EP3129027A4 - Modulators of caspase-6 - Google Patents

Modulators of caspase-6 Download PDF

Info

Publication number: EP3129027A4
Authority: EP; European Patent Office
Prior art keywords: caspase; modulators
Prior art date: 2014-02-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP15829650.9A

Other languages

German (de)

French (fr)

Other versions

EP3129027A1 (en

Inventor

Medhi Mike KHANKISCHPUR

Olga PETINA

Detlef Geffken

Dagmar ERNHOEFER

Michael Hayden

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of British Columbia

Universitaet Hamburg

Original Assignee

University of British Columbia

Universitaet Hamburg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-02-14

Filing date

2015-02-14

Publication date

2017-06-21

2015-02-14 Application filed by University of British Columbia, Universitaet Hamburg filed Critical University of British Columbia

2017-02-15 Publication of EP3129027A1 publication Critical patent/EP3129027A1/en

2017-06-21 Publication of EP3129027A4 publication Critical patent/EP3129027A4/en

Status Withdrawn legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/28—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having nitrogen atoms of imino groups acylated

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EP15829650.9A 2014-02-14 2015-02-14 Modulators of caspase-6 Withdrawn EP3129027A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201461939922P	2014-02-14	2014-02-14
US201462033401P	2014-08-05	2014-08-05
PCT/IB2015/000144 WO2016020732A1 (en)	2014-08-05	2015-02-14	Modulators of caspase-6

Publications (2)

Publication Number	Publication Date
EP3129027A1 EP3129027A1 (en)	2017-02-15
EP3129027A4 true EP3129027A4 (en)	2017-06-21

Family

ID=55263221

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP15829650.9A Withdrawn EP3129027A4 (en)	2014-02-14	2015-02-14	Modulators of caspase-6

Country Status (6)

Country	Link
EP (1)	EP3129027A4 (en)
JP (1)	JP2018522812A (en)
AU (1)	AU2015298491A1 (en)
CA (1)	CA2939655A1 (en)
DE (1)	DE112015001269T5 (en)
WO (1)	WO2016020732A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN107592861B (en)	2015-03-06	2021-06-08	法玛克亚公司	Fluorinated lysyl oxidase-like 2 inhibitor and use thereof
JP6800872B2 (en)	2015-03-06	2020-12-16	ファーマケア，インク．	Lysyl oxidase-like 2 inhibitor and its use
ES2880766T3 (en)	2016-02-09	2021-11-25	Pharmakea Inc	Quinolinone lysyl oxidase inhibitors similar to type 2 and uses thereof
BR112019004513A2 (en)	2016-09-07	2019-06-18	Pharmakea Inc	Uses of a Lysyl Oxidase-Like Inhibitor 2
MA46204A (en)	2016-09-07	2021-03-17	Pharmakea Inc	CRYSTALLINE FORMS OF LYSYL OXIDASE TYPE 2 INHIBITOR AND METHODS FOR MANUFACTURING THEM
AU2020386639A1 (en) *	2019-11-22	2022-06-02	Shangpharma Innovation Inc.	Caspase 6 inhibitors and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2010017408A1 (en) *	2008-08-06	2010-02-11	The Buck Institute For Age Research	Caspase inhibitors and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0818439B1 (en) *	1996-07-02	1999-10-13	Nisshin Flour Milling Co., Ltd.	Imide derivatives
ES2546815T3 (en) *	2006-12-15	2015-09-28	Bristol-Myers Squibb Company	Analogs of arylpropylamide, arylacrylamide, arylpropinamide or arylmethylurea as inhibitors of factor XIa

2015
- 2015-02-14 JP JP2016552512A patent/JP2018522812A/en active Pending
- 2015-02-14 WO PCT/IB2015/000144 patent/WO2016020732A1/en not_active Ceased
- 2015-02-14 EP EP15829650.9A patent/EP3129027A4/en not_active Withdrawn
- 2015-02-14 DE DE112015001269.9T patent/DE112015001269T5/en not_active Withdrawn
- 2015-02-14 AU AU2015298491A patent/AU2015298491A1/en not_active Abandoned
- 2015-02-14 CA CA2939655A patent/CA2939655A1/en not_active Abandoned

