EP2529793A3 - Compositions pour la régulation ou la modulation de la détection de quorum dans des bactéries, procédés d'utilisation de ces composés et méthodes permettant de réguler ou moduler la détection de quorum dans des bactéries - Google Patents
Compositions pour la régulation ou la modulation de la détection de quorum dans des bactéries, procédés d'utilisation de ces composés et méthodes permettant de réguler ou moduler la détection de quorum dans des bactéries Download PDFInfo
- Publication number
- EP2529793A3 EP2529793A3 EP20120178747 EP12178747A EP2529793A3 EP 2529793 A3 EP2529793 A3 EP 2529793A3 EP 20120178747 EP20120178747 EP 20120178747 EP 12178747 A EP12178747 A EP 12178747A EP 2529793 A3 EP2529793 A3 EP 2529793A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- methods
- bacteria
- quorum sensing
- regulating
- present disclosure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93373507P | 2007-06-08 | 2007-06-08 | |
| EP08828361A EP2155705A4 (fr) | 2007-06-08 | 2008-06-06 | Compositions permettant de réguler ou de moduler la détection du quorum dans une bactérie, procédés d'utilisation de ces composés et procédés de régulation et de modulation de la détection du quorum dans une bactérie |
Related Parent Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP08828361.9 Division | 2008-06-06 | ||
| EP08828361A Division EP2155705A4 (fr) | 2007-06-08 | 2008-06-06 | Compositions permettant de réguler ou de moduler la détection du quorum dans une bactérie, procédés d'utilisation de ces composés et procédés de régulation et de modulation de la détection du quorum dans une bactérie |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EP2529793A2 EP2529793A2 (fr) | 2012-12-05 |
| EP2529793A3 true EP2529793A3 (fr) | 2013-03-20 |
| EP2529793B1 EP2529793B1 (fr) | 2016-08-10 |
Family
ID=40388083
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP12178747.7A Not-in-force EP2529793B1 (fr) | 2007-06-08 | 2008-06-06 | Compositions pour la régulation ou la modulation de la détection de quorum dans des bactéries, procédés d'utilisation de ces composés et méthodes permettant de réguler ou moduler la détection de quorum dans des bactéries |
| EP08828361A Withdrawn EP2155705A4 (fr) | 2007-06-08 | 2008-06-06 | Compositions permettant de réguler ou de moduler la détection du quorum dans une bactérie, procédés d'utilisation de ces composés et procédés de régulation et de modulation de la détection du quorum dans une bactérie |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP08828361A Withdrawn EP2155705A4 (fr) | 2007-06-08 | 2008-06-06 | Compositions permettant de réguler ou de moduler la détection du quorum dans une bactérie, procédés d'utilisation de ces composés et procédés de régulation et de modulation de la détection du quorum dans une bactérie |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US8653258B2 (fr) |
| EP (2) | EP2529793B1 (fr) |
| WO (1) | WO2009029317A2 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5612269B2 (ja) * | 2009-04-24 | 2014-10-22 | 花王株式会社 | 歯周病マーカー |
| US8952192B2 (en) | 2011-03-24 | 2015-02-10 | University Of Maryland, College Park | Phosphorylated and branched dihydroxy-pentane-dione (DPD) analogs as quorum sensing inhibitors in bacteria |
| US10039777B2 (en) | 2012-03-20 | 2018-08-07 | Neuro-Lm Sas | Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders |
| WO2014060581A1 (fr) * | 2012-10-18 | 2014-04-24 | Seprox Biotech, S.L. | Utilisation de l'hydroxytirosol et de ses dérivés comme désactivateurs de quorum |
| EP3151733B1 (fr) * | 2014-06-06 | 2020-04-15 | The Regents Of The University Of Michigan | Compositions et méthodes de caractérisation et de diagnostic d'une maladie parodontale |
| WO2016191816A1 (fr) * | 2015-06-02 | 2016-12-08 | The University Of Melbourne | Capsules d'acide phenylborate sensibles au glucose pour l'administration d'insuline |
| CN106074469B (zh) * | 2015-06-19 | 2019-04-16 | 复旦大学附属华山医院 | 用于抗万古霉素耐药菌的药物组合物 |
