EP2723349A4 - Compositions de microarn-31 et leurs procédés d'utilisation dans des maladies auto-immunes - Google Patents

Compositions de microarn-31 et leurs procédés d'utilisation dans des maladies auto-immunes

Info

Publication number: EP2723349A4
Authority: EP; European Patent Office
Prior art keywords: microrna; compositions; methods; autoimmune disease; autoimmune
Prior art date: 2011-06-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP12804592.9A

Other languages

German (de)

English (en)

Other versions

EP2723349A2 (fr

Inventor

Yihong Yao

Nan Shen

Wei Fan

Yuanjia Tang

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

MedImmune LLC

Original Assignee

MedImmune LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-06-27

Filing date

2012-06-26

Publication date

2015-01-14

2012-06-26 Application filed by MedImmune LLC filed Critical MedImmune LLC

2014-04-30 Publication of EP2723349A2 publication Critical patent/EP2723349A2/fr

2015-01-14 Publication of EP2723349A4 publication Critical patent/EP2723349A4/fr

Status Withdrawn legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C12N2310/141—MicroRNAs, miRNAs

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

EP12804592.9A 2011-06-27 2012-06-26 Compositions de microarn-31 et leurs procédés d'utilisation dans des maladies auto-immunes Withdrawn EP2723349A4 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201161501482P	2011-06-27	2011-06-27
PCT/US2012/044197 WO2013003346A2 (fr)	2011-06-27	2012-06-26	Compositions de microarn-31 et leurs procédés d'utilisation dans des maladies auto-immunes

Publications (2)

Publication Number	Publication Date
EP2723349A2 EP2723349A2 (fr)	2014-04-30
EP2723349A4 true EP2723349A4 (fr)	2015-01-14

Family

ID=47424764

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP12804592.9A Withdrawn EP2723349A4 (fr)	2011-06-27	2012-06-26	Compositions de microarn-31 et leurs procédés d'utilisation dans des maladies auto-immunes

Country Status (8)

Country	Link
EP (1)	EP2723349A4 (fr)
JP (1)	JP2014521600A (fr)
KR (1)	KR20140066671A (fr)
AU (1)	AU2012275552A1 (fr)
BR (1)	BR112013033794A2 (fr)
CA (1)	CA2841158A1 (fr)
RU (1)	RU2014102217A (fr)
WO (1)	WO2013003346A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2021104208A1 (fr) *	2019-11-26	2021-06-03	中国科学院上海营养与健康研究所	Cible moléculaire de petits arn endogènes pour prévenir le vieillissement de la peau et le vieillissement prématuré et son application

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2009030153A1 (fr) *	2007-08-27	2009-03-12	Shanghai Institutes For Biological Sciences, Chinese Academy Of Sciences	Rôles de micro-arn dans le diagnostic et le traitement du lupus érythémateux systémique
WO2010065961A2 (fr) *	2008-12-05	2010-06-10	Whitehead Institute For Biomedical Research	Compositions et procédés concernant le mir-31

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1432724A4 (fr) *	2002-02-20	2006-02-01	Sirna Therapeutics Inc	Inhibition a mediation par interference d'arn de genes de map kinase

2012
- 2012-06-26 EP EP12804592.9A patent/EP2723349A4/fr not_active Withdrawn
- 2012-06-26 RU RU2014102217/15A patent/RU2014102217A/ru unknown
- 2012-06-26 JP JP2014518912A patent/JP2014521600A/ja active Pending
- 2012-06-26 WO PCT/US2012/044197 patent/WO2013003346A2/fr not_active Ceased
- 2012-06-26 BR BR112013033794A patent/BR112013033794A2/pt not_active IP Right Cessation
- 2012-06-26 CA CA2841158A patent/CA2841158A1/fr not_active Abandoned
- 2012-06-26 KR KR1020137035140A patent/KR20140066671A/ko not_active Withdrawn
- 2012-06-26 AU AU2012275552A patent/AU2012275552A1/en not_active Abandoned

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2009030153A1 (fr) *	2007-08-27	2009-03-12	Shanghai Institutes For Biological Sciences, Chinese Academy Of Sciences	Rôles de micro-arn dans le diagnostic et le traitement du lupus érythémateux systémique
WO2010065961A2 (fr) *	2008-12-05	2010-06-10	Whitehead Institute For Biomedical Research	Compositions et procédés concernant le mir-31

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
FAN WEI ET AL: "Identification of microRNA-31 as a Novel Regulator Contributing to Impaired IL-2 Production in T cells From Patients With Systemic Lupus Erythematosus", ARTHRITIS & RHEUMATISM, vol. 63, no. 10, Suppl. S, 1922, October 2011 (2011-10-01), & 75TH ANNUAL SCIENTIFIC MEETING OF THE AMERICAN-COLLEGE-OF-RHEUMATOLOGY/46TH ANNUAL SCIENTIFIC MEETIN; CHICAGO, IL, USA; NOVEMBER 04 -09, 2011, pages S749 - S750, XP002731678 *
GOMEZ-MARTIN D ET AL: "Interleukin 2 and systemic lupus erythematosus", AUTOIMMUNITY REVIEWS, ELSEVIER, AMSTERDAM, NL, vol. 9, no. 1, 1 September 2009 (2009-09-01), pages 34 - 39, XP026574987, ISSN: 1568-9972, [retrieved on 20090306], DOI: 10.1016/J.AUTREV.2009.02.035 *
RUJUAN DAI ET AL: "Identification of a Common Lupus Disease-Associated microRNA Expression Pattern in Three Different Murine Models of Lupus", PLOS ONE, vol. 5, no. 12, 10 December 2010 (2010-12-10), pages e14302, XP055148831, DOI: 10.1371/journal.pone.0014302 *
S. VALASTYAN ET AL: "Concurrent Suppression of Integrin 5, Radixin, and RhoA Phenocopies the Effects of miR-31 on Metastasis", CANCER RESEARCH, vol. 70, no. 12, 15 June 2010 (2010-06-15), pages 5147 - 5154, XP055148658, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-10-0410 *
WEI FAN ET AL: "Identification of microRNA-31 as a novel regulator contributing to impaired interleukin-2 production in T cells from patients with systemic lupus erythematosus", ARTHRITIS & RHEUMATISM, vol. 64, no. 11, 27 October 2012 (2012-10-27), pages 3715 - 3725, XP055148804, ISSN: 0004-3591, DOI: 10.1002/art.34596 *

Also Published As

Publication number	Publication date
BR112013033794A2 (pt)	2019-09-24
WO2013003346A3 (fr)	2013-02-28
JP2014521600A (ja)	2014-08-28
EP2723349A2 (fr)	2014-04-30
RU2014102217A (ru)	2015-08-10
AU2012275552A1 (en)	2014-02-06
WO2013003346A2 (fr)	2013-01-03
KR20140066671A (ko)	2014-06-02
CA2841158A1 (fr)	2013-01-03

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Legal Events

Date	Code	Title	Description
2014-03-28	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2014-04-30	17P	Request for examination filed	Effective date: 20140116
2014-04-30	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2014-10-01	DAX	Request for extension of the european patent (deleted)
2015-01-07	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 31/7088 20060101AFI20141128BHEP Ipc: C12N 15/113 20100101ALI20141128BHEP
2015-01-14	A4	Supplementary search report drawn up and despatched	Effective date: 20141212
2015-12-18	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2016-01-20	18D	Application deemed to be withdrawn	Effective date: 20150723