[go: up one dir, main page]

EP2529793A3 - Compositions pour la régulation ou la modulation de la détection de quorum dans des bactéries, procédés d'utilisation de ces composés et méthodes permettant de réguler ou moduler la détection de quorum dans des bactéries - Google Patents

Compositions pour la régulation ou la modulation de la détection de quorum dans des bactéries, procédés d'utilisation de ces composés et méthodes permettant de réguler ou moduler la détection de quorum dans des bactéries Download PDF

Info

Publication number
EP2529793A3
EP2529793A3 EP20120178747 EP12178747A EP2529793A3 EP 2529793 A3 EP2529793 A3 EP 2529793A3 EP 20120178747 EP20120178747 EP 20120178747 EP 12178747 A EP12178747 A EP 12178747A EP 2529793 A3 EP2529793 A3 EP 2529793A3
Authority
EP
European Patent Office
Prior art keywords
methods
bacteria
quorum sensing
regulating
present disclosure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP20120178747
Other languages
German (de)
English (en)
Other versions
EP2529793B1 (fr
EP2529793A2 (fr
Inventor
Binghe Wang
Nantin Ni
Junfeng Wamg
Chung-Dar Lu
Han-Ting Chou
Minyong Li
Shilong Zheng
Yunfeg Cheng
Hanjing Peng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Georgia State University Research Foundation Inc
Original Assignee
Georgia State University Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgia State University Research Foundation Inc filed Critical Georgia State University Research Foundation Inc
Publication of EP2529793A2 publication Critical patent/EP2529793A2/fr
Publication of EP2529793A3 publication Critical patent/EP2529793A3/fr
Application granted granted Critical
Publication of EP2529793B1 publication Critical patent/EP2529793B1/fr
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30Hetero atoms other than halogen
    • C07D333/34Sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/025Boronic and borinic acid compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
EP12178747.7A 2007-06-08 2008-06-06 Compositions pour la régulation ou la modulation de la détection de quorum dans des bactéries, procédés d'utilisation de ces composés et méthodes permettant de réguler ou moduler la détection de quorum dans des bactéries Not-in-force EP2529793B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93373507P 2007-06-08 2007-06-08
EP08828361A EP2155705A4 (fr) 2007-06-08 2008-06-06 Compositions permettant de réguler ou de moduler la détection du quorum dans une bactérie, procédés d'utilisation de ces composés et procédés de régulation et de modulation de la détection du quorum dans une bactérie

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP08828361.9 Division 2008-06-06
EP08828361A Division EP2155705A4 (fr) 2007-06-08 2008-06-06 Compositions permettant de réguler ou de moduler la détection du quorum dans une bactérie, procédés d'utilisation de ces composés et procédés de régulation et de modulation de la détection du quorum dans une bactérie

Publications (3)

Publication Number Publication Date
EP2529793A2 EP2529793A2 (fr) 2012-12-05
EP2529793A3 true EP2529793A3 (fr) 2013-03-20
EP2529793B1 EP2529793B1 (fr) 2016-08-10

Family

ID=40388083

Family Applications (2)

Application Number Title Priority Date Filing Date
EP12178747.7A Not-in-force EP2529793B1 (fr) 2007-06-08 2008-06-06 Compositions pour la régulation ou la modulation de la détection de quorum dans des bactéries, procédés d'utilisation de ces composés et méthodes permettant de réguler ou moduler la détection de quorum dans des bactéries
EP08828361A Withdrawn EP2155705A4 (fr) 2007-06-08 2008-06-06 Compositions permettant de réguler ou de moduler la détection du quorum dans une bactérie, procédés d'utilisation de ces composés et procédés de régulation et de modulation de la détection du quorum dans une bactérie

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP08828361A Withdrawn EP2155705A4 (fr) 2007-06-08 2008-06-06 Compositions permettant de réguler ou de moduler la détection du quorum dans une bactérie, procédés d'utilisation de ces composés et procédés de régulation et de modulation de la détection du quorum dans une bactérie

Country Status (3)

