EP3004870A4 - Diagnostic différentiel de tumeurs bénignes - Google Patents
Diagnostic différentiel de tumeurs bénignes Download PDFInfo
- Publication number
- EP3004870A4 EP3004870A4 EP13885931.9A EP13885931A EP3004870A4 EP 3004870 A4 EP3004870 A4 EP 3004870A4 EP 13885931 A EP13885931 A EP 13885931A EP 3004870 A4 EP3004870 A4 EP 3004870A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- differential diagnosis
- benign tumors
- benign
- tumors
- diagnosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 238000003748 differential diagnosis Methods 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3563—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solids; Preparation of samples therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3577—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N2021/3595—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using FTIR
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/12—Circuits of general importance; Signal processing
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Optics & Photonics (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18214760.3A EP3489659B1 (fr) | 2013-05-28 | 2013-11-14 | Procédé pour indiquer la présence de tumeurs bénignes à l'aide d'un échantillon de cellules mononucléaires périphériques (pbmc) |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361827933P | 2013-05-28 | 2013-05-28 | |
| PCT/IL2013/050945 WO2014191980A1 (fr) | 2013-05-28 | 2013-11-14 | Diagnostic différentiel de tumeurs bénignes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP18214760.3A Division EP3489659B1 (fr) | 2013-05-28 | 2013-11-14 | Procédé pour indiquer la présence de tumeurs bénignes à l'aide d'un échantillon de cellules mononucléaires périphériques (pbmc) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EP3004870A1 EP3004870A1 (fr) | 2016-04-13 |
| EP3004870A4 true EP3004870A4 (fr) | 2017-03-01 |
| EP3004870B1 EP3004870B1 (fr) | 2019-01-02 |
Family
ID=51988105
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP13885931.9A Not-in-force EP3004870B1 (fr) | 2013-05-28 | 2013-11-14 | Diagnostic différentiel de tumeurs bénignes |
| EP18214760.3A Not-in-force EP3489659B1 (fr) | 2013-05-28 | 2013-11-14 | Procédé pour indiquer la présence de tumeurs bénignes à l'aide d'un échantillon de cellules mononucléaires périphériques (pbmc) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP18214760.3A Not-in-force EP3489659B1 (fr) | 2013-05-28 | 2013-11-14 | Procédé pour indiquer la présence de tumeurs bénignes à l'aide d'un échantillon de cellules mononucléaires périphériques (pbmc) |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US9804145B2 (fr) |
| EP (2) | EP3004870B1 (fr) |
| ES (1) | ES2877332T3 (fr) |
| WO (1) | WO2014191980A1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013533960A (ja) | 2010-06-01 | 2013-08-29 | トドス メディカル リミテッド | がんの診断 |
| US9719937B2 (en) | 2011-05-11 | 2017-08-01 | Todos Medical Ltd. | Diagnosis of cancer |
| EP3004870B1 (fr) | 2013-05-28 | 2019-01-02 | Todos Medical Ltd. | Diagnostic différentiel de tumeurs bénignes |
| WO2015009970A1 (fr) | 2013-07-18 | 2015-01-22 | Erythron Llc | Mesures spectroscopiques avec un détecteur de réseaux parallèles |
| US10149620B2 (en) * | 2013-12-23 | 2018-12-11 | The University Of North Carolina At Charlotte | Methods and systems using LED sources to create contrast agents for mid-infrared imaging of blood vessels |
| WO2015131151A2 (fr) | 2014-02-28 | 2015-09-03 | Erythron, Llc | Méthode et appareil de détermination de marqueurs de santé par analyse d'un échantillon de sang |
| WO2016168090A1 (fr) | 2015-04-14 | 2016-10-20 | Nueon, Inc. | Méthode et appareil pour déterminer des marqueurs de santé par analyse de sang |
| GB2537875A (en) * | 2015-04-29 | 2016-11-02 | Imp Innovations Ltd | Infrared imaging of biological material |
