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EP2863837A1 - Dispositif pour immobiliser une cavité buccale ouverte d'un rongeur - Google Patents

Dispositif pour immobiliser une cavité buccale ouverte d'un rongeur

Info

Publication number
EP2863837A1
EP2863837A1 EP13739348.4A EP13739348A EP2863837A1 EP 2863837 A1 EP2863837 A1 EP 2863837A1 EP 13739348 A EP13739348 A EP 13739348A EP 2863837 A1 EP2863837 A1 EP 2863837A1
Authority
EP
European Patent Office
Prior art keywords
base plate
rodent
fixing
legs
bracket
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP13739348.4A
Other languages
German (de)
English (en)
Other versions
EP2863837B1 (fr
Inventor
Michael Stapf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP2863837A1 publication Critical patent/EP2863837A1/fr
Application granted granted Critical
Publication of EP2863837B1 publication Critical patent/EP2863837B1/fr
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D15/00—Mouth openers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D3/00—Appliances for supporting or fettering animals for operative purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D3/00—Appliances for supporting or fettering animals for operative purposes
    • A61D2003/003—Appliances for supporting or fettering animals for operative purposes with head or neck restraining means

Definitions

  • the present invention relates to a device for fixing an open oral cavity of a rodent
  • mice such as the intratracheal
  • a pharmaceutical agent in particular a pharmaceutical agent or a medicament.
  • the oral cavity For intratracheal, pulmonary or dental administration of substances or active substances in anesthetized rodents, such as mice, the oral cavity must be opened and kept open.
  • a manual opening or keeping open the oral cavity such as by grasping the upper and / or lower jaw of the rodent with his hands does not hinder this
  • the device should also be through To design a simplistic and easy-to-operate structure.
  • the claimed device is designed for fixing an open oral cavity, thus for opening an oral cavity of a rodent, in particular an anesthetized rodent, in order to treat the animal intratracheally, intrapulmonary or dental.
  • the device has insofar a base plate with a bearing surface for the rodent, which in particular for
  • the head of the rodent serves, as well as a first, protruding from the base plate headband and a second, also protruding from the base plate headband.
  • the first headband is provided for fixing an upper jaw of the rodent, while the second
  • Holding bracket is designed for fixing a lower jaw of the rodent.
  • the first and / or the second headband can be fixed or fixed at a variable distance from the base plate.
  • both the first and the second headband preferably continuously on the
  • Base plate are slidably held, so that the headband depending on the size and anatomical nature of the
  • fixing rodents individually for opening or for Keep open the corresponding oral cavity are adjustable. It is also conceivable that one of the headband is preferably held continuously displaceable on the base plate and in particular the other headband is firmly held on the base plate or rotatably movable, for example. Swiveling, is held.
  • Supine on the base plate comes to rest, so that the first, provided for fixing the upper jaw headband typically has a smaller distance from the base plate than the second headband, which is provided for fixing the lower jaw of the rodent and designed accordingly.
  • Headband a U-shaped contour with two through the
  • Base plate protruding through first legs.
  • the first headband is arranged by the slidably guided in the base plate first leg height adjustable on the base plate.
  • Jaws in different positions to the base plate and thereby made largely stepless.
  • the enclosing the free ends of the first leg and against each other approximately clamped by a screw clamping jaws can exert a mechanical tension on the legs in a clamping or locking position, so that they are fixable with respect to their position on the base plate.
  • the first headband can in particular as a curved
  • Metal wire may be formed, wherein, for example, protruding from the bottom of the base plate free ends of the first leg can also be manually compressed and locked in this compressed configuration of the jaws.
  • the at least slightly curved locking of the first leg in particular counteracts an upward pulling out of the first retaining clip from the base plate.
  • the first retaining bracket with a U-shaped contour further preferably extends in a plane perpendicular to the plane of the base plate.
  • the second, also with respect to the base plate adjustably formed headband has a roughly M-like contour with two in the
  • the guide member has a roughly
  • variable anatomical features of the rodent are variable anatomical features of the rodent.
  • Throwing bow preferably detachable and / or pivotable
  • the throw-over bow can be arranged with the free ends of its legs on the second legs of the second retaining clip, wherein the free ends of the legs of the throw-over bow are oriented from above to the base plate facing.
  • the throw-over bracket extends in a plane perpendicular to the base plate or perpendicular to the latter
  • Headband lying between the spaced lateral guide members a U- or V-like contour with a substantially perpendicular to the second legs
  • the contour of the second retaining clip is designed such that a central portion can come to lie sufficiently deep within the oral cavity, while the second
  • Retaining holding guide members outside the oral cavity of the rodent can remain.
  • the guide members, on which the second retaining clip is displaceably guided in each case displaceably guided in a bush, wherein the
  • the guide members are arranged approximately parallel to the surface normal of the base plate slidably on this.
