EP3119749A4 - Procédé de préparation de composé antifongique - Google Patents

Procédé de préparation de composé antifongique Download PDF

Info

Publication number: EP3119749A4
Authority: EP; European Patent Office
Prior art keywords: antifungal compound; compound process; antifungal; compound
Prior art date: 2014-03-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP15765715.6A

Other languages

German (de)

English (en)

Other versions

EP3119749A1 (fr

Inventor

William J. HOESKTRA

Christopher M. YATES

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Mycovia Pharmaceuticals Inc

Original Assignee

Viamet Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-03-19

Filing date

2015-03-19

Publication date

2017-12-13

2015-03-19 Application filed by Viamet Pharmaceuticals Inc filed Critical Viamet Pharmaceuticals Inc

2017-01-25 Publication of EP3119749A1 publication Critical patent/EP3119749A1/fr

2017-12-13 Publication of EP3119749A4 publication Critical patent/EP3119749A4/fr

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/26—Radicals substituted by halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Communicable Diseases (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Obesity (AREA)
Biomedical Technology (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EP15765715.6A 2014-03-19 2015-03-19 Procédé de préparation de composé antifongique Withdrawn EP3119749A4 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201461955554P	2014-03-19	2014-03-19
PCT/US2015/021436 WO2015143137A1 (fr)	2014-03-19	2015-03-19	Procédé de préparation de composé antifongique

Publications (2)

Publication Number	Publication Date
EP3119749A1 EP3119749A1 (fr)	2017-01-25
EP3119749A4 true EP3119749A4 (fr)	2017-12-13

Family

ID=54145308

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP15765715.6A Withdrawn EP3119749A4 (fr)	2014-03-19	2015-03-19	Procédé de préparation de composé antifongique

Country Status (6)

Country	Link
US (1)	US9802914B2 (fr)
EP (1)	EP3119749A4 (fr)
JP (2)	JP2017512777A (fr)
AU (1)	AU2015231270B2 (fr)
CA (1)	CA2942927A1 (fr)
WO (1)	WO2015143137A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP6518683B2 (ja) *	2014-03-19	2019-05-22	ヴィアメットファーマスーティカルズ（エヌシー），インコーポレイテッド	抗真菌化合物の調製方法
AU2015231234B2 (en)	2014-03-19	2019-04-04	Mycovia Pharmaceuticals, Inc.	Antifungal compound process
AU2015231220B2 (en)	2014-03-19	2019-04-04	The United States Of America, As Represented By The Secretary, Department Of Health & Human Services	Antifungal compound process
EA037587B1 (ru)	2014-03-19	2021-04-19	Майковиа Фармасьютикалс, Инк.	Способ получения противогрибковых соединений
MX382905B (es) *	2014-03-19	2025-03-13	Viamet Pharmaceuticals Nc Inc	2-(2,4-difluorofenil)-1,1-difluoro-1-(5-sustituido-piridin-2-il)-3-(1h-tetrazol-1-il)propan-2-oles y procesos para su preparacion.
AU2015231270B2 (en) *	2014-03-19	2019-03-07	Viamet Pharmaceuticals (NC), Inc.	Antifungal compound process
JP2017514790A (ja)	2014-03-19	2017-06-08	ヴィアメットファーマスーティカルズ，インコーポレイテッド	抗真菌化合物の調製方法
JP6572234B2 (ja)	2014-03-19	2019-09-04	ヴィアメットファーマスーティカルズ（エヌシー），インコーポレイテッド	抗真菌化合物の調製方法
MX371291B (es)	2014-03-19	2020-01-24	Viamet Pharmaceuticals Nc Inc	2-(2,4-difluorofenil)-1,1-difluoro-1-(5-sustituido-piridin-2-il)- 3-(1h-tetrazol-1-il)propan-2-oles y procedimientos para su preparacion.
JP6606508B2 (ja)	2014-03-19	2019-11-13	マイコヴィアファーマシューティカルズ，インコーポレイテッド	抗真菌化合物の調製方法
MX391538B (es)	2015-09-18	2025-03-21	Mycovia Pharmaceuticals Inc	Proceso de compuesto antifungico.
WO2017117393A1 (fr) *	2015-12-30	2017-07-06	Viamet Pharmaceuticals, Inc.	Composés inhibiteurs de métallo-enzymes

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2000344744A (ja) *	1999-06-04	2000-12-12	Ss Pharmaceut Co Ltd	アセトフェノン誘導体およびその製法
JP5266430B2 (ja) *	2010-04-24	2013-08-21	ヴィアメットファーマスーティカルズ，インコーポレイテッド	金属酵素阻害化合物
CA2839691A1 (fr)	2011-06-19	2012-12-27	Viamet Pharmaceuticals, Inc.	Composes inhibiteurs de metalloenzymes
CA2839769A1 (fr)	2011-06-19	2012-12-27	Viamet Pharmaceuticals, Inc.	Composes inhibiteurs de metalloenzymes
AU2012273007A1 (en) *	2011-06-23	2014-01-30	Viamet Pharmaceuticals (NC), Inc.	Metalloenzyme inhibitor compounds
AU2013209516A1 (en) *	2012-01-20	2014-08-28	Viamet Pharmaceuticals (NC), Inc.	Metalloenzyme inhibitor compounds
EA201491386A1 (ru)	2012-01-20	2014-11-28	Вайамет Фармасьютикалс, Инк.	Соединения, ингибирующие металлоферменты
JP6518683B2 (ja) *	2014-03-19	2019-05-22	ヴィアメットファーマスーティカルズ（エヌシー），インコーポレイテッド	抗真菌化合物の調製方法
AU2015231270B2 (en) *	2014-03-19	2019-03-07	Viamet Pharmaceuticals (NC), Inc.	Antifungal compound process
JP6572234B2 (ja) *	2014-03-19	2019-09-04	ヴィアメットファーマスーティカルズ（エヌシー），インコーポレイテッド	抗真菌化合物の調製方法

