSA-N alpha-maltotetraose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)O[C@H](O[C@@H]2[C@H](O[C@H](O[C@@H]3[C@H](O[C@H](O)[C@H](O)[C@H]3O)CO)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-ZLBHSGTGSA-N 0.000 claims description 9
- 239000008187 granular material Substances 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 8
- 239000000945 filler Substances 0.000 claims description 8
- 239000003921 oil Substances 0.000 claims description 8
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 7
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 7
- 229920002774 Maltodextrin Polymers 0.000 claims description 7
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 7
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 7
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 7
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 7
- 235000013355 food flavoring agent Nutrition 0.000 claims description 7
- 235000019198 oils Nutrition 0.000 claims description 7
- 239000000600 sorbitol Substances 0.000 claims description 7
- 235000010356 sorbitol Nutrition 0.000 claims description 7
- 229940088594 vitamin Drugs 0.000 claims description 7
- 229930003231 vitamin Natural products 0.000 claims description 7
- 235000013343 vitamin Nutrition 0.000 claims description 7
- 239000011782 vitamin Substances 0.000 claims description 7
- KVHQNWGLVVERFR-ACMTZBLWSA-N (3s)-3-amino-4-[[(2s)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid;6-methyl-2,2-dioxooxathiazin-4-one Chemical compound CC1=CC(=O)[NH2+]S(=O)(=O)O1.[O-]C(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 KVHQNWGLVVERFR-ACMTZBLWSA-N 0.000 claims description 6
- NUFKRGBSZPCGQB-FLBSXDLDSA-N (3s)-3-amino-4-oxo-4-[[(2r)-1-oxo-1-[(2,2,4,4-tetramethylthietan-3-yl)amino]propan-2-yl]amino]butanoic acid;pentahydrate Chemical compound O.O.O.O.O.OC(=O)C[C@H](N)C(=O)N[C@H](C)C(=O)NC1C(C)(C)SC1(C)C.OC(=O)C[C@H](N)C(=O)N[C@H](C)C(=O)NC1C(C)(C)SC1(C)C NUFKRGBSZPCGQB-FLBSXDLDSA-N 0.000 claims description 6
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 claims description 6
- 239000004377 Alitame Substances 0.000 claims description 6
- 108010011485 Aspartame Proteins 0.000 claims description 6
- 239000004385 Aspartame-acesulfame salt Substances 0.000 claims description 6
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 6
- GGLIEWRLXDLBBF-UHFFFAOYSA-N Dulcin Chemical compound CCOC1=CC=C(NC(N)=O)C=C1 GGLIEWRLXDLBBF-UHFFFAOYSA-N 0.000 claims description 6
- 239000004386 Erythritol Substances 0.000 claims description 6
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 6
- 229930195725 Mannitol Natural products 0.000 claims description 6
- 101710084933 Miraculin Proteins 0.000 claims description 6
- 108050004114 Monellin Proteins 0.000 claims description 6
- 239000004384 Neotame Substances 0.000 claims description 6
- 101000865553 Pentadiplandra brazzeana Defensin-like protein Proteins 0.000 claims description 6
- 244000228451 Stevia rebaudiana Species 0.000 claims description 6
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 6
- 239000004376 Sucralose Substances 0.000 claims description 6
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 6
- YGCFIWIQZPHFLU-UHFFFAOYSA-N acesulfame Chemical compound CC1=CC(=O)NS(=O)(=O)O1 YGCFIWIQZPHFLU-UHFFFAOYSA-N 0.000 claims description 6
- 229960005164 acesulfame Drugs 0.000 claims description 6
- 235000019409 alitame Nutrition 0.000 claims description 6
- 108010009985 alitame Proteins 0.000 claims description 6
- 239000000605 aspartame Substances 0.000 claims description 6
- 235000010357 aspartame Nutrition 0.000 claims description 6
- 229960003438 aspartame Drugs 0.000 claims description 6
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 6
- 235000019413 aspartame-acesulfame salt Nutrition 0.000 claims description 6
- 239000011230 binding agent Substances 0.000 claims description 6
- 229920002678 cellulose Polymers 0.000 claims description 6
- 108010010165 curculin Proteins 0.000 claims description 6
- 229940109275 cyclamate Drugs 0.000 claims description 6
- HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 claims description 6
- 239000003995 emulsifying agent Substances 0.000 claims description 6
- 235000019414 erythritol Nutrition 0.000 claims description 6
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 6
- 229940009714 erythritol Drugs 0.000 claims description 6
- 238000005469 granulation Methods 0.000 claims description 6
- 230000003179 granulation Effects 0.000 claims description 6
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 6
- 239000000905 isomalt Substances 0.000 claims description 6
- 235000010439 isomalt Nutrition 0.000 claims description 6
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 claims description 6
- 239000000832 lactitol Substances 0.000 claims description 6
- 235000010448 lactitol Nutrition 0.000 claims description 6
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 claims description 6
- 229960003451 lactitol Drugs 0.000 claims description 6
- 235000010449 maltitol Nutrition 0.000 claims description 6
- 239000000845 maltitol Substances 0.000 claims description 6
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 6
- 229940035436 maltitol Drugs 0.000 claims description 6
- 239000000594 mannitol Substances 0.000 claims description 6
- 235000010355 mannitol Nutrition 0.000 claims description 6
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 6
- 235000010755 mineral Nutrition 0.000 claims description 6
- 239000011707 mineral Substances 0.000 claims description 6
- ARGKVCXINMKCAZ-UZRWAPQLSA-N neohesperidin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O[C@H]3[C@@H]([C@H](O)[C@@H](O)[C@H](C)O3)O)=CC(O)=C2C(=O)C1 ARGKVCXINMKCAZ-UZRWAPQLSA-N 0.000 claims description 6
- ARGKVCXINMKCAZ-UHFFFAOYSA-N neohesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(CO)O3)OC3C(C(O)C(O)C(C)O3)O)=CC(O)=C2C(=O)C1 ARGKVCXINMKCAZ-UHFFFAOYSA-N 0.000 claims description 6
- 235000019412 neotame Nutrition 0.000 claims description 6
- HLIAVLHNDJUHFG-HOTGVXAUSA-N neotame Chemical compound CC(C)(C)CCN[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 HLIAVLHNDJUHFG-HOTGVXAUSA-N 0.000 claims description 6
- 108010070257 neotame Proteins 0.000 claims description 6
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 6
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 claims description 6
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims description 6
- 235000019204 saccharin Nutrition 0.000 claims description 6
- 229940081974 saccharin Drugs 0.000 claims description 6
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 6
- 229940013618 stevioside Drugs 0.000 claims description 6
- 235000019202 steviosides Nutrition 0.000 claims description 6
- 235000019408 sucralose Nutrition 0.000 claims description 6
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 6
- 239000000892 thaumatin Substances 0.000 claims description 6
- 235000010436 thaumatin Nutrition 0.000 claims description 6
- 239000000811 xylitol Substances 0.000 claims description 6
- 235000010447 xylitol Nutrition 0.000 claims description 6
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 6
- 229960002675 xylitol Drugs 0.000 claims description 6
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 5
- 229920001817 Agar Polymers 0.000 claims description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 5
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 5
- 239000008272 agar Substances 0.000 claims description 5
- 235000010419 agar Nutrition 0.000 claims description 5
- 239000000416 hydrocolloid Substances 0.000 claims description 5
- 229920005862 polyol Polymers 0.000 claims description 5
- 150000003077 polyols Chemical class 0.000 claims description 5
- 239000003755 preservative agent Substances 0.000 claims description 5
- 239000001993 wax Substances 0.000 claims description 5
- QZOALWMSYRBZSA-PDSBIMDKSA-N (3r,5r,8r,9r,10r,13s,14r)-3-[(2r,3r,4s,5s,6r)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-10,13-dimethyl-17-[(1s)-1-[(2r,5s,6r)-5-methyl-6-[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@H]1C[C@H]2C(=O)C[C@@H]3[C@H]4CCC([C@]4(CC[C@H]3[C@@]2(C)CC1)C)[C@H](C)[C@@H]1O[C@H](O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)[C@@H](C)CC1)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O QZOALWMSYRBZSA-PDSBIMDKSA-N 0.000 claims description 4
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 claims description 4
- 244000215068 Acacia senegal Species 0.000 claims description 4
- 229920000084 Gum arabic Polymers 0.000 claims description 4
- QZOALWMSYRBZSA-UHFFFAOYSA-N Osladin Natural products C1CC(C)C(OC2C(C(O)C(O)C(C)O2)O)OC1C(C)C(C1(CCC2C3(C)CC4)C)CCC1C2CC(=O)C3CC4OC1OC(CO)C(O)C(O)C1OC1OC(C)C(O)C(O)C1O QZOALWMSYRBZSA-UHFFFAOYSA-N 0.000 claims description 4
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 4
- 235000010489 acacia gum Nutrition 0.000 claims description 4
- 239000000654 additive Substances 0.000 claims description 4
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 4
- 239000003963 antioxidant agent Substances 0.000 claims description 4
- 235000006708 antioxidants Nutrition 0.000 claims description 4
- 235000010980 cellulose Nutrition 0.000 claims description 4
- 239000001913 cellulose Substances 0.000 claims description 4
- 229920003086 cellulose ether Polymers 0.000 claims description 4
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 4
- 239000000314 lubricant Substances 0.000 claims description 4
- 239000008188 pellet Substances 0.000 claims description 4
- 229960002477 riboflavin Drugs 0.000 claims description 4
- 238000005550 wet granulation Methods 0.000 claims description 4
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 3
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 3
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 3
- 240000008042 Zea mays Species 0.000 claims description 3
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 3
- 230000000996 additive effect Effects 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- 235000010216 calcium carbonate Nutrition 0.000 claims description 3
- 239000000378 calcium silicate Substances 0.000 claims description 3
- 229910052918 calcium silicate Inorganic materials 0.000 claims description 3
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 3
- 235000005822 corn Nutrition 0.000 claims description 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 3
- 239000008298 dragée Substances 0.000 claims description 3
- 238000007908 dry granulation Methods 0.000 claims description 3
- 239000000194 fatty acid Substances 0.000 claims description 3
- 229930195729 fatty acid Natural products 0.000 claims description 3
- 150000004665 fatty acids Chemical class 0.000 claims description 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 238000010525 oxidative degradation reaction Methods 0.000 claims description 3
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims description 3
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 3
- 238000003825 pressing Methods 0.000 claims description 3
- 235000018102 proteins Nutrition 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 3
- 229960003495 thiamine Drugs 0.000 claims description 3
- 229940011671 vitamin b6 Drugs 0.000 claims description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 2
- 235000006491 Acacia senegal Nutrition 0.000 claims description 2
- 241000416162 Astragalus gummifer Species 0.000 claims description 2
- 229920000858 Cyclodextrin Polymers 0.000 claims description 2
- 239000001856 Ethyl cellulose Substances 0.000 claims description 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 2
- 244000134552 Plantago ovata Species 0.000 claims description 2
- 235000003421 Plantago ovata Nutrition 0.000 claims description 2
- 239000009223 Psyllium Substances 0.000 claims description 2
- 235000015125 Sterculia urens Nutrition 0.000 claims description 2
- 240000001058 Sterculia urens Species 0.000 claims description 2
- 229920001615 Tragacanth Polymers 0.000 claims description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 2
- 229930003451 Vitamin B1 Natural products 0.000 claims description 2
- 229930003779 Vitamin B12 Natural products 0.000 claims description 2
- 229930003471 Vitamin B2 Natural products 0.000 claims description 2
- 229930003761 Vitamin B9 Natural products 0.000 claims description 2
- 229930003316 Vitamin D Natural products 0.000 claims description 2
- 229930003427 Vitamin E Natural products 0.000 claims description 2
- 229930003448 Vitamin K Natural products 0.000 claims description 2
- 239000000205 acacia gum Substances 0.000 claims description 2
- 235000010443 alginic acid Nutrition 0.000 claims description 2
- 229920000615 alginic acid Polymers 0.000 claims description 2
- 239000012736 aqueous medium Substances 0.000 claims description 2
- 235000010418 carrageenan Nutrition 0.000 claims description 2
- 229920001525 carrageenan Polymers 0.000 claims description 2
- 229940097362 cyclodextrins Drugs 0.000 claims description 2
- 238000007907 direct compression Methods 0.000 claims description 2
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 2
- 229920001249 ethyl cellulose Polymers 0.000 claims description 2
- 239000007888 film coating Substances 0.000 claims description 2
- 238000009501 film coating Methods 0.000 claims description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 2
- 239000003906 humectant Substances 0.000 claims description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 2
- 239000001095 magnesium carbonate Substances 0.000 claims description 2
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims description 2
- 229920000609 methyl cellulose Polymers 0.000 claims description 2
- 235000010981 methylcellulose Nutrition 0.000 claims description 2
- 239000001923 methylcellulose Substances 0.000 claims description 2
- 239000006082 mold release agent Substances 0.000 claims description 2
- 229960003512 nicotinic acid Drugs 0.000 claims description 2
- 239000011736 potassium bicarbonate Substances 0.000 claims description 2
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 2
- 235000015497 potassium bicarbonate Nutrition 0.000 claims description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 2
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 2
- 229940070687 psyllium Drugs 0.000 claims description 2
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 2
- 235000010413 sodium alginate Nutrition 0.000 claims description 2
- 239000000661 sodium alginate Substances 0.000 claims description 2
- 229940005550 sodium alginate Drugs 0.000 claims description 2
- 235000017550 sodium carbonate Nutrition 0.000 claims description 2
- 239000006188 syrup Substances 0.000 claims description 2
- 235000020357 syrup Nutrition 0.000 claims description 2
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 2
- 239000011573 trace mineral Substances 0.000 claims description 2
- 235000013619 trace mineral Nutrition 0.000 claims description 2
- 235000010487 tragacanth Nutrition 0.000 claims description 2
- 239000000196 tragacanth Substances 0.000 claims description 2
- 229940116362 tragacanth Drugs 0.000 claims description 2
- 235000019155 vitamin A Nutrition 0.000 claims description 2
- 239000011719 vitamin A Substances 0.000 claims description 2
- 235000010374 vitamin B1 Nutrition 0.000 claims description 2
- 239000011691 vitamin B1 Substances 0.000 claims description 2
- 235000019163 vitamin B12 Nutrition 0.000 claims description 2
- 239000011715 vitamin B12 Substances 0.000 claims description 2
- 235000019164 vitamin B2 Nutrition 0.000 claims description 2
- 239000011716 vitamin B2 Substances 0.000 claims description 2
- 235000019158 vitamin B6 Nutrition 0.000 claims description 2
- 239000011726 vitamin B6 Substances 0.000 claims description 2
- 235000019159 vitamin B9 Nutrition 0.000 claims description 2
- 239000011727 vitamin B9 Substances 0.000 claims description 2
- 235000019166 vitamin D Nutrition 0.000 claims description 2
- 239000011710 vitamin D Substances 0.000 claims description 2
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 2
- 235000019165 vitamin E Nutrition 0.000 claims description 2
- 239000011709 vitamin E Substances 0.000 claims description 2
- 229940046009 vitamin E Drugs 0.000 claims description 2
- 235000019168 vitamin K Nutrition 0.000 claims description 2
- 239000011712 vitamin K Substances 0.000 claims description 2
- 150000003721 vitamin K derivatives Chemical class 0.000 claims description 2
- 229940045997 vitamin a Drugs 0.000 claims description 2
- 229940046008 vitamin d Drugs 0.000 claims description 2
- 229940046010 vitamin k Drugs 0.000 claims description 2
- 229940075420 xanthine Drugs 0.000 claims description 2
- 150000003722 vitamin derivatives Chemical class 0.000 claims 4
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims 1
- 229930003537 Vitamin B3 Natural products 0.000 claims 1
- 229930003571 Vitamin B5 Natural products 0.000 claims 1
- 229930003756 Vitamin B7 Natural products 0.000 claims 1
- 229930003268 Vitamin C Natural products 0.000 claims 1
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims 1
- 229960002079 calcium pantothenate Drugs 0.000 claims 1
- 125000005588 carbonic acid salt group Chemical group 0.000 claims 1
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 claims 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims 1
- 235000014380 magnesium carbonate Nutrition 0.000 claims 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 1
- 235000011181 potassium carbonates Nutrition 0.000 claims 1
- 235000019160 vitamin B3 Nutrition 0.000 claims 1
- 239000011708 vitamin B3 Substances 0.000 claims 1
- 239000011675 vitamin B5 Substances 0.000 claims 1
- 235000009492 vitamin B5 Nutrition 0.000 claims 1
- 235000011912 vitamin B7 Nutrition 0.000 claims 1
- 239000011735 vitamin B7 Substances 0.000 claims 1
- 235000019154 vitamin C Nutrition 0.000 claims 1
- 239000011718 vitamin C Substances 0.000 claims 1
- 235000013305 food Nutrition 0.000 description 170
- 235000000346 sugar Nutrition 0.000 description 123
- 229930006000 Sucrose Natural products 0.000 description 75
- 239000005720 sucrose Substances 0.000 description 75
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 74
- 235000013399 edible fruits Nutrition 0.000 description 73
- 230000002340 alkalosis Effects 0.000 description 70
- 235000015872 dietary supplement Nutrition 0.000 description 67
- 235000012970 cakes Nutrition 0.000 description 56
- 235000009508 confectionery Nutrition 0.000 description 56
- 235000015173 baked goods and baking mixes Nutrition 0.000 description 52
- 235000019634 flavors Nutrition 0.000 description 52
- 239000008194 pharmaceutical composition Substances 0.000 description 33
- LKDRXBCSQODPBY-JDJSBBGDSA-N D-allulose Chemical compound OCC1(O)OC[C@@H](O)[C@@H](O)[C@H]1O LKDRXBCSQODPBY-JDJSBBGDSA-N 0.000 description 31
- 239000002552 dosage form Substances 0.000 description 30
- 239000000047 product Substances 0.000 description 29
- 239000007788 liquid Substances 0.000 description 28
- 239000011248 coating agent Substances 0.000 description 24
- 238000000576 coating method Methods 0.000 description 23
- 235000008429 bread Nutrition 0.000 description 22
- 239000000843 powder Substances 0.000 description 20
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 18
- 238000003860 storage Methods 0.000 description 18
- 244000299461 Theobroma cacao Species 0.000 description 14
- 235000013361 beverage Nutrition 0.000 description 14
- 235000014594 pastries Nutrition 0.000 description 14
- 238000006243 chemical reaction Methods 0.000 description 13
- 235000015094 jam Nutrition 0.000 description 13
- 239000000779 smoke Substances 0.000 description 13
- 239000000284 extract Substances 0.000 description 12
- 230000001953 sensory effect Effects 0.000 description 12
- 235000013599 spices Nutrition 0.000 description 11
- 241001465754 Metazoa Species 0.000 description 10
- 235000021307 Triticum Nutrition 0.000 description 10
- 241000209140 Triticum Species 0.000 description 10
- 230000008901 benefit Effects 0.000 description 10
- 230000008859 change Effects 0.000 description 10
- 235000013339 cereals Nutrition 0.000 description 9
- 235000019589 hardness Nutrition 0.000 description 9
- 230000002906 microbiologic effect Effects 0.000 description 9
- 244000269722 Thea sinensis Species 0.000 description 8
- 244000078534 Vaccinium myrtillus Species 0.000 description 8
- 239000000969 carrier Substances 0.000 description 8
- 235000019219 chocolate Nutrition 0.000 description 8
- 235000013365 dairy product Nutrition 0.000 description 8
- 238000001035 drying Methods 0.000 description 8
- 238000009472 formulation Methods 0.000 description 8
- 239000002904 solvent Substances 0.000 description 8
- 238000001694 spray drying Methods 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 102000004190 Enzymes Human genes 0.000 description 7
- 108090000790 Enzymes Proteins 0.000 description 7
- 235000016623 Fragaria vesca Nutrition 0.000 description 7
- 240000009088 Fragaria x ananassa Species 0.000 description 7
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 7
- 239000006071 cream Substances 0.000 description 7
- 239000000975 dye Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 230000001339 gustatory effect Effects 0.000 description 7
- 229920001542 oligosaccharide Polymers 0.000 description 7
- 150000002482 oligosaccharides Polymers 0.000 description 7
- 239000008107 starch Substances 0.000 description 7
- 235000019587 texture Nutrition 0.000 description 7
- 240000000560 Citrus x paradisi Species 0.000 description 6
- 229930091371 Fructose Natural products 0.000 description 6
- 239000005715 Fructose Substances 0.000 description 6
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
- 235000009470 Theobroma cacao Nutrition 0.000 description 6
- 235000012545 Vaccinium macrocarpon Nutrition 0.000 description 6
- 235000002118 Vaccinium oxycoccus Nutrition 0.000 description 6
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 6
- 235000015895 biscuits Nutrition 0.000 description 6
- 235000015165 citric acid Nutrition 0.000 description 6
- 235000004634 cranberry Nutrition 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 6
- 235000014571 nuts Nutrition 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 230000000007 visual effect Effects 0.000 description 6
- 244000291564 Allium cepa Species 0.000 description 5
- 235000006576 Althaea officinalis Nutrition 0.000 description 5
- 244000208874 Althaea officinalis Species 0.000 description 5
- 235000005979 Citrus limon Nutrition 0.000 description 5
- 244000131522 Citrus pyriformis Species 0.000 description 5
- 239000005913 Maltodextrin Substances 0.000 description 5
- 235000003095 Vaccinium corymbosum Nutrition 0.000 description 5
- 240000001717 Vaccinium macrocarpon Species 0.000 description 5
- 235000017537 Vaccinium myrtillus Nutrition 0.000 description 5
- 239000013543 active substance Substances 0.000 description 5
- 239000002671 adjuvant Substances 0.000 description 5
- 235000021014 blueberries Nutrition 0.000 description 5
- 235000014121 butter Nutrition 0.000 description 5
- 235000013351 cheese Nutrition 0.000 description 5
- 239000008121 dextrose Substances 0.000 description 5
- 230000002255 enzymatic effect Effects 0.000 description 5
- 235000015110 jellies Nutrition 0.000 description 5
- 229940035034 maltodextrin Drugs 0.000 description 5
- 235000001035 marshmallow Nutrition 0.000 description 5
- 244000005700 microbiome Species 0.000 description 5
- 235000011962 puddings Nutrition 0.000 description 5
- 235000013616 tea Nutrition 0.000 description 5
- 235000012794 white bread Nutrition 0.000 description 5
- MIDXCONKKJTLDX-UHFFFAOYSA-N 3,5-dimethylcyclopentane-1,2-dione Chemical compound CC1CC(C)C(=O)C1=O MIDXCONKKJTLDX-UHFFFAOYSA-N 0.000 description 4
- 235000002732 Allium cepa var. cepa Nutrition 0.000 description 4
- 241000167854 Bourreria succulenta Species 0.000 description 4
- 235000002566 Capsicum Nutrition 0.000 description 4
- 241000220225 Malus Species 0.000 description 4
- 235000009421 Myristica fragrans Nutrition 0.000 description 4
- 239000006002 Pepper Substances 0.000 description 4
- 235000016761 Piper aduncum Nutrition 0.000 description 4
- 240000003889 Piper guineense Species 0.000 description 4
- 235000017804 Piper guineense Nutrition 0.000 description 4
- 235000008184 Piper nigrum Nutrition 0.000 description 4
- 240000007313 Tilia cordata Species 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- 235000013736 caramel Nutrition 0.000 description 4
- 235000019693 cherries Nutrition 0.000 description 4
- 239000013078 crystal Substances 0.000 description 4
- 238000001125 extrusion Methods 0.000 description 4
- 235000013410 fast food Nutrition 0.000 description 4
- 238000004108 freeze drying Methods 0.000 description 4
- 239000000543 intermediate Substances 0.000 description 4
- 239000008274 jelly Substances 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 229920001592 potato starch Polymers 0.000 description 4
- 235000012780 rye bread Nutrition 0.000 description 4
- 150000008163 sugars Chemical class 0.000 description 4
- 235000013618 yogurt Nutrition 0.000 description 4
- 235000009434 Actinidia chinensis Nutrition 0.000 description 3
- 244000298697 Actinidia deliciosa Species 0.000 description 3
- 235000009436 Actinidia deliciosa Nutrition 0.000 description 3
- 240000002234 Allium sativum Species 0.000 description 3
- 244000144730 Amygdalus persica Species 0.000 description 3
- 244000099147 Ananas comosus Species 0.000 description 3
- 235000007119 Ananas comosus Nutrition 0.000 description 3
- 235000004936 Bromus mango Nutrition 0.000 description 3
- 240000004160 Capsicum annuum Species 0.000 description 3