  • Displacement possibility of the two guide members perpendicular to the support surface of the base plate results in a corresponding vertical displacement of the second retaining bracket relative to the base plate.
  • the second headband can be both parallel to the plane of the bearing surface of the base plate as well as moved perpendicular thereto and locked accordingly.
  • the second leg facing away from the end portions of the guide members are coupled together via a carrier.
  • the carrier causes in this respect a parallel or coupled displacement of the two legs. The raising or lowering of one of the two guide members thus leads directly to a corresponding lowering or raising of the other
  • the carrier may in this case have an internal thread, which with a
  • the carrier or the adjusting screw cooperate with a spring element, so that a
  • Adjusting movement of the carrier against a spring tension can be done.
  • the base plate in its support brackets facing the support surface at least one recess which is the inclusion of a head portion of the
  • Rodents serves.
  • the shape or the geometric configuration of the recess is adapted to the shape of the male head portion of the rodent.
  • the depression serves in particular to receive a nose, eyes and / or forehead of the head of the rodent.
  • the base plate is pivotally mounted via a hinge to a stand. In this way, the base plate can be pivoted largely freely in space to the intratracheal, pulmonary or dental
  • Fig. 1 shows a possible imple mentation form of a device for
  • Fig. 2 shows the device according to the figure 1 in one
  • Fig. 3 shows the device according to the figure 1 in one
  • FIG. 4 the apparatus according to the figure 1 in a further perspective view viewed obliquely from the front, with folded-over thimble.
  • a device 10 for fixing an open oral cavity of a rodent is shown in various views.
  • the device 10 has a substantially planar base plate 12, the one shown in the figure 1, in various Pivoting positions lockable joint 24 is fixed to a base 22.
  • the plate has at one in the figure 1 facing the viewer, front end approximately centrally a
  • the base plate 12 is further connected via a screwed into the plate holder 20 with the hinge 24 and with the base 22.
  • a first U-shaped retaining clip 16 is arranged at the front edge of the base plate 12 facing the observer in FIG. 1. This has, as shown in Figure 2, two downwardly projecting legs 15, 17, by means of which the first bracket 16 passes through the base plate 12. The free ends of the legs 15, 17 are between two over a
  • Clamping screw 62 interconnected jaws 58, 60 can be clamped, as shown in the beginning in Figure 3.
  • the two jaws 58, 60 are part of this
  • Clamping device 56 by means of which the infinitely adjustable in height first retaining clip 16 relative to the base plate 12 is fixable.
  • the first headband 16 serves to fix an upper jaw of a rodent lying with its back on the base plate 12.
  • the second bracket 18 has an approximately M-shaped
  • the second retaining bracket 18 has at its opposite end portions each substantially rectilinear legs 28, 30, each passing through a cylindrical guide member 42, 44 and
  • Bushings 48, 46 down and project from the bottom of the base plate 12. There are the downwardly projecting ends of the guide members 42, 44 via an approximately parallel to the plane of the base plate 12 extending support 52nd
  • the second bracket 18 which similar to the first bracket 16 from a
  • Metal wire is formed, between the guide members 42, 44 a U- or V-shaped bent shape, wherein a central portion 19 is approximately perpendicular to the outer
  • Bracket 16 is arranged, that is, the distance of the central portion 19 of the second retaining bracket 18 to the front
  • Edge portion of the base plate 12 is greater than the distance - II of the first retaining clip 16 to the front edge of the base plate 12th
  • Holding bracket 18 is also a cap bracket 26 removably mounted or pivotally mounted.
  • the throw-over yoke 26 can be transferred from a locking position shown for example in FIG. 1 into a folded-up position shown in FIG. In this folded or pivoted position, for example, the anesthetized rodent can be placed in supine position on the base plate 12. Then, the hull or body of the animal can be fixed by folding down the capstan 26 on the base plate 12.
  • the cap bracket 26 can be adjustably arranged on the legs 28, 30.
  • individual fixing members 34, 26 are provided for the cap bracket 26, by means of fixing screws 38 steplessly in the longitudinal direction of the legs 28, 30th
  • End sections an internal thread for receiving
  • fixing screws 40 thus a variable and continuous adjustment of the second retaining clip 18 can be achieved parallel to the bearing surface of the base plate 12.
  • the two guide members 42, 44 with each other coupling carrier 52 is also provided with a screw 50 in
  • the set screw 50 has a carrier 52 passing through thread 54, which is supported upwards to the bottom of the base plate 12 through an end stop 53 on the underside of the base plate 12. Because the
  • Adjusting screw 50 is in threaded engagement with the carrier 52 and further supported on the stop 53 on the underside of the base plate 12, a displacement of the carrier 52 perpendicular to the plane of the base plate 12 can be brought about by turning the screw 50, which leads to a vertical displacement of two hereby coupled guide members 42, 44 and arranged thereon the second bracket 18 leads.
  • a compression or tension spring 64 may be arranged so that an initiated via the screw 50 adjustment movement of the carrier 52 against a spring 64 can be provided by the restoring force.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Husbandry (AREA)
  • Catching Or Destruction (AREA)