| CN111684019B (zh) | 2018-02-13 | 2022-08-02 | 住友化学株式会社 | 组合物及成形体 |
| US11638759B2 (en) | 2019-08-13 | 2023-05-02 | Darlene E. McCord | Non-activated, amorphous, pH neutral, two-part bedside-ready clay delivery system that treats pathogen infections in humans and animals |
| WO2023076855A1 (fr) | 2021-10-25 | 2023-05-04 | Mccord Darlene E | Compositions d'argile médicinale enrobées, compositions pharmaceutiques et administration de sources de cations et leurs procédés d'utilisation |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2063870A (en) * | 1979-07-05 | 1981-06-10 | Bellon Labor Sa Roger | 1-aryl-4-arylsulphonyl-1h-pyrazolol-3 compounds and processes for their preparation |
| US5308860A (en) * | 1993-01-15 | 1994-05-03 | Rohm And Haas Company | Cyanosulfonylethyltriazoles |
| WO1999010321A2 (fr) * | 1997-08-29 | 1999-03-04 | The Johns Hopkins University | Composes antimicrobiens |
| WO2002047681A1 (fr) * | 2000-12-14 | 2002-06-20 | Unisearch Limited | Regulation de la virulence de bacteries |
| WO2003018029A1 (fr) * | 2001-08-24 | 2003-03-06 | Quorex Pharmaceuticals, Inc. | Agents antibacteriens bases sur une liaison toxoanion |
| WO2003077844A2 (fr) * | 2002-03-13 | 2003-09-25 | Takara Bio, Inc. | Effet d'un traitement au 4,5-dihydroxy- 2-cyclopentene-1-one (dhcp) sur l'expression genique et la densite bacterienne (quorum sensing) |
| WO2004004712A1 (fr) * | 2002-07-09 | 2004-01-15 | Fasgen, Llc | Methodes de traitement d'infections microbiennes chez les humains et les animaux |
| US20040180829A1 (en) * | 2000-05-10 | 2004-09-16 | Bassler Bonnie L. | Compounds and methods for regulating bacterial growth and pathogenesis |
| WO2005005598A2 (fr) * | 2003-04-11 | 2005-01-20 | New York University | Prevention et traitement des infections provoquees par b.anthracis : b.anthracis mutante ne possedant pas l'activite luxs, et inhibition par des furanones de la croissance et du 'quorum sensing'' par le biais de ai-2, et production de toxines |
| WO2005021559A2 (fr) * | 2003-09-02 | 2005-03-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Oxazaborolidines constituant des effecteurs bacteriens |
| WO2005100384A2 (fr) * | 2004-04-12 | 2005-10-27 | The Trustees Of Princeton University | Composes ai-2 et analogues bases sur la structure lsrb de salmonella typhimurium |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8506792D0 (en) | 1985-03-15 | 1985-04-17 | Janssen Pharmaceutica Nv | Derivatives of y-cyclodextrin |
| JPH01221375A (ja) * | 1988-02-27 | 1989-09-04 | Nippon Nohyaku Co Ltd | ジチオラン誘導体 |
| AU3201095A (en) * | 1994-07-27 | 1996-02-22 | G.D. Searle & Co. | Substituted thiazoles for the treatment of inflammation |
| JP2002504122A (ja) * | 1997-06-13 | 2002-02-05 | ノースウエスタン ユニバーシティー | ベータラクタマーゼ阻害剤及びその使用方法 |
| IL160010A0 (en) * | 2001-07-23 | 2004-06-20 | Univ Ramot | Methods and compositions for treating fungal infections |
| MXPA04010555A (es) * | 2002-04-25 | 2005-02-17 | Pharmacia Corp | Acidos piperidinil- y piperazinil-sulfonilmetil hidroxamicos y su uso como inhibidores de proteasa. |
| WO2003105860A1 (fr) * | 2002-06-14 | 2003-12-24 | Novo Nordisk A/S | Utilisation pharmaceutique d'acides boroniques et de leurs esters |
| US20040147561A1 (en) * | 2002-12-27 | 2004-07-29 | Wenge Zhong | Pyrid-2-one derivatives and methods of use |
| WO2006050236A2 (fr) * | 2004-11-01 | 2006-05-11 | Nuada, Llc | Composes et methodes d'utilisation de ceux-ci |
| JP2008519853A (ja) * | 2004-11-12 | 2008-06-12 | トラスティーズ オブ タフツ カレッジ | リパーゼ阻害物質 |
| US7589239B2 (en) * | 2005-09-02 | 2009-09-15 | Auspex Pharmaceuticals | Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders |
-
2008
- 2008-06-06 EP EP12178747.7A patent/EP2529793B1/fr not_active Not-in-force
- 2008-06-06 EP EP08828361A patent/EP2155705A4/fr not_active Withdrawn
- 2008-06-06 WO PCT/US2008/066028 patent/WO2009029317A2/fr not_active Ceased
- 2008-06-06 US US12/597,825 patent/US8653258B2/en active Active
