EP3058103A4 - Detecting and monitoring mutations in histiocytosis - Google Patents

Detecting and monitoring mutations in histiocytosis Download PDF

Info

Publication number: EP3058103A4
Authority: EP; European Patent Office
Prior art keywords: histiocytosis; detecting; mutations; monitoring; monitoring mutations
Prior art date: 2013-10-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP14853756.6A

Other languages

German (de)

French (fr)

Other versions

EP3058103A2 (en

Inventor

Filip JANKU

Mark G. Erlander

Cecile Rose VIBAT

Karena Kosco

Omar Abdel-Wahab

Eli L. DIAMOND

David M. HYMAN

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Cardiff Oncology Inc

Original Assignee

Trovagene Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-10-19

Filing date

2014-10-18

Publication date

2017-05-17

2014-10-18 Application filed by Trovagene Inc filed Critical Trovagene Inc

2016-08-24 Publication of EP3058103A2 publication Critical patent/EP3058103A2/en

2017-05-17 Publication of EP3058103A4 publication Critical patent/EP3058103A4/en

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Analytical Chemistry (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Immunology (AREA)
Pathology (AREA)
Physics & Mathematics (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Hospice & Palliative Care (AREA)
Oncology (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

EP14853756.6A 2013-10-19 2014-10-18 Detecting and monitoring mutations in histiocytosis Withdrawn EP3058103A4 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US201361893218P	2013-10-19	2013-10-19
US201461977611P	2014-04-09	2014-04-09
US201462006261P	2014-06-01	2014-06-01
US201462040366P	2014-08-21	2014-08-21
PCT/US2014/061281 WO2015058175A2 (en)	2013-10-19	2014-10-18	Detecting and monitoring mutations in histiocytosis

Publications (2)

Publication Number	Publication Date
EP3058103A2 EP3058103A2 (en)	2016-08-24
EP3058103A4 true EP3058103A4 (en)	2017-05-17

Family

ID=52828866

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP14853756.6A Withdrawn EP3058103A4 (en)	2013-10-19	2014-10-18	Detecting and monitoring mutations in histiocytosis

Country Status (4)

Country	Link
EP (1)	EP3058103A4 (en)
HK (1)	HK1222206A1 (en)
IL (1)	IL244733A0 (en)
WO (1)	WO2015058175A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP3359694A4 (en) *	2015-10-09	2019-07-17	Guardant Health, Inc.	POPULATION-BASED TREATMENT RECOMMENDATION DEVICE USING DNA WITHOUT CELLS

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2008106453A2 (en) *	2007-02-26	2008-09-04	John Wayne Cancer Institute	Utility of b-raf dna mutation in diagnosis and treatment of cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20100285469A1 (en) *	2007-10-10	2010-11-11	Philadelphia Health & Education d/b/a Drexel University College of Medicine	Method of tumor screening
EP2771486A1 (en) *	2011-10-24	2014-09-03	Trovagene, Inc.	Methods of detecting braf mutations in cancer

2014
- 2014-10-18 HK HK16110254.2A patent/HK1222206A1/en unknown
- 2014-10-18 EP EP14853756.6A patent/EP3058103A4/en not_active Withdrawn
- 2014-10-18 WO PCT/US2014/061281 patent/WO2015058175A2/en not_active Ceased
2016
- 2016-03-22 IL IL244733A patent/IL244733A0/en unknown

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2008106453A2 (en) *	2007-02-26	2008-09-04	John Wayne Cancer Institute	Utility of b-raf dna mutation in diagnosis and treatment of cancer

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ALAIN R THIERRY ET AL: "Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA", vol. 20, no. 4, 1 April 2014 (2014-04-01), pages 430 - 435, XP002730498, ISSN: 1078-8956, Retrieved from the Internet <URL:http://www.nature.com/nm/journal/v20/n4/full/nm.3511.html> [retrieved on 20140323], DOI: 10.1038/NM.3511 *
DIAMOND ELI ET AL.,: "Detection of an NRAS mutation in Erdheim-Chester disease", BLOOD, 8 August 2013 (2013-08-08), United States, pages 1089, XP055362342, Retrieved from the Internet <URL:http://www.bloodjournal.org/content/bloodjournal/122/6/1089.full.pdf> *
FILIP JANKU ET AL: "BRAF V600E mutations in urine and plasma cell-free DNA from patients with Erdheim-Chester disease", ONCOTARGET, vol. 5, no. 11, 13 May 2014 (2014-05-13), United States, pages 3607 - 3610, XP055153092, DOI: 10.18632/oncotarget.1964 *
G. BADALIAN-VERY ET AL: "Recurrent BRAF mutations in Langerhans cell histiocytosis", BLOOD, vol. 116, no. 11, 16 September 2010 (2010-09-16), pages 1919 - 1923, XP055027891, ISSN: 0006-4971, DOI: 10.1182/blood-2010-04-279083 *
J. HAROCHE ET AL: "High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses", BLOOD, vol. 120, no. 13, 9 August 2012 (2012-08-09), & 53RD ANNUAL MEETING AND EXPOSITION OF THE AMERICAN-SOCIETY-OF-HEMATOLOGY (ASH); SAN DIEGO, CA, USA; DECEMBER 10 -13, 2011, pages 2700 - 2703, XP055362341, ISSN: 0006-4971, DOI: 10.1182/blood-2012-05-430140 *
TAKESHI SATOH ET AL: "B-RAF Mutant Alleles Associated with Langerhans Cell Histiocytosis, a Granulomatous Pediatric Disease", PLOS ONE, vol. 7, no. 4, 10 April 2012 (2012-04-10), pages e33891, XP055362288, DOI: 10.1371/journal.pone.0033891 *
THIERRY LECOMTE ET AL: "Detection of free-circulating tumor-associated DNA in plasma of colorectal cancer patients and its association with prognosis", INTERNATIONAL JOURNAL OF CANCER, vol. 100, no. 5, 10 August 2002 (2002-08-10), pages 542 - 548, XP055071717, ISSN: 0020-7136, DOI: 10.1002/ijc.10526 *

Also Published As

Publication number	Publication date
HK1222206A1 (en)	2017-06-23
WO2015058175A2 (en)	2015-04-23
EP3058103A2 (en)	2016-08-24
WO2015058175A3 (en)	2015-06-25
IL244733A0 (en)	2016-04-21

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Legal Events

Date	Code	Title	Description
2016-07-22	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2016-08-24	17P	Request for examination filed	Effective date: 20160229
2016-08-24	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2016-08-24	AX	Request for extension of the european patent	Extension state: BA ME
2017-01-25	DAX	Request for extension of the european patent (deleted)
2017-05-17	A4	Supplementary search report drawn up and despatched	Effective date: 20170418
2017-05-17	RIC1	Information provided on ipc code assigned before grant	Ipc: C12Q 1/68 20060101AFI20170410BHEP
2017-06-23	REG	Reference to a national code	Ref country code: HK Ref legal event code: DE Ref document number: 1222206 Country of ref document: HK
2018-01-04	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2018-05-11	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2018-06-13	18D	Application deemed to be withdrawn	Effective date: 20171121
2023-05-12	REG	Reference to a national code	Ref country code: HK Ref legal event code: WD Ref document number: 1222206 Country of ref document: HK