- 235000008534 Capsicum annuum var annuum Nutrition 0.000 description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 3
- 240000006432 Carica papaya Species 0.000 description 3
- 235000009467 Carica papaya Nutrition 0.000 description 3
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 3
- 241001672694 Citrus reticulata Species 0.000 description 3
- 241001454694 Clupeiformes Species 0.000 description 3
- 235000017788 Cydonia oblonga Nutrition 0.000 description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical class C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
- 235000011430 Malus pumila Nutrition 0.000 description 3
- 235000015103 Malus silvestris Nutrition 0.000 description 3
- 240000007228 Mangifera indica Species 0.000 description 3
- 235000014826 Mangifera indica Nutrition 0.000 description 3
- 240000005561 Musa balbisiana Species 0.000 description 3
- 235000018290 Musa x paradisiaca Nutrition 0.000 description 3
- 244000270834 Myristica fragrans Species 0.000 description 3
- 240000007594 Oryza sativa Species 0.000 description 3
- 235000007164 Oryza sativa Nutrition 0.000 description 3
- 235000008753 Papaver somniferum Nutrition 0.000 description 3
- 235000000370 Passiflora edulis Nutrition 0.000 description 3
- 244000288157 Passiflora edulis Species 0.000 description 3
- 235000009827 Prunus armeniaca Nutrition 0.000 description 3
- 244000018633 Prunus armeniaca Species 0.000 description 3
- 241000198945 Prunus domestica subsp. syriaca Species 0.000 description 3
- 235000006029 Prunus persica var nucipersica Nutrition 0.000 description 3
- 235000006040 Prunus persica var persica Nutrition 0.000 description 3
- 244000017714 Prunus persica var. nucipersica Species 0.000 description 3
- 240000004350 Prunus spinosa Species 0.000 description 3
- 235000010829 Prunus spinosa Nutrition 0.000 description 3
- 241000220324 Pyrus Species 0.000 description 3
- 235000001537 Ribes X gardonianum Nutrition 0.000 description 3
- 235000001535 Ribes X utile Nutrition 0.000 description 3
- 235000002357 Ribes grossularia Nutrition 0.000 description 3
- 244000171263 Ribes grossularia Species 0.000 description 3
- 235000016919 Ribes petraeum Nutrition 0.000 description 3
- 244000281247 Ribes rubrum Species 0.000 description 3
- 235000002355 Ribes spicatum Nutrition 0.000 description 3
- 235000017848 Rubus fruticosus Nutrition 0.000 description 3
- 240000007651 Rubus glaucus Species 0.000 description 3
- 235000011034 Rubus glaucus Nutrition 0.000 description 3
- 235000009122 Rubus idaeus Nutrition 0.000 description 3
- 244000151637 Sambucus canadensis Species 0.000 description 3
- 235000018735 Sambucus canadensis Nutrition 0.000 description 3
- 235000009184 Spondias indica Nutrition 0.000 description 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 3
- 235000011941 Tilia x europaea Nutrition 0.000 description 3
- 235000009754 Vitis X bourquina Nutrition 0.000 description 3
- 235000012333 Vitis X labruscana Nutrition 0.000 description 3
- 240000006365 Vitis vinifera Species 0.000 description 3
- 235000014787 Vitis vinifera Nutrition 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 3
- 235000019513 anchovy Nutrition 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 235000019568 aromas Nutrition 0.000 description 3
- 230000033228 biological regulation Effects 0.000 description 3
- 235000021029 blackberry Nutrition 0.000 description 3
- 235000007123 blue elder Nutrition 0.000 description 3
- 239000001511 capsicum annuum Substances 0.000 description 3
- 239000000460 chlorine Chemical class 0.000 description 3
- 235000016213 coffee Nutrition 0.000 description 3
- 235000013353 coffee beverage Nutrition 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- 238000005034 decoration Methods 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 235000007124 elderberry Nutrition 0.000 description 3
- 238000005538 encapsulation Methods 0.000 description 3
- 235000008995 european elder Nutrition 0.000 description 3
- 238000011049 filling Methods 0.000 description 3
- 235000013312 flour Nutrition 0.000 description 3
- 235000012041 food component Nutrition 0.000 description 3
- 239000005417 food ingredient Substances 0.000 description 3
- 239000008369 fruit flavor Substances 0.000 description 3
- 235000004611 garlic Nutrition 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 235000015243 ice cream Nutrition 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 229960001375 lactose Drugs 0.000 description 3
- 239000004571 lime Substances 0.000 description 3
- 235000001510 limonene Nutrition 0.000 description 3
- 229940087305 limonene Drugs 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 235000013336 milk Nutrition 0.000 description 3
- 239000008267 milk Substances 0.000 description 3
- 210000004080 milk Anatomy 0.000 description 3
- 235000015145 nougat Nutrition 0.000 description 3
- 239000001702 nutmeg Substances 0.000 description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 3
- 235000010987 pectin Nutrition 0.000 description 3
- 239000001814 pectin Substances 0.000 description 3
- 229920001277 pectin Polymers 0.000 description 3
- 239000000825 pharmaceutical preparation Substances 0.000 description 3
- 229940127557 pharmaceutical product Drugs 0.000 description 3
- 235000013550 pizza Nutrition 0.000 description 3
- 235000013406 prebiotics Nutrition 0.000 description 3
- 239000002243 precursor Substances 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 235000009566 rice Nutrition 0.000 description 3
- 235000011888 snacks Nutrition 0.000 description 3
- UIIMBOGNXHQVGW-UHFFFAOYSA-M sodium bicarbonate Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 239000011975 tartaric acid Substances 0.000 description 3
- 235000002906 tartaric acid Nutrition 0.000 description 3
- 238000012549 training Methods 0.000 description 3
- ULDHMXUKGWMISQ-VIFPVBQESA-N (+)-carvone Chemical compound CC(=C)[C@H]1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-VIFPVBQESA-N 0.000 description 2
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 2
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 2
- 206010003402 Arthropod sting Diseases 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 2
- 240000007124 Brassica oleracea Species 0.000 description 2
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 description 2
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 description 2
- 235000017336 Capparis spinosa Nutrition 0.000 description 2
- 235000005747 Carum carvi Nutrition 0.000 description 2
- 240000000467 Carum carvi Species 0.000 description 2
- BAVONGHXFVOKBV-UHFFFAOYSA-N Carveol Chemical compound CC(=C)C1CC=C(C)C(O)C1 BAVONGHXFVOKBV-UHFFFAOYSA-N 0.000 description 2
- 241000283153 Cetacea Species 0.000 description 2
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- 229920002261 Corn starch Polymers 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- 235000015655 Crocus sativus Nutrition 0.000 description 2
- 244000124209 Crocus sativus Species 0.000 description 2
- 229920002785 Croscarmellose sodium Polymers 0.000 description 2
- 241000219112 Cucumis Species 0.000 description 2
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 2
- 244000007835 Cyamopsis tetragonoloba Species 0.000 description 2
- 235000002767 Daucus carota Nutrition 0.000 description 2
- 244000000626 Daucus carota Species 0.000 description 2
- 240000002943 Elettaria cardamomum Species 0.000 description 2
- 206010072104 Fructose intolerance Diseases 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 206010019878 Hereditary fructose intolerance Diseases 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical class [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- 244000165082 Lavanda vera Species 0.000 description 2
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 2
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 2
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical class [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- 240000003183 Manihot esculenta Species 0.000 description 2
- 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 2
- 244000062730 Melissa officinalis Species 0.000 description 2
- 235000005135 Micromeria juliana Nutrition 0.000 description 2
- 240000009023 Myrrhis odorata Species 0.000 description 2
- 235000007265 Myrrhis odorata Nutrition 0.000 description 2
- 241000198694 Passiflora pallida Species 0.000 description 2
- XCOJIVIDDFTHGB-UEUZTHOGSA-N Perillartine Chemical compound CC(=C)[C@H]1CCC(\C=N\O)=CC1 XCOJIVIDDFTHGB-UEUZTHOGSA-N 0.000 description 2
- 244000062780 Petroselinum sativum Species 0.000 description 2
- 235000012550 Pimpinella anisum Nutrition 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical class [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 235000014443 Pyrus communis Nutrition 0.000 description 2
- 244000088415 Raphanus sativus Species 0.000 description 2
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 235000007315 Satureja hortensis Nutrition 0.000 description 2
- 240000002114 Satureja hortensis Species 0.000 description 2
- 240000003768 Solanum lycopersicum Species 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 2
- 244000223014 Syzygium aromaticum Species 0.000 description 2
- 235000009499 Vanilla fragrans Nutrition 0.000 description 2
- 244000263375 Vanilla tahitensis Species 0.000 description 2
- 235000012036 Vanilla tahitensis Nutrition 0.000 description 2
- 235000006886 Zingiber officinale Nutrition 0.000 description 2
- 244000273928 Zingiber officinale Species 0.000 description 2
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 239000013566 allergen Substances 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 239000003674 animal food additive Substances 0.000 description 2
- 235000012665 annatto Nutrition 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 235000015241 bacon Nutrition 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 2
- FDSDTBUPSURDBL-LOFNIBRQSA-N canthaxanthin Chemical compound CC=1C(=O)CCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)CCC1(C)C FDSDTBUPSURDBL-LOFNIBRQSA-N 0.000 description 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 2
- 235000005300 cardamomo Nutrition 0.000 description 2
- 125000001547 cellobiose group Chemical group 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- 235000019804 chlorophyll Nutrition 0.000 description 2
- 229930002875 chlorophyll Natural products 0.000 description 2
- 235000017803 cinnamon Nutrition 0.000 description 2
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 238000004040 coloring Methods 0.000 description 2
- 238000005056 compaction Methods 0.000 description 2
- 238000010411 cooking Methods 0.000 description 2
- 235000014510 cooky Nutrition 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000008120 corn starch Substances 0.000 description 2
- 235000012495 crackers Nutrition 0.000 description 2
- 235000012777 crisp bread Nutrition 0.000 description 2
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 2
- 239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 description 2
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 description 2
- 235000021185 dessert Nutrition 0.000 description 2
- 235000011850 desserts Nutrition 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000007941 film coated tablet Substances 0.000 description 2
- 235000013373 food additive Nutrition 0.000 description 2
- 239000002778 food additive Substances 0.000 description 2
- 235000011194 food seasoning agent Nutrition 0.000 description 2
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 235000008397 ginger Nutrition 0.000 description 2
- 235000011868 grain product Nutrition 0.000 description 2
- 235000009569 green tea Nutrition 0.000 description 2
- 235000012907 honey Nutrition 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 239000003978 infusion fluid Substances 0.000 description 2
- 239000001102 lavandula vera Substances 0.000 description 2
- 235000018219 lavender Nutrition 0.000 description 2
- 239000004579 marble Substances 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 239000003094 microcapsule Substances 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 239000008601 oleoresin Substances 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 235000012771 pancakes Nutrition 0.000 description 2
- 235000012658 paprika extract Nutrition 0.000 description 2
- 235000011197 perejil Nutrition 0.000 description 2
- 235000015108 pies Nutrition 0.000 description 2
- 230000008092 positive effect Effects 0.000 description 2
- 235000012434 pretzels Nutrition 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 235000011835 quiches Nutrition 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 235000013974 saffron Nutrition 0.000 description 2
- 239000004248 saffron Substances 0.000 description 2
- 235000002020 sage Nutrition 0.000 description 2
- 235000015424 sodium Nutrition 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 239000000829 suppository Substances 0.000 description 2
- 235000019605 sweet taste sensations Nutrition 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 239000004408 titanium dioxide Substances 0.000 description 2
- 235000010215 titanium dioxide Nutrition 0.000 description 2
- 235000015149 toffees Nutrition 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 description 2
- 239000012808 vapor phase Substances 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 239000005418 vegetable material Substances 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- BAVONGHXFVOKBV-ZJUUUORDSA-N (-)-trans-carveol Natural products CC(=C)[C@@H]1CC=C(C)[C@@H](O)C1 BAVONGHXFVOKBV-ZJUUUORDSA-N 0.000 description 1
- CTMLKIKAUFEMLE-FTNGGYTGSA-N (2s)-4-[(e)-2-[(2s)-2-carboxy-6-hydroxy-5-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,3-dihydroindol-1-yl]ethenyl]-2,3-dihydropyridine-2,6-dicarboxylic acid Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=C1)O)=CC2=C1N(\C=C\C=1C[C@H](N=C(C=1)C(O)=O)C(O)=O)[C@H](C(O)=O)C2 CTMLKIKAUFEMLE-FTNGGYTGSA-N 0.000 description 1
- JKQXZKUSFCKOGQ-JLGXGRJMSA-N (3R,3'R)-beta,beta-carotene-3,3'-diol Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-JLGXGRJMSA-N 0.000 description 1
- VYIRVAXUEZSDNC-TXDLOWMYSA-N (3R,3'S,5'R)-3,3'-dihydroxy-beta-kappa-caroten-6'-one Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC(=O)[C@]1(C)C[C@@H](O)CC1(C)C VYIRVAXUEZSDNC-TXDLOWMYSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- BJHIKXHVCXFQLS-UHFFFAOYSA-N 1,3,4,5,6-pentahydroxyhexan-2-one Chemical compound OCC(O)C(O)C(O)C(=O)CO BJHIKXHVCXFQLS-UHFFFAOYSA-N 0.000 description 1
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- DFMMVLFMMAQXHZ-DOKBYWHISA-N 8'-apo-beta,psi-caroten-8'-al Chemical compound O=CC(/C)=C/C=C/C(/C)=C/C=C/C=C(\C)/C=C/C=C(\C)/C=C/C1=C(C)CCCC1(C)C DFMMVLFMMAQXHZ-DOKBYWHISA-N 0.000 description 1
- 240000004507 Abelmoschus esculentus Species 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 241001280436 Allium schoenoprasum Species 0.000 description 1
- 235000001270 Allium sibiricum Nutrition 0.000 description 1
- 235000009328 Amaranthus caudatus Nutrition 0.000 description 1
- 240000001592 Amaranthus caudatus Species 0.000 description 1
- 244000144725 Amygdalus communis Species 0.000 description 1
- 235000011437 Amygdalus communis Nutrition 0.000 description 1
- 244000226021 Anacardium occidentale Species 0.000 description 1
- 241000272517 Anseriformes Species 0.000 description 1
- 235000007258 Anthriscus cerefolium Nutrition 0.000 description 1
- 240000002022 Anthriscus cerefolium Species 0.000 description 1
- 240000007087 Apium graveolens Species 0.000 description 1
- 235000015849 Apium graveolens Dulce Group Nutrition 0.000 description 1
- 235000010591 Appio Nutrition 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 240000005528 Arctium lappa Species 0.000 description 1
- 235000003130 Arctium lappa Nutrition 0.000 description 1
- 235000008078 Arctium minus Nutrition 0.000 description 1
- 235000011330 Armoracia rusticana Nutrition 0.000 description 1
- 240000003291 Armoracia rusticana Species 0.000 description 1
- 235000003092 Artemisia dracunculus Nutrition 0.000 description 1
- 240000001851 Artemisia dracunculus Species 0.000 description 1
- 235000016425 Arthrospira platensis Nutrition 0.000 description 1
- 240000002900 Arthrospira platensis Species 0.000 description 1
- 241000972773 Aulopiformes Species 0.000 description 1
- 235000000832 Ayote Nutrition 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000023514 Barrett esophagus Diseases 0.000 description 1
- 235000012284 Bertholletia excelsa Nutrition 0.000 description 1
- 244000205479 Bertholletia excelsa Species 0.000 description 1
- 235000018185 Betula X alpestris Nutrition 0.000 description 1
- 235000018212 Betula X uliginosa Nutrition 0.000 description 1
- 241000219495 Betulaceae Species 0.000 description 1
- 244000017106 Bixa orellana Species 0.000 description 1
- 235000007689 Borago officinalis Nutrition 0.000 description 1
- 240000004355 Borago officinalis Species 0.000 description 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000219198 Brassica Species 0.000 description 1
- 244000174111 Brassica adpressa Species 0.000 description 1
- 235000003351 Brassica cretica Nutrition 0.000 description 1
- 235000011299 Brassica oleracea var botrytis Nutrition 0.000 description 1
- 235000017647 Brassica oleracea var italica Nutrition 0.000 description 1
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 description 1
- 235000012905 Brassica oleracea var viridis Nutrition 0.000 description 1
- 240000003259 Brassica oleracea var. botrytis Species 0.000 description 1
- 244000178937 Brassica oleracea var. capitata Species 0.000 description 1
- 244000304217 Brassica oleracea var. gongylodes Species 0.000 description 1
- 235000003343 Brassica rupestris Nutrition 0.000 description 1
- RTMBGDBBDQKNNZ-UHFFFAOYSA-L C.I. Acid Blue 3 Chemical compound [Ca+2].C1=CC(N(CC)CC)=CC=C1C(C=1C(=CC(=C(O)C=1)S([O-])(=O)=O)S([O-])(=O)=O)=C1C=CC(=[N+](CC)CC)C=C1.C1=CC(N(CC)CC)=CC=C1C(C=1C(=CC(=C(O)C=1)S([O-])(=O)=O)S([O-])(=O)=O)=C1C=CC(=[N+](CC)CC)C=C1 RTMBGDBBDQKNNZ-UHFFFAOYSA-L 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical class [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 244000191482 Cantharellus cibarius Species 0.000 description 1
- 235000015722 Cantharellus cibarius Nutrition 0.000 description 1
- 241000873224 Capparaceae Species 0.000 description 1
- 244000140995 Capparis spinosa Species 0.000 description 1
- VYIRVAXUEZSDNC-LOFNIBRQSA-N Capsanthyn Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC(=O)C2(C)CC(O)CC2(C)C VYIRVAXUEZSDNC-LOFNIBRQSA-N 0.000 description 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 description 1
- 244000020518 Carthamus tinctorius Species 0.000 description 1
- 235000009025 Carya illinoensis Nutrition 0.000 description 1
- 244000068645 Carya illinoensis Species 0.000 description 1
- 240000003538 Chamaemelum nobile Species 0.000 description 1
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical class [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical class [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 241000252203 Clupea harengus Species 0.000 description 1
- 244000155563 Cnicus benedictus Species 0.000 description 1
- 235000007856 Cnicus benedictus Nutrition 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 235000009046 Convallaria majalis Nutrition 0.000 description 1
- 244000068485 Convallaria majalis Species 0.000 description 1
- 244000018436 Coriandrum sativum Species 0.000 description 1
- 235000002787 Coriandrum sativum Nutrition 0.000 description 1
- 241001137251 Corvidae Species 0.000 description 1
- 240000009226 Corylus americana Species 0.000 description 1
- 235000001543 Corylus americana Nutrition 0.000 description 1
- 235000007466 Corylus avellana Nutrition 0.000 description 1
- 235000009917 Crataegus X brevipes Nutrition 0.000 description 1
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 description 1
- 235000009685 Crataegus X maligna Nutrition 0.000 description 1
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 description 1
- 235000009486 Crataegus bullatus Nutrition 0.000 description 1
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 description 1
- 235000009682 Crataegus limnophila Nutrition 0.000 description 1
- 240000000171 Crataegus monogyna Species 0.000 description 1
- 235000004423 Crataegus monogyna Nutrition 0.000 description 1
- 235000002313 Crataegus paludosa Nutrition 0.000 description 1
- 235000009840 Crataegus x incaedua Nutrition 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 240000008067 Cucumis sativus Species 0.000 description 1
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 1
- 235000009854 Cucurbita moschata Nutrition 0.000 description 1
- 240000001980 Cucurbita pepo Species 0.000 description 1
- 235000009804 Cucurbita pepo subsp pepo Nutrition 0.000 description 1
- 241000219130 Cucurbita pepo subsp. pepo Species 0.000 description 1
- 235000003954 Cucurbita pepo var melopepo Nutrition 0.000 description 1
- 235000007129 Cuminum cyminum Nutrition 0.000 description 1
- 244000304337 Cuminum cyminum Species 0.000 description 1
- 235000003392 Curcuma domestica Nutrition 0.000 description 1
- 244000008991 Curcuma longa Species 0.000 description 1
- 244000019459 Cynara cardunculus Species 0.000 description 1
- 235000019106 Cynara scolymus Nutrition 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- DFMMVLFMMAQXHZ-IZEVWJMWSA-N E 160e Natural products CC(=C/C=C/C(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)/C)C=O DFMMVLFMMAQXHZ-IZEVWJMWSA-N 0.000 description 1
- 239000004278 EU approved seasoning Substances 0.000 description 1
- 244000133098 Echinacea angustifolia Species 0.000 description 1
- 241000195955 Equisetum hyemale Species 0.000 description 1
- 235000016622 Filipendula ulmaria Nutrition 0.000 description 1
- 244000061544 Filipendula vulgaris Species 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical class FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 240000006927 Foeniculum vulgare Species 0.000 description 1
- 235000004204 Foeniculum vulgare Nutrition 0.000 description 1
- 244000307700 Fragaria vesca Species 0.000 description 1
- 241000195480 Fucus Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 244000258271 Galium odoratum Species 0.000 description 1
- 235000008526 Galium odoratum Nutrition 0.000 description 1
- 235000008100 Ginkgo biloba Nutrition 0.000 description 1
- 244000194101 Ginkgo biloba Species 0.000 description 1
- 241000208690 Hamamelis Species 0.000 description 1
- HYQNKKAJVPMBDR-HIFRSBDPSA-N Hernandulcin Chemical compound CC(C)=CCC[C@](C)(O)[C@@H]1CCC(C)=CC1=O HYQNKKAJVPMBDR-HIFRSBDPSA-N 0.000 description 1
- HYQNKKAJVPMBDR-UHFFFAOYSA-N Hernandulcin Natural products CC(C)=CCCC(C)(O)C1CCC(C)=CC1=O HYQNKKAJVPMBDR-UHFFFAOYSA-N 0.000 description 1
- 240000004153 Hibiscus sabdariffa Species 0.000 description 1
- 235000001018 Hibiscus sabdariffa Nutrition 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 235000017309 Hypericum perforatum Nutrition 0.000 description 1
- 244000141009 Hypericum perforatum Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 235000008227 Illicium verum Nutrition 0.000 description 1
- 240000007232 Illicium verum Species 0.000 description 1
- 229920001202 Inulin Polymers 0.000 description 1
- 244000017020 Ipomoea batatas Species 0.000 description 1
- 235000002678 Ipomoea batatas Nutrition 0.000 description 1
- 235000010254 Jasminum officinale Nutrition 0.000 description 1
- 240000005385 Jasminum sambac Species 0.000 description 1
- 240000007049 Juglans regia Species 0.000 description 1
- 235000009496 Juglans regia Nutrition 0.000 description 1
- 235000003228 Lactuca sativa Nutrition 0.000 description 1
- 240000008415 Lactuca sativa Species 0.000 description 1
- 240000006550 Lantana camara Species 0.000 description 1
- 235000013628 Lantana involucrata Nutrition 0.000 description 1
- 240000005183 Lantana involucrata Species 0.000 description 1
- 235000017858 Laurus nobilis Nutrition 0.000 description 1
- 241000212322 Levisticum officinale Species 0.000 description 1
- 241000234435 Lilium Species 0.000 description 1
- CCEFMUBVSUDRLG-XNWIYYODSA-N Limonene-1,2-epoxide Chemical compound C1[C@H](C(=C)C)CCC2(C)OC21 CCEFMUBVSUDRLG-XNWIYYODSA-N 0.000 description 1
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 description 1
- 235000018330 Macadamia integrifolia Nutrition 0.000 description 1
- 240000000912 Macadamia tetraphylla Species 0.000 description 1
- 235000003800 Macadamia tetraphylla Nutrition 0.000 description 1
- 235000000060 Malva neglecta Nutrition 0.000 description 1
- 240000000982 Malva neglecta Species 0.000 description 1
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 1
- 235000010654 Melissa officinalis Nutrition 0.000 description 1
- ABSPRNADVQNDOU-UHFFFAOYSA-N Menaquinone 1 Natural products C1=CC=C2C(=O)C(CC=C(C)C)=C(C)C(=O)C2=C1 ABSPRNADVQNDOU-UHFFFAOYSA-N 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- 235000006677 Monarda citriodora ssp. austromontana Nutrition 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
- 244000187664 Nerium oleander Species 0.000 description 1
- 239000006057 Non-nutritive feed additive Substances 0.000 description 1
- ZVKOASAVGLETCT-UOGKPENDSA-N Norbixin Chemical compound OC(=O)/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(\C)/C=C/C=C(\C)/C=C/C(O)=O ZVKOASAVGLETCT-UOGKPENDSA-N 0.000 description 1
- JERYLJRGLVHIEW-UENHKZIGSA-N Norbixin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C(=O)O)C=CC=CC=CC(=O)O JERYLJRGLVHIEW-UENHKZIGSA-N 0.000 description 1
- AYRXSINWFIIFAE-UHFFFAOYSA-N O6-alpha-D-Galactopyranosyl-D-galactose Natural products OCC1OC(OCC(O)C(O)C(O)C(O)C=O)C(O)C(O)C1O AYRXSINWFIIFAE-UHFFFAOYSA-N 0.000 description 1