| WO2017165403A1 (fr) | 2016-03-21 | 2017-09-28 | Nueon Inc. | Procédés et appareil de spectrométrie à maillage poreux |
| WO2018085699A1 (fr) | 2016-11-04 | 2018-05-11 | Nueon Inc. | Lancette et analyseur de sang combinés |
| EP3602011A2 (fr) | 2017-03-31 | 2020-02-05 | University of Strathclyde | Système de spectroscopie infrarouge |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992014134A1 (fr) * | 1991-02-04 | 1992-08-20 | National Research Council Of Canada | Procede permettant de detecter la presence d'anomalies dans des cellules exfoliees par spectroscopie a infrarouge |
| AU2730095A (en) * | 1994-06-28 | 1996-01-25 | Patrick T.T. Wong | Infrared spectroscopy of a sample treated with preservative |
| US5945674A (en) * | 1997-07-30 | 1999-08-31 | Vysis, Inc. | Method of identifying cellular types in a biological sample supported on an absorptive substrate by infrared spectroscopy |
| US20020027649A1 (en) * | 2000-07-08 | 2002-03-07 | Victor Chudner | Method for blood infrared spectroscopy diagnosing of inner organs pathology |
| US20020164810A1 (en) * | 2000-12-05 | 2002-11-07 | Vysis | Method and system for diagnosing pathology in biological samples by detection of infrared spectral markers |
| WO2011121588A1 (fr) * | 2010-03-29 | 2011-10-06 | Ben Gurion University Of The Negev Research And Development Authority | Procédé et système de détection et de surveillance d'un cancer hématologique |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4912050A (en) | 1986-02-26 | 1990-03-27 | The Beth Israel Hospital Association | Process for the screening of cancer using nuclear magnetic resonance |
| US4832483A (en) | 1987-09-03 | 1989-05-23 | New England Medical Center Hospitals, Inc. | Method of using resonance raman spectroscopy for detection of malignancy disease |
| US5197470A (en) | 1990-07-16 | 1993-03-30 | Eastman Kodak Company | Near infrared diagnostic method and instrument |
| US5168162A (en) * | 1991-02-04 | 1992-12-01 | Cornell Research Foundation, Inc. | Method of detecting the presence of anomalies in exfoliated cells using infrared spectroscopy |
| US5261410A (en) * | 1991-02-07 | 1993-11-16 | Alfano Robert R | Method for determining if a tissue is a malignant tumor tissue, a benign tumor tissue, or a normal or benign tissue using Raman spectroscopy |
| DE69231614T2 (de) | 1991-02-26 | 2001-05-03 | Massachusetts Institute Of Technology, Cambridge | Molekularspektroskopieverfahren und -einrichtungen zur gewebediagnose |
| EP0644412A3 (fr) | 1993-09-17 | 1995-08-09 | Boehringer Mannheim Gmbh | Procédé pour l'analyse des liquides et des suspensions ayant un intéret clinique. |
| US5697373A (en) | 1995-03-14 | 1997-12-16 | Board Of Regents, The University Of Texas System | Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies |
| US5733739A (en) | 1995-06-07 | 1998-03-31 | Inphocyte, Inc. | System and method for diagnosis of disease by infrared analysis of human tissues and cells |
| US5766549A (en) * | 1995-11-14 | 1998-06-16 | Coulter International Corp. | Apparatus for drying blood smear slides |
| AUPN825796A0 (en) | 1996-02-26 | 1996-03-14 | Ashdown, Martin | The application of infrared (ir) spectrometry to the investigations of components of blood and other body fluids |
| US5945675A (en) | 1996-03-18 | 1999-08-31 | Pacific Northwest Research Foundation | Methods of screening for a tumor or tumor progression to the metastatic state |
| AU8172998A (en) | 1997-06-27 | 1999-01-19 | Pacific Northwest Research Institute | Methods of differentiating metastatic and non-metastatic tumors |
| US6274871B1 (en) | 1998-10-22 | 2001-08-14 | Vysis, Inc. | Method and system for performing infrared study on a biological sample |
| US6251616B1 (en) | 1999-01-14 | 2001-06-26 | Biocrystal Ltd. | Methods and assay kits for detecting altered mononuclear cell phenotype related to a pro-tumor immune response |