Country Link
US (1) US8653258B2 (fr)
EP (2) EP2529793B1 (fr)
WO (1) WO2009029317A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5612269B2 (ja) * 2009-04-24 2014-10-22 花王株式会社 歯周病マーカー
US8952192B2 (en) 2011-03-24 2015-02-10 University Of Maryland, College Park Phosphorylated and branched dihydroxy-pentane-dione (DPD) analogs as quorum sensing inhibitors in bacteria
US10039777B2 (en) 2012-03-20 2018-08-07 Neuro-Lm Sas Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders
WO2014060581A1 (fr) * 2012-10-18 2014-04-24 Seprox Biotech, S.L. Utilisation de l'hydroxytirosol et de ses dérivés comme désactivateurs de quorum
EP3151733B1 (fr) * 2014-06-06 2020-04-15 The Regents Of The University Of Michigan Compositions et méthodes de caractérisation et de diagnostic d'une maladie parodontale
WO2016191816A1 (fr) * 2015-06-02 2016-12-08 The University Of Melbourne Capsules d'acide phenylborate sensibles au glucose pour l'administration d'insuline
CN106074469B (zh) * 2015-06-19 2019-04-16 复旦大学附属华山医院 用于抗万古霉素耐药菌的药物组合物
CN111684019B (zh) 2018-02-13 2022-08-02 住友化学株式会社 组合物及成形体
US11638759B2 (en) 2019-08-13 2023-05-02 Darlene E. McCord Non-activated, amorphous, pH neutral, two-part bedside-ready clay delivery system that treats pathogen infections in humans and animals
WO2023076855A1 (fr) 2021-10-25 2023-05-04 Mccord Darlene E Compositions d'argile médicinale enrobées, compositions pharmaceutiques et administration de sources de cations et leurs procédés d'utilisation

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2063870A (en) * 1979-07-05 1981-06-10 Bellon Labor Sa Roger 1-aryl-4-arylsulphonyl-1h-pyrazolol-3 compounds and processes for their preparation
US5308860A (en) * 1993-01-15 1994-05-03 Rohm And Haas Company Cyanosulfonylethyltriazoles
WO1999010321A2 (fr) * 1997-08-29 1999-03-04 The Johns Hopkins University Composes antimicrobiens
WO2002047681A1 (fr) * 2000-12-14 2002-06-20 Unisearch Limited Regulation de la virulence de bacteries
WO2003018029A1 (fr) * 2001-08-24 2003-03-06 Quorex Pharmaceuticals, Inc. Agents antibacteriens bases sur une liaison toxoanion
WO2003077844A2 (fr) * 2002-03-13 2003-09-25 Takara Bio, Inc. Effet d'un traitement au 4,5-dihydroxy- 2-cyclopentene-1-one (dhcp) sur l'expression genique et la densite bacterienne (quorum sensing)
WO2004004712A1 (fr) * 2002-07-09 2004-01-15 Fasgen, Llc Methodes de traitement d'infections microbiennes chez les humains et les animaux
US20040180829A1 (en) * 2000-05-10 2004-09-16 Bassler Bonnie L. Compounds and methods for regulating bacterial growth and pathogenesis
WO2005005598A2 (fr) * 2003-04-11 2005-01-20 New York University Prevention et traitement des infections provoquees par b.anthracis : b.anthracis mutante ne possedant pas l'activite luxs, et inhibition par des furanones de la croissance et du 'quorum sensing'' par le biais de ai-2, et production de toxines
WO2005021559A2 (fr) * 2003-09-02 2005-03-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Oxazaborolidines constituant des effecteurs bacteriens
WO2005100384A2 (fr) * 2004-04-12 2005-10-27 The Trustees Of Princeton University Composes ai-2 et analogues bases sur la structure lsrb de salmonella typhimurium

