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EP2976362A4 - Anticorps et procédés permettant de traiter des maladies associées aux récepteurs des strogènes - Google Patents

Anticorps et procédés permettant de traiter des maladies associées aux récepteurs des strogènes Download PDF

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Publication number
EP2976362A4
EP2976362A4 EP14770917.4A EP14770917A EP2976362A4 EP 2976362 A4 EP2976362 A4 EP 2976362A4 EP 14770917 A EP14770917 A EP 14770917A EP 2976362 A4 EP2976362 A4 EP 2976362A4
Authority
EP
European Patent Office
Prior art keywords
antibodies
methods
estrogen receptor
associated diseases
treating estrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP14770917.4A
Other languages
German (de)
English (en)
Other versions
EP2976362B1 (fr
EP2976362A1 (fr
Inventor
Xueming Qian
Kun Meng
Feng Chen
Xiao Shang
Jing Wang
Lu Li
Congya ZHOU
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Shenogen Pharma Group Ltd
Original Assignee
Beijing Shenogen Pharma Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Shenogen Pharma Group Ltd filed Critical Beijing Shenogen Pharma Group Ltd
Publication of EP2976362A1 publication Critical patent/EP2976362A1/fr
Publication of EP2976362A4 publication Critical patent/EP2976362A4/fr
Application granted granted Critical
Publication of EP2976362B1 publication Critical patent/EP2976362B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10532106B2 (en) 2014-10-29 2020-01-14 Bicyclerd Limited Bicyclic peptide ligands specific for MT1-MMP
AR103173A1 (es) 2014-12-22 2017-04-19 Novarits Ag Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17
KR102046862B1 (ko) * 2015-03-20 2019-11-20 화이자 인코포레이티드 Cti 약물작용발생단을 함유하는 이관능성 세포독성제
KR102493853B1 (ko) * 2016-08-19 2023-01-30 브리스톨-마이어스 스큅 컴퍼니 세코-시클로프로파피롤로인돌 화합물, 그의 항체-약물 접합체, 및 제조 및 사용 방법
CN111183147B (zh) 2017-08-04 2024-07-05 拜斯科技术开发有限公司 Cd137特异性的双环肽配体
JP2021514953A (ja) 2018-02-23 2021-06-17 バイスクルテクス・リミテッド 多量体二環式ペプチドリガンド
US11180531B2 (en) 2018-06-22 2021-11-23 Bicycletx Limited Bicyclic peptide ligands specific for Nectin-4
GB201820295D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for MT1-MMP
GB201820325D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for psma
GB201820288D0 (en) 2018-12-13 2019-01-30 Bicycle Tx Ltd Bicycle peptide ligaands specific for MT1-MMP
WO2020128526A1 (fr) 2018-12-21 2020-06-25 Bicycletx Limited Ligands peptidiques bicycliques spécifiques pour pd-l1
TWI862640B (zh) 2019-07-30 2024-11-21 英商拜西可泰克斯有限公司 異質雙環肽複合物
US20220031858A1 (en) 2020-08-03 2022-02-03 Bicycle TX Limited Novel linkers
WO2023165142A1 (fr) * 2022-03-01 2023-09-07 苏州智核生物医药科技有限公司 Polypeptide de liaison à her2 et son utilisation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996039518A1 (fr) * 1995-06-05 1996-12-12 Bionebraska, Inc. Polypeptides fixant le plomb et nucleotides codants afferent
WO2005102387A2 (fr) * 2004-03-29 2005-11-03 Pdl Biopharma, Inc. Utilisation therapeutique des anticorps anti-cs1
WO2008052005A2 (fr) * 2006-10-25 2008-05-02 Shenogen Pharma Group Ltd. Composés et procédés pour traiter des maladies liées à un récepteur d'oestrogène
WO2015014284A1 (fr) * 2013-07-31 2015-02-05 北京盛诺基医药科技有限公司 Méthode de traitement du cancer du sein

