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EP2571626B1 - Dispositif de distribution comprenant un récipient en verre scellé muni d'un piston coulissant - Google Patents

Dispositif de distribution comprenant un récipient en verre scellé muni d'un piston coulissant Download PDF

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Publication number
EP2571626B1
EP2571626B1 EP11716802.1A EP11716802A EP2571626B1 EP 2571626 B1 EP2571626 B1 EP 2571626B1 EP 11716802 A EP11716802 A EP 11716802A EP 2571626 B1 EP2571626 B1 EP 2571626B1
Authority
EP
European Patent Office
Prior art keywords
seal
container
dispenser according
actuating
basic body
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP11716802.1A
Other languages
German (de)
English (en)
Other versions
EP2571626A1 (fr
Inventor
Andy Greter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medmix Systems AG
Original Assignee
Medmix Systems AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medmix Systems AG filed Critical Medmix Systems AG
Publication of EP2571626A1 publication Critical patent/EP2571626A1/fr
Application granted granted Critical
Publication of EP2571626B1 publication Critical patent/EP2571626B1/fr
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/325—Containers having parallel or coaxial compartments, provided with a piston or a movable bottom for discharging contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C17/00—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces
    • B05C17/005—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes
    • B05C17/00586—Means, generally located near the nozzle, for piercing or perforating the front part of a cartridge
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C17/00—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces
    • B05C17/005—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes
    • B05C17/00596—The liquid or other fluent material being supplied from a rigid removable cartridge having no active dispensing means, i.e. the cartridge requiring cooperation with means of the handtool to expel the material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C17/00—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces
    • B05C17/005—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes
    • B05C17/00553—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes with means allowing the stock of material to consist of at least two different components
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49826—Assembling or joining

Definitions

  • the present invention relates to a discharge device, comprising a container with a hollow base body in which a piston is slidably disposed.
  • a discharge device comprising a container with a hollow base body in which a piston is slidably disposed.
  • Such containers are referred to below as syringe-like containers.
  • the discharge device further comprises a container holder for receiving the double-sealed container and an actuating element for cooperation with a piston arranged inside the container.
  • WO 2005/016783 discloses a variety of discharge devices of this type, in which, inter alia, both sides sealed plastic containers can be used with in-lying piston in corresponding container holders.
  • the container holder has hollow piercing elements which pierce its outlet-side or distal seal when the container is fully inserted.
  • the pistons are initially located outside the container and are used to pierce a proximal seal.
  • a normal disposable hypodermic syringe comprises a hollow, cylindrical syringe body made of plastic, in which a piston is slidably disposed.
  • the piston is usually fixedly connected to a piston rod which extends in the proximal direction of the syringe body out.
  • an actuating flange is formed, and the syringe body are usually formed opposite two retaining flanges.
  • the syringe is held between forefinger and middle or ring finger. With the thumb pressure is exerted on the actuating flange, to discharge an in-syringe product through a distal outlet port.
  • the corresponding counterforce is absorbed by the retaining flanges.
  • syringes which comprise two or more parallel or concentrically arranged interconnected syringe bodies in which two or more identical or different components are received and from which the components can be dispensed by displacement of corresponding pistons.
  • These components may be, for example, two different components of a pharmaceutical product, which are only just prior to administration or two or more components of a bone cement or a medical or non-medical adhesive, eg, a fibrin-based medical adhesive.
  • Many other applications of multiple syringes are known or conceivable. Often, such multiple syringes are adapted to be connected to a mixer to mix the ejected components immediately after leaving the multiple syringe.
  • the pistons are often connected to each other via a common actuator.
  • Syringe-like containers also find application in the form of cartridges for special dispensers.
  • the outer shape of the container is often adapted for use in a particular dispenser.
  • a dispenser with a cartridge for two components is eg in WO 2008/009143 disclosed.
  • the product may be e.g. to be a volatile, aggressive, hygroscopic or oxygen-sensitive substance.
  • the product may be e.g. to be a volatile, aggressive, hygroscopic or oxygen-sensitive substance.