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2063870A (en) * | 1979-07-05 | 1981-06-10 | Bellon Labor Sa Roger | 1-aryl-4-arylsulphonyl-1h-pyrazolol-3 compounds and processes for their preparation |
| US5308860A (en) * | 1993-01-15 | 1994-05-03 | Rohm And Haas Company | Cyanosulfonylethyltriazoles |
| WO1999010321A2 (fr) * | 1997-08-29 | 1999-03-04 | The Johns Hopkins University | Composes antimicrobiens |
| US20040180829A1 (en) * | 2000-05-10 | 2004-09-16 | Bassler Bonnie L. | Compounds and methods for regulating bacterial growth and pathogenesis |
| WO2002047681A1 (fr) * | 2000-12-14 | 2002-06-20 | Unisearch Limited | Regulation de la virulence de bacteries |
| WO2003018029A1 (fr) * | 2001-08-24 | 2003-03-06 | Quorex Pharmaceuticals, Inc. | Agents antibacteriens bases sur une liaison toxoanion |
| WO2003077844A2 (fr) * | 2002-03-13 | 2003-09-25 | Takara Bio, Inc. | Effet d'un traitement au 4,5-dihydroxy- 2-cyclopentene-1-one (dhcp) sur l'expression genique et la densite bacterienne (quorum sensing) |
| WO2004004712A1 (fr) * | 2002-07-09 | 2004-01-15 | Fasgen, Llc | Methodes de traitement d'infections microbiennes chez les humains et les animaux |
| WO2005005598A2 (fr) * | 2003-04-11 | 2005-01-20 | New York University | Prevention et traitement des infections provoquees par b.anthracis : b.anthracis mutante ne possedant pas l'activite luxs, et inhibition par des furanones de la croissance et du 'quorum sensing'' par le biais de ai-2, et production de toxines |
| WO2005021559A2 (fr) * | 2003-09-02 | 2005-03-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Oxazaborolidines constituant des effecteurs bacteriens |
| WO2005100384A2 (fr) * | 2004-04-12 | 2005-10-27 | The Trustees Of Princeton University | Composes ai-2 et analogues bases sur la structure lsrb de salmonella typhimurium |
Non-Patent Citations (13)
| Title |
|---|
| BARNIKOW, GUENTER ET AL: "Synthesis of CH-acidic thionocarboxylic acid esters", ZEITSCHRIFT FUER CHEMIE ( 1968 ), 8(9), 335 CODEN: ZECEAL; ISSN: 0044-2402, 1969 * |
| BRITSUN V N ET AL: "Cycloacylation of Phenylsulfonyl-N-R-thioacetamides by Compounds Containing an Activated Multiple Bond", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, KLUWER ACADEMIC PUBLISHERS-CONSULTANTS BUREAU, NE, vol. 41, no. 11, 1 November 2005 (2005-11-01), pages 1437 - 1438, XP019276255, ISSN: 1573-8353 * |
| DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1969, BARNIKOW, GUENTER ET AL: "Synthesis of CH-acidic thionocarboxylic acid esters", XP002683472, retrieved from STN Database accession no. 1969:11077 * |
| DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1971, HUPPATZ, J. L.: "Convenient synthesis of ethyl sulfonylacetates", XP002683470, retrieved from STN Database accession no. 1971:87535 * |
| DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1992, ZHOU, WEIQING ET AL: "Chemoselective oxidation of organic sulfides to sulfones with sodium perborate", XP002683473, retrieved from STN Database accession no. 1992:591428 * |
| DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2001, ZAKRZEWSKI, ANDRZEJ ET AL: "Investigations of fungicidal properties of substituted phenylsulphonylacetic acid esters and amides", XP002683468, retrieved from STN Database accession no. 2001:824035 * |
| HUPPATZ, J. L.: "Convenient synthesis of ethyl sulfonylacetates", AUSTRALIAN JOURNAL OF CHEMISTRY ( 1971 ), 24(3), 653-5 CODEN: AJCHAS; ISSN: 0004-9425, 1971, XP002683471 * |
| LEE JIN YOUNG ET AL: "Radical alkylation of bis(silyloxy)enamine derivatives of organic nitro compounds.", ANGEWANDTE CHEMIE (INTERNATIONAL ED. IN ENGLISH) 18 SEP 2006 LNKD- PUBMED:16906611, vol. 45, no. 37, 18 September 2006 (2006-09-18), pages 6182 - 6186, XP002683469, ISSN: 1433-7851 * |
| LI MINYONG ET AL: "Structure-based discovery and experimental verification of novel Al-2 quorum sensing inhibitors against Vibrio harveyi", CHEMMEDCHEM, vol. 3, no. 8, August 2008 (2008-08-01), pages 1242 - 1249, XP002683475, ISSN: 1860-7179 * |
