EP2679270A4 - GLP-1 ANALOG COMPOSITION FOR MICRO NEEDLE DEVICES - Google Patents

GLP-1 ANALOG COMPOSITION FOR MICRO NEEDLE DEVICES

Info

Publication number: EP2679270A4
Authority: EP; European Patent Office
Prior art keywords: glp; micro needle; needle devices; analog composition; analog
Prior art date: 2011-02-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

EP12749490.4A

Other languages

German (de)

French (fr)

Other versions

EP2679270A1 (en

EP2679270B1 (en

Inventor

Takuya UMEMOTO

Toshiyuki Matsudo

Seiji Tokumoto

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Hisamitsu Pharmaceutical Co Inc

Original Assignee

Hisamitsu Pharmaceutical Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-02-24

Filing date

2012-02-23

Publication date

2015-04-01

2012-02-23 Application filed by Hisamitsu Pharmaceutical Co Inc filed Critical Hisamitsu Pharmaceutical Co Inc

2014-01-01 Publication of EP2679270A1 publication Critical patent/EP2679270A1/en

2015-04-01 Publication of EP2679270A4 publication Critical patent/EP2679270A4/en

2016-11-09 Application granted granted Critical

2016-11-09 Publication of EP2679270B1 publication Critical patent/EP2679270B1/en

Status Active legal-status Critical Current

2032-02-23 Anticipated expiration legal-status Critical

Links

DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical class C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Bioinformatics & Cheminformatics (AREA)
Oil, Petroleum & Natural Gas (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Inorganic Chemistry (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Obesity (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EP12749490.4A 2011-02-24 2012-02-23 Glp-1 analogue composition for microneedle devices Active EP2679270B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2011038695		2011-02-24
PCT/JP2012/054465 WO2012115208A1 (en)	2011-02-24	2012-02-23	Glp-1 analogue composition for microneedle devices

Publications (3)

Publication Number	Publication Date
EP2679270A1 EP2679270A1 (en)	2014-01-01
EP2679270A4 true EP2679270A4 (en)	2015-04-01
EP2679270B1 EP2679270B1 (en)	2016-11-09

Family

ID=46720982

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP12749490.4A Active EP2679270B1 (en)	2011-02-24	2012-02-23	Glp-1 analogue composition for microneedle devices

Country Status (6)

Country	Link
US (1)	US20130323293A1 (en)
EP (1)	EP2679270B1 (en)
JP (1)	JP5675952B2 (en)
CN (1)	CN103391798A (en)
TW (1)	TWI547294B (en)
WO (1)	WO2012115208A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI576111B (en) *	2011-02-25	2017-04-01	久光製藥股份有限公司	Adjuvant for transdermal or transmucosal administration and pharmaceutical preparation contaning the same
US9993549B2 (en)	2013-10-31	2018-06-12	Hisamitsu Pharmaceutical Co., Inc.	Adjuvant composition, adjuvant preparation containing same, and kit
JP6712224B2 (en) *	2014-09-11	2020-06-17	久光製薬株式会社	Micro needle device
JP6621754B2 (en) *	2014-10-27	2019-12-18	久光製薬株式会社	Microneedle device containing recombinant follicle stimulating hormone
DE102017112573A1 (en) *	2017-06-07	2018-12-13	Lts Lohmann Therapie-Systeme Ag	Microneedle system for the application of glucagon-like peptide analogues
SG11202003627PA (en) *	2017-10-31	2020-05-28	Medimmune Ltd	Oral delivery of glp-1 peptide analogs
CN112741897A (en) *	2019-10-29	2021-05-04	南京滕恩医药有限公司	Composition of micro-array drug delivery system of glucagon-like peptide-1 receptor agonist
CN114306917A (en) *	2021-01-12	2022-04-12	广州新济药业科技有限公司	Soluble microneedle patch and preparation method thereof
KR102685131B1 (en) *	2023-10-25	2024-07-15	주식회사 스몰랩	Composition for microneedle comprising liraglutide with enhanced stability and it uses