  • Many commercial plastics e.g.
  • the commonly used polyethylene has a relatively high permeability to light molecules and therefore forms an insufficient barrier to diffusion of contents from the interior of the container to the outside or foreign matter such as water or volatiles and gases from the outside of the container to the inside. In a container of such a plastic stored products can thereby change their properties during prolonged storage in an undesirable manner.
  • a carpule is a syringe-like container with a distal extraction opening and a proximal actuation opening.
  • the distal extraction port is closed by a septum closure, i. through a puncturable cover of e.g. Rubber, which is usually held mechanically by a crimped aluminum edge on the container.
  • a septum closure i. through a puncturable cover of e.g. Rubber, which is usually held mechanically by a crimped aluminum edge on the container.
  • a slidable piston is inserted, which closes the container proximally.
  • diffusion through the sealing points of the piston and / or the septum can not be reliably ruled out.
  • the GB 2,152,590 discloses a plastic container which is closed on both sides by a removable seal. In the container there is a displaceable piston in order to discharge a flowable foodstuff received in the container after the seals have been removed.
  • the US 5,197,618 discloses a container which is open only on one side and which is closed by a peel-off seal.
  • the WO 2009/058343 discloses a plastic container which is closed at its proximal end with a seal and at its distal end has a predetermined breaking point at which a break-off closure is removable. In the container a sliding piston is added.
  • a container which comprises a hollow base body made of mineral glass with a distal outlet opening and with a proximal actuating opening, wherein the actuating opening is suitable and intended to introduce an actuating element into the interior of the base body.
  • a piston is arranged displaceably along a longitudinal direction in order to discharge a flowable product present in the main body between the piston and the outlet opening out of the container.
  • the Outlet opening closed by a first severable seal, which is cohesively applied (“sealed”) to a first bearing surface surrounding the outlet opening, and the actuating opening is closed by a second seal which is sealed, which is applied cohesively on a second bearing surface surrounding the actuating opening.
  • the product received in the container may be any flowable product, in particular a liquid, suspension or emulsion, gel, paste or other form of high viscosity flowable product, powder, etc.
  • the product is in one Recorded product receiving area of the container, which is preferably directly limited by the main body, the piston and the first seal, ie there is no further cladding between the product and the body, the piston and the first (distal) seal.
  • the container is thus opened immediately for a product discharge by the first seal is severed or removed.
  • another closure e.g. a septum closure, be present, which additionally closes the distal outlet opening.
  • Such additional closure is then preferably located within that portion of the container that is closed by the first seal, such that the first seal effectively reduces diffusion that could still occur through the additional closure alone.
  • the first and the second seal are applied over the respective opening on the base body on a bearing surface cohesively and sealingly, eg glued or welded (eg by laser welding, ultrasonic welding or other known methods).
  • the first and / or second seal is inductively sealed onto the corresponding bearing surface.
  • the seal comprises at least one electrically conductive layer and at least one thermoplastic adhesive layer.
  • the seal is pressed onto the relevant bearing surface with the adhesive layer towards the bearing surface and exposed to an alternating electromagnetic field which induces eddy currents in the conductive layer. This heats the seal and softens the adhesive layer. This creates an adhesive bond between the support surface and the seal.
  • the use of a basic body made of mineral glass is particularly advantageous because, in contrast to metallic coated plastic containers, no eddy currents are produced in the main body and the product in the container heats up only slightly.
  • the respective bearing surface preferably extends transversely, in particular perpendicular to the longitudinal direction.
  • a support flange extending inwards or outwards transversely to the longitudinal direction can be formed at the distal end and / or at the proximal end, which increases the support surface for the respective seal.
  • Each of the seals preferably consists of a relatively thin, flat material, wherein the two seals may consist of the same or of different materials.
  • the seals are preferably thin, especially in relation to the area covered by the seal, with a thickness of less than 1/10 of the extent perpendicular to the thickness, and preferably thinner than 2 mm or even 1 mm.
  • the seals are thinner than the side wall portion of the base body in which the piston is displaceable.