- 235000010676 Ocimum basilicum Nutrition 0.000 description 1
- 240000007926 Ocimum gratissimum Species 0.000 description 1
- 235000011203 Origanum Nutrition 0.000 description 1
- 240000000783 Origanum majorana Species 0.000 description 1
- 241001184198 Orthosiphon Species 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 240000004371 Panax ginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 241000218996 Passiflora Species 0.000 description 1
- 240000004370 Pastinaca sativa Species 0.000 description 1
- 235000017769 Pastinaca sativa subsp sativa Nutrition 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- OOUTWVMJGMVRQF-DOYZGLONSA-N Phoenicoxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)C(=O)C(O)CC1(C)C)C=CC=C(/C)C=CC2=C(C)C(=O)CCC2(C)C OOUTWVMJGMVRQF-DOYZGLONSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical class [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 235000006990 Pimenta dioica Nutrition 0.000 description 1
- 240000008474 Pimenta dioica Species 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 235000016787 Piper methysticum Nutrition 0.000 description 1
- 240000005546 Piper methysticum Species 0.000 description 1
- 235000003447 Pistacia vera Nutrition 0.000 description 1
- 240000006711 Pistacia vera Species 0.000 description 1
- 235000010582 Pisum sativum Nutrition 0.000 description 1
- 240000004713 Pisum sativum Species 0.000 description 1
- 241000369592 Platycephalus richardsoni Species 0.000 description 1
- 235000019484 Rapeseed oil Nutrition 0.000 description 1
- 240000001890 Ribes hudsonianum Species 0.000 description 1
- 235000016954 Ribes hudsonianum Nutrition 0.000 description 1
- 235000001466 Ribes nigrum Nutrition 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 244000178231 Rosmarinus officinalis Species 0.000 description 1
- 235000005291 Rumex acetosa Nutrition 0.000 description 1
- 244000173853 Sanguisorba officinalis Species 0.000 description 1
- 241001125046 Sardina pilchardus Species 0.000 description 1
- 241000269821 Scombridae Species 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 235000003434 Sesamum indicum Nutrition 0.000 description 1
- 244000040738 Sesamum orientale Species 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000001744 Sodium fumarate Substances 0.000 description 1
- 244000061458 Solanum melongena Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000009337 Spinacia oleracea Nutrition 0.000 description 1
- 244000300264 Spinacia oleracea Species 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical class [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 description 1
- 235000019486 Sunflower oil Nutrition 0.000 description 1
- 240000001949 Taraxacum officinale Species 0.000 description 1
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 description 1
- 244000125380 Terminalia tomentosa Species 0.000 description 1
- 235000005212 Terminalia tomentosa Nutrition 0.000 description 1
- 235000006468 Thea sinensis Nutrition 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- 235000007303 Thymus vulgaris Nutrition 0.000 description 1
- 240000002657 Thymus vulgaris Species 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 244000291414 Vaccinium oxycoccus Species 0.000 description 1
- 235000013832 Valeriana officinalis Nutrition 0.000 description 1
- 244000126014 Valeriana officinalis Species 0.000 description 1
- 244000172533 Viola sororia Species 0.000 description 1
- 241000219094 Vitaceae Species 0.000 description 1
- 244000195452 Wasabia japonica Species 0.000 description 1
- 235000000760 Wasabia japonica Nutrition 0.000 description 1
- JKQXZKUSFCKOGQ-LQFQNGICSA-N Z-zeaxanthin Natural products C([C@H](O)CC=1C)C(C)(C)C=1C=CC(C)=CC=CC(C)=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-LQFQNGICSA-N 0.000 description 1
- 241000482268 Zea mays subsp. mays Species 0.000 description 1
- QOPRSMDTRDMBNK-RNUUUQFGSA-N Zeaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCC(O)C1(C)C)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C QOPRSMDTRDMBNK-RNUUUQFGSA-N 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 238000010669 acid-base reaction Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 229910000288 alkali metal carbonate Inorganic materials 0.000 description 1
- 150000008041 alkali metal carbonates Chemical class 0.000 description 1
- ZVKOASAVGLETCT-UOAMSCJGSA-N all-trans norbixin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C(=O)O)C=CC=C(/C)C=CC(=O)O ZVKOASAVGLETCT-UOAMSCJGSA-N 0.000 description 1
- JKQXZKUSFCKOGQ-LOFNIBRQSA-N all-trans-Zeaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C JKQXZKUSFCKOGQ-LOFNIBRQSA-N 0.000 description 1
- 235000020224 almond Nutrition 0.000 description 1
- LKDRXBCSQODPBY-ZXXMMSQZSA-N alpha-D-fructopyranose Chemical compound OC[C@]1(O)OC[C@@H](O)[C@@H](O)[C@@H]1O LKDRXBCSQODPBY-ZXXMMSQZSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 235000010210 aluminium Nutrition 0.000 description 1
- 235000012735 amaranth Nutrition 0.000 description 1
- 239000004178 amaranth Substances 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 235000012706 ammonia caramel Nutrition 0.000 description 1
- 239000004125 ammonia caramel Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000001670 anatto Substances 0.000 description 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 1
- 239000010362 annatto Substances 0.000 description 1
- 235000010208 anthocyanin Nutrition 0.000 description 1
- 239000004410 anthocyanin Substances 0.000 description 1
- 229930002877 anthocyanin Natural products 0.000 description 1
- 150000004636 anthocyanins Chemical class 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 235000013549 apple pie Nutrition 0.000 description 1
- 235000021016 apples Nutrition 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 235000016520 artichoke thistle Nutrition 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 239000004176 azorubin Substances 0.000 description 1
- 235000012820 baking ingredients and mixes Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000020279 black tea Nutrition 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- 235000012813 breadcrumbs Nutrition 0.000 description 1
- 235000012713 brown FK Nutrition 0.000 description 1
- 239000004109 brown FK Substances 0.000 description 1
- 239000008372 bubblegum flavor Substances 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 238000009924 canning Methods 0.000 description 1
- 235000012682 canthaxanthin Nutrition 0.000 description 1
- 239000001659 canthaxanthin Substances 0.000 description 1
- 229940008033 canthaxanthin Drugs 0.000 description 1
- 235000015116 cappuccino Nutrition 0.000 description 1
- WRANYHFEXGNSND-LOFNIBRQSA-N capsanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC(=O)C2(C)CCC(O)C2(C)C WRANYHFEXGNSND-LOFNIBRQSA-N 0.000 description 1
- 235000018889 capsanthin Nutrition 0.000 description 1
- 239000001325 capsicum annuum l. var. longum oleoresin Substances 0.000 description 1
- 239000001722 capsicum frutescens oleoresin Substances 0.000 description 1
- 229940050948 capsicum oleoresin Drugs 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 150000001746 carotenes Chemical class 0.000 description 1
- 235000005473 carotenes Nutrition 0.000 description 1
- 229930007646 carveol Natural products 0.000 description 1
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Natural products CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 1
- 235000020226 cashew nut Nutrition 0.000 description 1
- OIQPTROHQCGFEF-UHFFFAOYSA-L chembl1371409 Chemical compound [Na+].[Na+].OC1=CC=C2C=C(S([O-])(=O)=O)C=CC2=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 OIQPTROHQCGFEF-UHFFFAOYSA-L 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 235000009520 chilled ready meals Nutrition 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 150000001805 chlorine compounds Chemical class 0.000 description 1
- 229940106705 chlorophyll Drugs 0.000 description 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
- 239000001752 chlorophylls and chlorophyllins Substances 0.000 description 1
- 239000008370 chocolate flavor Substances 0.000 description 1
- 239000011651 chromium Chemical class 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000010941 cobalt Chemical class 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical class [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 description 1
- JZGWEIPJUAIDHM-QURGRASLSA-N cochineal red a Chemical compound C1=CC=C2C(/N=N/C3=C4C(=CC(=CC4=CC=C3O)S(O)(=O)=O)S(O)(=O)=O)=CC=C(S(O)(=O)=O)C2=C1 JZGWEIPJUAIDHM-QURGRASLSA-N 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000012050 conventional carrier Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 235000021532 culinary herbs Nutrition 0.000 description 1
- 235000003373 curcuma longa Nutrition 0.000 description 1
- 235000012754 curcumin Nutrition 0.000 description 1
- 239000004148 curcumin Substances 0.000 description 1
- 229940109262 curcumin Drugs 0.000 description 1
- 235000019503 curry powder Nutrition 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 150000001991 dicarboxylic acids Chemical class 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 description 1
- 238000002050 diffraction method Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 239000002526 disodium citrate Substances 0.000 description 1
- 235000019262 disodium citrate Nutrition 0.000 description 1
- MSJMDZAOKORVFC-SEPHDYHBSA-L disodium fumarate Chemical compound [Na+].[Na+].[O-]C(=O)\C=C\C([O-])=O MSJMDZAOKORVFC-SEPHDYHBSA-L 0.000 description 1
- CEYULKASIQJZGP-UHFFFAOYSA-L disodium;2-(carboxymethyl)-2-hydroxybutanedioate Chemical compound [Na+].[Na+].[O-]C(=O)CC(O)(C(=O)O)CC([O-])=O CEYULKASIQJZGP-UHFFFAOYSA-L 0.000 description 1
- YSVBPNGJESBVRM-UHFFFAOYSA-L disodium;4-[(1-oxido-4-sulfonaphthalen-2-yl)diazenyl]naphthalene-1-sulfonate Chemical compound [Na+].[Na+].C1=CC=C2C(N=NC3=C(C4=CC=CC=C4C(=C3)S([O-])(=O)=O)O)=CC=C(S([O-])(=O)=O)C2=C1 YSVBPNGJESBVRM-UHFFFAOYSA-L 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 235000012489 doughnuts Nutrition 0.000 description 1
- 239000008126 dulcin Substances 0.000 description 1
- NWNUTSZTAUGIGA-UHFFFAOYSA-N dulcin Natural products C12CC(C)(C)CCC2(C(=O)OC2C(C(O)C(O)C(COC3C(C(O)C(O)CO3)O)O2)O)C(O)CC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1OC1OC(CO)C(O)C(O)C1O NWNUTSZTAUGIGA-UHFFFAOYSA-N 0.000 description 1
- 235000014134 echinacea Nutrition 0.000 description 1
- 239000008157 edible vegetable oil Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- IINNWAYUJNWZRM-UHFFFAOYSA-L erythrosin B Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=C(I)C(=O)C(I)=C2OC2=C(I)C([O-])=C(I)C=C21 IINNWAYUJNWZRM-UHFFFAOYSA-L 0.000 description 1
- 235000012732 erythrosine Nutrition 0.000 description 1
- 239000004174 erythrosine Substances 0.000 description 1
- 229940011411 erythrosine Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- PUSKHXMZPOMNTQ-UHFFFAOYSA-N ethyl 2,1,3-benzoselenadiazole-5-carboxylate Chemical compound CCOC(=O)C1=CC=C2N=[Se]=NC2=C1 PUSKHXMZPOMNTQ-UHFFFAOYSA-N 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000020988 fatty fish Nutrition 0.000 description 1
- 229960005191 ferric oxide Drugs 0.000 description 1
- 235000019688 fish Nutrition 0.000 description 1
- 235000012779 flatbread Nutrition 0.000 description 1
- FVTCRASFADXXNN-SCRDCRAPSA-N flavin mononucleotide Chemical compound OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O FVTCRASFADXXNN-SCRDCRAPSA-N 0.000 description 1
- 239000011737 fluorine Chemical class 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000002864 food coloring agent Nutrition 0.000 description 1
- 239000000576 food coloring agent Substances 0.000 description 1
- 239000000989 food dye Substances 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 235000013611 frozen food Nutrition 0.000 description 1
- 235000014132 frozen ready meals Nutrition 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 235000011087 fumaric acid Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- DLRVVLDZNNYCBX-CQUJWQHSSA-N gentiobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-CQUJWQHSSA-N 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000021021 grapes Nutrition 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 235000019514 herring Nutrition 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 235000012171 hot beverage Nutrition 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- COHYTHOBJLSHDF-BUHFOSPRSA-N indigo dye Chemical compound N\1C2=CC=CC=C2C(=O)C/1=C1/C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-BUHFOSPRSA-N 0.000 description 1
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 235000014109 instant soup Nutrition 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 229940029339 inulin Drugs 0.000 description 1
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical class II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 235000013980 iron oxide Nutrition 0.000 description 1
- 239000000177 juniperus communis l. berry Substances 0.000 description 1
- 235000008960 ketchup Nutrition 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 239000001645 levisticum officinale Substances 0.000 description 1
- 229930007453 limonene-1,2-epoxide Natural products 0.000 description 1
- 239000000944 linseed oil Substances 0.000 description 1
- 235000021388 linseed oil Nutrition 0.000 description 1
- 239000012263 liquid product Substances 0.000 description 1
- 235000012680 lutein Nutrition 0.000 description 1
- 239000001656 lutein Substances 0.000 description 1
- 229960005375 lutein Drugs 0.000 description 1
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 description 1
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 description 1
- 235000012661 lycopene Nutrition 0.000 description 1
- 239000001751 lycopene Substances 0.000 description 1
- 229960004999 lycopene Drugs 0.000 description 1
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 description 1
- 239000001115 mace Substances 0.000 description 1
- 235000020640 mackerel Nutrition 0.000 description 1
- 239000011777 magnesium Chemical class 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000013048 microbiological method Methods 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 150000002763 monocarboxylic acids Chemical class 0.000 description 1
- 150000002772 monosaccharides Chemical group 0.000 description 1
- HWPKGOGLCKPRLZ-UHFFFAOYSA-M monosodium citrate Chemical compound [Na+].OC(=O)CC(O)(C([O-])=O)CC(O)=O HWPKGOGLCKPRLZ-UHFFFAOYSA-M 0.000 description 1
- 239000002524 monosodium citrate Substances 0.000 description 1
- 235000018342 monosodium citrate Nutrition 0.000 description 1
- 235000012459 muffins Nutrition 0.000 description 1
- 235000010460 mustard Nutrition 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 1
- 229940012843 omega-3 fatty acid Drugs 0.000 description 1
- 239000006014 omega-3 oil Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 239000001688 paprika extract Substances 0.000 description 1
- DYUUPIKEWLHQGQ-SDXBLLFJSA-N paprika oleoresin Chemical compound C(\[C@]12[C@@](O1)(C)C[C@@H](O)CC2(C)C)=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=C[C@H]1C(C)=C[C@H](O)CC1(C)C DYUUPIKEWLHQGQ-SDXBLLFJSA-N 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 235000012736 patent blue V Nutrition 0.000 description 1
- 239000004177 patent blue V Substances 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 235000021017 pears Nutrition 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 239000011574 phosphorus Chemical class 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- MBWXNTAXLNYFJB-NKFFZRIASA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-NKFFZRIASA-N 0.000 description 1
- 235000019175 phylloquinone Nutrition 0.000 description 1
- 239000011772 phylloquinone Substances 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 229960001898 phytomenadione Drugs 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 235000020233 pistachio Nutrition 0.000 description 1
- 235000012830 plain croissants Nutrition 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 239000001253 polyvinylpolypyrrolidone Substances 0.000 description 1
- 235000012731 ponceau 4R Nutrition 0.000 description 1
- 239000004175 ponceau 4R Substances 0.000 description 1
- 239000011591 potassium Chemical class 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- KYKNRZGSIGMXFH-ZVGUSBNCSA-M potassium bitartrate Chemical compound [K+].OC(=O)[C@H](O)[C@@H](O)C([O-])=O KYKNRZGSIGMXFH-ZVGUSBNCSA-M 0.000 description 1
- 229940111695 potassium tartrate Drugs 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 235000013324 preserved food Nutrition 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 230000000529 probiotic effect Effects 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 235000015136 pumpkin Nutrition 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 150000003216 pyrazines Chemical class 0.000 description 1
- 235000008160 pyridoxine Nutrition 0.000 description 1
- 239000011677 pyridoxine Substances 0.000 description 1
- 235000012752 quinoline yellow Nutrition 0.000 description 1
- 239000004172 quinoline yellow Substances 0.000 description 1
- IZMJMCDDWKSTTK-UHFFFAOYSA-N quinoline yellow Chemical compound C1=CC=CC2=NC(C3C(C4=CC=CC=C4C3=O)=O)=CC=C21 IZMJMCDDWKSTTK-UHFFFAOYSA-N 0.000 description 1
- 229940051201 quinoline yellow Drugs 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 229960003471 retinol Drugs 0.000 description 1
- 235000020944 retinol Nutrition 0.000 description 1
- 239000011607 retinol Substances 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 229910052701 rubidium Inorganic materials 0.000 description 1
- IGLNJRXAVVLDKE-UHFFFAOYSA-N rubidium atom Chemical compound [Rb] IGLNJRXAVVLDKE-UHFFFAOYSA-N 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 235000019512 sardine Nutrition 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 235000015067 sauces Nutrition 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 235000003513 sheep sorrel Nutrition 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 229940009188 silver Drugs 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 239000011734 sodium Chemical class 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229940001593 sodium carbonate Drugs 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229940005573 sodium fumarate Drugs 0.000 description 1
- 235000019294 sodium fumarate Nutrition 0.000 description 1
- 239000001476 sodium potassium tartrate Substances 0.000 description 1
- 235000011006 sodium potassium tartrate Nutrition 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 229940082787 spirulina Drugs 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 235000021012 strawberries Nutrition 0.000 description 1
- 125000000185 sucrose group Chemical group 0.000 description 1
- 235000012094 sugar confectionery Nutrition 0.000 description 1
- 239000011593 sulfur Chemical class 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 235000012756 tartrazine Nutrition 0.000 description 1
- 239000004149 tartrazine Substances 0.000 description 1
- 229960000943 tartrazine Drugs 0.000 description 1
- UJMBCXLDXJUMFB-GLCFPVLVSA-K tartrazine Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-GLCFPVLVSA-K 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 229940116411 terpineol Drugs 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- 239000001585 thymus vulgaris Substances 0.000 description 1
- 229910052718 tin Inorganic materials 0.000 description 1
- 235000012167 tiramisu Nutrition 0.000 description 1
- 229960005196 titanium dioxide Drugs 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 150000003628 tricarboxylic acids Chemical class 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 150000004043 trisaccharides Chemical class 0.000 description 1
- YJCJAUSWVUZMSY-UHFFFAOYSA-K trisodium;4-[(2,4-diamino-5-methylphenyl)diazenyl]benzenesulfonate;4-[[2,4-diamino-5-[(4-sulfonatophenyl)diazenyl]phenyl]diazenyl]benzenesulfonate Chemical compound [Na+].[Na+].[Na+].C1=C(N)C(C)=CC(N=NC=2C=CC(=CC=2)S([O-])(=O)=O)=C1N.NC1=CC(N)=C(N=NC=2C=CC(=CC=2)S([O-])(=O)=O)C=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 YJCJAUSWVUZMSY-UHFFFAOYSA-K 0.000 description 1
- 235000013976 turmeric Nutrition 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000016788 valerian Nutrition 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 235000021470 vitamin B5 (pantothenic acid) Nutrition 0.000 description 1
- 235000021467 vitamin B7(Biotin) Nutrition 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 229940045999 vitamin b 12 Drugs 0.000 description 1
- 229940021056 vitamin d3 Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 235000020234 walnut Nutrition 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 description 1
- 235000010930 zeaxanthin Nutrition 0.000 description 1
- 239000001775 zeaxanthin Substances 0.000 description 1
- 229940043269 zeaxanthin Drugs 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
- A23L33/24—Cellulose or derivatives thereof
-
- A—HUMAN NECESSITIES
- A21—BAKING; EDIBLE DOUGHS
- A21D—TREATMENT OF FLOUR OR DOUGH FOR BAKING, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS
- A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
- A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
- A21D2/14—Organic oxygen compounds
- A21D2/18—Carbohydrates
- A21D2/188—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
- A23L21/10—Marmalades; Jams; Jellies; Other similar fruit or vegetable compositions; Simulated fruit products
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/70—Fixation, conservation, or encapsulation of flavouring agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/70—Fixation, conservation, or encapsulation of flavouring agents
- A23L27/72—Encapsulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
Definitions
- the invention relates to a composition intended for consumption or for consumption comprising cellobiose, wherein the content of cellobiose is at least 0.001 wt .-%, based on the total weight of the composition.
- the invention further relates to a process for the preparation of such a composition and to the use thereof.
- the cellobiose is in combination with alkalosis.
- ingredients such as e.g. Flavors and colorings can be supplied to food continuously over long periods of consistent quality, without variations in the properties of the natural products used significantly affecting the properties of the food.
- the ingredients used are able to compensate for such fluctuations, if necessary.
- ingredients such as e.g. Flavors and colors are fragile and must be protected from heat, oxidation and light, as well as from reactions with other substances, to ensure adequate storage stability.
- Well-suited and widely used methods for stabilizing such ingredients are extrusion technology, spray drying, freeze drying and spray encapsulation.
- the powders obtained by spray-drying or spray-encapsulation are sometimes characterized by good storage stability and high retention, so that the release of the ingredient takes place in a controlled manner at the desired time.
- Flavors are often volatile, such as limonene.
- a solvent often water, is removed by evaporation, retaining the volatile ingredients, even if they are more volatile than the solvent. This is possible because during the spraying process only a portion of the volatile ingredients in the vapor phase passes until a semi-permeable crust has formed on the dried particles, which restrains the rest of the volatile ingredients therein (selective diffusion).
- small particles or drops of the ingredients are trapped by an outer coating material.
- an embedding of the ingredients in a homogeneous or heterogeneous matrix is possible. In both cases, you get a well manageable solid material in which the ingredient is stable and safe.
- DE 10 2010 020640 AI relates to a feed or a feed additive containing: (i)> 25 wt .-% polysaccharides or cereals and / or (ii) ⁇ 35 wt .-% total protein and amino acids, characterized in that Cellobiose or where the feed or feed additive cellobiose is assigned as an additional feed component.
- EP 0 316 254 A2 relates to a process for the preparation of jams, jams, jellies, cakes, pastries, creams, puddings, pancakes, donuts, frozen desserts, and their combination with dairy products such as yoghurt, ice cream, desserts. Solids are added to the end products to reduce calories: a) non-metabolized beta-oligo- and polysaccharides, such as cellobiose, gentiobiose, etc. b) enzymatic hydrolysates of cellulose or cellulose.
- EP 1 930 012 A1 relates to a cellooligosaccharide composition containing as its main constituent at least one cellooligosaccharide selected from the group consisting of cellobiose, celiotriose, cetotetraose, cellopentaose and cellohexaose, which in powder form at an angle of repose of 60 ° or less has a mean L / D value of 3.0 or less and a bulk density of 0.80 g / ml or less.
- US 2007/0014854 relates to granules which contain sparingly soluble active substances.
- US 2014/221640 AI relates to an antitumor agent containing cellobiose as an active ingredient.
- WO 2007/113856 relates to tablets which disintegrate in the mouth and contain calcium silicate.
- WO 2012/030308 A2 relates to a pharmaceutical composition containing a carrier and one or more active agents for the treatment of respiratory diseases such as asthma and COPD.
- WO 2012/046346 AI relates to a tea extract containing at least tannin, an amino acid and cellobiose, wherein cellobiose is contained in an amount of 0.8-10% by weight relative to the total solids content of the tea extract.