| PERSSON TOBIAS ET AL: "Rational design and synthesis of new quorum-sensing inhibitors derived from acylated homoserine lactones and natural products from garlic.", ORGANIC & BIOMOLECULAR CHEMISTRY 21 JAN 2005 LNKD- PUBMED:15632967, vol. 3, no. 2, 21 January 2005 (2005-01-21), pages 253 - 262, XP002683474, ISSN: 1477-0520 * |
| ZAKRZEWSKI, ANDRZEJ ET AL: "Investigations of fungicidal properties of substituted phenylsulphonylacetic acid esters and amides", PESTYCYDY (WARSAW) ( 2001 ), (1-2), 21-28 CODEN: PSTYDL; ISSN: 0208-8703, 2001 * |
| ZHONG ET AL: "Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 17, no. 19, 6 August 2007 (2007-08-06), pages 5384 - 5389, XP022249722, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2007.07.045 * |
| ZHOU, WEIQING ET AL: "Chemoselective oxidation of organic sulfides to sulfones with sodium perborate", WUJI HUAXUE XUEBAO ( 1992 ), 8(1), 88-90 CODEN: WHUXEO; ISSN: 1001-4861, 1992 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009029317A3 (fr) | 2009-08-20 |
| EP2155705A2 (fr) | 2010-02-24 |
| EP2155705A4 (fr) | 2012-02-15 |
| WO2009029317A2 (fr) | 2009-03-05 |
| EP2529793B1 (fr) | 2016-08-10 |
| EP2529793A2 (fr) | 2012-12-05 |
| US20100137249A1 (en) | 2010-06-03 |
| US8653258B2 (en) | 2014-02-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2529793A3 (fr) | Compositions pour la régulation ou la modulation de la détection de quorum dans des bactéries, procédés d'utilisation de ces composés et méthodes permettant de réguler ou moduler la détection de quorum dans des bactéries | |
| WO2008011453A3 (fr) | HÉTÉROCYCLES AROMATIQUES D'AZOLE SUBSTITUÉS, UTILISÉS EN TANT QU'INHIBITEURS DE LLβ-HSD-1 | |
| WO2008153793A3 (fr) | Modulateurs de sécrétase gamma | |
| WO2007133683A3 (fr) | Compositions formulées anti-tiques et anti-insectes | |
| WO2008116129A3 (fr) | Analogues d'imidazolopyrimidine et leur utilisation comme inhibiteurs de pi3 kinase et de mtor | |
| WO2008079460A3 (fr) | Inhibiteurs de kinase pour la prévention ou le traitement d'une infection pathogène et procédé d'utilisation de ceux-ci | |
| WO2008070016A3 (fr) | Inhibiteurs de l'activité akt | |
| WO2008073933A3 (fr) | Composés 4-phényle-6-(2,2,2-trifluoro-1-phényléthoxy) à base de pyrimidine et procédés concernant leur utilisation | |
| WO2010123919A3 (fr) | Inhibiteurs pipéridiniques de la janus kinase 3 | |
| WO2009114810A3 (fr) | Utilisation d'ellagitannines comme inhibiteurs de la détection du quorum bactérien | |
| NZ594341A (en) | Combinations of tralopyril and zinc chloride | |
| GEP20125511B (en) | Mapk/erk kinase inhibitors | |
| CY1108794T1 (el) | Σπειροκυκλικα παραγωγα κυκλοεξανιου | |
| WO2008016662A3 (fr) | Biocide pour liquides de stimulation et de traitement des puits | |
| WO2011038318A3 (fr) | Compositions comprenant du dibromomalonamide et leur utilisation comme biocides | |
| MA32776B1 (fr) | Inhibiteurs de l'akt et de la p70 s6 kinase | |
| WO2009141541A3 (fr) | Utilisation d' inhibiteurs de kif13a et d ' ap-1 pour inhiber la melanogenese | |
| MX2012003739A (es) | Composicones de dibromomalonamida y su uso como biocidas. | |
| WO2009040952A1 (fr) | Médicament renfermant un dérivé de benzophénone ou son sel | |
| WO2009094560A3 (fr) | Thiénopyranones en tant qu'inhibiteurs de kinase | |
| FR2929509B1 (fr) | L'utilisation de glycosides d'alkyle ou de melanges de glycosides d'alkyle en tant qu'agents destines a inhiber la croissance microbienne, et compositions contenant lesdits glycosides d'alkyle. | |
| WO2009023664A3 (fr) | Sulfonamides à substitution azépine et diazépine utilisés pour inhiber la 11-bêta-hydroxystéroïde déshydrogénase de type-1 | |
| MX2012003738A (es) | Composiciones de dibromomalonamida y su uso como biocidas. | |
| WO2008153792A3 (fr) | Modulateurs de sécrétase gamma | |
| MX345326B (es) | Composiciones de dibromomalonamida y su uso como biocidas. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| AC | Divisional application: reference to earlier application |