  • each of the seals may be formed, for example, in the form of a single-layer or multi-layer film or be formed by a laminate of several layers, wherein a layer facing away from the openings, for example, may consist of paper or cardboard.
  • each of the seals comprises a carrier, for example made of plastic, paper or cardboard, which is provided with at least one barrier layer.
  • the barrier layer can consist, for example, of a diffusion-reducing polymer, for example polyparaxylylene (parylene), which can be obtained by suitable processes, for example by lamination or by physical or chemical vapor deposition
  • the barrier layer contains a metal or a metal compound or consists essentially of a metal or a metal compound.
  • the metal of the barrier layer may in particular be selected from the following metals and their alloys: aluminum, titanium, chromium, silver and copper. Aluminum is preferred.
  • the thickness of the barrier layer is preferably about 20 nanometers to 20 micrometers.
  • Each of the seals can also be made entirely of metal or metal and an adhesive layer.
  • Each of the seals may have a weakened area, e.g. a perforation, to facilitate the severing.
  • the basic body is made of a mineral glass based on silicate. Such glasses are often referred to as mineral glass, to distinguish them from glassy, amorphous plastics such as PMMA.
  • the main body may be coated inside and / or outside, e.g. with a lacquer layer or with a protective layer. Preferably, such a coating of the body is transparent to allow it to visually inspect the contents of the container.
  • the main body can have at least one holding flange arranged in the region of the actuating opening and extending transversely to the longitudinal direction, which serves to hold the container with respect to the longitudinal direction during dispensing.
  • the container may take on an actual syringe shape. If such a retaining flange is present, it is preferred if it is aligned on its proximal side with that region of the base body which limits the actuating opening, and if the second seal is applied to the flange, i. when the retaining flange also serves as a proximal support flange for the second seal.
  • the container can accommodate a single product or several separate products.
  • the container may have at least one second hollow base body connected to the first base body, with an interior, with one Outer side, with a distal second outlet opening and with a proximal second actuating opening.
  • a second piston may be arranged displaceably in the interior of the second basic body in order to discharge a second product present in the interior of the second basic body from the container.
  • On the second outlet opening and the second actuating opening then a pierceable seal is also sealed in each case.
  • the first outlet opening and the second outlet opening may be closed together by the first seal, and the first actuating opening and the second actuating opening may be jointly closed by the second seal.
  • the container according to the invention is supplemented in the context of the invention by an actuating element and a container holder to a discharge device.
  • the actuator is then adapted to cooperate with the piston inside the body to discharge the product from the container.
  • the actuating element has at least one separating element, which is designed to sever the second seal.
  • the separator may be e.g. to act a cutting element, a piercing element or a combination of such elements.
  • the actuating element may comprise a ram extending along a longitudinal direction.
  • This plunger is then designed to cooperate at its distal end with a proximal rear side of the piston.
  • the separating element may then comprise a cutting edge arranged in an outer edge region of the distal end, which is designed to sever the second seal in an area immediately adjacent to the basic body. This ensures a clean separation.
  • the complete discharge device also comprises a container holder which at least partially accommodates at least one container of the type specified above.
  • a first seal piercing member is provided to seal the first seal upon insertion of the container into the container holder or to cut in the distal direction during movement in the container holder.
  • this may be a hollow piercing element which has a Fluid channel forms to direct the product contained in the container to a removal opening of the container holder.
  • the piercing element can be formed like a spike.
  • On the container holder in the region of the removal opening preferably a connection structure for connection of an accessory, such as a cannula, a mixer or a spray head is formed.
  • the filling preferably takes place through the outlet opening.
  • FIGS. 1 to 6 a discharge device for the basic explanation of the present invention is illustrated in various views.
  • the discharge device comprises a container 100, which in the FIGS. 2 and 3 is shown alone, a container holder 200 and a non-inventive actuator 230, the only in the Fig. 6 is shown.
  • FIG. 7 An actuating element for a discharge device according to the invention is in FIG. 7 shown, which will be discussed later.