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8506792D0 (en) 1985-03-15 1985-04-17 Janssen Pharmaceutica Nv Derivatives of y-cyclodextrin
JPH01221375A (ja) * 1988-02-27 1989-09-04 Nippon Nohyaku Co Ltd ジチオラン誘導体
AU3201095A (en) * 1994-07-27 1996-02-22 G.D. Searle & Co. Substituted thiazoles for the treatment of inflammation
JP2002504122A (ja) * 1997-06-13 2002-02-05 ノースウエスタン ユニバーシティー ベータラクタマーゼ阻害剤及びその使用方法
IL160010A0 (en) * 2001-07-23 2004-06-20 Univ Ramot Methods and compositions for treating fungal infections
MXPA04010555A (es) * 2002-04-25 2005-02-17 Pharmacia Corp Acidos piperidinil- y piperazinil-sulfonilmetil hidroxamicos y su uso como inhibidores de proteasa.
WO2003105860A1 (fr) * 2002-06-14 2003-12-24 Novo Nordisk A/S Utilisation pharmaceutique d'acides boroniques et de leurs esters
US20040147561A1 (en) * 2002-12-27 2004-07-29 Wenge Zhong Pyrid-2-one derivatives and methods of use
WO2006050236A2 (fr) * 2004-11-01 2006-05-11 Nuada, Llc Composes et methodes d'utilisation de ceux-ci
JP2008519853A (ja) * 2004-11-12 2008-06-12 トラスティーズ オブ タフツ カレッジ リパーゼ阻害物質
US7589239B2 (en) * 2005-09-02 2009-09-15 Auspex Pharmaceuticals Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2063870A (en) * 1979-07-05 1981-06-10 Bellon Labor Sa Roger 1-aryl-4-arylsulphonyl-1h-pyrazolol-3 compounds and processes for their preparation
US5308860A (en) * 1993-01-15 1994-05-03 Rohm And Haas Company Cyanosulfonylethyltriazoles
WO1999010321A2 (fr) * 1997-08-29 1999-03-04 The Johns Hopkins University Composes antimicrobiens
US20040180829A1 (en) * 2000-05-10 2004-09-16 Bassler Bonnie L. Compounds and methods for regulating bacterial growth and pathogenesis
WO2002047681A1 (fr) * 2000-12-14 2002-06-20 Unisearch Limited Regulation de la virulence de bacteries
WO2003018029A1 (fr) * 2001-08-24 2003-03-06 Quorex Pharmaceuticals, Inc. Agents antibacteriens bases sur une liaison toxoanion
WO2003077844A2 (fr) * 2002-03-13 2003-09-25 Takara Bio, Inc. Effet d'un traitement au 4,5-dihydroxy- 2-cyclopentene-1-one (dhcp) sur l'expression genique et la densite bacterienne (quorum sensing)
WO2004004712A1 (fr) * 2002-07-09 2004-01-15 Fasgen, Llc Methodes de traitement d'infections microbiennes chez les humains et les animaux
WO2005005598A2 (fr) * 2003-04-11 2005-01-20 New York University Prevention et traitement des infections provoquees par b.anthracis : b.anthracis mutante ne possedant pas l'activite luxs, et inhibition par des furanones de la croissance et du 'quorum sensing'' par le biais de ai-2, et production de toxines
WO2005021559A2 (fr) * 2003-09-02 2005-03-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Oxazaborolidines constituant des effecteurs bacteriens
WO2005100384A2 (fr) * 2004-04-12 2005-10-27 The Trustees Of Princeton University Composes ai-2 et analogues bases sur la structure lsrb de salmonella typhimurium

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
BARNIKOW, GUENTER ET AL: "Synthesis of CH-acidic thionocarboxylic acid esters", ZEITSCHRIFT FUER CHEMIE ( 1968 ), 8(9), 335 CODEN: ZECEAL; ISSN: 0044-2402, 1969 *
BRITSUN V N ET AL: "Cycloacylation of Phenylsulfonyl-N-R-thioacetamides by Compounds Containing an Activated Multiple Bond", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, KLUWER ACADEMIC PUBLISHERS-CONSULTANTS BUREAU, NE, vol. 41, no. 11, 1 November 2005 (2005-11-01), pages 1437 - 1438, XP019276255, ISSN: 1573-8353 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1969, BARNIKOW, GUENTER ET AL: "Synthesis of CH-acidic thionocarboxylic acid esters", XP002683472, retrieved from STN Database accession no. 1969:11077 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1971, HUPPATZ, J. L.: "Convenient synthesis of ethyl sulfonylacetates", XP002683470, retrieved from STN Database accession no. 1971:87535 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1992, ZHOU, WEIQING ET AL: "Chemoselective oxidation of organic sulfides to sulfones with sodium perborate", XP002683473, retrieved from STN Database accession no. 1992:591428 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2001, ZAKRZEWSKI, ANDRZEJ ET AL: "Investigations of fungicidal properties of substituted phenylsulphonylacetic acid esters and amides", XP002683468, retrieved from STN Database accession no. 2001:824035 *
HUPPATZ, J. L.: "Convenient synthesis of ethyl sulfonylacetates", AUSTRALIAN JOURNAL OF CHEMISTRY ( 1971 ), 24(3), 653-5 CODEN: AJCHAS; ISSN: 0004-9425, 1971, XP002683471 *
LEE JIN YOUNG ET AL: "Radical alkylation of bis(silyloxy)enamine derivatives of organic nitro compounds.", ANGEWANDTE CHEMIE (INTERNATIONAL ED. IN ENGLISH) 18 SEP 2006 LNKD- PUBMED:16906611, vol. 45, no. 37, 18 September 2006 (2006-09-18), pages 6182 - 6186, XP002683469, ISSN: 1433-7851 *
LI MINYONG ET AL: "Structure-based discovery and experimental verification of novel Al-2 quorum sensing inhibitors against Vibrio harveyi", CHEMMEDCHEM, vol. 3, no. 8, August 2008 (2008-08-01), pages 1242 - 1249, XP002683475, ISSN: 1860-7179 *
PERSSON TOBIAS ET AL: "Rational design and synthesis of new quorum-sensing inhibitors derived from acylated homoserine lactones and natural products from garlic.", ORGANIC & BIOMOLECULAR CHEMISTRY 21 JAN 2005 LNKD- PUBMED:15632967, vol. 3, no. 2, 21 January 2005 (2005-01-21), pages 253 - 262, XP002683474, ISSN: 1477-0520 *
ZAKRZEWSKI, ANDRZEJ ET AL: "Investigations of fungicidal properties of substituted phenylsulphonylacetic acid esters and amides", PESTYCYDY (WARSAW) ( 2001 ), (1-2), 21-28 CODEN: PSTYDL; ISSN: 0208-8703, 2001 *
ZHONG ET AL: "Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 17, no. 19, 6 August 2007 (2007-08-06), pages 5384 - 5389, XP022249722, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2007.07.045 *
ZHOU, WEIQING ET AL: "Chemoselective oxidation of organic sulfides to sulfones with sodium perborate", WUJI HUAXUE XUEBAO ( 1992 ), 8(1), 88-90 CODEN: WHUXEO; ISSN: 1001-4861, 1992 *