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20060030838A1 (en) *	2004-07-02	2006-02-09	Gonnelli Robert R	Methods and devices for delivering GLP-1 and uses thereof
WO2006138719A2 (en) *	2005-06-17	2006-12-28	Georgia Tech Research Corporation	Coated microstructures and method of manufacture thereof
WO2009029847A1 (en) *	2007-08-30	2009-03-05	Curedm, Inc.	Compositions and methods of using proislet peptides and analogs thereof
WO2010092163A2 (en) *	2009-02-13	2010-08-19	Boehringer Ingelheim International Gmbh	Antidiabetic medications
EP2540337A1 (en) *	2010-02-24	2013-01-02	Hisamitsu Pharmaceutical Co., Inc.	Micro-needle device and preparation method

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6268343B1 (en) *	1996-08-30	2001-07-31	Novo Nordisk A/S	Derivatives of GLP-1 analogs
JP4153999B2 (en)	1996-12-20	2008-09-24	アルザ・コーポレーション	Compositions and methods for enhancing transdermal agent flow
GB0017999D0 (en)	2000-07-21	2000-09-13	Smithkline Beecham Biolog	Novel device
AU2003301064A1 (en) *	2002-12-17	2004-07-14	Massachusetts Institute Of Technology	Stimuli-responsive systems for controlled drug delivery
US20040186046A1 (en) *	2003-03-17	2004-09-23	Pfizer Inc	Treatment of type 1 diabetes with PDE5 inhibitors
MXPA06013168A (en)	2004-05-13	2007-05-15	Johnson & Johnson	Apparatus and method for transdermal delivery of parathyroid hormone agents.
US20090136554A1 (en)	2007-10-23	2009-05-28	Alza Corporation	Transdermal sustained release drug delivery
CA2739876A1 (en) *	2008-10-07	2010-04-15	Tuo Jin	Phase-transition polymeric microneedles
JP2010131123A (en) *	2008-12-03	2010-06-17	Medorekkusu:Kk	Method of carrying medicament to microneedle array
EP2431362A4 (en) *	2009-05-14	2012-10-10	Dainippon Sumitomo Pharma Co	3-(4-aminophenyl)-2-furancarboxylic acid derivative and pharmaceutically acceptable salt thereof
WO2010143689A1 (en) *	2009-06-10	2010-12-16	久光製薬株式会社	Microneedle device
JP2012188352A (en) *	2009-07-13	2012-10-04	Dainippon Sumitomo Pharma Co Ltd	3-(4-substituted alkyl-phenyl)-2-furancarboxylic acid derivative and pharmaceutically acceptable salt of the same
DK2498801T3 (en) *	2009-11-13	2018-05-07	Sanofi Aventis Deutschland	PHARMACEUTICAL COMPOSITION INCLUDING desPro36Exendin-4 (1-39) -Lys6-NH2 AND METHIONIN

2012
- 2012-02-23 EP EP12749490.4A patent/EP2679270B1/en active Active
- 2012-02-23 WO PCT/JP2012/054465 patent/WO2012115208A1/en not_active Ceased
- 2012-02-23 JP JP2013501126A patent/JP5675952B2/en active Active
- 2012-02-23 CN CN2012800101228A patent/CN103391798A/en active Pending
- 2012-02-23 US US13/995,404 patent/US20130323293A1/en not_active Abandoned
- 2012-02-24 TW TW101106227A patent/TWI547294B/en active

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20060030838A1 (en) *	2004-07-02	2006-02-09	Gonnelli Robert R	Methods and devices for delivering GLP-1 and uses thereof
WO2006138719A2 (en) *	2005-06-17	2006-12-28	Georgia Tech Research Corporation	Coated microstructures and method of manufacture thereof
WO2009029847A1 (en) *	2007-08-30	2009-03-05	Curedm, Inc.	Compositions and methods of using proislet peptides and analogs thereof
WO2010092163A2 (en) *	2009-02-13	2010-08-19	Boehringer Ingelheim International Gmbh	Antidiabetic medications
EP2540337A1 (en) *	2010-02-24	2013-01-02	Hisamitsu Pharmaceutical Co., Inc.	Micro-needle device and preparation method

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHRISTENSEN M ET AL: "Lixisenatide, a novel GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus", I DRUGS: THE INVESTIGATIONAL DRUGS JOURNAL, CURRENT DRUGS LTD, GB, vol. 12, no. 8, 1 August 2009 (2009-08-01), pages 503 - 513, XP009163477, ISSN: 2040-3410 *
See also references of WO2012115208A1 *