2015
- 2015-03-19 AU AU2015231270A patent/AU2015231270B2/en not_active Ceased
- 2015-03-19 JP JP2016557561A patent/JP2017512777A/ja active Pending
- 2015-03-19 US US15/126,330 patent/US9802914B2/en not_active Expired - Fee Related
- 2015-03-19 CA CA2942927A patent/CA2942927A1/fr not_active Abandoned
- 2015-03-19 WO PCT/US2015/021436 patent/WO2015143137A1/fr not_active Ceased
- 2015-03-19 EP EP15765715.6A patent/EP3119749A4/fr not_active Withdrawn
2019
- 2019-02-06 JP JP2019019367A patent/JP2019089811A/ja active Pending

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *

Also Published As

Publication number	Publication date
JP2017512777A (ja)	2017-05-25
US20170081309A1 (en)	2017-03-23
US9802914B2 (en)	2017-10-31
CA2942927A1 (fr)	2015-09-24
JP2019089811A (ja)	2019-06-13
AU2015231270B2 (en)	2019-03-07
WO2015143137A1 (fr)	2015-09-24
AU2015231270A1 (en)	2016-09-29
EP3119749A1 (fr)	2017-01-25

Publication	Publication Date	Title
EP3297998A4 (fr)	2018-11-14	Composés antifongiques
EP3196187A4 (fr)	2018-04-18	Nouveau composé
EP3119755A4 (fr)	2017-08-23	Procédé de préparation d'un composé antifongique
ZA201801404B (en)	2018-12-19	Antifungal compound process
EP3286169A4 (fr)	2018-11-21	Nouveaux composés
EP3119754A4 (fr)	2017-12-13	Préparation d'un composé antifongique
EP3238101A4 (fr)	2018-06-06	Opérations de graphe
EP3119745A4 (fr)	2017-08-23	Procédé de préparation d'un composé antifongique
EP3325449A4 (fr)	2019-01-09	Composés
EP3099695A4 (fr)	2017-07-12	Composés
EP3102198A4 (fr)	2017-07-26	Composés antidiabétiques
EP3184866A4 (fr)	2018-05-30	Vanne composite
EP3224246A4 (fr)	2018-07-18	Composés de 4-oxoquinoléine
EP3255991A4 (fr)	2018-07-04	Picolinamides utilisés en tant que fongicides
EP3099694A4 (fr)	2017-06-14	Composés
EP3119746A4 (fr)	2017-08-16	Procédé de préparation d'un composé antifongique
EP3119748A4 (fr)	2017-08-30	Procédé de préparation d'un composé antifongique
EP3172208A4 (fr)	2017-12-06	Composés
EP3119749A4 (fr)	2017-12-13	Procédé de préparation de composé antifongique
EP3119764A4 (fr)	2017-08-02	Procédé de préparation d'un composé antifongique
EP3119771A4 (fr)	2017-11-22	Procédé associé à un composé antifongique
EP3135114A4 (fr)	2017-09-27	Composé diaryl-azole
EP3214086A4 (fr)	2018-04-18	Composé de dihydropyrrolopyrazole substitué
EP3148975A4 (fr)	2018-01-03	Nouveaux composés
EP3110792A4 (fr)	2017-09-27	Composés d'aminocarbonylcarbamate

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2016-11-30	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2016-12-23	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2016-12-23	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2017-01-25	17P	Request for examination filed	Effective date: 20160915
2017-01-25	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2017-01-25	AX	Request for extension of the european patent	Extension state: BA ME
2017-06-28	DAV	Request for validation of the european patent (deleted)
2017-06-28	DAX	Request for extension of the european patent (deleted)
2017-08-16	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 31/41 20060101ALI20170707BHEP Ipc: A61P 31/04 20060101ALI20170707BHEP Ipc: C07D 213/26 20060101ALI20170707BHEP Ipc: C07D 257/04 20060101AFI20170707BHEP
2017-12-13	A4	Supplementary search report drawn up and despatched	Effective date: 20171113
2017-12-13	RIC1	Information provided on ipc code assigned before grant	Ipc: C07D 213/26 20060101ALI20171107BHEP Ipc: A61K 31/41 20060101ALI20171107BHEP Ipc: C07D 257/04 20060101AFI20171107BHEP Ipc: A61P 31/04 20060101ALI20171107BHEP
2018-02-28	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: VIAMET PHARMACEUTICALS (NC), INC.
2018-11-30	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: EXAMINATION IS IN PROGRESS
2019-01-02	17Q	First examination report despatched	Effective date: 20181203
2019-07-10	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: MYCOVIA PHARMACEUTICALS, INC.
2020-01-31	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2020-03-04	18D	Application deemed to be withdrawn	Effective date: 20191003