EP2841444A4 - Procédé de préparation de stéroïdes 17-substitués - Google Patents

Procédé de préparation de stéroïdes 17-substitués

Info

Publication number: EP2841444A4
Authority: EP; European Patent Office
Prior art keywords: preparation; substituted steroids; steroids; substituted
Prior art date: 2012-04-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP13780667.5A

Other languages

German (de)

English (en)

Other versions

EP2841444A1 (fr

Inventor

Craig E Dixon

Qingbo Lu

Boris Gorin

Erwin Schreiner

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Alphora Research Inc

Original Assignee

Alphora Research Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-04-23

Filing date

2013-04-22

Publication date

2015-11-04

2013-04-22 Application filed by Alphora Research Inc filed Critical Alphora Research Inc

2015-03-04 Publication of EP2841444A1 publication Critical patent/EP2841444A1/fr

2015-11-04 Publication of EP2841444A4 publication Critical patent/EP2841444A4/fr

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)

EP13780667.5A 2012-04-23 2013-04-22 Procédé de préparation de stéroïdes 17-substitués Withdrawn EP2841444A4 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201261637048P	2012-04-23	2012-04-23
US201261642253P	2012-05-03	2012-05-03
PCT/CA2013/050311 WO2013159225A1 (fr)	2012-04-23	2013-04-22	Procédé de préparation de stéroïdes 17-substitués

Publications (2)

Publication Number	Publication Date
EP2841444A1 EP2841444A1 (fr)	2015-03-04
EP2841444A4 true EP2841444A4 (fr)	2015-11-04

Family

ID=49482082

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP13780667.5A Withdrawn EP2841444A4 (fr)	2012-04-23	2013-04-22	Procédé de préparation de stéroïdes 17-substitués

Country Status (3)

Country	Link
EP (1)	EP2841444A4 (fr)
CA (1)	CA2871314A1 (fr)
WO (1)	WO2013159225A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2014016830A1 (fr) *	2012-07-25	2014-01-30	Mapi Pharma Ltd.	Procédé et intermédiaires utilisés pour la préparation de l'acétate d'abiratérone
WO2015200837A1 (fr) *	2014-06-27	2015-12-30	Fl Therapeutics Llc	Dérivés d'abiratérone et complexes non covalents avec l'albumine
EP3280448B1 (fr)	2015-04-10	2020-12-30	Capsugel Belgium NV	Formulations lipidiques d'acétate d'abiratérone
CN105503992A (zh) *	2016-01-22	2016-04-20	江苏联环药业股份有限公司	一种醋酸阿比特龙的制备方法
CN107722101A (zh) *	2017-11-03	2018-02-23	郑州大学	甾体吡啶类衍生物及其制备方法和应用
DK3935068T3 (da)	2019-03-06	2023-12-04	Propella Therapeutics Inc	Abirateron-prodrugs
WO2022174134A1 (fr)	2021-02-15	2022-08-18	Propella Therapeutics, Inc.	Promédicaments d'abiratérone
CN117683073A (zh) *	2023-12-15	2024-03-12	江苏希迪制药有限公司	醋酸阿比特龙的合成方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2938030A (en) *	1956-10-03	1960-05-24	Ciba Pharm Prod Inc	New steroids substituted by a heterocyclic nitrogen-containing ring in 17-position
WO1993020097A1 (fr) *	1992-03-31	1993-10-14	British Technology Group Ltd.	Steroïdes substitues-17 utiles pour le traitement du cancer
WO1995009178A1 (fr) *	1993-09-30	1995-04-06	British Technology Group Limited	Synthese de steroides a base de 17-(3-pyridyl)
CN101768199A (zh) *	2009-12-24	2010-07-07	深圳万乐药业有限公司	醋酸阿比特龙的多晶型物及其制备方法
CN102321142A (zh) *	2011-09-29	2012-01-18	重庆医药工业研究院有限责任公司	一种醋酸阿比特龙晶型及其制备方法
WO2013030410A2 (fr) *	2011-12-23	2013-03-07	Crystal Pharma, S.A.U.	Synthèse d'abiraterone et de composés associés
WO2014016830A1 (fr) *	2012-07-25	2014-01-30	Mapi Pharma Ltd.	Procédé et intermédiaires utilisés pour la préparation de l'acétate d'abiratérone

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN102898495B (zh) *	2012-11-12	2014-11-26	浙江神洲药业有限公司	醋酸阿比特龙酯的制备方法

2013
- 2013-04-22 WO PCT/CA2013/050311 patent/WO2013159225A1/fr not_active Ceased
- 2013-04-22 CA CA2871314A patent/CA2871314A1/fr not_active Abandoned
- 2013-04-22 EP EP13780667.5A patent/EP2841444A4/fr not_active Withdrawn