Ref document number: 2155705 Country of ref document: EP Kind code of ref document: P |
|
| AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR |
|
| RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: CHENG, YUNFEG Inventor name: WANG, BINGHE Inventor name: PENG, HANJING Inventor name: LU, CHUNG-DAR Inventor name: WAMG, JUNFENG Inventor name: LI, MINYONG Inventor name: NI, NANTIN Inventor name: ZHENG, SHILONG Inventor name: CHOU, HAN-TING |
|
| PUAL | Search report despatched |
Free format text: ORIGINAL CODE: 0009013 |
|
| RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: LI, MINYONG Inventor name: NI, NANTIN Inventor name: WAMG, JUNFENG Inventor name: PENG, HANJING Inventor name: ZHENG, SHILONG Inventor name: CHENG, YUNFEG Inventor name: CHOU, HAN-TING Inventor name: LU, CHUNG-DAR Inventor name: WANG, BINGHE |
|
| AK | Designated contracting states |
Kind code of ref document: A3 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR |
|
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07F 5/02 20060101ALI20130211BHEP Ipc: A61P 31/04 20060101AFI20130211BHEP Ipc: C07D 279/20 20060101ALI20130211BHEP Ipc: A61K 31/69 20060101ALI20130211BHEP Ipc: C07C 317/44 20060101ALI20130211BHEP Ipc: C07D 333/34 20060101ALI20130211BHEP Ipc: C07C 39/10 20060101ALI20130211BHEP Ipc: C07F 5/00 20060101ALI20130211BHEP |
|
| 17P | Request for examination filed |
Effective date: 20130920 |
|
| RBV | Designated contracting states (corrected) |
Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR |
|
| 17Q | First examination report despatched |
Effective date: 20140416 |
|
| GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
| INTG | Intention to grant announced |
Effective date: 20151222 |
|
| RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: WANG, JUNFENG Inventor name: ZHENG, SHILONG Inventor name: WANG, BINGHE Inventor name: CHENG, YUNFEG Inventor name: PENG, HANJING Inventor name: LI, MINYONG Inventor name: LU, CHUNG-DAR Inventor name: NI, NANTING Inventor name: CHOU, HAN-TING |
|
| RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: PENG, HANJING Inventor name: LU, CHUNG-DAR Inventor name: WANG, JUNFENG Inventor name: ZHENG, SHILONG Inventor name: NI, NANTING Inventor name: LI, MINYONG Inventor name: CHENG, YUNFENG Inventor name: WANG, BINGHE Inventor name: CHOU, HAN-TING |
|
| GRAS | Grant fee paid |
Free format text: ORIGINAL CODE: EPIDOSNIGR3 |
|
| GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
| AC | Divisional application: reference to earlier application |
Ref document number: 2155705 Country of ref document: EP Kind code of ref document: P |
|
| AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR |
|
| REG | Reference to a national code |
Ref country code: GB Ref legal event code: FG4D |
|
| REG | Reference to a national code |
Ref country code: CH Ref legal event code: EP Ref country code: AT Ref legal event code: REF Ref document number: 818443 Country of ref document: AT Kind code of ref document: T Effective date: 20160815 |
|
| REG | Reference to a national code |
Ref country code: IE Ref legal event code: FG4D |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R096 Ref document number: 602008045656 Country of ref document: DE |
|
| REG | Reference to a national code |
Ref country code: LT Ref legal event code: MG4D |
|
| REG | Reference to a national code |
Ref country code: NL Ref legal event code: MP Effective date: 20160810 |
|
| REG | Reference to a national code |