- JP 2009 159908 A relates to a frozen dessert containing cellooligosaccharides.
- the frozen dessert is low in calories and has a foam stability.
- JP 2009 142187 A relates to low calorie sweets which are mixed with cellooligosaccharides.
- JP 2009 125064 A relates to chocolate obtained by mixing cellooligosaccharide with a cocoa component.
- JP 2009 185228 A relates to a low-calorie gelling agent and gel strength which contains a combination of cello-oligosaccharides with agar.
- JP 2010 226995 A relates to frozen food and beverages containing 0.01 to 10 wt .-% cellooligosaccharide.
- JP 2011 026411 A relates to a powder composition containing at least one component selected from a perfume, a pigment, and a functional substance and cellobiose.
- the advantages can be multilayered and in particular arise during storage of the preparation.
- Nutritional value e.g., dietetics, allergens; and or
- ingredients for food, food supplement, gourmet or other food, feed or for pharmaceuticals in a form which have advantages over conventional formulations of the ingredients, for example in terms of storage stability and release.
- oxidation-sensitive, light-sensitive or otherwise unstable ingredients can be provided in a storage-stable form.
- cellobiose preferably in combination with alkalosis, in preparations which are intended for consumption or for consumption, can fulfill a number of functions, so that the preparations have advantages over conventional preparations.
- cellobiose preferably in combination with alkalosis, optionally in combination with conventional carriers, which are used as encapsulating materials, a has positive influence on the properties of the ingredients.
- shelf life or the storage stability of ingredients such as aromas, etc. by cellobiose, preferably in combination with alkalosis be significantly extended.
- the sugar content of preparations can be reduced by replacing other sugars, for example sucrose or fructose, with cellobiose, preferably in combination with alkalose.
- other sugars for example sucrose or fructose
- cellobiose preferably in combination with alkalose.
- calorie-reduced allergen-free preparations can be prepared, which may also be suitable for diabetics.
- cellobiose preferably in combination with alkalosis, gives a beautiful tan in products which are heated, in particular by Maillard reaction, i. Reaction with amine compounds.
- cellobiose preferably in combination with alkalosis, provides protection against fat oxidation, acts as a release agent in certain applications, but acts as a binder in other applications. Further advantages will be explained below in connection with specific aspects and embodiments of the invention.
- a first aspect of the invention relates to a preferably solid, semi-solid or liquid composition which is intended for consumption or for consumption and cellobiose, preferably in combination with alkalosis, and optionally comprises one or more carriers, wherein the content of cellobiose , preferably in combination with alkalosis, is at least 0.001 wt%, more preferably at least 0.005 wt%, even more preferably at least 0.01 wt%, most preferably at least 0.05 wt%, and most preferably at least 0 , 1 wt .-%, each based on the total weight of the composition.
- all amounts, weights and percentages which are directed to the invention preferred combination of cellobiose with alkalosis (preferably D-alkalosis), to the total amount of cellobiose and alkalosis, unless expressly defined otherwise.
- the amounts, weights and percentages are directed to cellobiose as such, i. not on the preferred combination with alkalosis, they are only related to the amount of cellobiose, without it being important whether in addition possibly even alkalosis is present or not.
- composition of the invention is intended for consumption or for consumption.
- the composition of the invention is an intermediate and intended to be added to a product which is then intended to be consumed or ingested as such.
- this product is preferably selected from (i) food, dietary supplement, pleasure or other foods; (ii) feed; and (iii) medicines.
- the consumption or intake of the composition according to the invention then takes place in the course of consumption or intake of the product.
- the composition according to the invention is marketed as such and / or intended as such for consumption or for consumption.
- the composition of the invention is then in turn selected from (i) food, dietary supplement, pleasure or other foods; (ii) feed; and (iii) medicines.
- composition according to the invention is a feed or an intermediate intended to be added to a feed, it is consumed by animals.
- composition according to the invention is a food, dietary supplement, pleasure or other foodstuff or an intermediate product which is intended to be added to a foodstuff, dietary supplement, indulgence or other food, then so it is consumed or ingested by humans (children or adults).
- composition according to the invention is a medicament or an intermediate intended to be added to a medicament, it is ingested by animals or humans (children or adults).
- composition of the invention is intended for consumption or for consumption, it is physiologically acceptable and is usually subject to regulatory approval procedures.
- the composition according to the invention is officially approved for marketing in the EU.
- the composition of the invention is solid, semi-solid or liquid.
- the composition of the invention is solid, it is preferably particulate, wherein it may be present as a loosely particulate composition (powder, granules, etc.) or as a compacted particulate composition (pellet, tablet, etc.).
- the composition according to the invention comprises a large number of particles (particles), which preferably form a powder or granules.
- the powder or granules are in solid form or as a suspension in a suitable liquid.
- the composition according to the invention is semisolid, it is preferably pasty.
- the composition according to the invention is liquid, it is preferably aqueous.
- the composition according to the invention may comprise several phases, for example solid / liquid (for example suspensions) or liquid / liquid (for example emulsions).
- the composition of the invention contains cellobiose, i. 4-0-ß-D-glucopyranosyl-D-glucose.
- the cellobiose is present as such in the composition of the invention, i. the cellobiose is not chemically modified, for example with acid chlorides or other reagents that form covalent bonds with cellobiose.
- the cellobiose is particulate in the composition of the invention.
- the particle size distribution of cellobiose can be adjusted according to the invention.
- the particulate cellobiose has a particle size distribution, after which 90% of the particles have a particle size in the range of 1.0 to 2.20 mm, or 0.5 to 1.25 mm, or 0.2 to 0.75 mm, or 0.2 to 0.50 mm, or 0 , 1 to 0.35 mm, or less than 0.1 mm, or less than 0.05 mm.
- the mean particle size is in the range of less than 50 ⁇ , or less than 100 ⁇ , or less than 250 ⁇ , or in the range of 200 to 400 ⁇ , or in the range of 400 to 850 ⁇ .
- the mean particle size (grain size) can be changed by crystallization or grinding and adjusted, for example by sieving, and standard methods can be determined, for example by laser diffractometry.
- the average particle size (d50) is preferably at most 250 ⁇ , more preferably at most 200 ⁇ and more preferably less than 170 ⁇ . Particularly preferably, the average particle size (d50) in the range of 5 to 150 ⁇ , more preferably 10 to 100 ⁇ , more preferably 10 to 50 ⁇ and is particularly preferably 25 ⁇ 5 ⁇ .
- the solid, semi-solid or liquid composition according to the invention preferably comprises
- Ingredients according to the invention are basically any admixtures, which can be added to foods, dietary supplements, indulgence or other foods, feeds or medicines, in particular also adjuvants, supplements, additives and ingredients.
- the ingredient is suitable for consumption by humans or animals and can in principle have very different properties.
- the ingredient is Novel Food as defined in the Novel Food Regulation (EC No. 258/97 of the European Parliament and of the Council on Novel Foods and Novel Food Ingredients of 27 January 1997 (OJ No L 1997/43/1)).
- the ingredient according to the invention is preferably a food ingredient within the meaning of Article 1 (2) f) of this Ordinance.
- the ingredient is a processing aid within the meaning of the German Food, Commodities and Feed Code, in particular an enzyme or an enzyme preparation.
- the ingredient in the composition according to the invention is suitable for altering foods, food supplements, indulgences or other foods, feeds or medicaments olfactorily and / or gustatory and / or visually.
- the ingredient is preferably relatively less stable on storage, in particular volatile, susceptible to decomposition, sensitive to oxidation, photosensitive, and / or reactive in any other way.
- the ingredient is selected from the group consisting of flavors, colors, nutrients, spices, sweeteners, sugar substitutes, enzymes, microorganisms (e.g., probiotic bacteria), pharmaceutical excipients, drugs, and mixtures thereof.
- the ingredient is an aroma
- flavors according to the invention preferably flavorings, natural flavorings, artificial flavorings, nature identical flavors, smoke flavors, smoke flavorings, aroma extracts, reaction flavors, thermally derived reaction flavors, flavor precursors, and mixtures thereof.
- the term "flavor” in the context of the invention and according to Regulation (EC) No. 1334/2008 of 16.12.2008 includes any product as such is not intended to be consumed and added to foods to give them or change their particular odor and / or taste.
- the terms "flavoring agent,” “natural flavoring agent”, “aroma extract”, “thermally obtained reaction flavoring agent”, “smoke flavoring agent” and “flavoring precursor” are preferably defined as in Regulation (EC) No. 1334/2008 of 16.12.2008 (Official Gazette European Union, L 354/34, 31.12.2008).
- Flavors are products that are added to foods, dietary supplements, indulgence or other foods, feeds or medicines to give them a particular odor and / or flavor.
- An aroma may include toothy flavorings, aroma extracts, thermally derived reaction flavors, smoke flavors, and flavor precursors.
- any flavoring substances and mixtures thereof are suitable according to the invention.
- Flavorings are chemically defined substances with aroma properties. Flavorings are chemically defined substances with taste-giving properties, which are used for the production of flavors. There are different natural, nature-identical and artificial flavorings.
- Flavorings are often readily volatile and can preferably be divided chemically into hydrocarbons, alcohols, aldehydes, ketones, ethers, esters, terpenes, aromatics, phenols and / or pyrazines. Flavors can be hydrophilic or hydrophobic. Preferred flavors are hydrophobic, such as tooth-rich essential oils.
- Natural flavorings are flavorings obtained by suitable physical, enzymatic or microbiological processes from plant, animal or microbiological sources used as such or prepared for human consumption by one or more conventional food preparation methods. Natural flavors are substances that occur naturally and have been detected in nature. Natural flavors are made with physical, enzymatic or Microbiological process from plant, animal or microbiological starting materials produced, for example by extraction and distillation.
- Aroma extracts are obtained by physical, microbiological or enzymatic methods either from foods or from substances of plant, animal or microbiological origin, which are not food. Aroma extracts are often complex mixtures whose composition may vary depending on the raw materials used.
- flavor extracts are non-flavored products derived from i) foods, by appropriate physical, enzymatic or microbiological processes, used as such or prepared for human consumption by one or more conventional food preparation processes, and / or or (ii) non-food substances of plant, animal or microbiological origin, by appropriate physical, enzymatic or microbiological processes, which substances are used as such or prepared by one or more conventional food preparation processes.
- Reaction flavors are obtained by controlled heating of a mixture of various ingredients that do not necessarily have flavor properties themselves.
- Toasted aromas are an example of reaction aromas.
- thermally derived reaction flavors are products obtained by heating a mixture of various ingredients which are not necessarily flavored by themselves, at least one ingredient of which contains nitrogen (amino group) and another is a reducing sugar; suitable ingredients for the production of thermally obtained reaction flavors are: i) food and / or ii) starting materials other than food.
- Smoke flavorings are made from smoke used in conventional food smoking processes. For this purpose, certain woods are burned under controlled conditions. The smoke is introduced into water, fractionated and purified. This condensates are obtained from which are produced using excipients smoke flavorings. In particular, smoke flavors are products obtained by fractionation and purification of fumed smoke resulting in primary smoke condensates, primary tar fractions and / or smoke flavors produced therefrom.
- the ingredient in the composition of the invention is a fruit flavor (fruit flavor), which is preferably selected from the group consisting of forest fruits, elderberries, apples, pears, cherries, lemon, lime, Orange, grapefruit, cranberry, blueberry, cranberry, raspberry, strawberry, blackberry, gooseberry, currant, quince, banana, peach, tangerine, nectarine, fig, dates , Grape, kiwi, apricot, mirabelle, rosehip, mango, papaya, pineapple, pomelo, melon, sharon fruit, passion fruit, sloe, plum and plum flavor.
- fruit flavor preferably selected from the group consisting of forest fruits, elderberries, apples, pears, cherries, lemon, lime, Orange, grapefruit, cranberry, blueberry, cranberry, raspberry, strawberry, blackberry, gooseberry, currant, quince, banana, peach, tangerine, nectarine, fig, dates , Grape, kiwi, apricot,
- the ingredient in the composition of the invention is an aroma (eg, vegetable flavor, legume flavor, mushroom flavor, cereal flavor) which is preferably selected from the group consisting of cabbage, red cabbage, kale, lettuce, and spinach. , Tomato, pepper, cucumber, kohlrabi, parsnip, parsley root, zucchini, aubergine, fennel, carrot, carrot, pumpkin, broccoli, celery, radish, radish, mangetout -, okra, pea, bean, mushroom, porcini, chanterelle, potato, corn and rice flavor.
- an aroma eg, vegetable flavor, legume flavor, mushroom flavor, cereal flavor
- the ingredient in the composition of the invention is a dairy flavor preferably selected from the group consisting of cheese, cream cheese, yoghurt, quark, ricotta, butter and cream flavor.
- the ingredient in the composition of the invention is an herbal flavor, which is preferably selected from the group consisting of woodruff, pimpinelle, savory, borage, sorrel, lovage, parsley, chive, Laurel, peppermint, tarragon, chamomile, chervil, basil, lavender, oregano, mint, sage, rosemary, thyme, marjoram and lemon balm.
- an herbal flavor which is preferably selected from the group consisting of woodruff, pimpinelle, savory, borage, sorrel, lovage, parsley, chive, Laurel, peppermint, tarragon, chamomile, chervil, basil, lavender, oregano, mint, sage, rosemary, thyme, marjoram and lemon balm.
- the ingredient in the composition of the invention is a flower flavor, which is preferably selected from the group consisting of lavender, rose, violet, oleander, jasmine, lily and lily of the valley aroma.
- the ingredient in the composition of the present invention is a fancy flavor or flavor of a food imitation selected, for example, from the group consisting of tutti frutti, cookie, tiramisu, marzipan and bubblegum flavor.
- the ingredient in the composition of the invention is a spice flavor, which is preferably selected from the group consisting of vanilla, cinnamon, anise, star anise, caper, garlic, paprika, juniper berry, Onion, allspice, caraway, poppy seed, cumin, pepper, nutmeg, clove, saffron, cardamom and chiliaroma.
- a spice flavor which is preferably selected from the group consisting of vanilla, cinnamon, anise, star anise, caper, garlic, paprika, juniper berry, Onion, allspice, caraway, poppy seed, cumin, pepper, nutmeg, clove, saffron, cardamom and chiliaroma.
- the ingredient in the composition of the invention is a nut fruit flavor, which is preferably selected from the group consisting of pine nut, pistachio, sesame, almond, cashew nut, hazelnut, walnut, coconut, Macadamia nut, pecan nut, brazil nut and peanut flavor.
- the ingredient in the composition of the invention is a tea flavor, which is preferably selected from the group consisting of green tea, black tea, Roibusch, Matetee-, Mallow blossom, Linden blossom, and Kombuchaaroma.
- the ingredient in the composition of the invention is a caramel, honey, coffee, cappuccino, cocoa, nougat or chocolate flavor.
- the ingredient is a dye, preferably a food dye.
- Food colors are food ingredients or coloring foods that are commonly used to make foods look better and to satisfy consumer color expectations. You can also compensate for processing-related color losses.
- the ingredient is a dye from the group consisting of Allra red AC, aluminum, amaranth, anthocyanins, azorubin, betanine, brown FK, Braun HT, Brilliant Blue FCF, Brillant Black BN, calcium carbonate, canthaxanthin, carotene (annatto (norbixin) , Capsanthin, lycopene, 8'-apo- ⁇ -caroten-8'-al, ethyl-8'-apo- ⁇ -caroten-8'-oat), quinoline yellow, chlorophyll, cochineal red A, curcumin, iron oxide, erythrosine, yellow-orange S, Gold, Green S, Indigotin, Koschenille, Copper-containing complexes of Chlorophylls and Chlorophylline, Lactoflavin, Litholrubin BK, Lutein, Patent Blue V, Biochar, Riboflavin (Vitamin B2), Riboflavin-5
- Preferred ingredients are also naturally colored ingredients which are approved for use in foods, e.g. Paprika, sweet potato powder, etc.
- the ingredient is a nutrient.
- Nutrients are various organic and inorganic substances that are taken up by living beings for their life support and processed in the metabolism. According to the invention, nutrients include carbohydrates, fats, oils, fatty acids, proteins, vitamins, minerals, vegetable materials and herbal preparations.
- Preferred oils are vegetable oils, which are preferably selected from the group consisting of rapeseed oil, sunflower oil, linseed oil, palm oil, olive oil, coconut oil and peanut oil.
- Preferred fats are animal fats, which are preferably selected from the group consisting of whales of whales and seals, tallow of cattle and sheep, lard of pigs and geese, butter and concentrated lard, fat of fatty fish such as herring, sardine and anchovy, salmon, mackerel , or eel.
- oils and fats also comprise oleoresins, which are preferably selected from the group consisting of paprika oleoresin, capsicum oleoresin, pepper oleoresin (black, white, green), turmeric, nutmeg, mace, cardamom, Coriander and ginger.
- Fatty acids preferably include saturated and unsaturated fatty acids, with ⁇ -3 fatty acids being particularly preferred.
- Preferred vitamins are selected from the group consisting of vitamin A (retinol), vitamin B1 (thiamine), vitamin B2 (riboflavin), vitamin B3 (niacin), vitamin B5 (pantothenic acid), vitamin B6 (Pyridoxine), Vitamin B7 (Biotin), Vitamin B9 (Folic Acid), Vitamin B12 (Cobalamin), Vitamin C (Ascorbic Acid), Vitamin D (Ergo- / Cholecalciferol), Vitamin E (Tocopherol) and Vitamin K (Phylloquinone).
- Preferred minerals include lot elements and trace elements.
- Preferred minerals are compounds, in particular inorganic salts of calcium, chlorine, potassium, magnesium, phosphorus, sulfur, sodium, chromium, cobalt, iron, fluorine, iodine, copper, manganese, molybdenum, selenium, silicon, vanadium, zinc, arsenic, boron , Rubidium and tin.
- Preferred vegetable materials and herbal preparations are those ingredients which are commonly referred to in the English language as "botanicals". These are obtained as derived preparations from plants, algae, fungi or lichens. Examples are plant extracts and include preparations derived from garlic, echinacea, ginkgo biloba, ginseng, harpagpphytum, kava, St. John's wort, green tea, valerian, Missouri grapes, artichokes, hawthorn, burdock, birch, alder thorn, blackcurrant, blessed thistle, Fucus, Hamamelis, Horse Chestnut, Melissa, Orthosiphon, Passiflora, Dandelion, Horsetail, Meadowsweet, Sage, or Spirulina.
- the ingredient is a spice, spice mixture or seasoning.
- Preferred spices, spice blends or seasonings are selected from
- inorganic materials e.g. Saline
- Plants or parts of plants, fresh, dried or processed e.g. Culinary herbs, bay leaves;
- Flowers or flower parts e.g. Saffron, cloves, capers;
- Bark ground, e.g. Cinnamon
- Plant roots or rhizomes e.g. Onions, garlic, ginger, horseradish;
- Fruits or seeds of the plants e.g. Nutmeg, pepper, paprika, juniper berries, vanilla, caraway, anise, cocoa;
- animal substances e.g. Honey, lard, butter, meat extract, dried fish, anchovies (anchovies), shrimp paste; and
- Spice preparations e.g. Mustard, curry powder, chutney, wasabi.
- the ingredient is a sweetener component.
- the sweetener component according to the invention basically comprises all physiologically acceptable substances which produce a sweet taste, but are not carbohydrates.
- the sweetening component comprises sweeteners and / or sugar substitutes.
- Preferred sweeteners are selected from the group consisting of acesulfame, aspartame, aspartame-acesulfame salt, cyclamate, neohesperidin, neotame, saccharin, sucralose, stevioside, thaumatin, alitame, Brazzein, Dulcin, Hernandulcine, Lugdunam, Monellin, Pentadin, Curculin, Miraculin, Osladin, Perillartin, Stevia, and mixtures thereof.
- Preferred sugar substitutes are selected from the group consisting of sorbitol, xylitol, mannitol, isomalt, maltitol, lactitol, erythritol and mixtures thereof.
- the ingredient in the composition of the invention is a prebiotic.
- the ingredient in the composition of the invention is alkalosis, preferably D-allulose (D-Psicose).
- the ingredient is a pharmaceutical excipient, preferably selected from the group consisting of fillers, binders, lubricants, lubricants, flow regulators, mold release agents, emulsifiers, gelling agents, wrapping agents, disintegrants, antioxidants, preservatives, humectants, sweeteners, and Flavoring agents.
- the ingredient is a drug, i. a pharmacologically active substance.
- the drug is for oral administration.
- the composition according to the invention contains one or more carriers.
- Many ingredients such as Flavorings are already very effective in low dosage. They are therefore difficult to process in concentrated form. Therefore, according to the invention, preferably diluents are used for excipients which are preferably mixed with the ingredients and the cellobiose.
- the carrier together with the cellobiose forms a matrix in which the ingredient is embedded.
- Suitable supports according to the invention are in principle all conventionally used excipients.
- the carrier is selected from the group consisting of monosaccharides, disaccharides, trisaccharides, other oligosaccharides, polysaccharides, hydrocolloids, polyols, waxes, paraffins, fats, oils and mixtures thereof.
- polysaccharides also include their derivatives and are preferably selected from the group consisting of starches (in particular selected from hydrolyzed starches and modified starches), maltodextrins, corn syrup, cyclodextrins, xanthine, curdan, cellulose, cellulose esters, cellulose ethers, gum arabic, tragacanth , Karaya, Ghatti, agar, gum acacia, alginates, carrageenans, fucellan, psyllium and sodium alginate.
- Preferred cellulose ethers include methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose and carboxymethylcellulose.
- a mixture of two carriers which is particularly preferred according to the invention comprises starch and maltodextrin.
- the relative weight ratio cellobiose: ingredient, preferably allulose is in the range of 1000: 1 to 1: 1000, more preferably 500: 1 to 1: 500, even more preferably 100: 1 to 1: 100, most preferably 50: 1 to 1:50, most preferably 20: 1 to 1:20, and most preferably 10: 1 to 1:10.
- the content of cellobiose ranges from 0.01 to 99.99 wt.%, more preferably 0.1 to 80 wt.%, even more preferably 0.2 to 60 wt.%, most preferably 0.5 to 50 Wt .-%, and particularly from 1.0 to 25 wt .-%, each based on the total weight of the composition; and or
- the content of ingredient preferably allulose, in the range of 0.01 to 99.99 wt.%, more preferably 0.1 to 80 wt.%, even more preferably 0.2 to 60 wt.%, most preferably 0 From 5 to 50% by weight, and more preferably from 1.0 to 25% by weight, based in each case on the total weight of the composition; and or
- the content of carrier ranges from 0 to 99.98 wt.%, more preferably 0.1 to 95 wt.%, even more preferably 0.2 to 90 wt.%, most preferably 0.5 to 85 wt. -%, and in particular from 1.0 to 80 wt .-%, each based on the total weight of the composition.
- the content of cellobiose is at least 0.1% by weight, more preferably at least 0.5% by weight, even more preferably at least 1.0% by weight, most preferably at least 2 , 5 wt .-%, and in particular at least 5.0 wt .-%, each based on the total weight of the composition.
- the content of cellobiose, preferably in combination with allulose is 40 ⁇ 15% by weight, more preferably 35 ⁇ 10% by weight, or 40 ⁇ 10% by weight, or 45 ⁇ 10% by weight. %.
- the content of cellobiose, preferably in combination with allulose is 60 ⁇ 15% by weight, more preferably 65 ⁇ 10% by weight, or 60 ⁇ 10% by weight, or 65 ⁇ 10% by weight. %.
- the content of cellobiose, preferably in combination with allulose is 80 ⁇ 15% by weight, more preferably 85 ⁇ 10% by weight, or 80 ⁇ 10% by weight, or 85 ⁇ 10% by weight. ,
- the content of sucrose in the composition according to the invention is at most 50% by weight, more preferably at most 40% by weight, even more preferably at most 30% by weight, particularly preferably at most 20% by weight, most preferably at most 10 Wt .-%, and particularly preferably at most 5% by weight, each based on the total weight of the composition.
- the composition according to the invention contains at most 1% by weight of sucrose, especially no sucrose at all.
- the composition according to the invention in addition to cellobiose, preferably in combination with allulose, contains no mono-, di- or oligosaccharides at all. In a preferred embodiment, in addition to cellobiose, preferably in combination with allulose, the composition according to the invention additionally contains allulose, in particular D-allulose, but preferably no additional mono-, di- or oligosaccharides.
