EP2680843A4 - Dérivés de composés amino-hétéroaryles substitués par des pyrazoles - Google Patents

Dérivés de composés amino-hétéroaryles substitués par des pyrazoles

Info

Publication number: EP2680843A4
Authority: EP; European Patent Office
Prior art keywords: pyrazole; derivatives; substituted amino; heteroaryl compounds; heteroaryl
Prior art date: 2011-03-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP20120751813

Other languages

German (de)

English (en)

Other versions

EP2680843A2 (fr

Inventor

Craig Masse

Bhaumik Pandya

Ian Robert Silverman

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Concert Pharmaceuticals Inc

Original Assignee

Concert Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-03-03

Filing date

2012-03-01

Publication date

2015-05-06

2012-03-01 Application filed by Concert Pharmaceuticals Inc filed Critical Concert Pharmaceuticals Inc

2014-01-08 Publication of EP2680843A2 publication Critical patent/EP2680843A2/fr

2015-05-06 Publication of EP2680843A4 publication Critical patent/EP2680843A4/fr

Status Withdrawn legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP20120751813 2011-03-03 2012-03-01 Dérivés de composés amino-hétéroaryles substitués par des pyrazoles Withdrawn EP2680843A4 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201161448887P	2011-03-03	2011-03-03
PCT/US2012/027341 WO2012119006A2 (fr)	2011-03-03	2012-03-01	Dérivés de composés amino-hétéroaryles substitués par des pyrazoles

Publications (2)

Publication Number	Publication Date
EP2680843A2 EP2680843A2 (fr)	2014-01-08
EP2680843A4 true EP2680843A4 (fr)	2015-05-06

Family

ID=46758504

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP20120751813 Withdrawn EP2680843A4 (fr)	2011-03-03	2012-03-01	Dérivés de composés amino-hétéroaryles substitués par des pyrazoles

Country Status (5)

Country	Link
EP (1)	EP2680843A4 (fr)
AU (1)	AU2012223281A1 (fr)
CA (1)	CA2829025A1 (fr)
MX (1)	MX2013010067A (fr)
WO (1)	WO2012119006A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN103304552B (zh) *	2012-03-09	2016-12-28	广东东阳光药业有限公司	取代的吡啶化合物及其使用方法和用途
MX2015008187A (es)	2012-12-20	2016-02-05	Concert Pharmaceuticals Inc	Inhibidores de alk deuterados.
CN104650049B (zh) *	2013-08-28	2018-06-08	广东东阳光药业有限公司	取代的吡啶化合物及其使用方法和用途
UA124857C2 (uk)	2017-05-16	2021-12-01	Вертекс Фармасьютикалз Інкорпорейтед	Дейтеровані піридонаміди і їх проліки як модулятори натрієвих каналів
CN114437058A (zh) *	2020-10-30	2022-05-06	珠海宇繁生物科技有限责任公司	氘代hpk1激酶抑制剂及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AP2373A (en) *	2004-08-26	2012-03-07	Pfizer	Enantiomerically pure aminoheteroaryl compounds asprotein kinase inhibitors.
BRPI0619424B1 (pt) *	2005-12-05	2022-02-08	Pfizer Products Inc	Uso de inibidores c-met/hgfrs para a fabricação de medicamentos
WO2007126964A2 (fr) *	2006-03-31	2007-11-08	Schering Corporation	Inhibiteurs de kinase
CN101967140A (zh) *	2010-09-14	2011-02-09	郑州泰基鸿诺药物科技有限公司	氘代克里唑蒂尼及其衍生物、制备方法和应用

2012
- 2012-03-01 CA CA2829025A patent/CA2829025A1/fr not_active Abandoned
- 2012-03-01 WO PCT/US2012/027341 patent/WO2012119006A2/fr not_active Ceased
- 2012-03-01 EP EP20120751813 patent/EP2680843A4/fr not_active Withdrawn
- 2012-03-01 AU AU2012223281A patent/AU2012223281A1/en not_active Abandoned
- 2012-03-01 MX MX2013010067A patent/MX2013010067A/es not_active Application Discontinuation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *

