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EP2765227A3 - Compositions and methods for identifying autism spectrum disorders - Google Patents

Compositions and methods for identifying autism spectrum disorders Download PDF

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Publication number
EP2765227A3
EP2765227A3 EP14000228.8A EP14000228A EP2765227A3 EP 2765227 A3 EP2765227 A3 EP 2765227A3 EP 14000228 A EP14000228 A EP 14000228A EP 2765227 A3 EP2765227 A3 EP 2765227A3
Authority
EP
European Patent Office
Prior art keywords
methods
autism spectrum
compositions
spectrum disorders
identifying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP14000228.8A
Other languages
German (de)
French (fr)
Other versions
EP2765227A2 (en
Inventor
Valerie Wailin Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
George Washington University
Original Assignee
George Washington University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by George Washington University filed Critical George Washington University
Publication of EP2765227A2 publication Critical patent/EP2765227A2/en
Publication of EP2765227A3 publication Critical patent/EP2765227A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides methods of identifying DNA methylation profiles for neurological and psychiatric conditions including autism spectrum disorders, methods of treating such conditions, and methods of identifying therapeutics for the treatment of such neurological and psychiatric conditions.
EP14000228.8A 2010-04-06 2011-04-06 Compositions and methods for identifying autism spectrum disorders Withdrawn EP2765227A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32117210P 2010-04-06 2010-04-06
EP11766672.7A EP2558622A4 (en) 2010-04-06 2011-04-06 COMPOSITIONS AND METHODS FOR IDENTIFYING AUTISM SPECTRUM DISORDERS

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP11766672.7A Division EP2558622A4 (en) 2010-04-06 2011-04-06 COMPOSITIONS AND METHODS FOR IDENTIFYING AUTISM SPECTRUM DISORDERS

Publications (2)

Publication Number Publication Date
EP2765227A2 EP2765227A2 (en) 2014-08-13
EP2765227A3 true EP2765227A3 (en) 2014-12-10

Family

ID=44763268

Family Applications (2)

Application Number Title Priority Date Filing Date
EP11766672.7A Withdrawn EP2558622A4 (en) 2010-04-06 2011-04-06 COMPOSITIONS AND METHODS FOR IDENTIFYING AUTISM SPECTRUM DISORDERS
EP14000228.8A Withdrawn EP2765227A3 (en) 2010-04-06 2011-04-06 Compositions and methods for identifying autism spectrum disorders

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP11766672.7A Withdrawn EP2558622A4 (en) 2010-04-06 2011-04-06 COMPOSITIONS AND METHODS FOR IDENTIFYING AUTISM SPECTRUM DISORDERS

Country Status (3)

Country Link
US (1) US20140187430A1 (en)
EP (2) EP2558622A4 (en)
WO (1) WO2011127194A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140274767A1 (en) * 2013-01-23 2014-09-18 The Johns Hopkins University Dna methylation markers for metastatic prostate cancer
US10842807B2 (en) 2016-06-13 2020-11-24 Washington University Methods of treating neurodegenerative disorders comprising DNA methyltransferase inhibitors
CN107944222B (en) * 2016-10-13 2020-04-14 中南大学 A method for detecting the occurrence time of cases using the correlation between DNA methylation levels in human peripheral blood and biological rhythms
WO2018107294A1 (en) * 2016-12-15 2018-06-21 The Hospital For Sick Children Dna methylation markers for neuropsychiatric disorders and methods, uses and kits thereof
AU2018275252A1 (en) * 2017-06-01 2019-12-19 Genome Profiling, Llc Identification of epigenetic signatures indicating cerebral palsy
JP7466927B2 (en) * 2018-08-10 2024-04-15 ニューヨーク ユニバーシティ Use of IGF-2 receptor agonist ligands to treat angelman syndrome and autism
KR20210075069A (en) 2018-08-10 2021-06-22 뉴욕 유니버시티 Use of mannose 6 phosphate and variants thereof for improving memory and reducing memory impairment
CN108977461B (en) * 2018-08-21 2021-09-10 中国科学院昆明植物研究所 Application of protein encoded by pPMB1 gene or pPMB1 gene in improving dehydration resistance of plants
US20210180130A1 (en) * 2019-12-13 2021-06-17 Seawire Consultoria e Comercio LDA Detection and treatment of autism spectrum disorders
CN113122631A (en) * 2020-01-14 2021-07-16 上海鹍远生物技术有限公司 Reagent for detecting DNA methylation and application
WO2022020824A2 (en) * 2020-07-22 2022-01-27 Washington State University Methods of identifying autism spectrum disorder
US20250146051A1 (en) * 2022-02-28 2025-05-08 The Johns Hopkins University Methods for identifying risk of autism
WO2024184854A1 (en) * 2023-03-07 2024-09-12 Pomorski Uniwersytet Medyczny W Szczecinie Methods, systems and assosiated computer program products for discriminating type of biological sample of an organism using epigenetic modification information

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100029009A1 (en) * 2008-07-28 2010-02-04 Greenwood Genetic Center, Inc. Methods for Determining Dysregulation of Methylation of Brain Expressed Genes on the X Chromosome to Diagnose Autism Spectrum Disorders

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US5262300A (en) 1988-11-30 1993-11-16 The Salk Institute For Biological Studies Receptors: their identification, characterization, preparation and use
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
EP0483249B1 (en) 1989-07-18 2003-04-23 OSI Pharmaceuticals, Inc. Method of transcriptionally modulating gene expression and of discovering chemicals capable of functioning as gene expression modulators
US5545522A (en) 1989-09-22 1996-08-13 Van Gelder; Russell N. Process for amplifying a target polynucleotide sequence using a single primer-promoter complex
US5453362A (en) 1992-12-04 1995-09-26 Tularik Inc. Eukaryotic transcription protein; host cell factor
US5534410A (en) 1993-01-28 1996-07-09 The Regents Of The University Of California TATA-binding protein associated factors drug screens
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
US5563036A (en) 1994-04-29 1996-10-08 Tularik, Inc. Transcription factor-DNA binding assay
US5612455A (en) 1994-07-05 1997-03-18 Tularik, Inc. Nuclear factors and binding assay
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JP2000501290A (en) 1995-11-30 2000-02-08 リサーチ ディベロップメント ファンデーション Screening assays for compounds that stimulate somatostatin and insulin production
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Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
A. NGUYEN ET AL: "Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain", THE FASEB JOURNAL, vol. 24, no. 8, 7 April 2010 (2010-04-07), pages 3036 - 3051, XP055126230, ISSN: 0892-6638, DOI: 10.1096/fj.10-154484 *
VALERIE W. HU: "From Genes to Environment: Using Integrative Genomics to Build a "Systems-Level" Understanding of Autism Spectrum Disorders", CHILD DEVELOPMENT, vol. 84, no. 1, 12 January 2013 (2013-01-12), pages 89 - 103, XP055126241, ISSN: 0009-3920, DOI: 10.1111/j.1467-8624.2012.01759.x *

Also Published As

Publication number Publication date
EP2765227A2 (en) 2014-08-13
EP2558622A4 (en) 2013-07-24
EP2558622A1 (en) 2013-02-20
US20140187430A1 (en) 2014-07-03
WO2011127194A1 (en) 2011-10-13

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