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EP2986704A4 - CONTACTLESS MICRO-DROPLECTOR DISPENSER AND CORRESPONDING METHOD - Google Patents

CONTACTLESS MICRO-DROPLECTOR DISPENSER AND CORRESPONDING METHOD

Info

Publication number
EP2986704A4
EP2986704A4 EP14784764.4A EP14784764A EP2986704A4 EP 2986704 A4 EP2986704 A4 EP 2986704A4 EP 14784764 A EP14784764 A EP 14784764A EP 2986704 A4 EP2986704 A4 EP 2986704A4
Authority
EP
European Patent Office
Prior art keywords
droplector
dispenser
corresponding method
contactless micro
contactless
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP14784764.4A
Other languages
German (de)
French (fr)
Other versions
EP2986704A1 (en
EP2986704B1 (en
Inventor
Jay J Li
Normand P Desmarais
James E Rasmussen
Eric Cowden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Inc
Original Assignee
Siemens Healthcare Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Healthcare Diagnostics Inc filed Critical Siemens Healthcare Diagnostics Inc
Publication of EP2986704A1 publication Critical patent/EP2986704A1/en
Publication of EP2986704A4 publication Critical patent/EP2986704A4/en
Application granted granted Critical
Publication of EP2986704B1 publication Critical patent/EP2986704B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02Burettes; Pipettes
    • B01L3/0241Drop counters; Drop formers
    • B01L3/0265Drop counters; Drop formers using valves to interrupt or meter fluid flow, e.g. using solenoids or metering valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02Burettes; Pipettes
    • B01L3/0241Drop counters; Drop formers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02Burettes; Pipettes
    • B01L3/0241Drop counters; Drop formers
    • B01L3/0268Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16Reagents, handling or storing thereof
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0832Geometry, shape and general structure cylindrical, tube shaped
    • B01L2300/0838Capillaries
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/18Means for temperature control
    • B01L2300/1894Cooling means; Cryo cooling
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/02Drop detachment mechanisms of single droplets from nozzles or pins
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/02Drop detachment mechanisms of single droplets from nozzles or pins
    • B01L2400/021Drop detachment mechanisms of single droplets from nozzles or pins non contact spotting by inertia, i.e. abrupt deceleration of the nozzle or pin
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/08Regulating or influencing the flow resistance
    • B01L2400/082Active control of flow resistance, e.g. flow controllers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • B01L7/50Cryostats
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027General features of the devices
    • G01N2035/1034Transferring microquantities of liquid

Landscapes

  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Nozzles (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
EP14784764.4A 2013-04-19 2014-04-09 Non-contact micro droplet dispenser Active EP2986704B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361813700P 2013-04-19 2013-04-19
PCT/US2014/033415 WO2014172152A1 (en) 2013-04-19 2014-04-09 Non-contact micro droplet dispenser and method

Publications (3)

Publication Number Publication Date
EP2986704A1 EP2986704A1 (en) 2016-02-24
EP2986704A4 true EP2986704A4 (en) 2016-12-07
EP2986704B1 EP2986704B1 (en) 2019-04-03

Family

ID=51731763

Family Applications (1)

Application Number Title Priority Date Filing Date
EP14784764.4A Active EP2986704B1 (en) 2013-04-19 2014-04-09 Non-contact micro droplet dispenser

Country Status (4)

Country Link
US (1) US10486152B2 (en)
EP (1) EP2986704B1 (en)
JP (1) JP6433982B2 (en)
WO (1) WO2014172152A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102016225209A1 (en) * 2016-12-15 2018-06-21 Hamilton Bonaduz Ag Pipetting device for improved pulse-like liquid pipetting
CA3101599A1 (en) * 2018-06-20 2019-12-26 Gen-Probe Incorporated Method and apparatus for freezing dispensed droplets of liquid
EP3944914A1 (en) * 2020-07-30 2022-02-02 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Nozzle and method for forming microdroplets
CN114273106B (en) * 2021-12-30 2023-02-03 杭州电子科技大学 Pneumatic micro-droplet generator and preparation process thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4977785A (en) * 1988-02-19 1990-12-18 Extrel Corporation Method and apparatus for introduction of fluid streams into mass spectrometers and other gas phase detectors
WO1999031481A2 (en) * 1997-12-12 1999-06-24 Scientific Detectors Limited Transport detector with oxide surface coating
US20030168586A1 (en) * 2001-06-08 2003-09-11 Kentaro Yamaguchi Cold spray mass spectrometric device
WO2004088283A2 (en) * 2003-03-28 2004-10-14 Monsanto Technology Llc Apparatus and methods for providing sex-sorted animal sperm
US20040238427A1 (en) * 2003-05-29 2004-12-02 Shuzo Maruyama Fractionating/collecting device of liquid chromatograph
US20050147536A1 (en) * 2004-01-06 2005-07-07 Shimadzu Corporation Fractionating apparatus

