EP3019005A4 - MRAP2 INACTIVATIONS - Google Patents

MRAP2 INACTIVATIONS

Info

Publication number: EP3019005A4
Authority: EP; European Patent Office
Prior art keywords: mrap2; inactivations; mrap2 inactivations
Prior art date: 2013-07-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

EP14822448.8A

Other languages

German (de)

French (fr)

Other versions

EP3019005A1 (en

EP3019005B1 (en

Inventor

Joseph A Majzoub

Masato Asai

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Effstock LLC

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-07-10

Filing date

2014-07-09

Publication date

2016-12-21

2014-07-09 Application filed by Individual filed Critical Individual

2016-05-18 Publication of EP3019005A1 publication Critical patent/EP3019005A1/en

2016-12-21 Publication of EP3019005A4 publication Critical patent/EP3019005A4/en

2019-02-20 Application granted granted Critical

2019-02-20 Publication of EP3019005B1 publication Critical patent/EP3019005B1/en

Status Active legal-status Critical Current

2034-07-09 Anticipated expiration legal-status Critical

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/20—Animal model comprising regulated expression system
- A01K2217/206—Animal model comprising tissue-specific expression system, e.g. tissue specific expression of transgene, of Cre recombinase
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Environmental Sciences (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Veterinary Medicine (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Biodiversity & Conservation Biology (AREA)
Animal Husbandry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Cell Biology (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Immunology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EP14822448.8A 2013-07-10 2014-07-09 Mrap2 knockouts Active EP3019005B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201361844666P	2013-07-10	2013-07-10
PCT/US2014/045934 WO2015006437A1 (en)	2013-07-10	2014-07-09	Mrap2 knockouts

Publications (3)

Publication Number	Publication Date
EP3019005A1 EP3019005A1 (en)	2016-05-18
EP3019005A4 true EP3019005A4 (en)	2016-12-21
EP3019005B1 EP3019005B1 (en)	2019-02-20

Family

ID=52280563

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP14822448.8A Active EP3019005B1 (en)	2013-07-10	2014-07-09	Mrap2 knockouts

Country Status (8)

Country	Link
US (2)	US20160143256A1 (en)
EP (1)	EP3019005B1 (en)
JP (1)	JP6443811B2 (en)
KR (1)	KR102297747B1 (en)
CN (1)	CN105555132B (en)
AU (1)	AU2014287250A1 (en)
CA (1)	CA2917961A1 (en)
WO (1)	WO2015006437A1 (en)

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US9359599B2 (en)	2013-08-22	2016-06-07	President And Fellows Of Harvard College	Engineered transcription activator-like effector (TALE) domains and uses thereof
US9228207B2 (en)	2013-09-06	2016-01-05	President And Fellows Of Harvard College	Switchable gRNAs comprising aptamers
US9388430B2 (en)	2013-09-06	2016-07-12	President And Fellows Of Harvard College	Cas9-recombinase fusion proteins and uses thereof
US9526784B2 (en)	2013-09-06	2016-12-27	President And Fellows Of Harvard College	Delivery system for functional nucleases
US20150165054A1 (en)	2013-12-12	2015-06-18	President And Fellows Of Harvard College	Methods for correcting caspase-9 point mutations
EP3177718B1 (en)	2014-07-30	2022-03-16	President and Fellows of Harvard College	Cas9 proteins including ligand-dependent inteins
AU2015355546B2 (en)	2014-12-03	2021-10-14	Agilent Technologies, Inc.	Guide RNA with chemical modifications
CN114231527A (en)	2015-04-06	2022-03-25	里兰斯坦福初级大学理事会	Chemically modified guide RNAs for CRISPR/CAS-mediated gene regulation
WO2017070633A2 (en)	2015-10-23	2017-04-27	President And Fellows Of Harvard College	Evolved cas9 proteins for gene editing
CN108883176A (en) *	2016-03-28	2018-11-23	东丽株式会社	The treatment of cancer and/or prophylactic compositions
WO2017170338A1 (en) *	2016-03-28	2017-10-05	東レ株式会社	Immunity inducing agent
KR101863653B1 (en) *	2016-06-02	2018-06-05	전남대학교 산학협력단	Knock in vector for expressing lactoferrin and knock in method using thereof
US10767175B2 (en)	2016-06-08	2020-09-08	Agilent Technologies, Inc.	High specificity genome editing using chemically modified guide RNAs
WO2018027078A1 (en)	2016-08-03	2018-02-08	President And Fellows Of Harard College	Adenosine nucleobase editors and uses thereof
JP7201153B2 (en)	2016-08-09	2023-01-10	プレジデントアンドフェローズオブハーバードカレッジ	Programmable CAS9-recombinase fusion protein and uses thereof
US11542509B2 (en)	2016-08-24	2023-01-03	President And Fellows Of Harvard College	Incorporation of unnatural amino acids into proteins using base editing
EP3526320A1 (en)	2016-10-14	2019-08-21	President and Fellows of Harvard College	Aav delivery of nucleobase editors
WO2018119359A1 (en)	2016-12-23	2018-06-28	President And Fellows Of Harvard College	Editing of ccr5 receptor gene to protect against hiv infection
EP3592853A1 (en)	2017-03-09	2020-01-15	President and Fellows of Harvard College	Suppression of pain by gene editing
KR20190123328A (en)	2017-03-09	2019-10-31	프레지던트 앤드 펠로우즈 오브 하바드 칼리지	Cancer vaccine
JP2020510439A (en)	2017-03-10	2020-04-09	プレジデントアンドフェローズオブハーバードカレッジ	Base-editing factor from cytosine to guanine
KR102687373B1 (en)	2017-03-23	2024-07-23	프레지던트 앤드 펠로우즈 오브 하바드 칼리지	Nucleobase editing agent comprising a nucleic acid programmable DNA binding protein
US11560566B2 (en)	2017-05-12	2023-01-24	President And Fellows Of Harvard College	Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
EP3658573A1 (en)	2017-07-28	2020-06-03	President and Fellows of Harvard College	Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace)
US11319532B2 (en)	2017-08-30	2022-05-03	President And Fellows Of Harvard College	High efficiency base editors comprising Gam
EP3697906A1 (en)	2017-10-16	2020-08-26	The Broad Institute, Inc.	Uses of adenosine base editors
US12406749B2 (en)	2017-12-15	2025-09-02	The Broad Institute, Inc.	Systems and methods for predicting repair outcomes in genetic engineering
EP3797160A1 (en)	2018-05-23	2021-03-31	The Broad Institute Inc.	Base editors and uses thereof
WO2020092453A1 (en)	2018-10-29	2020-05-07	The Broad Institute, Inc.	Nucleobase editors comprising geocas9 and uses thereof
WO2020154500A1 (en)	2019-01-23	2020-07-30	The Broad Institute, Inc.	Supernegatively charged proteins and uses thereof
SG11202109882VA (en)	2019-03-19	2021-10-28	Broad Inst Inc	Methods and compositions for editing nucleotide sequences
EP3956349A1 (en)	2019-04-17	2022-02-23	The Broad Institute, Inc.	Adenine base editors with reduced off-target effects
US12435330B2 (en)	2019-10-10	2025-10-07	The Broad Institute, Inc.	Methods and compositions for prime editing RNA
KR20230019843A (en)	2020-05-08	2023-02-09	더 브로드 인스티튜트, 인코퍼레이티드	Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence
CN115232812B (en) *	2021-07-12	2025-10-24	南京启真基因工程有限公司	A method for constructing nuclear transfer donor cells for a pig model of severe early-onset obesity with MRAP2 gene mutation
JP2024534945A (en)	2021-09-10	2024-09-26	アジレント・テクノロジーズ・インク	Guide RNA for Prime Editing with Chemical Modifications