Also Published As

Publication number	Publication date
TW201247260A (en)	2012-12-01
US20130323293A1 (en)	2013-12-05
EP2679270A1 (en)	2014-01-01
JP5675952B2 (en)	2015-02-25
EP2679270B1 (en)	2016-11-09
JPWO2012115208A1 (en)	2014-07-07
TWI547294B (en)	2016-09-01
CN103391798A (en)	2013-11-13
WO2012115208A1 (en)	2012-08-30

Publication	Publication Date	Title
EP2679270A4 (en)	2015-04-01	GLP-1 ANALOG COMPOSITION FOR MICRO NEEDLE DEVICES
HUE049240T2 (en)	2020-09-28	A composition comprising an oxytomodulin analog for the treatment of diabetes
EP2704743A4 (en)	2014-11-05	COMPOSITIONS FOR INHIBITING MASP-2 DEPENDENT SUPPLEMENT ACTIVATION
EP2670811A4 (en)	2014-02-19	INK SET FOR INK JET
EP2743286A4 (en)	2015-03-25	RESIN COMPOSITION FOR RESISTS
EP2809381A4 (en)	2015-08-05	INJECTION DEVICES
EP2701773A4 (en)	2014-09-24	DOSE GUIDES FOR INJECTION SYRINGE
EP2895526A4 (en)	2016-03-09	BRANCHED POLYAMINES FOR THE ADMINISTRATION OF BIOLOGICALLY
EP2683306A4 (en)	2014-06-04	SLEEVE FOR REMOVABLE LANCETTE OF AUTOPIQUEUR
UA26516S (en)	2014-03-11	DEVICE FOR INJECTIONS
EP2726803A4 (en)	2015-03-11	INJECTION LANCES IMMERSE FROM THE TOP
EP2740977A4 (en)	2015-01-28	VALVE OF NEEDLE
EP2810151A4 (en)	2015-09-30	EXTENSION ACTIVATION FOR RELATED DOCUMENTS
ZA201309711B (en)	2014-08-27	A new therapeutical composition containing apomorphine as active ingredient
EP2776905A4 (en)	2015-07-29	INTERACTION MODELS FOR DEVICES OF INDIRECT INTERACTION
EP2849654A4 (en)	2016-06-15	DENTAL DEVICES FOR RECONSTRUCTING EXTRACTION ALVEOL
EP2736030A4 (en)	2015-04-29	SYRINGE ACTUATION DEVICE
PL2708123T3 (en)	2019-12-31	Liquid insecticide composition
EP2891692A4 (en)	2015-07-22	INK COMPOSITION
EP2780051A4 (en)	2015-08-19	NEW IMPROVED FORMULATIONS FOR COATING MEDICAL DEVICES
EP2692715A4 (en)	2014-11-05	GAZOGENIC AGENT COMPOSITION
EP2719400A4 (en)	2015-04-01	BIOCERAMIC MATERIALS FOR THE TREATMENT OF OSTEOMYELITE
EP2709593A4 (en)	2014-10-29	Multi-particulate pharmaceutical composition
EP2676656A4 (en)	2014-10-08	CURABLE COMPOSITION FOR DENTISTRY
EP2753626A4 (en)	2015-03-25	LLP2A-BISPHOSPHONATE CONJUGATES FOR THE TREATMENT OF OSTEOPOROSIS