| US7450229B2 (en) | 1999-01-25 | 2008-11-11 | Amnis Corporation | Methods for analyzing inter-cellular phenomena |
| US7132510B2 (en) | 2000-12-29 | 2006-11-07 | Bio-Technology General (Israel) Ltd. | Specific human antibodies for selective cancer therapy |
| US7524681B2 (en) | 2001-01-22 | 2009-04-28 | Andreas Wolf | Rapid assay for biological substances using FTIR |
| IL146521A0 (en) | 2001-11-15 | 2002-07-25 | Univ Ben Gurion | Novel optical method for diagnosis and grading of premalignant and malignant human colonic tissues |
| US8263664B2 (en) | 2002-05-19 | 2012-09-11 | University Of Utah Research Foundation | pH-sensitive polymeric micelles for drug delivery |
| US7257437B2 (en) * | 2002-07-05 | 2007-08-14 | The Regents Of The University Of California | Autofluorescence detection and imaging of bladder cancer realized through a cystoscope |
| JP2006514554A (ja) | 2002-11-21 | 2006-05-11 | ワイス | 腎細胞癌および他の固形腫瘍の診断法 |
| AU2004235395A1 (en) | 2003-04-29 | 2004-11-11 | Wyeth | Methods for prognosis and treatment of solid tumors |
| WO2006011487A1 (fr) | 2004-07-30 | 2006-02-02 | National University Corporation Chiba University | Procede servant a mesurer la concentration du glucose dans le sang en utilisant la spectroscopie infrarouge et instrument employant celui-ci |
| KR20070043868A (ko) * | 2004-08-02 | 2007-04-25 | 칠드런'즈 메디컬 센터 코포레이션 | 암에 대한 혈소판 바이오마커 |
| US20070003921A1 (en) | 2005-07-01 | 2007-01-04 | Andrus Paul G | Method of grading disease by Fourier Transform Infrared Spectroscopy |
| US20090175819A1 (en) | 2005-11-15 | 2009-07-09 | Apollo Life Sciences Limited | Molecule and chimeric molecules thereof |
| US20070161922A1 (en) * | 2006-01-09 | 2007-07-12 | Medical Optical Imaging Systems Ltd. | Method of infrared tomography, active and passive, for earlier diagnosis of breast cancer |
| US8774902B2 (en) * | 2006-06-01 | 2014-07-08 | Passive Imaging Medical Systems Engineering Ltd. (Pims) | Method of infrared thermography for earlier diagnosis of gastric colorectal and cervical cancer |
| JP5047962B2 (ja) | 2006-07-06 | 2012-10-10 | 株式会社疲労科学研究所 | 近赤外光を用いたガン、全身性エリテマトーデス(sle)又は抗リン脂質抗体症候群に関する検査・診断装置の作動方法 |
| US20100185064A1 (en) | 2007-01-05 | 2010-07-22 | Jadran Bandic | Skin analysis methods |
| EP2220505B1 (fr) | 2007-12-10 | 2015-10-28 | The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center | Procédés de diagnostic du cancer |
| RU2011102743A (ru) | 2008-06-26 | 2012-08-10 | Дана-Фарбер Кэнсер Инститьют, Инк. (Us) | Характерные признаки и детерминанты, связанные с метастазированием, и способы их применения |
| US20100210023A1 (en) | 2008-09-22 | 2010-08-19 | The Regents Of The University Of California | Salivary metabolic biomarkers for human oral cancer detection |
| AU2009313985B2 (en) * | 2008-11-12 | 2014-07-31 | Ventana Medical Systems, Inc. | Methods and apparatuses for heating slides carrying specimens |
| JP2013533960A (ja) | 2010-06-01 | 2013-08-29 | トドス メディカル リミテッド | がんの診断 |
| SG179311A1 (en) * | 2010-09-22 | 2012-04-27 | Univ Singapore | Methods and apparatus relating to integrated nir fluorescence and reflectance imaging and spectroscopy with polarization for improving tissue diagnosis and characterization |
| US9719937B2 (en) | 2011-05-11 | 2017-08-01 | Todos Medical Ltd. | Diagnosis of cancer |
| US20140087397A1 (en) | 2012-09-25 | 2014-03-27 | Children's Hospital Medical Center | Biomarkers for fanconi anemia |
| US9891108B2 (en) * | 2012-10-03 | 2018-02-13 | The Research Foundation For The State University Of New York | Spectroscopic method for Alzheimer's disease diagnosis |
| EP3004870B1 (fr) | 2013-05-28 | 2019-01-02 | Todos Medical Ltd. | Diagnostic différentiel de tumeurs bénignes |
-
2013
- 2013-11-14 EP EP13885931.9A patent/EP3004870B1/fr not_active Not-in-force