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3380584A (en) * 1965-06-04 1968-04-30 Atomic Energy Commission Usa Particle separator
JPS5372773A (en) * 1976-12-10 1978-06-28 Hitachi Ltd Direct reductive denitration method of ammonia
JP3137953B2 (en) * 1999-03-30 2001-02-26 科学技術振興事業団 Electrospray mass spectrometry method and apparatus
JP2001272640A (en) 2000-03-27 2001-10-05 Fujitsu Ltd Liquid crystal dropping device and liquid crystal dropping method
HUP0302232A2 (en) * 2000-05-09 2003-10-28 Xy, Inc. High purity x-chromosome bearing and y-chromosome bearing populations of spermatozoa
AUPR846501A0 (en) * 2001-10-26 2001-11-15 Btf Pty Ltd A cytometer
ATE377763T1 (en) 2002-01-25 2007-11-15 Innovadyne Technologies Inc CONTACTLESS METHOD FOR DISTRIBUTING SMALL LIQUID VOLUME
AU2004209426B2 (en) * 2003-01-29 2008-04-17 454 Life Sciences Corporation Method for preparing single-stranded DNA libraries
US20050014753A1 (en) * 2003-04-04 2005-01-20 Irm Llc Novel compounds and compositions as protein kinase inhibitors
US7294309B1 (en) * 2003-05-15 2007-11-13 Takeda San Diego, Inc. Small volume liquid handling apparatus and method
SG149007A1 (en) * 2003-09-10 2009-01-29 Althea Technologies Inc Expression profiling using microarrays
JP2005292478A (en) * 2004-03-31 2005-10-20 Shibaura Mechatronics Corp Method and apparatus for dropping liquid substance
EP1896610A2 (en) 2005-05-03 2008-03-12 Handylab, Inc. Lyophilized pellets
AU2006287175A1 (en) * 2005-09-01 2007-03-08 Precision Therapeutics, Inc. Chemo-sensitivity assays using tumor cells exhibiting persistent phenotypic characteristics
WO2007123720A2 (en) * 2006-03-30 2007-11-01 Cornell Research Foundation, Inc. System and method for increased cooling rates in rapid cooling of small biological samples
US20100216230A1 (en) * 2006-09-28 2010-08-26 Cornell Research Foundation, Inc. Systems for Increased Cooling and Thawing Rates of Protein Solutions and Cells for Optimized Cryopreservation and Recovery
US20090095825A1 (en) 2007-10-11 2009-04-16 Nordson Corporation Dispenser nozzle having differential hardness

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4977785A (en) * 1988-02-19 1990-12-18 Extrel Corporation Method and apparatus for introduction of fluid streams into mass spectrometers and other gas phase detectors
WO1999031481A2 (en) * 1997-12-12 1999-06-24 Scientific Detectors Limited Transport detector with oxide surface coating
US20030168586A1 (en) * 2001-06-08 2003-09-11 Kentaro Yamaguchi Cold spray mass spectrometric device
WO2004088283A2 (en) * 2003-03-28 2004-10-14 Monsanto Technology Llc Apparatus and methods for providing sex-sorted animal sperm
US20040238427A1 (en) * 2003-05-29 2004-12-02 Shuzo Maruyama Fractionating/collecting device of liquid chromatograph
US20050147536A1 (en) * 2004-01-06 2005-07-07 Shimadzu Corporation Fractionating apparatus

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2014172152A1 *

Also Published As

Publication number Publication date
WO2014172152A1 (en) 2014-10-23
US10486152B2 (en) 2019-11-26
EP2986704A1 (en) 2016-02-24
JP6433982B2 (en) 2018-12-05
EP2986704B1 (en) 2019-04-03
JP2016524521A (en) 2016-08-18
US20160074857A1 (en) 2016-03-17

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