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2010017408A1 (en) *	2008-08-06	2010-02-11	The Buck Institute For Age Research	Caspase inhibitors and uses thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DIETER HUBMANN ET AL: "N-(3-Phenyl-2-propynoyl)benzamide", MOLECULES, 1 January 1999 (1999-01-01), pages M107, XP055372338, Retrieved from the Internet <URL:http://www.mdpi.org/molbank/m0107.htm> [retrieved on 20170512] *
NILOUFAR ANSARI ET AL: "Attenuation of LPS-induced apoptosis in NGF-differentiated PC12 cells via NF-B pathway and regulation of cellular redox status by an oxazine derivative", BIOCHIMIE, MASSON, PARIS, FR, vol. 93, no. 5, 20 November 2011 (2011-11-20), pages 899 - 908, XP028192107, ISSN: 0300-9084, [retrieved on 20110202], DOI: 10.1016/J.BIOCHI.2011.01.012 *
OLGA PETINA ET AL: "Preparation of Arylpropynamides and Their Reaction with Malonyl Acid Derivatives", SYNTHESIS, vol. 45, no. 06, 15 February 2013 (2013-02-15), STUTTGART, DE., pages 803 - 809, XP055372325, ISSN: 0039-7881, DOI: 10.1055/s-0032-1316851 *
RONA K GRAHAM ET AL: "Caspase-6 and neurodegeneration", TRENDS IN NEUROSCIENCE, vol. 34, no. 12, December 2011 (2011-12-01), pages 646 - 656, XP028119167, ISSN: 0166-2236, [retrieved on 20110917], DOI: 10.1016/J.TINS.2011.09.001 *

Also Published As

Publication number	Publication date
AU2015298491A1 (en)	2016-09-01
WO2016020732A1 (en)	2016-02-11
JP2018522812A (en)	2018-08-16
DE112015001269T5 (en)	2017-06-08
CA2939655A1 (en)	2016-02-11
EP3129027A1 (en)	2017-02-15

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Legal Events

Date	Code	Title	Description
2017-01-13	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2017-01-13	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2017-02-15	17P	Request for examination filed	Effective date: 20160818
2017-02-15	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2017-02-15	AX	Request for extension of the european patent	Extension state: BA ME
2017-05-24	DAX	Request for extension of the european patent (deleted)
2017-06-21	A4	Supplementary search report drawn up and despatched	Effective date: 20170523
2017-06-21	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 31/535 20060101AFI20170517BHEP Ipc: A61P 25/14 20060101ALI20170517BHEP Ipc: C07D 265/06 20060101ALI20170517BHEP Ipc: A61K 31/165 20060101ALI20170517BHEP Ipc: C07C 251/28 20060101ALI20170517BHEP Ipc: A61P 25/28 20060101ALI20170517BHEP
2017-07-26	RIN1	Information on inventor provided before grant (corrected)	Inventor name: GEFFKEN, DETLEF Inventor name: KHANKISCHPUR, MEDHI, MIKE Inventor name: HAYDEN, MICHAEL Inventor name: ERNHOEFER, DAGMAR Inventor name: PETINA, OLGA
2018-02-16	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN
2018-02-28	RIC1	Information provided on ipc code assigned before grant	Ipc: C07C 251/28 20060101ALI20180122BHEP Ipc: A61P 25/28 20060101ALI20180122BHEP Ipc: A61P 25/14 20060101ALI20180122BHEP Ipc: A61K 31/165 20060101ALI20180122BHEP Ipc: A61K 45/06 20060101ALI20180122BHEP Ipc: C07D 265/06 20060101ALI20180122BHEP Ipc: A61K 31/535 20060101AFI20180122BHEP
2018-03-21	18W	Application withdrawn	Effective date: 20180209