- 2013-11-14 EP EP18214760.3A patent/EP3489659B1/fr not_active Not-in-force
- 2013-11-14 US US14/894,128 patent/US9804145B2/en not_active Expired - Fee Related
- 2013-11-14 ES ES18214760T patent/ES2877332T3/es active Active
- 2013-11-14 WO PCT/IL2013/050945 patent/WO2014191980A1/fr not_active Ceased
-
2017
- 2017-10-17 US US15/785,801 patent/US10732165B2/en active Active
-
2020
- 2020-07-29 US US16/942,714 patent/US11513112B2/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992014134A1 (fr) * | 1991-02-04 | 1992-08-20 | National Research Council Of Canada | Procede permettant de detecter la presence d'anomalies dans des cellules exfoliees par spectroscopie a infrarouge |
| AU2730095A (en) * | 1994-06-28 | 1996-01-25 | Patrick T.T. Wong | Infrared spectroscopy of a sample treated with preservative |
| US5945674A (en) * | 1997-07-30 | 1999-08-31 | Vysis, Inc. | Method of identifying cellular types in a biological sample supported on an absorptive substrate by infrared spectroscopy |
| US20020027649A1 (en) * | 2000-07-08 | 2002-03-07 | Victor Chudner | Method for blood infrared spectroscopy diagnosing of inner organs pathology |
| US20020164810A1 (en) * | 2000-12-05 | 2002-11-07 | Vysis | Method and system for diagnosing pathology in biological samples by detection of infrared spectral markers |
| WO2011121588A1 (fr) * | 2010-03-29 | 2011-10-06 | Ben Gurion University Of The Negev Research And Development Authority | Procédé et système de détection et de surveillance d'un cancer hématologique |
Non-Patent Citations (5)
| Title |
|---|
| ELA OSTROVSKY ET AL: "Detection of Cancer Using Advanced Computerized Analysis of Infrared Spectra of Peripheral Blood", IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, IEEE SERVICE CENTER, PISCATAWAY, NJ, USA, vol. 60, no. 2, 1 February 2013 (2013-02-01), pages 343 - 353, XP011487358, ISSN: 0018-9294, DOI: 10.1109/TBME.2012.2226882 * |
| M. KHANMOHAMMADI ET AL: "Chemometrics assisted investigation of variations in infrared spectra of blood samples obtained from women with breast cancer: a new approach for cancer diagnosis", EUROPEAN JOURNAL OF CANCER CARE, vol. 19, no. 3, 1 May 2010 (2010-05-01), pages 352 - 359, XP055143919, ISSN: 0961-5423, DOI: 10.1111/j.1365-2354.2008.01062.x * |
| See also references of WO2014191980A1 * |
| SYLWIA OLSZTYNSKA-JANUS ET AL: "Spectroscopic techniques in the study of human tissues and their components. Part I: IR spectroscopy", ACTA OF BIOENGINEERING AND BIOMECHANICS REVIEW ARTICLE, vol. 14, 1 January 2012 (2012-01-01), XP055177752, DOI: 10.5277/abb120314 * |
| UDI ZELIG ET AL: "Pre-screening and follow-up of childhood acute leukemia using biochemical infrared analysis of peripheral blood mononuclear cells", BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - GENERAL SUBJECTS, ELSEVIER, AMSTERDAM, NL, vol. 1810, no. 9, 15 June 2011 (2011-06-15), pages 827 - 835, XP028243467, ISSN: 0304-4165, [retrieved on 20110623], DOI: 10.1016/J.BBAGEN.2011.06.010 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3004870A1 (fr) | 2016-04-13 |
| EP3489659A1 (fr) | 2019-05-29 |
| US20180196028A1 (en) | 2018-07-12 |
| EP3004870B1 (fr) | 2019-01-02 |
| WO2014191980A1 (fr) | 2014-12-04 |
| US9804145B2 (en) | 2017-10-31 |
| US20160153958A1 (en) | 2016-06-02 |
| US11513112B2 (en) | 2022-11-29 |
| US20200355669A1 (en) | 2020-11-12 |
| EP3489659B1 (fr) | 2021-03-03 |
| ES2877332T3 (es) | 2021-11-16 |
| US10732165B2 (en) | 2020-08-04 |
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Ipc: A61B 5/00 20060101ALI20170119BHEP Ipc: G01N 33/487 20060101ALI20170119BHEP Ipc: G01N 21/3577 20140101ALI20170119BHEP Ipc: G01N 21/359 20140101AFI20170119BHEP Ipc: G01N 21/3563 20140101ALI20170119BHEP Ipc: G01N 21/35 20140101ALI20170119BHEP Ipc: G01N 33/48 20060101ALI20170119BHEP |
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