  • the container 100 comprises a hollow body 110 formed of a silicate-based mineral glass.
  • the main body has a cylindrical side wall region, to which a taper 114 adjoins in the region of the distal end of the container.
  • a radially outwardly projecting first, distal support flange 115 is formed, which radially surrounds an outlet opening 111.
  • a radially outwardly projecting second, proximal support flange 112 is formed which radially surrounds a proximal actuation opening 113.
  • a piston 120 which is displaceable along a longitudinal direction and with a circumferential seal 121 is arranged in the interior of the cylindrical side wall region of the base body 110.
  • the distal outlet opening 111 is closed by a first seal 150.
  • the first support flange 115 forms a first bearing surface extending perpendicularly to the longitudinal direction, onto which the seal 150 is applied (sealed) in a material-locking manner.
  • the proximal end of the main body 110 is closed by a second seal 160.
  • the second support flange 112 forms a perpendicular to Longitudinally extending second support surface on which the second seal 160 is applied cohesively.
  • Both the first seal 150 and the second seal 160 are applied to the respective support flange by an inductive sealing process.
  • each of the two seals 150, 160 has a multilayer structure.
  • a thermoplastic adhesive layer on the surface of the seal points to the respective support flange.
  • This adhesive layer is followed by a metallic, electrically conductive barrier layer.
  • other layers may be present. These further layers may be connected to the metallic barrier layer to the outside, but may also be present between the barrier layer and the adhesive layer.
  • the seal is pressed onto the support surface and exposed to an electromagnetic alternating field. As a result, eddy currents develop in the metallic barrier layer, which heat the metallic barrier layer and thus also the further layers of the seal.
  • thermoplastic adhesive layer softens and forms an intimate connection with the respective bearing surface. After switching off the electromagnetic alternating field and the cooling of the seal so creates a liquid and gas-tight connection between the base body 110 and the respective seal 150, 160.
  • inductive sealing methods are known in the art for a long time.
  • the adhesive layer may also be formed on the respective support flange instead of on the seal.
  • the main body 110 consists of a mineral glass.
  • mineral glasses are not electrically conductive and, on the other hand, are also relatively poor heat conductors.
  • only a small heat transfer between the respective seal 150, 160 and the main body 110 takes place during inductive sealing. This avoids that the product received in the container 100 is excessively heated.
  • the main body 110 would consist of a metallically coated plastic, the main body 110 would also be heated by the electromagnetic alternating field, so that heating of the product in the container could not be avoided in this case.
  • the container holder 200 has two parallel, cylindrical receiving areas 210 into which the two containers are inserted from the proximal side.
  • an insert 220 is used, on which a mandrel-like piercing element 221 pointing in the proximal direction is formed.
  • the piercing element 221 is hollow and, together with the remaining insert, defines a fluid channel 222, which is in each case provided in a removal opening 215 (FIG. Fig. 4 ) of the container holder opens.
  • the discharge device further comprises an actuating element 230 in the form of a double plunger.
  • the actuating element forms for each of the two pistons 120 each have a piston rod 231, at the distal end of a feed flange 232 is formed, which cooperates with the respective piston 120.
  • the two piston rods 231 are interconnected by a common actuating flange.
  • a (not shown) latching element may be present to hold the respective container in this storage position in a releasable latching connection.
  • the user To eject the products from the containers 100, the user first inserts the two containers 100 in the distal direction into the container holder 200. If a locking element of the aforementioned type is present, the user overcomes this increased force or solves the aforementioned locking connection in a different way.
  • the piercing elements 221 pierce the respective first seal 150 and establish a fluid connection between the interior of the respective container and the respective removal opening 215.
  • the proximal bearing flange 112 abuts a stop edge 212 of the container holder formed by an annular recess in a retaining flange 211 of the container holder.
  • the user removes the two second (proximal) seals 160 and pushes the actuator 230 from the proximal end into the actuation openings 113 of the two containers 100 to advance the two pistons 120 of the containers 100 and so on the respective products received in the containers 100 through the respective outlet opening 111 eject.