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE30985E (en) 1978-01-01 1982-06-29 Serum-free cell culture media
US4560655A (en) 1982-12-16 1985-12-24 Immunex Corporation Serum-free cell culture medium and process for making same
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US4879231A (en) 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
GB8516415D0 (en) 1985-06-28 1985-07-31 Celltech Ltd Culture of animal cells
US4927762A (en) 1986-04-01 1990-05-22 Cell Enterprises, Inc. Cell culture medium with antioxidant
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
EP0435911B1 (fr) 1988-09-23 1996-03-13 Cetus Oncology Corporation Milieu de culture de cellules pour l'amelioration de la croissance des cellules, de la longivite de la culture et de l'expression du produit
EP0402226A1 (fr) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Vecteurs de transformation de la levure yarrowia
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
AU3178993A (en) 1991-11-25 1993-06-28 Enzon, Inc. Multivalent antigen-binding proteins
US6005079A (en) 1992-08-21 1999-12-21 Vrije Universiteit Brussels Immunoglobulins devoid of light chains
EP0656946B2 (fr) 1992-08-21 2010-03-31 Vrije Universiteit Brussel Immunoglobulines exemptes de chaines legeres
DE69427974T2 (de) 1993-04-29 2001-12-06 Unilever N.V., Rotterdam Herstellung von antikörpern oder funktionstüchtig gemachten teilen davon, abgeleitet von schweren ketten von immunglobulinen von camelidae
EP2256133B1 (fr) 1997-01-08 2016-12-14 Sigma-Aldrich Co. LLC Bio-conjugaison de macromolécules
DE10015520A1 (de) 2000-03-30 2001-10-04 Merck Patent Gmbh Verfahren zur 1,3-dipolaren Cycloaddition organischer Verbindungen
EP1490483B1 (fr) 2001-04-19 2015-06-03 The Scripps Research Institute Incorporation in vivo d'acides amines non naturels
ATE469135T1 (de) 2002-05-30 2010-06-15 Scripps Research Inst Kupferkatalysierte ligierung von aziden und acetylenen
WO2004055160A2 (fr) 2002-12-13 2004-07-01 The Trustees Of Columbia University In The City Of New York Methodes de couplage biomoleculaire par cycloaddition 1,3-dipolaire
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
WO2005003294A2 (fr) 2003-06-18 2005-01-13 The Scripps Research Institute Additions de code genetique d'aminoacide reactif artificiel
WO2005038002A2 (fr) 2003-10-14 2005-04-28 The Scripps Research Institute Integration specifique a un site d'acides amines actifs pour une oxydoreduction, dans des proteines
NZ583292A (en) 2003-11-06 2012-03-30 Seattle Genetics Inc Monomethylvaline compounds capable of conjugation to ligands
CA2559144C (fr) * 2004-03-10 2014-01-21 Creighton University Variant d'epissage er-alpha 36 de recepteur d'estrogene alpha
KR20070034512A (ko) 2004-06-18 2007-03-28 암브룩스, 인코포레이티드 신규 항원-결합 폴리펩티드 및 이의 용도
GB2438982A (en) 2004-12-22 2007-12-12 Ambrx Inc Compostions containing, methods involving, and uses of non-natural amino acids and polypeptides
CA2590429C (fr) 2004-12-22 2014-10-07 Ambrx, Inc. Compositions de synthetase d'aminoacyl-arnt et utilisations correspondantes
JP5290756B2 (ja) 2005-09-26 2013-09-18 メダレックス インコーポレイテッド 抗体−薬剤コンジュゲート及びその使用
US7632492B2 (en) 2006-05-02 2009-12-15 Allozyne, Inc. Modified human interferon-β polypeptides
DK2202245T3 (en) 2007-09-26 2016-11-21 Chugai Pharmaceutical Co Ltd A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR
KR101554753B1 (ko) 2007-10-01 2015-09-22 브리스톨-마이어스 스큅 컴퍼니 메소텔린에 결합하는 인간 항체 및 이의 용도
PT2708559T (pt) 2008-04-11 2018-05-16 Chugai Pharmaceutical Co Ltd Molécula de ligação ao antigénio capaz de se ligar repetidamente a duas ou mais moléculas de antigénio
US8426402B2 (en) 2009-02-05 2013-04-23 Immunogen, Inc. Benzodiazepine derivatives
EP2396034A4 (fr) * 2009-02-10 2012-11-21 Shenogen Pharma Group Ltd Anticorps et méthodes de traitement de maladies associées à un récepteur d' strogène
CA2789416A1 (fr) * 2010-02-09 2011-08-18 Glaxosmithkline Llc Nouvelles utilisations
US8852599B2 (en) 2011-05-26 2014-10-07 Bristol-Myers Squibb Company Immunoconjugates, compositions for making them, and methods of making and use

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996039518A1 (fr) * 1995-06-05 1996-12-12 Bionebraska, Inc. Polypeptides fixant le plomb et nucleotides codants afferent
WO2005102387A2 (fr) * 2004-03-29 2005-11-03 Pdl Biopharma, Inc. Utilisation therapeutique des anticorps anti-cs1
WO2008052005A2 (fr) * 2006-10-25 2008-05-02 Shenogen Pharma Group Ltd. Composés et procédés pour traiter des maladies liées à un récepteur d'oestrogène
WO2015014284A1 (fr) * 2013-07-31 2015-02-05 北京盛诺基医药科技有限公司 Méthode de traitement du cancer du sein

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
L JIANG ET AL: "Crosstalk between Estrogen Receptor alpha 36, a Dominant Extra-Nuclear ER, and HER2 Promotes Tumor Cell Survival in Breast Cancer. |", CANCER RESEARCH, 15 December 2009 (2009-12-15), XP055300686, DOI: 10.1158/0008-5472.SABCS-09-2121 *
See also references of WO2014146575A1 *
YU GU ET AL: "The therapeutic target of estrogen receptor-alpha36 in estrogen-dependent tumors", JOURNAL OF TRANSLATIONAL MEDICINE, BIOMED CENTRAL, LONDON, GB, vol. 12, no. 1, 21 January 2014 (2014-01-21), pages 16, XP021174590, ISSN: 1479-5876, DOI: 10.1186/1479-5876-12-16 *
ZHAOYI WANG ET AL: "A variant of estrogen receptor-a, hER-a36: Transduction of estrogen- and antiestrogen-dependent membrane-initiated mitogenic signaling", PNAS, vol. 103, no. 24, 13 June 2006 (2006-06-13), pages 9063 - 9068, XP055300652 *

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