Also Published As

Publication number Publication date
WO2009029317A3 (fr) 2009-08-20
EP2155705A2 (fr) 2010-02-24
EP2155705A4 (fr) 2012-02-15
WO2009029317A2 (fr) 2009-03-05
EP2529793B1 (fr) 2016-08-10
EP2529793A2 (fr) 2012-12-05
US20100137249A1 (en) 2010-06-03
US8653258B2 (en) 2014-02-18

Similar Documents

Publication Publication Date Title
EP2529793A3 (fr) Compositions pour la régulation ou la modulation de la détection de quorum dans des bactéries, procédés d'utilisation de ces composés et méthodes permettant de réguler ou moduler la détection de quorum dans des bactéries
WO2008011453A3 (fr) HÉTÉROCYCLES AROMATIQUES D'AZOLE SUBSTITUÉS, UTILISÉS EN TANT QU'INHIBITEURS DE LLβ-HSD-1
WO2008153793A3 (fr) Modulateurs de sécrétase gamma
WO2007133683A3 (fr) Compositions formulées anti-tiques et anti-insectes
WO2008116129A3 (fr) Analogues d'imidazolopyrimidine et leur utilisation comme inhibiteurs de pi3 kinase et de mtor
WO2008079460A3 (fr) Inhibiteurs de kinase pour la prévention ou le traitement d'une infection pathogène et procédé d'utilisation de ceux-ci
WO2008070016A3 (fr) Inhibiteurs de l'activité akt
WO2008073933A3 (fr) Composés 4-phényle-6-(2,2,2-trifluoro-1-phényléthoxy) à base de pyrimidine et procédés concernant leur utilisation
WO2010123919A3 (fr) Inhibiteurs pipéridiniques de la janus kinase 3
WO2009114810A3 (fr) Utilisation d'ellagitannines comme inhibiteurs de la détection du quorum bactérien
NZ594341A (en) Combinations of tralopyril and zinc chloride
GEP20125511B (en) Mapk/erk kinase inhibitors
CY1108794T1 (el) Σπειροκυκλικα παραγωγα κυκλοεξανιου
WO2008016662A3 (fr) Biocide pour liquides de stimulation et de traitement des puits
WO2011038318A3 (fr) Compositions comprenant du dibromomalonamide et leur utilisation comme biocides
MA32776B1 (fr) Inhibiteurs de l'akt et de la p70 s6 kinase
WO2009141541A3 (fr) Utilisation d' inhibiteurs de kif13a et d ' ap-1 pour inhiber la melanogenese
MX2012003739A (es) Composicones de dibromomalonamida y su uso como biocidas.
WO2009040952A1 (fr) Médicament renfermant un dérivé de benzophénone ou son sel
WO2009094560A3 (fr) Thiénopyranones en tant qu'inhibiteurs de kinase
FR2929509B1 (fr) L'utilisation de glycosides d'alkyle ou de melanges de glycosides d'alkyle en tant qu'agents destines a inhiber la croissance microbienne, et compositions contenant lesdits glycosides d'alkyle.
WO2009023664A3 (fr) Sulfonamides à substitution azépine et diazépine utilisés pour inhiber la 11-bêta-hydroxystéroïde déshydrogénase de type-1
MX2012003738A (es) Composiciones de dibromomalonamida y su uso como biocidas.
WO2008153792A3 (fr) Modulateurs de sécrétase gamma
MX345326B (es) Composiciones de dibromomalonamida y su uso como biocidas.