Ref country code: AT Ref legal event code: MK05 Ref document number: 818443 Country of ref document: AT Kind code of ref document: T Effective date: 20160810 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: NL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160810 Ref country code: HR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160810 Ref country code: IS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20161210 Ref country code: IT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160810 Ref country code: LT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160810 Ref country code: FI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160810 Ref country code: NO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20161110 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LV Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160810 Ref country code: SE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160810 Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20161111 Ref country code: AT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160810 Ref country code: PL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160810 Ref country code: PT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20161212 Ref country code: ES Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160810 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: EE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160810 Ref country code: RO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160810 |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R097 Ref document number: 602008045656 Country of ref document: DE |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: DK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160810 Ref country code: BE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160810 Ref country code: SK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160810 Ref country code: CZ Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160810 Ref country code: BG Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20161110 |
|
| PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
| REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 10 |
|
| 26N | No opposition filed |
Effective date: 20170511 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160810 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MC Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160810 |
|
| REG | Reference to a national code |
Ref country code: CH Ref legal event code: PL |
|
| REG | Reference to a national code |
Ref country code: IE Ref legal event code: MM4A |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LI Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20170630 Ref country code: LU Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20170606 Ref country code: IE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20170606 Ref country code: CH Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20170630 |
|
| REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 11 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: FR Payment date: 20180626 Year of fee payment: 11 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20170606 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: DE Payment date: 20180627 Year of fee payment: 11 Ref country code: GB Payment date: 20180627 Year of fee payment: 11 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: HU Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO Effective date: 20080606 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: CY Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20160810 |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R119 Ref document number: 602008045656 Country of ref document: DE |
|
| GBPC | Gb: european patent ceased through non-payment of renewal fee |
Effective date: 20190606 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: TR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160810 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: DE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20200101 Ref country code: GB Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20190606 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: FR Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20190630 |