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2014
- 2014-07-09 JP JP2016525449A patent/JP6443811B2/en active Active
- 2014-07-09 US US14/903,621 patent/US20160143256A1/en not_active Abandoned
- 2014-07-09 KR KR1020167003290A patent/KR102297747B1/en active Active
- 2014-07-09 EP EP14822448.8A patent/EP3019005B1/en active Active
- 2014-07-09 CA CA2917961A patent/CA2917961A1/en not_active Abandoned
- 2014-07-09 CN CN201480049908.XA patent/CN105555132B/en active Active
- 2014-07-09 WO PCT/US2014/045934 patent/WO2015006437A1/en not_active Ceased
- 2014-07-09 AU AU2014287250A patent/AU2014287250A1/en not_active Abandoned
2018
- 2018-12-06 US US16/211,672 patent/US20190313614A1/en not_active Abandoned

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Also Published As

Publication number	Publication date
JP2016523561A (en)	2016-08-12
CA2917961A1 (en)	2015-01-15
JP6443811B2 (en)	2018-12-26
KR102297747B1 (en)	2021-09-06
EP3019005A1 (en)	2016-05-18
CN105555132B (en)	2018-07-17
US20190313614A1 (en)	2019-10-17
CN105555132A (en)	2016-05-04
WO2015006437A1 (en)	2015-01-15
KR20160042884A (en)	2016-04-20
EP3019005B1 (en)	2019-02-20
US20160143256A1 (en)	2016-05-26
AU2014287250A1 (en)	2016-02-18

Publication	Publication Date	Title
EP3019005A4 (en)	2016-12-21	MRAP2 INACTIVATIONS
BR302013003501S1 (en)	2014-06-03	SANDALIA CONFIGURATION
BR302013003421S1 (en)	2014-06-03	SANDALIA CONFIGURATION
BR302013003349S1 (en)	2014-08-26	SANDALIA CONFIGURATION
BR302013003271S1 (en)	2014-06-10	SANDALIA CONFIGURATION
BR302013003145S1 (en)	2014-06-03	SANDALIA CONFIGURATION
BR302013002900S1 (en)	2014-07-15	SANDALIA CONFIGURATION
BR302013002902S1 (en)	2014-07-15	CHINELO CONFIGURATION
BR302013002901S1 (en)	2014-07-15	CHINELO CONFIGURATION
BR302013002878S1 (en)	2014-07-15	CHINELO CONFIGURATION
BR302013002876S1 (en)	2014-07-15	CHINELO CONFIGURATION
BR302013002875S1 (en)	2014-07-15	CHINELO CONFIGURATION
BR302013002692S1 (en)	2014-06-03	SANDALIA CONFIGURATION
BR302013002654S1 (en)	2014-12-09	SANDALIA CONFIGURATION
BR302013002446S1 (en)	2014-06-24	SANDALIA CONFIGURATION
BR302013002445S1 (en)	2014-06-24	SANDALIA CONFIGURATION
BR302013002433S1 (en)	2014-06-24	SANDALIA CONFIGURATION
BR302013002432S1 (en)	2014-06-24	SANDALIA CONFIGURATION
BR302013002367S1 (en)	2014-06-03	CHINELO CONFIGURATION
BR302013002327S1 (en)	2014-06-24	CHINELO CONFIGURATION
BR302013002296S1 (en)	2014-06-03	SANDALIA CONFIGURATION
BR302013002229S1 (en)	2015-06-09	Bag-applied configuration
BR302013002104S1 (en)	2014-06-03	CHINELO CONFIGURATION
BR302013002086S1 (en)	2014-06-03	CHINELO CONFIGURATION
BR302013002085S1 (en)	2014-06-03	SANDALIA CONFIGURATION

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