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AC Divisional application: reference to earlier application

Ref document number: 2155705

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

RIN1 Information on inventor provided before grant (corrected)

Inventor name: CHENG, YUNFEG

Inventor name: WANG, BINGHE

Inventor name: PENG, HANJING

Inventor name: LU, CHUNG-DAR

Inventor name: WAMG, JUNFENG

Inventor name: LI, MINYONG

Inventor name: NI, NANTIN

Inventor name: ZHENG, SHILONG

Inventor name: CHOU, HAN-TING

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

RIN1 Information on inventor provided before grant (corrected)

Inventor name: LI, MINYONG

Inventor name: NI, NANTIN

Inventor name: WAMG, JUNFENG

Inventor name: PENG, HANJING

Inventor name: ZHENG, SHILONG

Inventor name: CHENG, YUNFEG

Inventor name: CHOU, HAN-TING

Inventor name: LU, CHUNG-DAR

Inventor name: WANG, BINGHE

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

RIC1 Information provided on ipc code assigned before grant

Ipc: C07F 5/02 20060101ALI20130211BHEP

Ipc: A61P 31/04 20060101AFI20130211BHEP

Ipc: C07D 279/20 20060101ALI20130211BHEP

Ipc: A61K 31/69 20060101ALI20130211BHEP

Ipc: C07C 317/44 20060101ALI20130211BHEP

Ipc: C07D 333/34 20060101ALI20130211BHEP

Ipc: C07C 39/10 20060101ALI20130211BHEP

Ipc: C07F 5/00 20060101ALI20130211BHEP

17P Request for examination filed

Effective date: 20130920

RBV Designated contracting states (corrected)

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

17Q First examination report despatched

Effective date: 20140416

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

INTG Intention to grant announced

Effective date: 20151222

RIN1 Information on inventor provided before grant (corrected)

Inventor name: WANG, JUNFENG

Inventor name: ZHENG, SHILONG

Inventor name: WANG, BINGHE

Inventor name: CHENG, YUNFEG

Inventor name: PENG, HANJING

Inventor name: LI, MINYONG

Inventor name: LU, CHUNG-DAR

Inventor name: NI, NANTING

Inventor name: CHOU, HAN-TING

RIN1 Information on inventor provided before grant (corrected)

Inventor name: PENG, HANJING

Inventor name: LU, CHUNG-DAR

Inventor name: WANG, JUNFENG

Inventor name: ZHENG, SHILONG

Inventor name: NI, NANTING

Inventor name: LI, MINYONG

Inventor name: CHENG, YUNFENG

Inventor name: WANG, BINGHE

Inventor name: CHOU, HAN-TING

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AC Divisional application: reference to earlier application

Ref document number: 2155705

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

Ref country code: AT

Ref legal event code: REF

Ref document number: 818443

Country of ref document: AT

Kind code of ref document: T

Effective date: 20160815

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602008045656

Country of ref document: DE

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

REG Reference to a national code

Ref country code: NL

Ref legal event code: MP

Effective date: 20160810

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 818443

Country of ref document: AT

Kind code of ref document: T

Effective date: 20160810

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160810

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160810

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20161210

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160810

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160810

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160810

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20161110

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160810

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160810

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20161111

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160810

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160810

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20161212

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160810

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160810

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160810

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602008045656

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160810

Ref country code: BE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160810

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160810

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160810

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20161110

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 10

26N No opposition filed

Effective date: 20170511

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160810

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160810

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170630

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170606

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170606

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170630

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 11

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20180626

Year of fee payment: 11

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170606

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20180627

Year of fee payment: 11

Ref country code: GB

Payment date: 20180627

Year of fee payment: 11

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20080606

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20160810

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 602008045656

Country of ref document: DE

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20190606

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160810

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200101

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190606

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190630