Also Published As

Publication number	Publication date
CA2829025A1 (fr)	2012-09-07
AU2012223281A1 (en)	2013-09-19
MX2013010067A (es)	2014-01-31
WO2012119006A3 (fr)	2014-04-17
WO2012119006A2 (fr)	2012-09-07
EP2680843A2 (fr)	2014-01-08

Publication	Publication Date	Title
IL286152A (en)	2021-10-31	Modified imidazopyridinyl-aminopyridine compounds
IL237581B (en)	2018-11-29	Derivatives of 6-oxo-pyrazinopyrrolopyrimidines
SG10201601802YA (en)	2016-04-28	Dispiropyrrolidine derivatives
ZA201401884B (en)	2019-11-27	New dihydroquinoline-2-one derivatives
HUE047354T2 (hu)	2020-04-28	Ivacaftor deuterizált származékai
LT2709986T (lt)	2017-05-25	Ivakaftoro deuterinti dariniai
IL233081A0 (en)	2014-08-03	History of Betulin
EP2709609A4 (fr)	2015-08-26	Composés hétérocycliques
SG11201401937YA (en)	2014-05-29	New aryl-quinoline derivatives
IL247638B (en)	2018-05-31	History of heteroaryl piperidine
SG11201400452TA (en)	2014-08-28	Derivatives of xanthone compounds
GB201120644D0 (en)	2012-01-11	Herbicidal uses of compounds
IL233001A0 (en)	2014-07-31	New iso-ergoline histories
EP2680843A4 (fr)	2015-05-06	Dérivés de composés amino-hétéroaryles substitués par des pyrazoles
SI2766342T1 (sl)	2016-09-30	Derivati fenil-gvanidina
EP2684869A4 (fr)	2014-08-20	Préparation de 3-mercaptopropionates
IL230977A (en)	2016-08-31	A crystalline form of relapaldib
ZA201308049B (en)	2016-08-31	3-ureidoisoquinolin-8-yl derivatives
EP2782902A4 (fr)	2015-08-26	Dérivés d'acide phénoxyisobutyrique
GB201108347D0 (en)	2011-06-29	Polymprphic form of compound
ZA201209319B (en)	2013-08-28	Cyclopropyl-indole derivatives
GB201108346D0 (en)	2011-06-29	Polymorphic form of compound

Legal Events

Date	Code	Title	Description
2013-12-06	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2014-01-08	17P	Request for examination filed	Effective date: 20131002
2014-01-08	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2014-01-08	AX	Request for extension of the european patent	Extension state: BA ME
2014-05-21	R17D	Deferred search report published (corrected)	Effective date: 20140417
2015-01-14	RIC1	Information provided on ipc code assigned before grant	Ipc: A01N 43/56 20060101AFI20141211BHEP Ipc: A61K 31/415 20060101ALI20141211BHEP
2015-05-06	A4	Supplementary search report drawn up and despatched	Effective date: 20150407
2015-05-06	RIC1	Information provided on ipc code assigned before grant	Ipc: A61P 35/00 20060101ALI20150330BHEP Ipc: A61K 31/517 20060101ALI20150330BHEP Ipc: A61K 31/4412 20060101ALI20150330BHEP Ipc: C07D 401/14 20060101ALI20150330BHEP Ipc: A01N 43/56 20060101AFI20150330BHEP Ipc: A61K 31/415 20060101ALI20150330BHEP Ipc: A61K 31/4545 20060101ALI20150330BHEP Ipc: A61K 45/06 20060101ALI20150330BHEP
2016-05-18	17Q	First examination report despatched	Effective date: 20160418
2016-12-23	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2017-01-25	18D	Application deemed to be withdrawn	Effective date: 20160830