EP2830608A4 - PHENYLUREA AND PHENYLCARBAMATE DERIVATIVES AS INHIBITORS OF PROTEIN AGGREGATION - Google Patents

PHENYLUREA AND PHENYLCARBAMATE DERIVATIVES AS INHIBITORS OF PROTEIN AGGREGATION

Info

Publication number: EP2830608A4
Authority: EP; European Patent Office
Prior art keywords: phenylurea; inhibitors; protein aggregation; phenylcarbamate derivatives; phenylcarbamate
Prior art date: 2012-03-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

EP13768915.4A

Other languages

German (de)

French (fr)

Other versions

EP2830608B1 (en

EP2830608A1 (en

EP2830608B8 (en

Inventor

Wolfgang Wrasidlo

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

UCB Biopharma SRL

Original Assignee

Neuropore Therapies Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-03-28

Filing date

2013-03-15

Publication date

2015-08-19

2013-03-15 Application filed by Neuropore Therapies Inc filed Critical Neuropore Therapies Inc

2015-02-04 Publication of EP2830608A1 publication Critical patent/EP2830608A1/en

2015-08-19 Publication of EP2830608A4 publication Critical patent/EP2830608A4/en

2019-12-11 Publication of EP2830608B1 publication Critical patent/EP2830608B1/en

2020-01-15 Application granted granted Critical

2020-01-15 Publication of EP2830608B8 publication Critical patent/EP2830608B8/en

Status Active legal-status Critical Current

2033-03-15 Anticipated expiration legal-status Critical

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Psychology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

EP13768915.4A 2012-03-28 2013-03-15 Phenyl-urea and phenyl-carbamate derivatives as inhibitors of protein aggregation Active EP2830608B8 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201261616771P	2012-03-28	2012-03-28
PCT/US2013/032552 WO2013148365A1 (en)	2012-03-28	2013-03-15	Phenyl-urea and phenyl-carbamate derivatives as inhibitors of protein aggregation

Publications (4)

Publication Number	Publication Date
EP2830608A1 EP2830608A1 (en)	2015-02-04
EP2830608A4 true EP2830608A4 (en)	2015-08-19
EP2830608B1 EP2830608B1 (en)	2019-12-11
EP2830608B8 EP2830608B8 (en)	2020-01-15

Family

ID=49261100

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP13768915.4A Active EP2830608B8 (en)	2012-03-28	2013-03-15	Phenyl-urea and phenyl-carbamate derivatives as inhibitors of protein aggregation

Country Status (15)

Country	Link
US (1)	US9527852B2 (en)
EP (1)	EP2830608B8 (en)
JP (1)	JP6159388B2 (en)
KR (1)	KR20150002713A (en)
CN (1)	CN104363903A (en)
AU (1)	AU2013240219A1 (en)
CA (1)	CA2867175A1 (en)
ES (1)	ES2768602T3 (en)
HK (1)	HK1202452A1 (en)
IL (1)	IL234825A0 (en)
IN (1)	IN2014DN08633A (en)
MX (1)	MX2014011615A (en)
NZ (1)	NZ631388A (en)
RU (1)	RU2014143242A (en)
WO (1)	WO2013148365A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TR201809440T4 (en)	2014-01-29	2018-07-23	Ucb Biopharma Sprl	Heteroaryl amides as inhibitors of protein aggregation.
WO2016040780A1 (en) *	2014-09-11	2016-03-17	Neuropore Therapies, Inc.	Aminomethyl- and methyloxy-linked tricyclic compounds as inhibitors of protein aggregation
ES2885049T3 (en)	2015-07-29	2021-12-13	UCB Biopharma SRL	Bis-heteroaryl derivatives as modulators of protein aggregation
KR20190111080A (en)	2017-01-26	2019-10-01	유씨비 바이오파마 에스피알엘	Bis-heteroaryl Derivatives As Regulators of Protein Aggregation
ES2884145T3 (en)	2017-01-26	2021-12-10	UCB Biopharma SRL	Bicyclic bis-heteroaryl derivatives as modulators of protein aggregation
EA201991753A1 (en)	2017-01-26	2020-01-14	Юсб Байофарма Спрл	Alcoxybisheteroaryl derivatives as protein aggregation modulators

Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2001036403A1 (en) *	1999-11-16	2001-05-25	Boehringer Ingelheim Pharmaceuticals, Inc.	Urea derivatives as anti-inflammatory agents
EP1402888A1 (en) *	2002-09-18	2004-03-31	Jerini AG	The use of substituted carbocyclic compounds as rotamases inhibitors
WO2004080950A1 (en) *	2003-03-14	2004-09-23	H. Lundbeck A/S	Substituted aniline derivatives
WO2004082677A1 (en) *	2003-03-21	2004-09-30	H. Lundbeck A/S	Substituted p-diaminobenzene derivatives
WO2007124423A2 (en) *	2006-04-21	2007-11-01	Smithkline Beecham Corporation	Il-8 receptor antagonists
WO2010036316A1 (en) *	2008-09-24	2010-04-01	Yangbo Feng	Urea and carbamate compounds and analogs as kinase inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6096758A (en) *	1996-01-26	2000-08-01	Byk Gulden Lomberg Chemische Fabrik Gmbh	3-methylimidazopyridines
US6617351B1 (en)	1998-07-31	2003-09-09	Eli Lilly And Company	Amide, carbamate, and urea derivatives
HU228960B1 (en) *	2000-10-30	2013-07-29	Kudos Pharm Ltd	Phthalazinone derivatives
US20050171172A1 (en) *	2003-11-13	2005-08-04	Ambit Biosciences Corporation	Amide derivatives as PDGFR modulators
UA95244C2 (en)	2005-06-22	2011-07-25	Плексикон, Инк.	Compounds and methods for kinase modulation, and indications therefor
WO2008044688A1 (en) *	2006-10-11	2008-04-17	Daiichi Sankyo Company, Limited	Urea derivative
WO2011084642A1 (en) *	2009-12-16	2011-07-14	Neuropore Therapies, Inc.	Compound suitable for the treatment of synucleopathies

2013
- 2013-03-15 CN CN201380017441.6A patent/CN104363903A/en active Pending
- 2013-03-15 CA CA2867175A patent/CA2867175A1/en not_active Abandoned
- 2013-03-15 JP JP2015503346A patent/JP6159388B2/en active Active
- 2013-03-15 US US14/388,783 patent/US9527852B2/en active Active
- 2013-03-15 MX MX2014011615A patent/MX2014011615A/en unknown
- 2013-03-15 ES ES13768915T patent/ES2768602T3/en active Active
- 2013-03-15 WO PCT/US2013/032552 patent/WO2013148365A1/en not_active Ceased
- 2013-03-15 EP EP13768915.4A patent/EP2830608B8/en active Active
- 2013-03-15 RU RU2014143242A patent/RU2014143242A/en not_active Application Discontinuation
- 2013-03-15 HK HK15103189.8A patent/HK1202452A1/en unknown
- 2013-03-15 NZ NZ631388A patent/NZ631388A/en not_active IP Right Cessation
- 2013-03-15 KR KR1020147030291A patent/KR20150002713A/en not_active Withdrawn
- 2013-03-15 AU AU2013240219A patent/AU2013240219A1/en not_active Abandoned
2014
- 2014-09-23 IL IL234825A patent/IL234825A0/en unknown
- 2014-10-15 IN IN8633DEN2014 patent/IN2014DN08633A/en unknown

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2001036403A1 (en) *	1999-11-16	2001-05-25	Boehringer Ingelheim Pharmaceuticals, Inc.	Urea derivatives as anti-inflammatory agents
EP1402888A1 (en) *	2002-09-18	2004-03-31	Jerini AG	The use of substituted carbocyclic compounds as rotamases inhibitors
WO2004080950A1 (en) *	2003-03-14	2004-09-23	H. Lundbeck A/S	Substituted aniline derivatives
WO2004082677A1 (en) *	2003-03-21	2004-09-30	H. Lundbeck A/S	Substituted p-diaminobenzene derivatives
WO2007124423A2 (en) *	2006-04-21	2007-11-01	Smithkline Beecham Corporation	Il-8 receptor antagonists
WO2010036316A1 (en) *	2008-09-24	2010-04-01	Yangbo Feng	Urea and carbamate compounds and analogs as kinase inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2013148365A1 *

Also Published As

Publication number	Publication date
ES2768602T3 (en)	2020-06-23
JP6159388B2 (en)	2017-07-05
KR20150002713A (en)	2015-01-07
CN104363903A (en)	2015-02-18
RU2014143242A (en)	2016-05-20
CA2867175A1 (en)	2013-10-03
US9527852B2 (en)	2016-12-27
HK1202452A1 (en)	2015-10-02
NZ631388A (en)	2016-01-29
EP2830608B1 (en)	2019-12-11
US20150166543A1 (en)	2015-06-18
WO2013148365A1 (en)	2013-10-03
AU2013240219A1 (en)	2014-10-09
IL234825A0 (en)	2014-12-31
IN2014DN08633A (en)	2015-05-22
EP2830608A1 (en)	2015-02-04
MX2014011615A (en)	2015-01-19
JP2015515465A (en)	2015-05-28
EP2830608B8 (en)	2020-01-15

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EP2819610A4 (en)	2015-11-04	DETERMINATION OF ANATOMIC ORIENTATIONS
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EP2895181A4 (en)	2016-03-30	TOPICAL COMPOSITIONS AND METHODS OF USE
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