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2938030A (en) *	1956-10-03	1960-05-24	Ciba Pharm Prod Inc	New steroids substituted by a heterocyclic nitrogen-containing ring in 17-position
WO1993020097A1 (fr) *	1992-03-31	1993-10-14	British Technology Group Ltd.	Steroïdes substitues-17 utiles pour le traitement du cancer
WO1995009178A1 (fr) *	1993-09-30	1995-04-06	British Technology Group Limited	Synthese de steroides a base de 17-(3-pyridyl)
CN101768199A (zh) *	2009-12-24	2010-07-07	深圳万乐药业有限公司	醋酸阿比特龙的多晶型物及其制备方法
CN102321142A (zh) *	2011-09-29	2012-01-18	重庆医药工业研究院有限责任公司	一种醋酸阿比特龙晶型及其制备方法
WO2013030410A2 (fr) *	2011-12-23	2013-03-07	Crystal Pharma, S.A.U.	Synthèse d'abiraterone et de composés associés
WO2014016830A1 (fr) *	2012-07-25	2014-01-30	Mapi Pharma Ltd.	Procédé et intermédiaires utilisés pour la préparation de l'acétate d'abiratérone

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
A. V. KAMERNITSKII ET AL: "Transformed steroids. 114. Direction of opening oxide ring of 16,17?-epoxy-17?-phenylandrost-4-en-3-one", BULLETIN OF THE ACADEMY OF SCIENCES OF THE USSR; DIVISION OF CHEMICAL SCIENCES, vol. 29, no. 8, 1 August 1980 (1980-08-01), pages 1363 - 1366, XP055213844, ISSN: 0568-5230, DOI: 10.1007/BF00950590 *
DATABASE WPI Week 201058, Derwent World Patents Index; AN 2010-K12540, XP002744750 *
DATABASE WPI Week 201233, Derwent World Patents Index; AN 2012-B86835, XP002744749 *
J. HEER: "Über Pyridyl-Steroide. I. Über Steroide, 141. Mitteilung", HELVETICA CHIMICA ACTA, vol. 39, no. 6, 1 January 1956 (1956-01-01), pages 1804 - 1813, XP055214017, ISSN: 0018-019X, DOI: 10.1002/hlca.19560390640 *
See also references of WO2013159225A1 *

Also Published As

Publication number	Publication date
WO2013159225A1 (fr)	2013-10-31
CA2871314A1 (fr)	2013-10-31
EP2841444A1 (fr)	2015-03-04

Publication	Publication Date	Title
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ZA201405824B (en)	2015-11-25	Process for the preparation of substituted phenylpropanones
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EP2817305A4 (fr)	2015-07-01	Procédé perfectionné pour la préparation d'aprépitant
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EP2906536A4 (fr)	2016-03-30	Procédé amélioré de préparation d'un intermédiaire de périndopril
IL233997A0 (en)	2014-09-30	Process for preparing derivatives of n-hydroxy-1-(1-alkyl-1h-tetrahazol-5-yl)-1-phenylmethaneimine
HUP1200543A2 (en)	2014-03-28	New method for the preparation of 17alpha-ethynyl steroids
PL2782924T3 (pl)	2017-07-31	Proces otrzymywania drospirenonu

Legal Events

Date	Code	Title	Description
2015-01-30	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2015-03-04	17P	Request for examination filed	Effective date: 20141124
2015-03-04	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2015-03-04	AX	Request for extension of the european patent	Extension state: BA ME
2015-07-29	DAX	Request for extension of the european patent (deleted)
2015-11-04	RA4	Supplementary search report drawn up and despatched (corrected)	Effective date: 20151002
2015-11-04	RIC1	Information provided on ipc code assigned before grant	Ipc: C07J 75/00 20060101ALI20150925BHEP Ipc: A61K 31/58 20060101ALI20150925BHEP Ipc: C07J 43/00 20060101AFI20150925BHEP Ipc: C07J 51/00 20060101ALI20150925BHEP Ipc: C07J 9/00 20060101ALI20150925BHEP
2017-05-18	GRAP	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOSNIGR1
2017-06-14	INTG	Intention to grant announced	Effective date: 20170519
2017-06-14	RIN1	Information on inventor provided before grant (corrected)	Inventor name: SCHREINER, ERWIN Inventor name: LU, QINGBO Inventor name: GORIN, BORIS Inventor name: DIXON, CRAIG E.
2018-02-23	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2018-03-28	18D	Application deemed to be withdrawn	Effective date: 20170930