- composition according to the invention preferably contains neither cellotriose nor cellotetraose, nor cellopentaose, nor cellohexaose.
- composition according to the invention contains maltodextrin and optionally also starch.
- the particles of the composition preferably have an average particle diameter in the range of 100 nm to 1.0 mm, more preferably in the range of 10 ⁇ m to 1.0 mm and in particular in the range of 100 ⁇ m to 500 ⁇ .
- Suitable methods for determining the mean particle diameter are known to a person skilled in the art. The determination is preferably carried out with the aid of lasers according to the Malvern method.
- the average particle diameter is at least 2.50 ⁇ , more preferably at least 5 ⁇ , more preferably at least 10 ⁇ , most preferably at least 25 ⁇ , and in particular at least 50 ⁇ .
- the particle diameter is at most 5.0 mm, more preferably at most 2.5 mm, even more preferably at most 1.0 mm, most preferably at most 750 ⁇ , and in particular at most 500 ⁇ .
- At most 50% by weight, more preferably at most 40% by weight, still more preferably at most 30% by weight, most preferably at most 20% by weight, and most preferably at most 10% by weight of Particle has a particle diameter that deviates by more than 50% of the average particle diameter up or down.
- composition according to the invention is particulate, in a preferred embodiment the particles of the composition are coated with a coating material.
- the coating material may be different or identical to the carrier.
- the coating material is selected from the group consisting of polysaccharides, HydrokoUoiden, polyols, waxes, paraffins, fats, oils and mixtures thereof.
- the content of the coating agent is in the range of 0 to 99.98% by weight, more preferably 0.1 to 95% by weight, still more preferably 0.2 to 90% by weight, on most preferably 0.5 to 85 wt .-%, and in particular from 1.0 to 80 wt .-%, each based on the total weight of the composition.
- Another aspect of the invention relates to a process for the preparation of the above-described composition according to the invention, comprising the bringing together of
- an ingredient other than cellobiose for a food, food supplement, luxury or other food, feed or medicine such as
- the cellobiose, the ingredient and optionally the carrier are preferably at least moistened with a solvent and then dried.
- a starting suspension can be used, which has about 40% o dry substance.
- the solvents used are preferably aqueous solvents, such as pure water.
- the drying is preferably carried out by spray drying, freeze drying or fluidized bed drying or extrusion. Suitable methods and conditions are known to a person skilled in the art.
- the method according to the invention comprises the steps:
- step (a) forming a particulate core containing at least a portion of the ingredient and at least a portion of the cellobiose; and (b) coating the particulate core obtained in step (a) with a coating agent.
- step (b) takes place by a fluidized bed process or by extrusion. Suitable methods and conditions are known to a person skilled in the art. Steps (a) and (b) can be carried out according to the invention successively or simultaneously.
- Another aspect of the invention relates to a solid, semi-solid or liquid composition obtainable by the process of the invention described above.
- composition according to the invention may be present in solid form, for example in the form of a powder, granules or in the form of microcapsules.
- Cellobiose, ingredient and optionally carrier can be distributed homogeneously over the individual particles.
- the particles are adapted to include an inner region (core) and an outer region (sheath or coating), the outer region substantially completely surrounding the inner region.
- the morphology and / or chemical composition of the inner region is different from the morphology and / or chemical composition of the outer region.
- the relative content of ingredient in the inner region is greater than in the outer region, wherein the outer region may possibly even contain no ingredient.
- such a preferred structure of the particles can be obtained in different ways.
- the inner region (core) is first produced in a first process step and then subsequently surrounded with the outer region (coating) in a second process step.
- Suitable processes are known to a person skilled in the art, wherein the coating is preferably carried out by a fluidized bed process.
- inner region (core) and outer region (shell) are produced simultaneously in a common process step.
- this common process step comprises drying, ie the removal of at least part of a solvent present. Suitable processes are known to a person skilled in the art, wherein the drying preferably takes place by freeze drying, spray drying or fluidized bed drying and extrusion.
- part of the optionally volatile ingredient may be allowed to pass into the vapor phase together with the solvent until a semipermeable crust has formed on the dried-on particles, forming the remainder the possibly volatile ingredient in it withholds.
- This crust then contains at most small amounts of ingredient as an outer region, whereas the core surrounded by the crust comprises, as the inner region, the majority of the ingredient contained in the respective particle.
- Microcapsules are particularly preferred according to the invention, wherein preferably at least a portion of the ingredient and at least a portion of the cellobiose are microencapsulated in the particles.
- the inventive microencapsulation of the ingredients preferably leads to a longer shelf life, a lower need for ingredient, a higher customer acceptance by improved sensory properties and / or better handling. Due to the microencapsulation, further processing can also be improved. In addition to reducing negative effects, it may be desirable to deliberately alter certain product characteristics, such as e.g. the flow properties of powders.
- Another aspect of the invention relates to a food, dietary supplement, pleasure or other food, a feed or a medicament containing the above-described inventive composition or the above-described, obtainable by the process according to the invention composition, wherein in one preferred embodiment is cellobiose in combination with alkalosis.
- Examples of foods, dietary supplements, indulgence or other foods, feeds or medicaments according to the invention include instant products, convenience food products, bakery products, snacks (chips, flips, crackers, pretzel sticks, nuts, popcorn, etc.) and flavored Foods and intermediates in their production.
- particularly preferred convenience food products comprise
- the content is preferably
- the feed or the pharmaceutical at least 0.001% by weight, more preferably at least 0.005% by weight, even more preferably at least 0.01% by weight, most preferably at least 0.05 Wt .-%, and particularly preferably at least 0.1 wt .-%, each based on the total weight of the food, dietary supplement, pleasure or other food, the feed or the drug; or 1.0 ⁇ 0.5 wt%, 2.0 ⁇ 1.5 wt%, 2.0 ⁇ 0.5 wt%, 3.0 ⁇ 2.5 wt%, 3 , 0 ⁇ 1.5% by weight, 3.0 ⁇ 0.5% by weight, 4.0 ⁇ 3.5% by weight, 4.0 ⁇ 2.5% by weight, 4.0 ⁇ 1.5 wt%, 4.0 ⁇ 0.5 wt%, 5.0 ⁇ 4.5 wt%, 5.0 ⁇ 3.5 wt%, 5.0 ⁇ 2 , 5% by weight, 5.0 ⁇ 1.5% by weight
- the feed or the drug at least 0.001 wt .-%, more preferably at least 0.005 wt .-%, more preferably at least 0.01 wt .-%, most preferably at least 0.05% by weight, and more preferably at least 0.1% by weight, based in each case on the total weight of the food, dietary supplement, pleasure or other food, feed or medicament; or 1.0 ⁇ 0.5 wt%, 2.0 ⁇ 1.5 wt%, 2.0 ⁇ 0.5 wt%, 3.0 ⁇ 2.5 wt%, 3 , 0 ⁇ 1.5% by weight, 3.0 ⁇ 0.5% by weight, 4.0 ⁇ 3.5% by weight, 4.0 ⁇ 2.5% by weight, 4.0 ⁇ 1.5 wt%, 4.0 ⁇ 0.5 wt%, 5.0 ⁇ 4.5 wt%, 5.0 ⁇ 3.5 wt%, 5.0 ⁇ 2 , 5% by weight,
- the feed or the drug at least 0.001% by weight, more preferably at least 0.005% by weight, even more preferably at least 0.01% by weight, most preferably at least 0.05% by weight, and more preferably at least 0.1% by weight, based in each case on the total weight of the food, dietary supplement, pleasure or other food, feed or medicament; or 1.0 ⁇ 0.5 wt%, 2.0 ⁇ 1.5 wt%, 2.0 ⁇ 0.5 wt%, 3.0 ⁇ 2.5 wt%, 3 , 0 ⁇ 1.5% by weight, 3.0 ⁇ 0.5% by weight, 4.0 ⁇ 3.5% by weight, 4.0 ⁇ 2.5% by weight, 4.0 ⁇ 1.5 wt%, 4.0 ⁇ 0.5 wt%, 5.0 ⁇ 4.5 wt%, 5.0 ⁇ 3.5 wt%, 5.0 ⁇ 2 , 5% by weight, 5.0 ⁇ 1.5% by weight, or 5.0 ⁇
- the content of sucrose in the food, food supplement, food or other food, feed or medicine according to the invention is at most 99.999% by weight, more preferably at most 90% by weight or at most 80 Wt .-%, more preferably at most 70 wt .-% or at most 60 wt .-%, particularly preferably at most 50 wt .-% or at most 40 wt .-%, most preferably at most 30 wt .-% or at most 20 wt.
- the food, food supplement, food or other food, feed or medicament according to the invention contains at most 1% by weight of sucrose, in particular no sucrose at all.
- the inventive food, dietary supplement, pleasure or other food, feed or drug in addition to cellobiose, preferably in combination with allulose contains no mono-, di- or oligosaccharides.
- composition according to the invention or the food, nutritional supplement, pleasure or other food, feed or medicament according to the invention is selected from the group consisting of pharmaceutical compositions, tabletop sweeteners, instant products, convenience food products, baked goods , Sweets, fruit preparations, snacks, and flavored foods
- composition according to the invention or the foodstuffs, dietary supplements, luxury foods or other foods, feedstuffs or medicaments according to the invention are a sweetener.
- the confectionery is solid, semi-solid or liquid.
- the confectionery of the invention comprises cellobiose, preferably in combination with allulose, wherein the content of cellobiose, preferably in combination with allulose, is at least 0.001% by weight, more preferably at least 0.005% by weight, more preferably at least 0.01% by weight .-%, most preferably at least 0.05 wt .-%, and particularly preferably at least 0.1 wt .-%, each based on the total weight of the confectionery product.
- the content of cellobiose, preferably in combination with allulose, in the confectionery according to the invention is 1.0 ⁇ 0.5% by weight, 2.0 ⁇ 1.5% by weight, 2.0 ⁇ 0.5 Wt .-%, 3.0 ⁇ 2.5 wt .-%, 3.0 ⁇ 1.5 wt .-%, 3.0 ⁇ 0.5 wt .-%, 4.0 ⁇ 3.5 wt.
- the content of cellobiose, preferably in combination with alkalose, in the confectionery according to the invention is 10 ⁇ 5% by weight, 20 ⁇ 15% by weight, 20 ⁇ 5% by weight, 30 ⁇ 25% by weight.
- Confectionery preferred according to the present invention includes confectionery such as pralines, liquid filled chocolates, candy, chewy candy, toffees, marshmallows, cotton candy, lokum and halva, cocoa products such as chocolate, sugar preserved fruits such as jam, jam, jelly and candied fruit, gummy bears and other fruit gums, nuts based specialties such as nougat and marzipan, as well as ice cream.
- the sugar content of confectionery can be reduced by adding other sugars, e.g. Fructose, by cellobiose, preferably in combination with alkalose.
- Fructose e.g. Fructose
- cellobiose preferably in combination with alkalose, provides protection against fat oxidation and also acts as a release agent in certain applications, e.g. in chewy candy or marshmallows.
- the total content of all carbohydrates which are present in the confectionery besides cellobiose, preferably in combination with alkalose, is at most 50% by weight, more preferably at most 40% by weight, even more preferably at most 30% by weight, more preferably at most 20% by weight, most preferably at most 10% by weight and in particular at most 5% by weight, based in each case on the total weight of the confectionery product.
- the confectionery is lactose-free.
- cellobiose in particular in liquid praline fillings, cellobiose, preferably in combination with alkalose, leads to a reduction in the content of the remaining carbohydrates and, in the case of an exchange of fructose by cellobiose, preferably in combination with alkalose, for the avoidance of allergens for consumers fructose intolerance.
- the content of fructose in the confectionery is at most 5 wt .-%, more preferably at most 1 wt .-%, more preferably at most 0.1 wt .-%, each based on the total weight of the confectionery.
- cellobiose preferably in combination with alkalose, can be used instead of hydrophobized dextrose and acts as a release agent.
- the content of dextrose, preferably hydrophobized dextrose in the sweet is at most 5 wt .-%, more preferably at most 1 wt .-%, more preferably at most 0.1 wt .-%, each based on the total weight of the confectionery product.
- the invention thus also relates to the use of cellobiose, preferably in combination with alkalosis, as (i) release agent, (ii) sugar substitute and / or (iii) for reducing or suppressing the oxidation of fats, preferably in confectionery.
- the fats are preferably contained in a confectionery.
- composition according to the invention or the food, nutritional supplement, luxury food or other food, feedstuff or medicament according to the invention is a tabletop sweetener.
- tabletop sweetener is understood to mean a liquid or solid composition which can be used instead of sugar, in particular instead of sucrose, in particular in order to reduce the caloric content of the food, dietary supplement, pleasure or other food sweetened therewith compared to the corresponding sweetening with the help of other carbohydrates, in particular sucrose.
- Tabletop Sweetener are very different and include the sweetening of hot drinks (tea, coffee, etc.), sweetening dough before baking, sweetening pastries after baking, etc.
- the liquid is preferably provided in containers, from which the liquid can be removed by drops and metered.
- the tabletop sweetener is solid, it may be used as a particulate composition, e.g. in the form of a free-flowing powder or granule, or as a compacted particulate composition, e.g. in the form of sweetener tablets.
- cellobiose preferably in combination with alkalosis, improves the sensory properties, in particular does not have a negative effect on the sensory properties.
- cellobiose preferably in combination with alkalosis, it is possible to produce tabletop sweeteners according to the invention which are allergen-free.
- the tabletop sweetener according to the invention is preferably lactose-free.
- the tabletop sweetener according to the invention comprises cellobiose, preferably in combination with alkalosis, the content of cellobiose, preferably in combination with alkalose, being at least 0.001% by weight, more preferably at least 0.005% by weight, even more preferably at least 0, 01 wt .-%, most preferably at least 0.05 wt .-%, and particularly preferably at least 0.1 wt .-%, each based on the total weight of the tabletop Sweeteners.
- the content of cellobiose, preferably in combination with alkalosis, in the tabletop sweetener according to the invention is 1.0 ⁇ 0.5% by weight, 2.0 ⁇ 1.5% by weight, 2.0 ⁇ 0 , 5 wt%, 3.0 ⁇ 2.5 wt%, 3.0 ⁇ 1.5 wt%, 3.0 ⁇ 0.5 wt%, 4.0 ⁇ 3.5 Wt .-%, 4.0 ⁇ 2.5 wt .-%, 4.0 ⁇ 1.5 wt .-%, 4.0 ⁇ 0.5 wt .-%, 5.0 ⁇ 4.5 wt.
- the content of cellobiose, preferably in combination with alkalosis, in the tabletop sweetener according to the invention is 10 ⁇ 5% by weight, 20 ⁇ 15% by weight, 20 ⁇ 5% by weight, 30 ⁇ 25 Wt .-%, 30 ⁇ 15 wt .-%, 30 ⁇ 5 wt .-%, 40 ⁇ 35 wt .-%, 40 ⁇ 25 wt .-%, 40 ⁇ 15 wt .-%, 40 ⁇ 5 wt.
- the tabletop sweetener according to the invention preferably contains a sweetener component, more preferably sweeteners and / or sugar substitutes.
- Preferred sweeteners are selected from the group consisting of acesulfame, aspartame, aspartame-acesulfame salt, cyclamate, neohesperidin, neotame, saccharin, sucralose, stevioside, thaumatin, alitame, brazzein, dulcine, hernandulcine, lugdunam, monellin, pentadine, curculin, miraculin , Osladin, Perillartin, Stevia, and their mixtures.
- Preferred sugar substitutes are selected from the group consisting of sorbitol, xylitol, mannitol, isomalt, maltitol, lactitol, erythritol and mixtures thereof.
- the tabletop sweetener according to the invention contains, in addition to cellobiose, preferably in combination with alkalosis, two different sweeteners, or two different sugar substitutes, or a sweetener and a sugar substitute.
- the content of the sweetener component in the tabletop sweetener according to the invention depends in particular on its sweetening power.
- the content of the sweetener component is in the range of 0.01 to 80% by weight, more preferably 0.1 to 60% by weight, based in each case on the total weight of the tabletop sweetener.
- the content of the sweetener component in the tabletop sweetener according to the invention is 1.0 ⁇ 0.5% by weight, 2.0 ⁇ 1.5% by weight, 2.0 ⁇ 0.5% by weight.
- % 3.0 ⁇ 2.5% by weight, 3.0 ⁇ 1.5% by weight, 3.0 ⁇ 0.5% by weight, 4.0 ⁇ 3.5% by weight, 4.0 ⁇ 2.5 wt%, 4.0 ⁇ 1.5 wt%, 4.0 ⁇ 0.5 wt%, 5.0 ⁇ 4.5 wt%, 5, 0 ⁇ 3.5 wt .-%, 5.0 ⁇ 2.5 wt .-%, 5.0 ⁇ 1.5 wt .-%, or 5.0 ⁇ 0.5 wt .-%, each based on the total weight of the tabletop sweetener.
- the content of the sweetener component in the tabletop sweetener according to the invention is 10 ⁇ 5 wt%, 20 ⁇ 15 wt%, 20 ⁇ 5 wt%, 30 ⁇ 25 wt%, 30 ⁇ 15 wt%, 30 ⁇ 5 wt%, 40 ⁇ 35 wt%, 40 ⁇ 25 wt%, 40 ⁇ 15 wt%, 40 ⁇ 5 wt%, 50 ⁇ 45 %
- 50 ⁇ 35% by weight 50 ⁇ 25% by weight, 50 ⁇ 15% by weight, 50 ⁇ 5% by weight, 60 ⁇ 35% by weight, 60 ⁇ 25% by weight.
- cellobiose preferably in combination with alkalosis
- the tabletop sweetener is provided in the form of sweetener tablets
- the cellobiose preferably in combination with alkalose
- Other benefits of cellobiose, preferably in combination with alkalosis may result as a dosing aid or prebiotic.
- the invention also relates to foods, dietary supplements, indulgence or other foods, feeds or medicaments comprising the tabletop sweetener according to the invention.
- the composition according to the invention or the food, nutritional supplement, luxury food or other food, feed or medicament according to the invention is a pharmaceutical composition, a pharmaceutical dosage form (pharmaceutical product) or a pharmaceutical excipient ,
- cellobiose preferably in combination with alkalosis, can fulfill different functions:
- cellobiose preferably in combination with alkalose, is suitable as such as a filler and / or compacting assistant and / or release agent;
- cellobiose preferably in combination with alkalosis, may stabilize other pharmaceutical excipients or ingredients;
- Cellobiose preferably in combination with alkalosis, can stabilize drugs (pharmacologically active substances).
- composition according to the invention or the food, nutritional supplement, pleasure or other food, feed or medicament according to the invention is a pharmaceutical composition or dosage form which is described in more detail below:
- the pharmaceutical composition or dosage form according to the invention may be solid, semi-solid or liquid.
- Solid pharmaceutical compositions or dosage forms of the invention include e.g. Powders, tablets, dragees, capsules, sachets, suppositories, effervescent tablets, etc.
- Liquid pharmaceutical compositions or dosage forms of the invention include e.g. Infusion solutions, injection solutions, juice preparations, tinctures etc.
- Semi-solid pharmaceutical compositions or dosage forms of the invention include e.g. Ointments and creams.
- the pharmaceutical composition or dosage form according to the invention is in the form of an effervescent tablet.
- the effervescent tablet preferably comprises an effervescent supplement which is suitable for producing an effervescent when the effervescent tablet is brought into contact with an aqueous medium.
- Effectivevescent additive in the sense of the description preferably means the combination of one or more acids with one or more bases, which react with one another when dissolving or dispersing the formulation and thus accelerate the physical decomposition of the effervescent tablet according to the invention by gas bubble formation.
- the effervescent tablet according to the invention preferably contains a crystalline or partially crystalline, water-soluble acid and a crystalline or partially crystalline, water-soluble salt of carbonic acid (bicarbonate or carbonate), which in a dry powder mixture has virtually no reaction with one another received.
- the acid-base reaction occurs only when the effervescent tablet dissolves in an aqueous liquid.
- the acid preferably causes a shift to a pH ⁇ 6.5, whereby C0 2 is expelled from the salt of carbonic acid to form gas bubbles.
- acids are preferably water-soluble, crystalline mono- or dicarboxylic acids, such as citric acid, malic acid, tartaric acid, adipic acid, fumaric acid, glutaric acid, ascorbic acid, succinic acid, malonic acid and / or maleic acid, more preferably citric acid.
- Acid salts of mono-, di- or tricarboxylic acids such as, for example, monosodium citrate, disodium citrate, sodium fumarate or potassium tartrate, can also be present.
- the bases used are preferably basic (alkaline) alkali metal bicarbonates and / or (alkaline) alkali metal carbonates.
- the suffix "(hydrogen) carbonate” means “hydrogencarbonate” or “carbonate”.
- the prefix "(earth) alkali” means "alkaline earth” or "alkali”.
- cellobiose has only low hygroscopicity and is therefore particularly suitable for effervescent tablets.
- Effervescent tablets are particularly susceptible to moisture, since even traces of water can initiate an autocatalytic decomposition.
- the possibly low hygroscopicity of cellobiose therefore proves to be particularly advantageous for effervescent tablets.
- composition or dosage form according to the invention may be for systemic (oral, peritoneal, transdermal, by injection or infusion, etc.), topical or local administration.
- the pharmaceutical composition or dosage form according to the invention comprises cellobiose, preferably in combination with alkalosis, wherein the content of cellobiose, preferably in combination with alkalosis, is at least 0.001% by weight, more preferably at least 0.005% by weight, more preferably at least 0 , 01 wt .-%, most preferably at least 0.05 wt .-%, and particularly preferably at least 0.1 wt .-%, each based on the total weight of the pharmaceutical composition or dosage form.
- the content of cellobiose, preferably in combination with allulose, in the pharmaceutical composition or dosage form according to the invention is 1.0 ⁇ 0.5% by weight, 2.0 ⁇ 1.5% by weight, 2.0 ⁇ 0.5% by weight, 3.0 ⁇ 2.5% by weight, 3.0 ⁇ 1.5% by weight, 3.0 ⁇ 0.5% by weight, 4.0 ⁇ 3, 5% by weight, 4.0 ⁇ 2.5% by weight, 4.0 ⁇ 1.5% by weight, 4.0 ⁇ 0.5% by weight, 5.0 ⁇ 4.5% by weight %, 5.0 ⁇ 3.5% by weight, 5.0 ⁇ 2.5% by weight, 5.0 ⁇ 1.5% by weight, or 5.0 ⁇ 0.5% by weight.
- the content of cellobiose, preferably in combination with allulose, in the pharmaceutical composition or dosage form according to the invention is 10 ⁇ 5% by weight, 20 ⁇ 15% by weight, 20 ⁇ 5% by weight, 30 ⁇ 25 Wt .-%, 30 ⁇ 15 wt .-%, 30 ⁇ 5 wt .-%, 40 ⁇ 35 wt .-%, 40 ⁇ 25 wt .-%, 40 ⁇ 15 wt%, 40 ⁇ 5 wt.
- % 50 ⁇ 45% by weight, 50 ⁇ 35% by weight, 50 ⁇ 25% by weight, 50 ⁇ 15% by weight, 50 ⁇ 5% by weight, 60 ⁇ 35% by weight %, 60 ⁇ 25 wt%, 60 ⁇ 15 wt%, 60 ⁇ 5 wt%, 70 ⁇ 25 wt%, 70 ⁇ 15 wt%, or 70 ⁇ 5 wt% , in each case based on the total weight of the pharmaceutical composition or dosage form.
- cellobiose preferably in combination with alkalosis, in pharmaceutical compositions or dosage forms as an excipient, preferably as a pharmaceutical excipient, more preferably as a filler and / or Kompaktierzkar and / or as a release agent and / or as a disintegrant can.
- cellobiose preferably in combination with alkalosis, can stabilize oxidation-sensitive substances (auxiliaries, active substances) against oxidative degradation and, if appropriate, be used for encapsulating such substances which are sensitive to oxidation.
- Exemplary properties of cellobiose include good flowability of the blends (flow control agents), good compressibility, good tablet hardness, high tablet abrasion resistance, low hygroscopicity, good solubility and good disintegration properties.
- tablets such as e.g. Sweetened tablets or film-coated tablets Crosslinked Sodium Carboxymethylcellulose (E468) or Crosspovidone (E1202).