Abstract

L'invention concerne un dispositif pour immobiliser la cavité buccale ouverte d'un rongeur, qui comprend une plaque de base (12) présentant une surface d'appui qui sert à appuyer au moins la tête d'un rongeur, un premier étrier (16) qui fait saillie sur la plaque de base (12) et sert à fixer la mâchoire supérieure du rongeur et un deuxième étrier (18) qui fait saillie sur la plaque de base (12) pour fixer la mâchoire inférieure du rongeur, le premier et le second étrier de retenue (16, 18) pouvant être fixés à la plaque de base (12) à une distance variable de cette plaque.
EP13739348.4A 2012-06-26 2013-06-25 Dispositif pour immobiliser une cavité buccale ouverte d'un rongeur Not-in-force EP2863837B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102012012545.3A DE102012012545A1 (de) 2012-06-26 2012-06-26 Tracheale Behandlungsplattform für narkotisierte Mäuse
PCT/DE2013/100231 WO2014000734A1 (fr) 2012-06-26 2013-06-25 Dispositif pour immobiliser une cavité buccale ouverte d'un rongeur

Publications (2)

Publication Number Publication Date
EP2863837A1 true EP2863837A1 (fr) 2015-04-29
EP2863837B1 EP2863837B1 (fr) 2017-10-04

Family

ID=48808128

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13739348.4A Not-in-force EP2863837B1 (fr) 2012-06-26 2013-06-25 Dispositif pour immobiliser une cavité buccale ouverte d'un rongeur

Country Status (3)

Country Link
EP (1) EP2863837B1 (fr)
DE (2) DE102012012545A1 (fr)
WO (1) WO2014000734A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113101004A (zh) * 2021-04-22 2021-07-13 广西医科大学 一种大鼠开口器

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104013478B (zh) * 2014-06-25 2016-03-09 李晓峰 实验用鼠固定筒
BR102016011369B1 (pt) * 2016-05-19 2022-09-27 Universidade Estadual De Campinas - Unicamp Dispositivo para imobilização animal durante procedimentos experimentais
US20230062009A1 (en) * 2021-08-25 2023-03-02 PLASBIO Co.,Ltd Experimental animal restrainer applicable to various drug administration method
CN113952073B (zh) * 2021-12-08 2023-08-15 华中科技大学同济医学院附属协和医院 一种实验用小型动物舌部固定开口器

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2827042A (en) * 1956-06-04 1958-03-18 Jr Harry H Berrier Small animal speculum
DE2131378A1 (de) * 1971-06-24 1972-12-28 Guenter Scheidt Spannvorrichtung fuer Werkstuecke
SU467728A1 (ru) * 1972-07-04 1975-04-25 Лаборатория Зрительной Рецепции Ан Армянской Сср Устройство дл фиксации подопотных птиц
JPS5440181A (en) * 1977-09-06 1979-03-28 Fumie Kanetake Fixing instrument for small animal
US5184604A (en) * 1991-10-29 1993-02-09 Brillante Jose C Animal mouth retractor

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
None *
See also references of WO2014000734A1 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113101004A (zh) * 2021-04-22 2021-07-13 广西医科大学 一种大鼠开口器
CN113101004B (zh) * 2021-04-22 2022-12-02 广西医科大学 一种大鼠开口器

Also Published As

Publication number Publication date
EP2863837B1 (fr) 2017-10-04
DE112013003226A5 (de) 2015-03-26
DE102012012545A1 (de) 2014-01-02
WO2014000734A1 (fr) 2014-01-03

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