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EP2838544A4 - Poly(acrylate) polymers for in vivo nucleic acid delivery - Google Patents

Poly(acrylate) polymers for in vivo nucleic acid delivery

Info

Publication number
EP2838544A4
EP2838544A4 EP12874655.9A EP12874655A EP2838544A4 EP 2838544 A4 EP2838544 A4 EP 2838544A4 EP 12874655 A EP12874655 A EP 12874655A EP 2838544 A4 EP2838544 A4 EP 2838544A4
Authority
EP
European Patent Office
Prior art keywords
acrylate
poly
polymers
nucleic acid
acid delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP12874655.9A
Other languages
German (de)
French (fr)
Other versions
EP2838544A1 (en
Inventor
Darren H Wakefield
Nicholas Rossi
David B Rozema
Lauren Almeida
Anthony L Perillo-Nicholas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arrowhead Pharmaceuticals Inc
Original Assignee
Arrowhead Research Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arrowhead Research Corp filed Critical Arrowhead Research Corp
Priority claimed from PCT/US2012/051973 external-priority patent/WO2013158141A1/en
Publication of EP2838544A1 publication Critical patent/EP2838544A1/en
Publication of EP2838544A4 publication Critical patent/EP2838544A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/34—Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate
    • C08F220/36—Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate containing oxygen in addition to the carboxy oxygen, e.g. 2-N-morpholinoethyl (meth)acrylate or 2-isocyanatoethyl (meth)acrylate
    • C08F220/365—Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate containing oxygen in addition to the carboxy oxygen, e.g. 2-N-morpholinoethyl (meth)acrylate or 2-isocyanatoethyl (meth)acrylate containing further carboxylic moieties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/34—Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Inorganic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
EP12874655.9A 2012-04-18 2012-08-23 Poly(acrylate) polymers for in vivo nucleic acid delivery Withdrawn EP2838544A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261625955P 2012-04-18 2012-04-18
PCT/US2012/051973 WO2013158141A1 (en) 2012-04-18 2012-08-23 Poly(acrylate) polymers for in vivo nucleic acid delivery

Publications (2)

Publication Number Publication Date
EP2838544A1 EP2838544A1 (en) 2015-02-25
EP2838544A4 true EP2838544A4 (en) 2015-10-14

Family

ID=52347562

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12874655.9A Withdrawn EP2838544A4 (en) 2012-04-18 2012-08-23 Poly(acrylate) polymers for in vivo nucleic acid delivery

Country Status (1)

Country Link
EP (1) EP2838544A4 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090048410A1 (en) * 2002-03-11 2009-02-19 Wakefield Darren H Membrane Active Heteropolymers
US20110207799A1 (en) * 2010-02-24 2011-08-25 Roche Madison Inc. Compositions for Targeted Delivery of siRNA
WO2012083046A2 (en) * 2010-12-17 2012-06-21 Arrowhead Research Corporation Galactose cluster-pharmacokinetic modulator targeting moiety for sirna

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090048410A1 (en) * 2002-03-11 2009-02-19 Wakefield Darren H Membrane Active Heteropolymers
US20110207799A1 (en) * 2010-02-24 2011-08-25 Roche Madison Inc. Compositions for Targeted Delivery of siRNA
WO2012083046A2 (en) * 2010-12-17 2012-06-21 Arrowhead Research Corporation Galactose cluster-pharmacokinetic modulator targeting moiety for sirna

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2013158141A1 *

Also Published As

Publication number Publication date
EP2838544A1 (en) 2015-02-25

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 20140324

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAX Request for extension of the european patent (deleted)
RA4 Supplementary search report drawn up and despatched (corrected)

Effective date: 20150910

RIC1 Information provided on ipc code assigned before grant

Ipc: C08L 33/06 20060101AFI20150904BHEP

17Q First examination report despatched

Effective date: 20170201

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20200303