Legal Events

Date	Code	Title	Description
2013-11-29	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2014-01-01	17P	Request for examination filed	Effective date: 20130625
2014-01-01	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2014-05-28	DAX	Request for extension of the european patent (deleted)
2015-04-01	RA4	Supplementary search report drawn up and despatched (corrected)	Effective date: 20150303
2015-04-01	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 38/26 20060101ALI20150225BHEP Ipc: A61M 37/00 20060101AFI20150225BHEP Ipc: A61K 47/10 20060101ALI20150225BHEP Ipc: A61K 9/00 20060101ALI20150225BHEP Ipc: A61K 47/02 20060101ALI20150225BHEP
2016-03-06	GRAP	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOSNIGR1
2016-03-23	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 47/10 20060101ALI20160218BHEP Ipc: A61K 38/26 20060101ALI20160218BHEP Ipc: A61M 37/00 20060101AFI20160218BHEP Ipc: A61K 9/00 20060101ALI20160218BHEP
2016-04-06	INTG	Intention to grant announced	Effective date: 20160307
2016-05-23	GRAP	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOSNIGR1
2016-06-22	INTG	Intention to grant announced	Effective date: 20160524
2016-06-22	RIN1	Information on inventor provided before grant (corrected)	Inventor name: UMEMOTO, TAKUYA Inventor name: MATSUDO, TOSHIYUKI Inventor name: TOKUMOTO, SEIJI
2016-10-05	GRAS	Grant fee paid	Free format text: ORIGINAL CODE: EPIDOSNIGR3
2016-10-07	GRAA	(expected) grant	Free format text: ORIGINAL CODE: 0009210
2016-11-09	AK	Designated contracting states	Kind code of ref document: B1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2016-11-09	REG	Reference to a national code	Ref country code: GB Ref legal event code: FG4D
2016-11-15	REG	Reference to a national code	Ref country code: AT Ref legal event code: REF Ref document number: 843320 Country of ref document: AT Kind code of ref document: T Effective date: 20161115 Ref country code: CH Ref legal event code: EP
2016-11-30	REG	Reference to a national code	Ref country code: IE Ref legal event code: FG4D
2016-12-22	REG	Reference to a national code	Ref country code: DE Ref legal event code: R096 Ref document number: 602012025160 Country of ref document: DE
2017-02-28	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: LV Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20161109
2017-03-10	REG	Reference to a national code	Ref country code: LT Ref legal event code: MG4D
2017-03-15	REG	Reference to a national code	Ref country code: NL Ref legal event code: MP Effective date: 20161109
2017-04-15	REG	Reference to a national code	Ref country code: AT Ref legal event code: MK05 Ref document number: 843320 Country of ref document: AT Kind code of ref document: T Effective date: 20161109
2017-04-28	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: NO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170209 Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170210 Ref country code: NL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20161109 Ref country code: SE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20161109 Ref country code: LT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20161109
2017-05-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: IS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170309 Ref country code: ES Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20161109 Ref country code: FI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20161109 Ref country code: BE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20170228 Ref country code: PL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20161109 Ref country code: PT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170309 Ref country code: HR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20161109 Ref country code: AT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20161109 Ref country code: RS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20161109
2017-07-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: DK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20161109 Ref country code: RO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20161109 Ref country code: EE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20161109 Ref country code: SK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20161109 Ref country code: CZ Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20161109
2017-08-10	REG	Reference to a national code	Ref country code: DE Ref legal event code: R097 Ref document number: 602012025160 Country of ref document: DE
2017-08-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: SM Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20161109 Ref country code: IT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20161109 Ref country code: BE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20161109 Ref country code: BG Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170209
2017-09-15	PLBE	No opposition filed within time limit	Free format text: ORIGINAL CODE: 0009261
2017-09-15	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT
2017-09-29	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: MC Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20161109
2017-09-29	REG	Reference to a national code	Ref country code: CH Ref legal event code: PL
2017-10-18	26N	No opposition filed	Effective date: 20170810
2017-10-25	GBPC	Gb: european patent ceased through non-payment of renewal fee	Effective date: 20170223
2017-10-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: CH Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20170228 Ref country code: LI Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20170228
2017-11-29	REG	Reference to a national code	Ref country code: IE Ref legal event code: MM4A
2017-11-30	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: SI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20161109
2017-12-01	REG	Reference to a national code	Ref country code: FR Ref legal event code: ST Effective date: 20171031
2017-12-29	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: LU Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20170223
2018-01-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: FR Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20170228
2018-02-28	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: IE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20170223 Ref country code: GB Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20170223
2018-09-28	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: MT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20170223
2019-06-28	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: HU Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO Effective date: 20120223
2019-10-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: CY Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20161109
2019-11-29	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: MK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20161109
2020-03-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: TR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20161109
2020-07-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: AL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20161109
2023-06-28	P01	Opt-out of the competence of the unified patent court (upc) registered	Effective date: 20230522
2025-04-11	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: DE Payment date: 20241231 Year of fee payment: 14