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EP3092318A4 - Procédés de définition et de prédiction de la réaction immunitaire à une allogreffe - Google Patents

Procédés de définition et de prédiction de la réaction immunitaire à une allogreffe Download PDF

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Publication number
EP3092318A4
EP3092318A4 EP15735285.7A EP15735285A EP3092318A4 EP 3092318 A4 EP3092318 A4 EP 3092318A4 EP 15735285 A EP15735285 A EP 15735285A EP 3092318 A4 EP3092318 A4 EP 3092318A4
Authority
EP
European Patent Office
Prior art keywords
allograft
defining
methods
immune response
predicting immune
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP15735285.7A
Other languages
German (de)
English (en)
Other versions
EP3092318A1 (fr
Inventor
Ryan O. Emerson
Ilan KIRSCH
James Mathew
Joseph LEVENTHAL
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Northwestern University
Adaptive Biotechnologies Corp
Original Assignee
Northwestern University
Adaptive Biotechnologies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Northwestern University, Adaptive Biotechnologies Corp filed Critical Northwestern University
Publication of EP3092318A1 publication Critical patent/EP3092318A1/fr
Publication of EP3092318A4 publication Critical patent/EP3092318A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP15735285.7A 2014-01-10 2015-01-09 Procédés de définition et de prédiction de la réaction immunitaire à une allogreffe Withdrawn EP3092318A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461925956P 2014-01-10 2014-01-10
US201462048711P 2014-09-10 2014-09-10
PCT/US2015/010904 WO2015106161A1 (fr) 2014-01-10 2015-01-09 Procédés de définition et de prédiction de la réaction immunitaire à une allogreffe

Publications (2)

Publication Number Publication Date
EP3092318A1 EP3092318A1 (fr) 2016-11-16
EP3092318A4 true EP3092318A4 (fr) 2017-08-16

Family

ID=53524388

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15735285.7A Withdrawn EP3092318A4 (fr) 2014-01-10 2015-01-09 Procédés de définition et de prédiction de la réaction immunitaire à une allogreffe

Country Status (5)

Country Link
US (1) US20160340729A1 (fr)
EP (1) EP3092318A4 (fr)
AU (1) AU2015204569A1 (fr)
CA (1) CA2936446A1 (fr)
WO (1) WO2015106161A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2387627T3 (en) 2009-01-15 2016-07-04 Adaptive Biotechnologies Corp Adaptive immunity profiling and methods for producing monoclonal antibodies
ES2662128T3 (es) 2012-03-05 2018-04-05 Adaptive Biotechnologies Corporation Determinación de cadenas de receptor inmunitario emparejadas a partir de la frecuencia de subunidades coincidentes
US9150905B2 (en) 2012-05-08 2015-10-06 Adaptive Biotechnologies Corporation Compositions and method for measuring and calibrating amplification bias in multiplexed PCR reactions
JP6449160B2 (ja) 2012-10-01 2019-01-09 アダプティブ バイオテクノロジーズ コーポレイション 適応免疫受容体多様性およびクローン性特性決定による免疫能力評価関連出願の相互参照
WO2015160439A2 (fr) 2014-04-17 2015-10-22 Adaptive Biotechnologies Corporation Quantification de génomes de cellules de l'immunité acquise dans un mélange complexe de cellules
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
ES2741740T3 (es) 2014-03-05 2020-02-12 Adaptive Biotechnologies Corp Métodos que usan moléculas sintéticas que contienen segmentos de nucleótidos aleatorios
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
EP3715455A1 (fr) 2014-10-29 2020-09-30 Adaptive Biotechnologies Corp. Détection simultanée hautement multiplexée d'acides nucléiques codant pour des hétérodimères de récepteurs de l'immunité adaptative appariés à partir de nombreux échantillons
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
CA2968543C (fr) 2014-11-25 2024-04-02 Adaptive Biotechnologies Corporation Caracterisation de la reponse immunitaire adaptative a la vaccination ou a l'infection a l'aide du sequencage du repertoire immunitaire
US11047008B2 (en) 2015-02-24 2021-06-29 Adaptive Biotechnologies Corporation Methods for diagnosing infectious disease and determining HLA status using immune repertoire sequencing
WO2016161273A1 (fr) 2015-04-01 2016-10-06 Adaptive Biotechnologies Corp. Procédé d'identification des récepteurs de lymphocytes t spécifiques à compatibilité humaine pour une cible antigénique
WO2017165614A1 (fr) * 2016-03-23 2017-09-28 The Methodist Hospital System Estimation de clonalité de tcr avant transplantation pour prédire la survie après transplantation hépatique
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
US11754552B2 (en) * 2017-06-09 2023-09-12 The Regents Of The University Of California Use of immune repertoire diversity for predicting transplant rejection
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements
AU2022245323A1 (en) 2021-03-24 2023-09-28 Genentech, Inc. Efficient tcr gene editing in t lymphocytes

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130136799A1 (en) * 2008-11-07 2013-05-30 Sequenta, Inc. Monitoring health and disease status using clonotype profiles

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012027503A2 (fr) * 2010-08-24 2012-03-01 Fred Hutchinson Cancer Research Center Procédé de mesure de l'immunité adaptative
JP6449160B2 (ja) * 2012-10-01 2019-01-09 アダプティブ バイオテクノロジーズ コーポレイション 適応免疫受容体多様性およびクローン性特性決定による免疫能力評価関連出願の相互参照

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130136799A1 (en) * 2008-11-07 2013-05-30 Sequenta, Inc. Monitoring health and disease status using clonotype profiles

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
H. MORRIS ET AL: "Tracking donor-reactive T cells: Evidence for clonal deletion in tolerant kidney transplant patients", SCIENCE TRANSLATIONAL MEDICINE, vol. 7, no. 272, 28 January 2015 (2015-01-28), pages 272ra10 - 272ra10, XP055389679, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.3010760 *
H. S. ROBINS ET AL: "Comprehensive assessment of T-cell receptor -chain diversity in T cells", BLOOD, vol. 114, no. 19, 5 November 2009 (2009-11-05), pages 4099 - 4107, XP055074444, ISSN: 0006-4971, DOI: 10.1182/blood-2009-04-217604 *
M. DZIUBIANAU ET AL: "TCR Repertoire Analysis by Next Generation Sequencing Allows Complex Differential Diagnosis of T Cell-Related Pathology", AMERICAN JOURNAL OF TRANSPLANTATION, vol. 13, no. 11, 10 September 2013 (2013-09-10), DK, pages 2842 - 2854, XP055389693, ISSN: 1600-6135, DOI: 10.1111/ajt.12431 *
See also references of WO2015106161A1 *

Also Published As

Publication number Publication date
CA2936446A1 (fr) 2015-07-16
AU2015204569A1 (en) 2016-07-21
EP3092318A1 (fr) 2016-11-16
US20160340729A1 (en) 2016-11-24
WO2015106161A1 (fr) 2015-07-16

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