- E468 Crosslinked Sodium Carboxymethylcellulose
- E1202 Crosspovidone
- These disintegrators cause the disintegration of the tablets by a volume expansion on contact with water. Tabletting experiments have shown that when using cellobiose, the use of these disintegrating agents can either be dispensed with completely or their amount can be drastically reduced. The disintegration times of the tablets are still in the same range as in formulations with conventional excipients and conventional disintegrants. Since the amount of disintegrants that can be used in the formulations is limited in foods, including dietary supplements, the difficulty of using cellobiose according to the invention in difficult formulations that are prone to delayed disintegration is new.
- the pharmaceutical composition or dosage form according to the invention is lactose-free and / or allergen-free and / or suitable for diabetics.
- composition according to the invention preferably contains no disintegrant.
- the composition of the invention was prepared by direct compression. In a preferred embodiment, the composition of the invention was prepared by granulation, preferably by wet granulation or dry granulation.
- the composition of the invention is monolithic.
- the composition according to the invention has a total weight in the range of 10 mg to 15 g, more preferably a total weight in the range of 20 mg to 1.5 g or in the range of 1.5 g to 10 g.
- the composition according to the invention contains no calcium silicate.
- composition according to the invention is intended for peroral administration, i. it decomposes when used as intended only in the digestive tract and not in the mouth or throat.
- a further aspect of the invention relates to a process for preparing a composition according to the invention described above, which is preferably solid and compacted, comprising the steps:
- step (b) pressing, preferably directly compressing the mixture obtained in step (a);
- step (c) optionally film coating the compact obtained in step (b).
- the process is carried out without wet granulation, preferably without granulation.
- the cellobiose is used in step (a) in the form of a granulate or between steps (a) and (b), the granulation of the mixture prepared in step (a), preferably as dry granulation.
- Another aspect of the invention relates to a solid compacted composition obtainable by the method of the invention described above.
- the composition according to the invention or the food, dietary supplement, pleasure or other food, feed or medicament according to the invention is a fruit preparation which is preferably preserved with sugar.
- the fruit preparation is selected from jam (for example jam 1: 1, jam 2: 1, jam 3: 1), jam, jelly and fruit spread.
- the fruit preparation comprises one or more fruits or extracts of these fruits selected from the group consisting of forest fruit, elderberry, apple, pear, cherry, lemon, lime, orange, grapefruit, cranberry, blueberry, cranberry, raspberry, Strawberry, blackberry, gooseberry, currant, quince, banana, peach, mandarin, nectarine, fig, date, grape, kiwi, apricot, Mirabelle, Rosehip, Mango, Papaya, Pineapple, Pomelo, Melon, Sharon fruit, Passion fruit, Blackthorn, Plum and Plum.
- these fruits selected from the group consisting of forest fruit, elderberry, apple, pear, cherry, lemon, lime, orange, grapefruit, cranberry, blueberry, cranberry, raspberry, Strawberry, blackberry, gooseberry, currant, quince, banana, peach, mandarin, nectarine, fig, date, grape, kiwi, apricot, Mirabelle, Rosehip, Mango, Papaya, Pineapple, Po
- the fruit preparation according to the invention comprises cellobiose, preferably in combination with alkalose, wherein the content of cellobiose, preferably in combination with alkalosis, is at least 0.001% by weight, more preferably at least 0.005% by weight, even more preferably at least 0.01% by weight .-%, most preferably at least 0.05 wt .-%, and particularly preferably at least 0.1 wt .-%, each based on the total weight of the fruit preparation.
- the content of cellobiose, preferably in combination with alkalosis, in the fruit preparation according to the invention is 1.0 ⁇ 0.5% by weight, 2.0 ⁇ 1.5% by weight, 2.0 ⁇ 0.5 Wt .-%, 3.0 ⁇ 2.5 wt .-%, 3.0 ⁇ 1.5 wt .-%, 3.0 ⁇ 0.5 wt .-%, 4.0 ⁇ 3.5 wt.
- the content of cellobiose, preferably in combination with alkalosis, in the fruit preparation according to the invention is 10 ⁇ 5% by weight, 20 ⁇ 15% by weight, 20 ⁇ 5% by weight, 30 ⁇ 25% by weight.
- the sugar content of fruit preparations can be reduced by replacing other sugars, in particular sucrose, by cellobiose, preferably in combination with alkalose.
- the Frucktzuritch invention have improved sensoriscke Eigensckaften. This has a particularly effect on a less sweet Geseckmacksein réelle and / or a frucktigeren Geseckmacksein réelle and / or an improved Mundge Stahlkl.
- Experimental evidence suggests that cellobiose, preferably in combination with alkalosis, improves the texture by a different gelling effect.
- the shelf life of the preparation of the preparation is improved by cellobiose, preferably in combination with alkalosis, and the content of dry matter is reduced.
- cellobiose preferably in combination with alkalosis
- Other benefits of cellobiose, preferably in combination with alkalosis, may result in being a prebiotic.
- the amount of sucrose in the printing composition is at least 50% by weight, more preferably at least 40% by weight, more preferably at least 30% by weight, most preferably at least 20% by weight, most preferably at least 10% by weight %, and particularly preferably at least 5% by weight, in each case based on the total amount of the pressed preparation.
- the pressure preparation mekr sucrose decalcifies as cellobiose.
- the amount of cellobiose in the formulation is at least 50% by weight, more preferably at least 40% by weight, more preferably at least 30%, most preferably at least 25%, most preferably at least 22%, 5 wt .-%, and particularly preferably at least 20 wt .-%, each based on the Automatgewickt of cellobiose and sucrose in the Frucktzurung.
- the content of cellobiose in the fruit preparation is at least 5.0 wt .-%, more preferably at least 7.5 wt .-%, even more preferably at least 10 wt .-%, particularly preferably at least 15 wt .-%, am most preferably at least 17.5% by weight, and most preferably at least 20% by weight, based in each case on the total weight of cellobiose and sucrose in the fruit preparation.
- the content of sucrose in the fruit preparation is at most 95% by weight, more preferably at most 92.5% by weight, even more preferably at most 90% by weight, particularly preferably at most 85% by weight, most preferably at most 82.5 wt .-%, and particularly preferably at most 80 wt .-%, each based on the total weight of cellobiose and sucrose in the fruit preparation.
- the content of sucrose in the fruit preparation is at least 50% by weight, more preferably at least 60% by weight, even more preferably at least 70% by weight, particularly preferably at least 75% by weight, most preferably at least 77, 5 wt .-%, and particularly preferably at least 80 wt .-%, each based on the total weight of cellobiose and sucrose in the fruit preparation.
- the fruit preparation according to the invention is contained in a dairy product.
- the dairy product is preferably selected from quark, cream cheese, yoghurt and other preparations whose fat content in relation to the dry matter is preferably in the range of 0.1 to 40 wt .-%.
- cellobiose preferably in combination with alkalosis, acts as a binder or emulsifier and effectively prevents syneresis.
- the invention thus also relates to the use of cellobiose, preferably in combination with alkalosis, as emulsifier or binder, preferably in compositions containing fruit preparations, preferably in combination with dairy products.
- the composition according to the invention or the food, food supplement, luxury food or other food, feed or medicament according to the invention is a gelling sugar.
- the gelling sugar cellobiose in combination with sucrose, in addition, however, no further carbohydrates or not more than 5 wt .-% further carbohydrates, based on the total weight of the gelling sugar.
- the content of cellobiose in the gelling sugar according to the invention is preferably 10 ⁇ 5% by weight, 20 ⁇ 15% by weight, 20 ⁇ 5% by weight, 30 ⁇ 25% by weight, 30 ⁇ 15% by weight. %, 30 ⁇ 5 wt%, 40 ⁇ 35 wt%, 40 ⁇ 25 wt%, 40 ⁇ 15 wt%, 40 ⁇ 5 wt%, 50 ⁇ 45 wt% , 50 ⁇ 35 wt%, 50 ⁇ 25 wt%, 50 ⁇ 15 wt%, 50 ⁇ 5 wt%, 60 ⁇ 35 wt%, 60 ⁇ 25 wt%, 60 ⁇ 15 wt%, 60 ⁇ 5 wt%, 70 ⁇ 25 wt%, 70 ⁇ 15 wt%, or 70 ⁇ 5 wt%, 80 ⁇ 15 wt%, 80 ⁇ 10 wt .-%, or 80 ⁇ 5 wt .-%, 90 ⁇ 10
- the gelling sugar contains more sucrose than cellobiose.
- the content of cellobiose in the gelling sugar is at most 50% by weight, more preferably at most 40% by weight, even more preferably at most 30% by weight, particularly preferably at most 25% by weight, most preferably at most 22.5 Wt .-%, and particularly preferably at most 20 wt .-%, in each case based on the total weight of cellobiose and sucrose in gelling sugar.
- the content of cellobiose in the gelling sugar is at least 5.0 wt%, more preferably at least 7.5 wt%, even more preferably at least 10 wt%, most preferably at least 15 wt%, most preferably at least 17.5 wt .-%, and particularly preferably at least 20 wt .-%, each based on the total weight of cellobiose and sucrose in gelling sugar.
- the content of sucrose in the gelling sugar is at most 95% by weight, more preferably at most 92.5% by weight, even more preferably at most 90% by weight, particularly preferably at most 85% by weight, most preferably at most 82 , 5 wt .-%, and particularly preferably at most 80 wt .-%, each based on the total weight of cellobiose and sucrose in gelling sugar.
- the content of sucrose in the gelling sugar is at least 50% by weight, more preferably at least 60% by weight, even more preferably at least 70% by weight, more preferably at least 75% by weight, most preferably at least 77.5 Wt .-%, and particularly preferably at least 80 wt .-%, each based on the total weight of cellobiose and sucrose in gelling sugar.
- the gelling sugar according to the invention preferably contains at least one gelling agent in addition to cellobiose and optionally sucrose.
- Gelling agents preferred according to the invention are selected from the group consisting of corn starch, potato starch, tapioca, rice flour, agar, guar, xanthan, pectin and gelatin.
- the content of gelling agent is preferably
- the gelling sugar according to the invention preferably comprises at least one acid, preferably an organic acid, more preferably a carboxylic acid, in particular a multicarboxylic acid.
- Preferred acids are citric acid and tartaric acid.
- the content of acid at least 0.001 wt%, at least 0.005 wt%, at least 0.01 wt%, at least 0.05 wt%, at least 0.1 wt%, at least 0.2 wt% , at least 0.3 wt%, at least 0.4 wt%, at least 0.5 wt%, at least 0.75 wt%, at least 1.0 wt%, at least 1.5 Wt .-%, at least 2.0 wt .-%, at least 2.5 wt .-%, or at least 3.0 wt .-%, based on the total weight of the gelling sugar; and or
- the canning sugar according to the invention substantially contains, in addition to cellobiose, optionally sucrose, optionally gelling agent and optionally acid
- the composition according to the invention or the food, food supplement, luxury food or other food, feed or medicament according to the invention is a baked good.
- Preferred baked goods include foods made from cereals or cereal products that are baked.
- the baked good is selected from the group consisting of bread, biscuits and pastry.
- Preferred baked goods include pizza, onion cake, tarte cake, bread and cake.
- the bread may be leavened or unleavened.
- Preferred breads include wheat bread, rye bread, wheat mixed bread, mixed rye bread, and breads including other cereals and mixtures thereof.
- Preferred breads are selected from the group consisting of white bread, e.g. German white bread, white bread, ciabatta, flatbread or baguette; Wheat mixed bread, such as French country bread, Black Forest bread or Wegators mares; Shredded wheat bread; Toast; and crispbread.
- the cake can be cake or sponge cake.
- Preferred cakes are selected from the group consisting of onion cake, tarte cake, bacon cake, quiche, pizza, apple cake, tree cake, bee sting cake, butter cake, egg cake, English cake, gugelhupf, yeast cake, blueberry cake, cheese cake, cherry cake, marble cake, poppy seed cake, moss cake, fruit cake, Panettone, Petit Gurgieau, plum cake, Russian pluck cake, sponge cake, sand cake, chocolate cake, stollen, crumble cake, muffins, lemon cake, cupcakes, doghnuts, etc.
- Biscuits according to the invention comprises baked goods made from bread dough which weigh no more than 250 g.
- Typical examples of biscuits are rolls, Kipferl, croissants and pretzels.
- Fine baked goods are distinguished from bread and biscuits preferably by a higher fat and sugar content, namely at least in total 1/9 of the flour content.
- Sweet pastries as well as lye pastries, crackers and savory biscuits, regardless of their preparation, are also part of the pastry.
- Classic pastries are cookies, cakes and pies.
- the baked good according to the invention comprises cellobiose, preferably in combination with AUulose, wherein the content of cellobiose, preferably in combination with AUulose, is at least 0.001% by weight, more preferably at least 0.005% by weight, even more preferably at least 0.01% by weight .-%, most preferably at least 0.05 wt .-%, and particularly preferably at least 0.1 wt .-%, each based on the total weight of the baked good.
- the content of cellobiose, preferably in combination with AUulose, in the baked good according to the invention is 1.0 ⁇ 0.5% by weight, 2.0 ⁇ 1.5% by weight, 2.0 ⁇ 0.5 Wt .-%, 3.0 ⁇ 2.5 wt .-%, 3.0 ⁇ 1.5 wt .-%, 3.0 ⁇ 0.5 wt .-%, 4.0 ⁇ 3.5 wt.
- the content of cellobiose, preferably in combination with aululose, in the baked good according to the invention is 10 ⁇ 5% by weight, 20 ⁇ 15% by weight, 20 ⁇ 5% by weight, 30 ⁇ 25% by weight.
- the sugar content of baked goods can be reduced by replacing other sugars, in particular sucrose, with cellobiose, preferably in combination with AUulose.
- the baked goods according to the invention have improved sensory properties. This especially affects a less sweet taste impression and / or an improved mouthfeel.
- cellobiose, preferably in combination with aurulose, in baked goods such as canned white bread, results in better crust browning, better dough stability, higher volume, lower baking losses, less mildew, a softer crumb and / or a fresher impression after storage in terms of taste and texture.
- sponge cakes lead cellobiose, preferably in combination with AUulose, to an improved browning, a lower baking loss, a softer crumb, a softer and moister crumb after storage and / or less mold.
- the content of sucrose in the baked good is at most 50% by weight, more preferably at most 40% by weight, even more preferably at most 30% by weight, particularly preferably at most 20% by weight, most preferably at most 10% by weight .-%, and more preferably at most 5 wt .-%, each based on the total weight of the baked good.
- the invention thus also relates to the use of cellobiose, preferably in combination with AUulose, as a baking agent.
- Cellobiose preferably in combination with AUULOSE, is preferably used as a baking agent to improve the dough quality and baking properties of bread and pastry, for example in terms of taste and smell, cut resistance and proper browning and curing.
- a further aspect of the invention relates to a baking agent composition
- a baking agent composition comprising cellobiose, preferably in combination with alkalose, and at least one food, such as malt, cereal products, potato flour, edible oils, milk and / or milk products, and optionally food additives, such as emulsifiers ( Lecithin), which have a positive effect on the baking process and the properties of the baked goods, the content of cellobiose, preferably in combination with alkalose, being at least 0.001% by weight, based on the total weight of the baking agent composition.
- emulsifiers Lecithin
- neither the composition according to the invention nor the food, food supplement, pleasure or other food, feed or medicament according to the invention comprise
- a food preparation comprising parts of slaughtered or killed warm-blooded animals intended for human consumption and cellobiose;
- a sugar mass for the production of baked goods and / or confectionery wherein the sugar mass comprises cellobiose, optionally lactose, and optionally sucrose and wherein the total content of all saccharides is at least 50% by weight, based on the total weight of the sugar mass; and or
- a beverage comprising cellobiose, wherein the content of cellobiose is at least 0.01% by weight, based on the total weight of the beverage.
- a further aspect of the invention relates to the use of the above-described composition according to the invention or the above-described composition obtainable by the method according to the invention for the olfactory and / or gustatory and / or visual modification of a food, dietary supplement, pleasure or other Food, feed or drug.
- Another aspect of the invention relates to a decorative sugar comprising cellobiose.
- the decorative sugar according to the invention can be used for or in the bakery products according to the invention described above as well as for the or in the baking compositions described above.
- the content of cellobiose preferably in combination with alkalosis, at least 20 wt .-%, at least 30 wt .-%, at least 40 wt .-%, at least 50 wt .-%, at least 60 wt .-% , at least 70 wt .-%, at least 80 wt .-%, at least 90 wt .-%, at least 95 wt .-%, or at least 99 wt .-%, each based on the total weight of the decorative sugar, or the decorative sugar is exclusively from cellobiose.
- the content of cellobiose is 10 ⁇ 5% by weight, 20 ⁇ 15% by weight, 20 ⁇ 5% by weight, 30 ⁇ 25% by weight, 30 ⁇ 15 wt%, 30 ⁇ 5 wt%, 40 ⁇ 35 wt%, 40 ⁇ 25 wt%, 40 ⁇ 15 wt%, 40 ⁇ 5 wt%, 50 ⁇ 45 wt%, 50 ⁇ 35 wt%, 50 ⁇ 25 wt%, 50 ⁇ 15 wt%, 50 ⁇ 5 wt%, 60 ⁇ 35 wt%, 60 ⁇ 25 wt% %, 60 ⁇ 15% by weight, 60 ⁇ 5% by weight, 70 ⁇ 25% by weight, 70 ⁇ 15% by weight, or 70 ⁇ 5% by weight, 80 ⁇ 15% by weight, 80 ⁇ 10% by weight, or 80 ⁇ 5% by weight, 90 ⁇ 10% by weight, or 90 ⁇ 5 wt .-%,
- the decorative sugar according to the invention contains, in addition to cellobiose, preferably in combination with AUulose, additionally sucrose.
- the content of cellobiose is higher than the content of sucrose. In another preferred embodiment, the content of cellobiose is less than the content of sucrose.
- the decorative sugar according to the invention contains, in addition to cellobiose, preferably in combination with AUulose, additionally a sweetener component, wherein the sweetener component comprises at least one sweetener and / or at least one sugar substitute.
- the sweetener is selected from the group consisting of acesulfame, aspartame, aspartame-acesulfame salt, cyclamate, neohesperidin, neotame, saccharin, sucralose, stevioside, thaumatin, alitame, brazzein, dulcine, hernandulcine, lugdunam, monellin, pentadine, curculin, Miraculin, Osladin, Perillartin, Stevia, and their mixtures.
- the sugar substitute is selected from the group consisting of sorbitol, xylitol, mannitol, isomalt, maltitol, lactitol, erythritol and mixtures thereof.
- the level of the sweetener component is 1.0 ⁇ 0.5 wt%, 2.0 ⁇ 1.5 wt%, 2.0 ⁇ 0.5 wt%, 3 , 0 ⁇ 2.5% by weight, 3.0 ⁇ 1.5% by weight, 3.0 ⁇ 0.5% by weight, 4.0 ⁇ 3.5% by weight, 4.0 ⁇ 2.5 wt%, 4.0 ⁇ 1.5 wt%, 4.0 ⁇ 0.5 wt%, 5.0 ⁇ 4.5 wt%, 5.0 ⁇ 3 , 5 wt .-%, 5.0 ⁇ 2.5 wt .-%, 5.0 ⁇ 1.5 wt .-%, or 5.0 ⁇ 0.5 wt .-%, each based on the total weight of decorative sugar.
- the content of the sweetener component is 10 ⁇ 5 wt%, 20 ⁇ 15 wt%, 20 ⁇ 5 wt%, 30 ⁇ 25 wt%, 30 ⁇ 15 wt%, 30 ⁇ 5 wt%, 40 ⁇ 35 wt%, 40 ⁇ 25 wt%, 40 ⁇ 15 wt%, 40 ⁇ 5 wt%, 50 ⁇ 45 wt%, 50 ⁇ 35 wt%, 50 ⁇ 25 wt%, 50 ⁇ 15 wt%, 50 ⁇ 5 wt%, 60 ⁇ 35 wt%, 60 ⁇ 25 wt%, 60 ⁇ 15 wt% %, 60 ⁇ 5 wt .-%, 70 ⁇ 25 wt .-%, 70 ⁇ 15 wt .-%, or 70 ⁇ 5 wt .-% is, in each case based on the total weight of the decorative sugar.
- the decorative sugar according to the invention can be regarded as cellobiose powder, wherein the mean particle diameter is preferably at most 130 ⁇ m. It has surprisingly been found that a cellobiose powder has a whiter optics compared to a sucrose powder of the same grain size, so that the decorative sugar according to the invention can advantageously be used for decoration on bakery products. It has furthermore been found that the cellobiose powder according to the invention makes it possible to achieve significantly more stable coverage in comparison with a moist environment. This in turn results in a greater stability of the surface z. B. pastries with fruit or pudding fills. In combination with starch and fat (as a coating), the protection against moisture is once again significantly greater.
- the decorative sugar according to the invention comprises cellobiose crystals, wherein the mean particle diameter is preferably at most 500 ⁇ m.
- the cellobiose crystals in comparison to a sucrose crystal of the same grain size, allow a much more stable covering in relation to a moist environment, so that the Decor sugar according to the invention can be used advantageously for decoration on baked goods even with this particle size.
- the cellobiose crystals are used as release agents, for example in marshmallows. This in turn results in a greater stability of the surface z. B. pastries with fruit or pudding fills. In combination with starch and fat (as a coating), the protection against moisture is once again significantly greater.
- the decorative sugar according to the invention can be regarded as Cellobiosehagelzucker, wherein the mean particle diameter is preferably in the range of 200 ⁇ to 5000 ⁇ . Also in this case, it was surprisingly found that the Cellobiosehagelzucker compared to a sucrose hail sugar of the same grain size allows a much more stable to wet environment coverage, so that the decorative sugar according to the invention can be used with this particle size advantageous for decoration on baked goods. It creates a crunchy texture with cellobiose.
- Another aspect of the invention relates to a cover or coating of a baked good which comprises the above-described decorative sugar.
- the cover or coating additionally comprises fat and / or starch.
- the baked good according to the invention preferably comprises the above-described covering or the coating described above.
- the baked good preferably comprises a fruit and / or pudding filling.
- Another aspect of the invention relates to the use of the decorative sugar described above for decorating baked goods. Another aspect of the invention relates to the use of the decorative sugar described above as a release agent in baked goods or confectionery.
- a further aspect of the invention relates to a method for the olfactory and / or gustatory and / or visual modification of a food, dietary supplement, pleasure or other foodstuff, feedstuff or pharmaceutical product, comprising the bringing together of the food, supplementation, pleasure and nutritional supplements. or other food, feed or pharmaceutical and the above-described composition according to the invention or the above-described composition of the invention obtainable by the method according to the invention.
- Another aspect of the invention relates to the use of cellobiose, preferably in combination with alkalosis, for prolonging the shelf life of an ingredient for a food, dietary supplement, pleasure or other food, feed or drug; and a method of prolonging the shelf life of an ingredient for a food, dietary supplement, indulgence or other food, feed or medicament comprising contacting the ingredient, preferably alkalosis, and cellobiose.
- AI to A16 of the invention are: AI: A particulate composition suitable and intended for consumption or ingestion, comprising cellobiose; an ingredient other than cellobiose for a food, food supplement, indulgence or other food, feed or medicine, preferably alkalosis; and optionally one or more carriers; wherein the content of cellobiose is preferably at least 0.001% by weight based on the total weight of the composition.
- A2 The composition according to embodiment AI, wherein the ingredient is selected from the group consisting of flavors, dyes, nutrients, spices, sweeteners, sugar substitutes, enzymes, microorganisms and mixtures thereof.
- A3 The composition according to embodiment AI or A2, wherein the ingredient is selected from natural flavorants, artificial flavorings, natioridentical flavorants, smoke flavorings, flavor extracts and reaction flavors.
- A4 The composition of any preceding embodiment wherein the carrier is selected from the group consisting of polysaccharides, hydrocolloids, polyols, waxes, paraffins, fats, oils, and mixtures thereof.
- A5 The composition according to any one of the preceding embodiments, wherein (i) the content of cellobiose ranges from 0.01 to 99.99% by weight based on the total weight of the composition; and / or (ii) the content of ingredient, preferably of alkalose, ranges from 0.01 to 99.99% by weight, based on the total weight of the composition; and / or (iii) the content of carrier ranges from 0 to 99.98% by weight, based on the total weight of the composition.
- A6 The composition according to any one of the preceding embodiments, wherein the particles of the particulate composition have an average particle diameter in the range of 100 nm to 1.0 mm ⁇ .
- A7 The composition according to any one of the preceding embodiments, wherein the particles of the particulate composition are coated with a coating material.
- A8 The composition according to any one of the preceding embodiments, which contains neither cellotriose nor cellotetraose, nor cellopentaose, nor cellohexaose.
- A9 A method of preparing the composition of any of embodiments AI to A8 comprising contacting cellobiose; an ingredient other than cellobiose for a food, nutritional supplement, indulgence or other food, feed or medicine; and optionally one or more carriers.
- A10 The method of embodiment A9, wherein the cellobiose, the ingredient and optionally the carrier are at least moistened with a solvent and then dried.
- Al l A particulate composition obtainable by the Method according to embodiment A9 or A10.
- A12 A food, nutritional supplement, indulgence or other food, feed or medicine containing the particulate composition according to any one of the embodiments AI to A8 or Al l.
- AI 3 Use of the composition according to one of the embodiments AI to A8 or Al for the olfactory and / or gustatory and / or visual modification of a food, dietary supplement, pleasure or other food, a feed or a drug.
- A14 A method for the olfactory and / or gustatory and / or visual alteration of a food, dietary supplement, pleasure or other food, feed or medicine comprising bringing together the food, dietary supplement, pleasure or other food, the Feed or the medicament and the composition according to one of the embodiments AI to A8 or Al l.
- AI 5 Use of cellobiose, preferably in combination with alkalosis, to prolong the shelf life of an ingredient in a food, nutritional supplement, pleasure or other food, feed or medicine.
- AI 6 A method of prolonging the shelf life of an ingredient for a food, dietary supplement, indulgence or other foodstuff, feed or drug comprising bringing the ingredient and cellobiose together, preferably in combination with alkalosis.
- Bl to BIO of the invention are: Bl: A confection comprising cellobiose, preferably in combination with alkalosis, wherein the content of cellobiose, preferably in combination with alkalosis, is at least 0.001% by weight, based on the total weight the sweet.
- B2 The confectionery according to embodiment Bl, which is solid, semi-solid or liquid.
- B3 The confectionery according to embodiment Bl or B2, wherein the content of fructose in the confectionery is at most 5 wt .-%, more preferably at most 1 wt .-%, more preferably at most 0.1 wt .-%, each based on the total weight the sweet.
- B5 The confectionery according to any one of the preceding embodiments, wherein the total content of all carbohydrates, in addition to cellobiose, preferably in combination with alkalosis, contained in the confectionery, at most 50 wt .-%, more preferably at most 40 wt .-%, more preferably at most 30 wt .-%, particularly preferably at most 20 wt .-%, most preferably at most 10 wt .-% and in particular at most 5 wt .-% is, in each case based on the total weight of the confectionery product.
- B6 The confectionery product according to any one of the preceding embodiments, which is selected from the group consisting of sugar confectionery, chocolates, liquid filled chocolates, candies, chewy candies, toffees, marshmallows, cotton candy, lokum and halva, cocoa products, chocolate, sugar-preserved fruits, Jam, jam, jelly, candied fruit, gummy bears, other fruit gums, nuts based specialties, nougat, marzipan and ice cream.
- B7 The confectionery according to any one of the preceding embodiments, which contains neither cellotriose, nor cellotetraose, nor cellopentaose, nor cellohexaose.
- B8 Use of cellobiose, preferably in combination with alkalosis, as (i) release agent, (ii) sugar substitute and / or (iii) for reducing or suppressing the oxidation of fats, preferably in confectionery.
- B9 The use according to embodiment B8, wherein the fats are contained in a confectionery.
- BIO The use according to embodiment B9, wherein the confectionery is a chewy candy.
- C1 to C13 of the invention are: Cl: A tabletop sweetener comprising cellobiose, preferably in combination with alkalosis, wherein the content of cellobiose, preferably in combination with alkalosis, is at least 0.001% by weight, based on the total weight of the tabletop sweetener.
- C2 The tabletop sweetener according to embodiment Cl, which is solid or liquid.
- C3 The tabletop sweetener according to embodiment C1 or C2, which is liquid, wherein the liquid is provided in a container, from which the liquid can be removed by drops and metered.
- C4 The tabletop sweetener according to embodiment C1 or C2, which is solid and present as a particulate composition or as a compacted particulate composition.
- C5 The tabletop sweetener according to any one of the preceding embodiments, wherein the content of cellobiose, preferably in combination with alkalosis, 1.0 ⁇ 0.5% by weight, 2.0 ⁇ 1.5% by weight, 2, 0 ⁇ 0.5 wt%, 3.0 ⁇ 2.5 wt%, 3.0 ⁇ 1.5 wt%, 3.0 ⁇ 0.5 wt%, 4.0 ⁇ 3.5% by weight, 4.0 ⁇ 2.5% by weight, 4.0 ⁇ 1.5% by weight, 4.0 ⁇ 0.5% by weight, 5.0 ⁇ 4, 5% by weight, 5.0 ⁇ 3.5% by weight, 5.0 ⁇ 2.5% by weight, 5.0 ⁇ 1.5% by weight, or 5.0 ⁇ 0.5 % By weight, based in each case on the total weight of the tabletop sweetener.
- C6 The tabletop sweetener according to any one of embodiments C1 to C4, wherein the content of cellobiose, preferably in combination with alkalosis, 10 ⁇ 5% by weight, 20 ⁇ 15% by weight, 20 ⁇ 5% by weight, 30 ⁇ 25 wt%, 30 ⁇ 15 wt%, 30 ⁇ 5 wt%, 40 ⁇ 35 wt%, 40 ⁇ 25 wt%, 40 ⁇ 15 wt%, 40 ⁇ 5% by weight, 50 ⁇ 45% by weight, 50 ⁇ 35% by weight, 50 ⁇ 25% by weight, 50 ⁇ 15% by weight, 50 ⁇ 5% by weight, 60 ⁇ 35% by weight %, 60 ⁇ 25% by weight, 60 ⁇ 15% by weight, 60 ⁇ 5% by weight, 70 ⁇ 25% by weight, 70 ⁇ 15% by weight, or 70 ⁇ 5% by weight.
- C8 The tabletop sweetener according to embodiment C7, wherein the sweetener is selected from the group consisting of acesulfame, aspartame, aspartame-acesulfame salt, cyclamate, neohesperidin, neotame, saccharin, sucralose, stevioside, thaumatin, alitame, brazzein, dulcine, Hernandulcin, lugdunam, monellin, pentadine, curculin, miraculin, osladine, perillartine, stevia, and mixtures thereof.
- the sweetener is selected from the group consisting of acesulfame, aspartame, aspartame-acesulfame salt, cyclamate, neohesperidin, neotame, saccharin, sucralose, stevioside, thaumatin, alitame, brazzein,
- C9 The tabletop sweetener according to embodiment C7 or C8, wherein the sugar substitute is selected from the group consisting of sorbitol, xylitol, mannitol, isomalt, maltitol, lactitol, erythritol and mixtures thereof.
- C10 The tabletop sweetener according to any one of embodiments C7 to C9, wherein the content of the sweetener component is 1.0 ⁇ 0.5 wt%, 2.0 ⁇ 1.5 wt%, 2.0 ⁇ 0 , 5 wt%, 3.0 ⁇ 2.5 wt%, 3.0 ⁇ 1.5 wt%, 3.0 ⁇ 0.5 wt%, 4.0 ⁇ 3.5 Wt .-%, 4.0 ⁇ 2.5 wt .-%, 4.0 ⁇ 1.5 wt .-%, 4.0 ⁇ 0.5 wt .-%, 5.0 ⁇ 4.5 wt.
- O l The tabletop sweetener according to any of embodiments C7 to C9, wherein the content of the sweetener component is 10 ⁇ 5% by weight, 20 ⁇ 15% by weight, 20 ⁇ 5% by weight, 30 ⁇ 25% by weight %, 30 ⁇ 15% by weight, 30 ⁇ 5% by weight, 40 ⁇ 35% by weight, 40 ⁇ 25% by weight, 40 ⁇ 15% by weight, 40 ⁇ 5% by weight.
- D1 to D10 of the invention are:
- D1 A pharmaceutical composition or dosage form comprising cellobiose, preferably in combination with allulose, wherein the content of cellobiose, preferably in combination with allulose, is at least 0.001% by weight on the total weight of the pharmaceutical composition or dosage form.
- D2 The pharmaceutical composition or dosage form according to embodiment D1, which is solid, semi-solid or liquid.
- D3 The pharmaceutical composition or dosage form according to embodiment Dl or D2, which is selected from the group consisting of powders, tablets, dragees, capsules, sachets, suppositories, effervescent tablets, infusion solutions, injection solutions, juice preparations, tinctures, ointments and creams.
- D4 The pharmaceutical composition or dosage form according to any one of the preceding embodiments, which is intended for systemic, topical or local administration.
- D5 The pharmaceutical composition or dosage form according to embodiment D4, wherein the dosage form is intended for oral administration.
- D6 The pharmaceutical composition or dosage form according to one of the preceding embodiments, wherein the content of cellobiose, preferably in combination with allulose, 1.0 ⁇ 0.5% by weight, 2.0 ⁇ 1.5% by weight, 2 , 0 ⁇ 0.5 wt%, 3.0 ⁇ 2.5 wt%, 3.0 ⁇ 1.5 wt%, 3.0 ⁇ 0.5 wt%, 4.0 ⁇ 3.5 wt%, 4.0 ⁇ 2.5 wt%, 4.0 ⁇ 1.5 wt%, 4.0 ⁇ 0.5 wt%, 5.0 ⁇ 4 , 5% by weight, 5.0 ⁇ 3.5% by weight, 5.0 ⁇ 2.5% by weight, 5.0 ⁇ 1.5% by weight, or 5.0 ⁇ 0, 5 wt .-%, in each case based on the total weight of the pharmaceutical composition or dosage form.
- D7 The pharmaceutical composition or dosage form according to any of embodiments Dl to D5, wherein the content of cellobiose, preferably in combination with allulose, 10 ⁇ 5% by weight, 20 ⁇ 15% by weight, 20 ⁇ 5% by weight , 30 ⁇ 25 wt%, 30 ⁇ 15 wt%, 30 ⁇ 5 wt%, 40 ⁇ 35 wt%, 40 ⁇ 25 wt%, 40 ⁇ 15 wt%, 40 ⁇ 5 wt%, 50 ⁇ 45 wt%, 50 ⁇ 35 wt%, 50 ⁇ 25 wt%, 50 ⁇ 15 wt%, 50 ⁇ 5 wt%, 60 ⁇ 35 Wt .-%, 60 ⁇ 25 wt .-%, 60 ⁇ 15 wt .-%, 60 ⁇ 5 wt .-%, 70 ⁇ 25 wt .-%, 70 ⁇ 15 wt .-%, or 70 ⁇ 5 wt .-%
- D8 The pharmaceutical composition or dosage form according to any one of the preceding embodiments, which contains neither cellotriose, nor cetotetraose, nor cellopentaose, nor cellohexaose.
- D9 Use of cellobiose, preferably in combination with allulose, in pharmaceutical compositions or dosage forms as adjuvant, preferably as pharmaceutical excipient, more preferably as filler and / or as compaction aid and / or as release agent and / or as disintegrant.
- D10 Use of cellobiose, preferably in combination with allulose, for preventing the oxidative degradation of substances which are sensitive to oxidation in pharmaceutical compositions or dosage forms.
- E1 to E15 of the invention are:
- E1 A fruit preparation comprising cellobiose, preferably in combination with allulose, wherein the content of cellobiose, preferably in combination with allulose, is at least 0.001% by weight, based on the total weight the fruit preparation.
- E2 The fruit preparation according to embodiment El, which is selected from jam (eg jam 2: 1, jam 3: 1), jam, jelly and fruit spread.
- E3 The fruit preparation according to embodiment E1 or E2 which comprises one or more fruits or extracts of these fruits selected from the group consisting of forest fruit, elderberry, apple, pear, cherry, lemon, lime, orange, grapefruit, cranberry, blueberry , Cranberry, raspberry, strawberry, blackberry, gooseberry, currant, quince, banana, peach, mandarin, nectarine, fig, date, grape, kiwi, apricot, mirabelle, rosehip, mango, papaya, pineapple, pomelo, melon, sharon fruit, passion fruit , Blackthorn, plum and Plum.
- E4 The fruit preparation according to any one of the preceding embodiments, wherein the content of cellobiose, preferably in combination with allulose, 1.0 ⁇ 0.5% by weight, 2.0 ⁇ 1.5% by weight, 2.0 ⁇ 0.5% by weight, 3.0 ⁇ 2.5% by weight, 3.0 ⁇ 1.5% by weight, 3.0 ⁇ 0.5% by weight, 4.0 ⁇ 3, 5% by weight, 4.0 ⁇ 2.5% by weight, 4.0 ⁇ 1.5% by weight, 4.0 ⁇ 0.5% by weight, 5.0 ⁇ 4.5% by weight %, 5.0 ⁇ 3.5% by weight, 5.0 ⁇ 2.5% by weight, 5.0 ⁇ 1.5% by weight, or 5.0 ⁇ 0.5% by weight. -%, in each case based on the total weight of the fruit preparation.
- E5 The fruit preparation according to one of embodiments E1 to E3, wherein the content of cellobiose, preferably in combination with allulose, 10 ⁇ 5% by weight, 20 ⁇ 15% by weight, 20 ⁇ 5% by weight, 30 ⁇ 25% by weight, 30 ⁇ 15% by weight, 30 ⁇ 5% by weight, 40 ⁇ 35% by weight, 40 ⁇ 25% by weight, 40 ⁇ 15% by weight, 40 ⁇ 5% by weight %, 50 ⁇ 45% by weight, 50 ⁇ 35% by weight, 50 ⁇ 25% by weight, 50 ⁇ 15% by weight, 50 ⁇ 5% by weight, 60 ⁇ 35% by weight.
- E7 The fruit preparation according to one of the preceding embodiments, which contains neither cellotriose, nor cellotetraose, nor cellopentaose, nor cellohexaose.
- E8 The fruit preparation according to any one of the preceding embodiments, which contains more sucrose than cellobiose.
- E9 The fruit preparation according to any one of the preceding embodiments, wherein the content of cellobiose in the fruit preparation is at most 50% by weight, more preferably at most 40% by weight, even more preferably at most 30% by weight, particularly preferably at most 25% by weight , most preferably at most 22.5 wt .-%, and particularly preferably at most 20 wt .-%, each based on the total weight of cellobiose and sucrose in the fruit preparation.
- E10 The fruit preparation according to any one of the preceding embodiments, wherein the content of cellobiose in the fruit preparation at least 5.0 wt .-%, more preferably at least 7.5 wt .-%, more preferably at least 10 wt .-%, particularly preferably at least 15 Wt .-%, most preferably at least 17.5 wt .-%, and particularly preferably at least 20 wt .-% is, in each case based on the total weight of cellobiose and sucrose in the fruit preparation.
- the fruit preparation according to any one of the preceding embodiments wherein the content of sucrose in the fruit preparation at most 95 wt .-%, more preferably at most 92.5 wt .-%, more preferably at most 90 wt .-%, particularly preferably at most 85 wt %, most preferably at most 82.5% by weight, and most preferably at most 80% by weight, in each case based on the total weight of cellobiose and sucrose in the fruit preparation.
- E12 The fruit preparation according to any one of the preceding embodiments, wherein the content of sucrose in the fruit preparation at least 50 wt .-%, more preferably at least 60 wt .-%, more preferably at least 70 wt .-%, particularly preferably at least 75 wt .-% , most preferably at least 77.5 wt .-%, and particularly preferably at least 80 wt .-%, each based on the total weight of cellobiose and sucrose in the fruit preparation.
- El 3 A dairy product comprising a fruit preparation according to one of the embodiments El to E12.
- E14 The dairy product according to embodiment E13, which is selected from quark, cream cheese, yoghurt and other preparations whose fat content in relation to the dry matter is preferably in the range of 0.1 to 40 wt .-%.
- E15 Use of cellobiose, preferably in combination with allulose, as emulsifier or binder, preferably in compositions containing fruit preparations, preferably in combination with dairy products.
- Particularly preferred embodiments Fl to F12 of the invention are: Fl: A baked good comprising cellobiose, preferably in combination with alkalosis, wherein the content of cellobiose, preferably in combination with alkalosis, is at least 0.001% by weight, based on the total weight the baked goods.
- F2 The baked goods according to embodiment Fl, which is selected from bread, biscuits and pastry.
- F3 The baked good according to embodiment Fl or F2, which is a bread selected from the group consisting of white bread, wheat mixed bread, wheat meal bread, rye bread, mixed rye bread, toasted bread, and crispbread; or which is a cake, preferably a sponge cake selected from the group consisting of onion cake, tarte cake, bacon cake, quiche, pizza, apple pie, Baumkuchen, Bee sting, butter cake, Eierschecke, English cake, Gugelhupf, yeast cake, blueberry pie, cheesecake, cherry pie, marble cake , Poppy seed cake, moss cake, fruit cake, panettone, petit goateau, plum cake, russian cakes, pancakes, chocolate cake, stollen, crumble cake and lemon cake.
- F4 The baked good according to any one of the preceding embodiments, wherein the content of cellobiose, preferably in combination with alkalosis, 1.0 ⁇ 0.5% by weight, 2.0 ⁇ 1.5% by weight, 2.0 ⁇ 0.5% by weight, 3.0 ⁇ 2.5% by weight, 3.0 ⁇ 1.5% by weight, 3.0 ⁇ 0.5% by weight, 4.0 ⁇ 3, 5% by weight, 4.0 ⁇ 2.5% by weight, 4.0 ⁇ 1.5% by weight, 4.0 ⁇ 0.5% by weight, 5.0 ⁇ 4.5% by weight %, 5.0 ⁇ 3.5% by weight, 5.0 ⁇ 2.5% by weight, 5.0 ⁇ 1.5% by weight, or 5.0 ⁇ 0.5% by weight.
- F5 The baked good according to any one of embodiments Fl to F3, wherein the content of cellobiose, preferably in combination with alkalose, 10 ⁇ 5 wt%, 20 ⁇ 15 wt .-%, 20 ⁇ 5 wt .-%, 30 ⁇ 25% by weight, 30 ⁇ 15% by weight, 30 ⁇ 5% by weight, 40 ⁇ 35% by weight, 40 ⁇ 25% by weight, 40 ⁇ 15% by weight, 40 ⁇ 5% by weight %, 50 ⁇ 45% by weight, 50 ⁇ 35% by weight, 50 ⁇ 25% by weight, 50 ⁇ 15% by weight, 50 ⁇ 5% by weight, 60 ⁇ 35% by weight.
- F7 The baked good according to one of the preceding embodiments, wherein the average particle size (d50) of the cellobiose, preferably in combination with alkalosis, is at most 250 ⁇ m, more preferably at most 200 ⁇ m and even more preferably less than 170 ⁇ m.
- F8 The baked good according to one of the preceding embodiments, which contains neither cellotriose, nor cellotetraose, nor cellopentaose, nor cellohexaose.
- F9 Use of cellobiose, preferably in combination with alkalosis, as a baking agent.
- F10 The use according to embodiment F9, wherein the average particle size (d50) of the cellobiose, preferably in combination with alkalosis, is at most 250 ⁇ m, more preferably at most 200 ⁇ m and even more preferably less than 170 ⁇ m.
- Fl 1 A caking composition comprising cellobiose, preferably in combination with alkalosis, and at least one food and optionally food additives, wherein the content of cellobiose, preferably in combination with alkalosis, is at least 0.001% by weight, based on the total weight of the caking composition.
- F12 The baking agent composition according to embodiment Fl 1, wherein the average particle size (d50) of cellobiose, preferably in combination with alkalosis, is at most 250 ⁇ m, more preferably at most 200 ⁇ m and even more preferably less than 170 ⁇ m.
- G1 to G21 of the invention are: G1: A decorative sugar comprising cellobiose.
- G3 The decorative sugar according to embodiment Gl or G2, wherein the content of cellobiose, preferably in combination with alkalosis, 10 ⁇ 5 wt .-%, 20 ⁇ 15 wt .-%, 20 ⁇ 5 wt .-%, 30 ⁇ 25 wt %, 30 ⁇ 15% by weight, 30 ⁇ 5% by weight, 40 ⁇ 35% by weight, 40 ⁇ 25% by weight, 40 ⁇ 15% by weight, 40 ⁇ 5% by weight.
- % 50 ⁇ 45 wt%, 50 ⁇ 35 wt%, 50 ⁇ 25 wt%, 50 ⁇ 15 wt%, 50 ⁇ 5 wt%, 60 ⁇ 35 wt%, 60 ⁇ 25 wt%, 60 ⁇ 15 wt%, 60 ⁇ 5 wt%, 70 ⁇ 25 wt%, 70 ⁇ 15 wt%, or 70 ⁇ 5 wt%, 80 ⁇ 15 wt .-%, 80 ⁇ 10 wt .-%, or 80 ⁇ 5 wt .-%, 90 ⁇ 10 wt .-%, or 90 ⁇ 5 wt .-%, each based on the total weight of the decorative sugar.
- G4 The decorative sugar according to one of the preceding embodiments, which additionally contains sucrose in addition to cellobiose, preferably in combination with alkalose.
- G5 The decorative sugar according to embodiment G4, wherein the content of cellobiose is higher than the content of sucrose.
- G6 The decorative sugar according to any one of the preceding embodiments, which in addition to cellobiose, preferably in combination with alkalosis, contains a sweetener component, wherein the sweetener component comprises at least one sweetener and / or at least one sugar substitute.
- G7 The decorative sugar according to embodiment G6, wherein the sweetener is selected from the group consisting of acesulfame, aspartame, aspartame-acesulfame salt, cyclamate, neohesperidin, neotame, saccharin, sucralose, stevioside, thaumatin, alitame, brazzein, dulcine, hernandulcine, Lugdunam, monellin, pentadine, curculin, miraculin, osladine, perillartine, stevia, and mixtures thereof.
- the sweetener is selected from the group consisting of acesulfame, aspartame, aspartame-acesulfame salt, cyclamate, neohesperidin, neotame, saccharin, sucralose, stevioside, thaumatin, alitame, brazzein, dulcine, her
- G8 The decorative sugar according to embodiment G6 or G7, wherein the sugar substitute is selected from the group consisting of sorbitol, xylitol, mannitol, isomalt, maltitol, lactitol, erythritol and mixtures thereof.
- G9 The decorative sugar according to any one of embodiments G6 to G8, wherein the content of the sweetener component is 1.0 ⁇ 0.5 wt%, 2.0 ⁇ 1.5 wt%, 2.0 ⁇ 0.5 Wt .-%, 3.0 ⁇ 2.5 wt .-%, 3.0 ⁇ 1.5 wt .-%, 3.0 ⁇ 0.5 wt .-%, 4.0 ⁇ 3.5 wt.
- G10 The decorative sugar according to any of embodiments G6 to G8, wherein the content of the sweetener component is 10 ⁇ 5% by weight, 20 ⁇ 15% by weight, 20 ⁇ 5% by weight, 30 ⁇ 25% by weight , 30 ⁇ 15 wt%, 30 ⁇ 5 wt%, 40 ⁇ 35 wt%, 40 ⁇ 25 wt%, 40 ⁇ 15 wt%, 40 ⁇ 5 wt%, 50 ⁇ 45 wt%, 50 ⁇ 35 wt%, 50 ⁇ 25 wt%, 50 ⁇ 15 wt%, 50 ⁇ 5 wt%, 60 ⁇ 35 wt%, 60 ⁇ 25 Wt .-%, 60 ⁇ 15 wt .-%, 60 ⁇ 5 wt .-%, 70 ⁇ 25 wt .-%, 70 ⁇ 15 wt .-%, or 70 ⁇ 5 wt .-% is, in each case based on the total weight of the decorative sugar.
- Gl 1 The decorative sugar according to one of the preceding embodiments, which has a mean particle diameter of at most 130 ⁇ .
- G12 The decorative sugar according to one of the embodiments G1 to G10, which has a mean particle diameter of at most 500 ⁇ m, preferably in the range of more than 130 ⁇ m to 500 ⁇ m.
- G13 The decorative sugar according to one of the embodiments G1 to G10, which has an average particle diameter in the range from 200 ⁇ m to 5,000 ⁇ m.
- G14 The decorative sugar according to one of the preceding embodiments, which contains neither cellotriose, nor cellotetraose, nor cellopentaose, nor cellohexaose.
- G15 A cover or a coating of a baked good comprising a decorative sugar according to one of the preceding embodiments.
- G16 The covering or coating according to embodiment Eq. 5, which additionally comprises fat and / or starch.
- Eq. 7 A baked good comprising a decorative sugar according to one of the embodiments E1 to G14.
- Gl 8 The baked goods after Embodiment Eq. 7, comprising a cover or coating according to embodiment Eq 5 or Eq. 6.
- G19 The baked good according to embodiment G17 or G18, which comprises a fruit and / or pudding filling.
- G20 Use of a decorative sugar according to one of embodiments GI to G14 for decorating baked goods.
- G21 Use of a decorative sugar according to one of the embodiments G1 to G14 as a release agent in baked goods or confectionery.
- HI to H16 of the invention are: HI: A gelling sugar comprising cellobiose.
- H2 The gelling sugar according to embodiment H1, which comprises cellobiose in combination with sucrose.
- H3 The gelling sugar according to embodiment Hl or H2, which in addition to cellobiose and optionally sucrose additionally comprises no further carbohydrates or which comprises not more than 5 wt .-% further carbohydrates, based on the total weight of the gelling sugar.
- H3 The gelling sugar according to any one of the preceding embodiments, wherein the content of cellobiose is 10 ⁇ 5% by weight, 20 ⁇ 15% by weight, 20 ⁇ 5% by weight, 30 ⁇ 25% by weight, 30 ⁇ 15 % By weight, 30 ⁇ 5% by weight, 40 ⁇ 35% by weight, 40 ⁇ 25% by weight, 40 ⁇ 15% by weight, 40 ⁇ 5% by weight, 50 ⁇ 45% by weight.
- H5 The gelling sugar according to any of the preceding embodiments, wherein the content of cellobiose in gelling sugar is at most 50% by weight, more preferably at most 40% by weight, even more preferably at most 30% by weight, particularly preferably at most 25% by weight most preferably at most 22.5 wt .-%, and particularly preferably at most 20 wt .-% is, in each case based on the total weight of cellobiose and sucrose in gelling sugar.
- H6 The gelling sugar according to any one of the preceding embodiments, wherein the content of cellobiose in gelling sugar at least 5.0 wt .-%, more preferably at least 7.5 wt .-%, more preferably at least 10 wt .-%, particularly preferably at least 15 wt .-%, most preferably at least 17.5 wt .-%, and particularly preferably at least 20 wt .-% is, in each case based on the total weight of cellobiose and sucrose in gelling sugar.
- H7 The gelling sugar according to any one of the preceding embodiments, wherein the content of sucrose in gelling sugar is at most 95% by weight, more preferably at most 92.5% by weight, even more preferably at most 90% by weight, particularly preferably at most 85% by weight. %, most preferably at most 82.5 wt .-%, and particularly preferably at most 80 wt .-% is, in each case based on the total weight of cellobiose and sucrose in gelling sugar.
- H8 The gelling sugar according to one of the preceding embodiments, wherein the content of sucrose in the gelling sugar is at least 50% by weight, more preferably at least 60% by weight, even more preferably at least 70% by weight, particularly preferably at least 75% by weight most preferably at least 77.5 wt .-%, and particularly preferably at least 80 wt .-%, each based on the total weight of cellobiose and sucrose in gelling sugar.
- H9 The gelling sugar according to any one of the preceding embodiments, wherein the gelling sugar contains at least one gelling agent.
- H10 The gelling sugar according to embodiment H9, wherein the gelling agent is selected from the group consisting of corn starch, potato starch, tapioca, rice flour, agar, guar, xanthan, pectin, gelatin and their mixture.
- the gelling agent is selected from the group consisting of corn starch, potato starch, tapioca, rice flour, agar, guar, xanthan, pectin, gelatin and their mixture.
- the gelling sugar according to embodiment H9 or H10 wherein the content of gelling agent at least 0.001 wt .-%, at least 0.005 wt .-%, at least 0.01 wt .-%, at least 0.05 wt .-%, at least 0 , 1 wt%, at least 0.2 wt%, at least 0.3 wt%, at least 0.4 wt%, at least 0.5% by weight, at least 0.75% by weight, at least 1.0% by weight, at least 1.5% by weight, at least 2.0% by weight, at least 2.5% by weight.
- % or at least 3.0% by weight, based on the total weight of gelling sugar; and / or at most 10 wt%, at most 5.0 wt%, at most 4.5 wt%, at most 4.0 wt%, at most 3.5 wt%, at most 3.0 Wt .-%, at most 2.5 wt .-%, at most 2.0 wt .-%, at most 1.5 wt .-%, at most 1.0 wt .-%, or at most 0.5 wt .-% is based on the total weight of gelling sugar.
- Hl 2 The gelling sugar according to one of the preceding embodiments, wherein the gelling sugar contains at least one acid, preferably an organic acid, particularly preferably a carboxylic acid, in particular a multicarboxylic acid.
- H13 The gelling sugar according to embodiment H12, wherein the acid is citric acid or tartaric acid.
- H14 The gelling sugar according to embodiment H12 or H13, wherein the acid content is at least 0.001% by weight, at least 0.005% by weight, at least 0.01% by weight, at least 0.05% by weight, at least 0, 1 wt%, at least 0.2 wt%, at least 0.3 wt%, at least 0.4 wt%, at least 0.5 wt%, at least 0.75 wt% , at least 1.0 wt%, at least 1.5 wt%, at least 2.0 wt%, at least 2.5 wt%, or at least 3.0 wt%, based on the total weight of gelling sugar; and / or at most 10 wt%, at most 5.0 wt%, at most 4.5 wt%, at most 4.0 wt%, at most 3.5 wt%, at most 3.0 Wt .-%, at most 2.5 wt .-%, at most 2.0 wt .-%, at most 1.5 wt .-%,
- Hl 5 The gelling sugar according to one of the preceding embodiments, wherein the gelling sugar in addition to cellobiose, optionally sucrose, optionally gelling agent and optionally acid substantially no further saccharides and / or no sweetener and / or no sugar substitutes and / or no antioxidants and / or no preservatives.
- H16 The gelling sugar according to one of the preceding embodiments, which contains neither cellotriose, nor cetotetraose, nor cellopentaose, nor cellohexaose.
- ZI to Z17 of the invention are: ZI: A composition intended for consumption or ingestion comprising cellobiose, the content of cellobiose being at least 0.001% by weight, based on the total weight of the composition.
- Z2 The composition according to embodiment ZI, which is solid.
- Z3 The composition according to embodiment ZI or Z2, which additionally contains at least one ingredient other than cellobiose for a food, dietary supplement, pleasure or other food, for a feed or for a drug.
- Z4 The composition according to embodiment Z3, wherein the relative weight ratio cellobiose: ingredient is in the range of 1,000: 1 to 1: 1,000.
- Z5 The composition according to embodiment Z3 or Z4, wherein the ingredient is selected from the group consisting of flavors, dyes, nutrients, spices, sweeteners, sugar substitutes, enzymes, microorganisms, pharmaceutical excipients, drugs and mixtures thereof.
- Z6 The composition according to any one of embodiments Z3 to Z5, wherein the ingredient is alkalose.
- Z7 The composition according to any one of the preceding embodiments, which contains at least one carrier selected from the group consisting of polysaccharides, hydrocolloids, polyols, waxes, paraffins, fats, oils and mixtures thereof.
- Z8 The composition according to any one of embodiments Z3 to Z7, wherein (i) the content of cellobiose ranges from 0.01 to 99.99% by weight based on the total weight of the composition; and / or (ii) the level of ingredient ranges from 0.01 to 99.99 weight percent, based on the total weight of the composition; and / or (iii) the content of carrier ranges from 0 to 99.98% by weight on the total weight of the composition.
- Z9 The composition according to any one of the preceding embodiments, wherein the composition is particulate and the particles (i) have a mean particle diameter in the range of 100 nm to 1.0 mm; and / or (ii) coated with a coating material.
- composition according to any one of the preceding embodiments which contains neither cellotriose nor cellotetraose, nor cellopentaose, nor cellohexaose.
- a method of making the composition of any of embodiments ZI to Z10 comprising contacting (i) cellobiose; (ii) an ingredient other than cellobiose for a food, nutritional supplement, pleasure or other food, feed or medicine; preferably selected from the group consisting of flavors, dyes, nutrients, spices, sweeteners, sugar substitutes, enzymes, microorganisms, pharmaceutical excipients, drugs and mixtures thereof; and (iii) if applicable, one or more carriers.
- ZI 2 The method according to embodiment ZI 1, wherein the cellobiose the ingredient and optionally the carrier is at least moistened with a solvent and then dried.
- ZI 3 A composition obtainable by the method of embodiment ZU or Z12.
- Z14 A food, nutritional supplement, indulgence or other food, feed or medicine containing the composition according to any one of embodiments ZI to Z10 or ZI 3.
- ZI 5 the food, dietary supplement, pleasure or other food, Feed or pharmaceutical composition according to embodiment ZI 4, wherein (i) the content of the composition is at least 0.001% by weight, based on the total weight of the food, dietary supplement, pleasure or other food, feed or medicine; and or
- the content of cellobiose is at least 0.001% by weight, based on the total weight of the food, food supplement, food or other food, feed or medicine;
- compositions selected from the group consisting of pharmaceutical compositions, tabletop sweeteners, instant products, convenience food products, bakery products, confectionery, fruit preparations, snacks, and flavored foods.
- Item 6 Use of the composition according to one of the embodiments ZI to Z10 or ZI 3 for the olfactory and / or gustatory and / or visual modification of a food, dietary supplement, pleasure or other food, a feed or a drug.
- Item 7 Use of cellobiose to increase the shelf life of an ingredient in a food, nutritional supplement, pleasure or other food, feed or medicine; preferably selected from the group consisting of flavors, dyes, nutrients, spices, sweeteners, sugar substitutes, enzymes, microorganisms, pharmaceutical excipients, drugs and mixtures thereof.
- Example 1 illustrate the invention, but are not intended to be limiting.
- Limonene (14% by weight) was spray-dried as an example flavoring with a matrix of starch (Hi-Cap 100, 16% by weight) and maltodextrin (DE10 or DE20, up to 70% by weight).
- Hi-Cap 100 16% by weight
- maltodextrin DE10 or DE20, up to 70% by weight
- no cellobiose was added.
- cellobiose was added in amounts between 1 and 25%, and the amount of maltodextrin correspondingly reduced.
- the samples were stored at 40 ° C after preparation.
- the analysis is sensory.
- a trained panel was trained over several weeks with the aid of spray-dried reference samples (without cellobiose). The samples were stored at 40 ° C and taken weekly from the drying oven, so that after six weeks, a scale had emerged. The panel was trained to safely place various stored samples in the correct order of storage life, i. to sort the samples according to the intensity of the resulting off-flavor.
- the samples without cellobiose show a false flavor much faster (e.g., R-terpineol, limonene-1,2-epoxide, (S) -carvone, carveol).
- the encapsulated limonene remains stable for longer.
- Wheat loaves were prepared with varying levels of cellobiose (1%, 3%, 5%). In each case, two different batches of cellobiose were used (CB12, CM), which differed in their grain size.
- Figure 1 shows the increase in pastry volume for all wheat breads of the invention compared to a wheat bread which did not contain cellobiose. On average, the pastry volume increased by about 3.2% (1.857 cm 3 vs. 1.916 cm 3 ).
- FIG. 2 shows the change in crumb firmness after storage of the wheat loaves for 24 h and for 96 h.
- 24-h creamer stability decreased by 4.7% (719 vs. 685), and 7.9% (1.510 vs. 1.391) after storage for 96 h.
- Sponge cakes were prepared with varying levels of cellobiose (1 wt%, 3 wt%, 5 wt%). Two different batches of cellobiose were also used (CB12, CM). The crumb moisture and the crumb firmness were examined and their change after storage for 1 Day, 7 days, 14 days, 21 days and 28 days after baking were measured. The results are shown in FIGS. 3 and 4.
- FIG. 3 shows the change in the crumb moisture for all the sponge cake according to the invention in comparison to a sponge cake which did not contain cellobiose.
- Figure 4 shows the change in crumb firmness for all the sponge cakes of the invention as compared to a sponge cake which did not contain cellobiose.
- Cellobiose was exemplified for other compresses such as e.g. Sweetener tablets or effervescent tablets used in film-coated tablets.
- Cellobiose should replace classical filling and pressing aids such as Lactose, maltodextrin, sorbitol, inulin, oligofructose, microcrystalline cellulose, di-calcium phosphate or polyvinlypyrrolidone.
- Such adjuvants are either nutritionally or detrimentally disadvantageous, e.g. Lactose, as this can lead to incompatibilities, or economically disadvantageous as polyvinlypyrrolidone, which has a much higher price than conventional excipients.
- Usual proportions of the excipients are between 70 to 95% of the total amount of the ingredients.
- Cellobiose was granulated in combination with a likewise more economically attractive modified potato starch.
- about 91% of the cellobiose granules were compressed with 8% of vitamin B 12 and about 1% of a mixture of stearic acid and stearate and coated with a commercially available coating.
- Such coatings are e.g. from hydrocolloids such as hydroxypropyl methylcellulose and other excipients such as talc, stearic acid, a medium chain triglyceride and a dye e.g. Titanium dioxide.
- the tablets After compression, the tablets had a hardness of 184 N and a disintegration time of 10 minutes. Thus, they were in the range of usual hardnesses, which can be between 120 N to 300 N.
- the tablets were stored at room temperature of 20 ° C and at 35 ° C for several months. Hardness and disintegration time of the tablets were measured at different times. The results are shown in the following table:
- the change in hardness during storage is shown in FIG.
- the change in the disintegration time in the course of storage is shown in FIG.
- the tablets stored at room temperature thus had a hardness of 212N and a disintegration time of 12 minutes.
- the tablets stored at 35 ° C. thus had a hardness of 177 N and 18.5 minutes of disintegration time.
- aqueous solutions containing 5% and 7.5% cellobiose, 0.02% o, and 0.04% o CMC and pure water were compared with a 5% sucrose solution.
- the products were compared in a beverage application.
- Such drinks can be prepared, for example, by dissolving suitable effervescent tablets.
- compositions of the beverage mixtures were as follows:
- CMC carboxymethylcellulose
- results from the panel could also be confirmed by means of a viscosity measurement, according to which the cellobiose batches have a similar mouthfeel as the batches with sucrose.
- a viscosity measurement according to which the cellobiose batches have a similar mouthfeel as the batches with sucrose.
- mixtures of cellobiose and sucrose were prepared with different relative weight fraction and measured the viscosity at different concentrations and different temperatures. All viscosity measurements were made with a Brookfield rotary viscometer.
- the stability of cellobiose against hydrolysis as a function of pH was determined.
- the cellobiose survives the simultaneous action of low pH and high temperature as opposed to sucrose.
- Benefits in the beverage arise here both in terms of color stability on heating and in terms of sensory stability in contrast to sucrose, which is hydrolyzed to fructose and glucose and thus identifies both a changed sweetness impression compared to the starting product and a slight yellowish Browning due to fructose.
- Example 7 [0270] The influence of cellobiose on the sensory properties of jams was investigated.
- the samples were 1: 1 strawberry jams, ie strawberry jams made with gelling sugar (1: 1).
- the sucrose was replaced by cellobiose to 0%, 5%, 10%, 15%, 20%>, 25% o, and 30%>.
- a gelling sugar of the following composition was prepared:
- sucrose When replaced by cellobiose, the corresponding amount of sucrose is omitted.
- wTSr weight of dry substance determined by refractometry
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
Abstract
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15152184 | 2015-01-22 | ||
| EP15181108 | 2015-08-14 | ||
| PCT/EP2016/051387 WO2016116627A1 (fr) | 2015-01-22 | 2016-01-22 | Cellobiose contenue dans des compositions à consommer ou à prendre par voie orale |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP3247403A1 true EP3247403A1 (fr) | 2017-11-29 |
Family
ID=55221435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP16701354.9A Withdrawn EP3247403A1 (fr) | 2015-01-22 | 2016-01-22 | Cellobiose contenue dans des compositions à consommer ou à prendre par voie orale |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP3247403A1 (fr) |
| DE (1) | DE202016008304U1 (fr) |
| WO (1) | WO2016116627A1 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108135223A (zh) * | 2015-10-22 | 2018-06-08 | 奇华顿股份有限公司 | 使用纤维二糖和/或阿洛酮糖掩蔽异味的方法 |
| EP3364776B1 (fr) * | 2015-10-22 | 2021-05-05 | Givaudan SA | Méthode pour accentuer le goût sucré grâce à la cellobiose |
| CN107772478A (zh) * | 2016-08-24 | 2018-03-09 | 南京逐陆医药科技有限公司 | 一种复合维生素片及其制备方法 |
| CN107912732A (zh) * | 2017-11-28 | 2018-04-17 | 安徽砀山海升果业有限责任公司 | 一种荔枝原浆的制备方法 |
| EP3758513A1 (fr) | 2018-02-28 | 2021-01-06 | c-LEcta GmbH | Enrichissement enzymatique in situ d'aliments avec des glucides fonctionnels |
| AU2022270951A1 (en) * | 2021-05-06 | 2023-10-26 | Cambridge Glycoscience Ltd | Freezing point modulation |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR871493B (en) | 1987-09-28 | 1987-10-07 | Viorul | New food processing method that preserves all the organic substances and their sustenance with controlled dietary value |
| US20070014854A1 (en) * | 2005-07-15 | 2007-01-18 | Ilan Zalit | Novel granulation process |
| US8349365B2 (en) * | 2005-09-27 | 2013-01-08 | Asahi Kasei Chemicals Corporation | Cellooligosaccharide-containing composition |
| CA2647551A1 (fr) * | 2006-03-31 | 2007-10-11 | Nippon Paper Chemicals Co., Ltd. | Composition destinee a une boisson ou a un aliment |
| JP5535616B2 (ja) * | 2006-03-31 | 2014-07-02 | ルビコン リサーチ プライベート リミテッド | 口腔内崩壊錠剤のための直接圧縮性複合材 |
| JP5340528B2 (ja) * | 2006-06-26 | 2013-11-13 | 旭化成ケミカルズ株式会社 | 内臓における脂質の低減剤 |
| JP5014018B2 (ja) * | 2006-10-18 | 2012-08-29 | 旭化成ケミカルズ株式会社 | ピロリ菌の抑制剤または静菌剤 |
| US20080107787A1 (en) * | 2006-11-02 | 2008-05-08 | The Coca-Cola Company | Anti-Diabetic Composition with High-Potency Sweetener |
| JP4731541B2 (ja) | 2007-11-28 | 2011-07-27 | 旭化成ケミカルズ株式会社 | セロオリゴ糖含有チョコレート |
| JP4731542B2 (ja) | 2007-12-13 | 2011-07-27 | 旭化成ケミカルズ株式会社 | セロオリゴ糖含有キャンディー |
| JP4726913B2 (ja) | 2008-01-09 | 2011-07-20 | 旭化成ケミカルズ株式会社 | セロオリゴ糖を含有する冷菓 |
| JP2009185228A (ja) | 2008-02-08 | 2009-08-20 | Asahi Kasei Chemicals Corp | ゲル化剤 |
| JP5155918B2 (ja) | 2009-03-26 | 2013-03-06 | 旭化成ケミカルズ株式会社 | 冷凍飲食品 |
| JP5550277B2 (ja) * | 2009-07-23 | 2014-07-16 | 長谷川香料株式会社 | 保存安定性に優れた粉末組成物 |
| DE102010020640A1 (de) | 2010-05-15 | 2011-11-17 | Pfeifer & Langen Kommanditgesellschaft | Futtermittel und Futtermittelzusatzstoff |
| TR201007250A2 (tr) | 2010-09-01 | 2012-03-21 | Bi̇lgi̇ç Mahmut | Selobioz içeren formülasyon. |
| JP5400970B2 (ja) | 2010-10-08 | 2014-01-29 | 長谷川香料株式会社 | 茶類エキス |
| WO2014030250A1 (fr) * | 2012-08-24 | 2014-02-27 | カクイ株式会社 | Agent antitumoral |
-
2016
- 2016-01-22 WO PCT/EP2016/051387 patent/WO2016116627A1/fr not_active Ceased
- 2016-01-22 EP EP16701354.9A patent/EP3247403A1/fr not_active Withdrawn
- 2016-01-22 DE DE202016008304.0U patent/DE202016008304U1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE202016008304U1 (de) | 2017-07-05 |
| WO2016116627A1 (fr) | 2016-07-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1804594B1 (fr) | Agglomeres compresses utilisables pour la consommation | |
| EP3247403A1 (fr) | Cellobiose contenue dans des compositions à consommer ou à prendre par voie orale | |
| AT390354B (de) | Verfahren zur herstellung von suesswaren | |
| US20090298952A1 (en) | Platable soluble dyes | |
| KR20130091643A (ko) | 쿠르쿠민 풍미의 마스킹 방법 | |
| Klinjapo et al. | Microencapsulation of color and flavor in confectionery products | |
| DE60024970T2 (de) | Betain und backprodukte | |
| RU2603913C1 (ru) | Способ производства сладких зерновых хлебцев | |
| EP2022503B1 (fr) | Extraits de vaccin encapsulés ayant une libération équilibrée dans l'estomac-intestin | |
| Adhikari | Additives and preservatives used in food processing and preservation, and their health implication | |
| CA2631054C (fr) | Substance de base servant a produire des produits alimentaires destines aux etres humains et des produits alimentaires destines aux animaux | |
| WO2016124652A1 (fr) | Matrice cerealiere comprenant au moins un nutriment et/ou une autre substance fonctionnelle | |
| US20070141217A1 (en) | High intensity sweeteners and coloring agent compositions | |
| TW202102124A (zh) | 乳化香料粉末的製造方法 | |
| Varzakas | Advances in food additives and contaminants | |
| AU2003264112B2 (en) | Food product providing sustained blood levels of exogenous substances | |
| RU2641014C2 (ru) | Ароматизирующая композиция, содержащая глюкозиды hmg | |
| EP0875156B1 (fr) | Proudits pour soutenir le traitement de dermatite atopique | |
| CN101166426A (zh) | 包含胶囊化香料的脂肪、蜡或油基食品成分 | |
| KR20170118458A (ko) | 짜먹는 강황젤리의 제조방법 | |
| US20130012599A1 (en) | Surface treatment for gasified consumable materials | |
| RU2537902C2 (ru) | Карамель леденцовая | |
| RU2442429C1 (ru) | Витаминизированная карамель | |
| JP2003047440A (ja) | 食品用トッピング及びその製造方法 | |
| JP3155918U (ja) | ビタミン強化と虫歯予防機能を有する農産物加工食品米菓煎餅。 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
| 17P | Request for examination filed |
Effective date: 20170822 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
| AX | Request for extension of the european patent |
Extension state: BA ME |
|
| DAV | Request for validation of the european patent (deleted) | ||
| DAX | Request for extension of the european patent (deleted) | ||
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: EXAMINATION IS IN PROGRESS |
|
| 17Q | First examination report despatched |
Effective date: 20190517 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
| PUAG | Search results despatched under rule 164(2) epc together with communication from examining division |
Free format text: ORIGINAL CODE: 0009017 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: EXAMINATION IS IN PROGRESS |
|
| 17Q | First examination report despatched |
Effective date: 20201204 |
|
| B565 | Issuance of search results under rule 164(2) epc |
Effective date: 20201204 |
|
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 47/26 20060101AFI20201202BHEP Ipc: A21D 2/18 20060101ALI20201202BHEP Ipc: A61K 31/7016 20060101ALI20201202BHEP Ipc: A23L 2/52 20060101ALI20201202BHEP Ipc: A23L 27/00 20160101ALI20201202BHEP Ipc: A61K 9/16 20060101ALI20201202BHEP Ipc: A23L 27/30 20160101ALI20201202BHEP Ipc: A61K 9/20 20060101ALI20201202BHEP Ipc: A23L 33/24 20160101ALI20201202BHEP Ipc: A23L 21/10 20160101ALI20201202BHEP |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20210615 |