  • the respective product passes through the corresponding fluid channel 222 to the corresponding removal opening 215.
  • the situation at the end of this discharge process is in the Fig. 6 shown.
  • a connection structure for an accessory 300 is formed, which is designed here as a static mixer.
  • the accessory receives the ejected products from the extraction port 215, mixes them together, and dispenses the mixture at its own distal end.
  • the connection of the accessory 300 with the container holder 200 takes place here via a bayonet-type connection.
  • Such an accessory and its connection to a discharge device is particularly in the document US 2001/0004082 described in detail, which is hereby incorporated by reference to the connection of the accessory with the discharge device.
  • the connection between the accessory and container holder may also be formed in other known manner, eg as a plug connection via luer cone.
  • FIGS Fig. 7 An actuator with a container for an embodiment of the present invention is shown in FIGS Fig. 7 illustrated. Equivalent parts are provided with the same reference numerals as for the example of the previously described figures.
  • the discharge device here does not include a separate container holder, but the user holds the container 100 directly in the hand while he pushes the actuator 230.
  • the actuating element 230 is therefore designed only as a simple plunger.
  • the main body 110 again consists of mineral glass, but in this embodiment is additionally provided with a coating 116 in the form of a coating.
  • the second seal 160 not before the insertion of the actuating member 230 into the actuating opening 113 to remove, but the actuator 230 pierces according to the invention when inserting the second seal 160.
  • a circumferential circular cutting edge 234th formed, which severes the seal 160 in an area immediately adjacent to the cylindrical side wall of the base body 110.
  • an annular recess is formed to receive the cutting edge 234.
  • the first seal 150 may be pierced by an accessory in this embodiment, or it may be manually removed prior to dispensing the contents of the container 100.
  • FIG. 12 illustrates another example not in accordance with the invention wherein the first seal 150 has a protruding pull tab 151 and the second seal 160 has a protruding pull tab 161.
  • the seals can be removed from the main body 110 in a particularly simple manner.
  • the severable seals 150 and 160 may also be applied by other means than inductive sealing, such as by gluing or ultrasonic welding. Depending on the method for applying the seals, the seals will also be constructed correspondingly different, with a multi-layered structure is preferred.
  • the container holder may also be constructed differently than in the first example described above and in particular also have other means for attaching an accessory.
  • such a container holder receives only a single container or more than two containers, and that the actuating element is designed to advance only a single piston or more than two pistons simultaneously.
  • LIST OF REFERENCE NUMBERS 100 container 210 reception area 110 Basic body (syringe body) 211 retaining flange 111 outlet 212 stop edge 112 proximal support flange 213 distal outlet area 113 actuating opening 214 terminal structure 114 rejuvenation 215 removal opening 115 distal support flange 220 commitment 116 coating 221 Piercing element 120 piston 222 fluid channel 121 O-ring 230 actuator 150 first seal 231 piston rod 151 flap 232 Vorschubflansch 160 second seal 233 actuating flange 161 flap 234 cutting edge 200 container holder 300 accessory

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Closures For Containers (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Packaging Frangible Articles (AREA)
  • Packaging For Recording Disks (AREA)

Claims (10)

  1. Dispositif de distribution, comprenant :
    au moins un récipient (100), comprenant un corps de base (110) creux ayant une ouverture de distribution (111) distale et une ouverture d'actionnement (113) proximale,
    où le corps de base (110) est constitué de verre minéral, ainsi qu'un piston (120) disposé de façon coulissante le long d'une direction longitudinale à l'intérieur du corps de base (110) afin de distribuer un produit fluable disposé dans le corps de base (110) depuis le récipient, où l'ouverture de distribution (111) est fermée au moyen d'un premier sceau (150) sectionnable, lequel est disposé par liaison de matière sur une première surface de d'appui entourant l'ouverture de distribution (111) et où l'ouverture d'actionnement (113) est fermée par un deuxième sceau (160) sectionable, lequel est disposé par liaison de matière sur une deuxième surface d'appui entourant l'ouverture d'actionnement (113) ;
    un support de récipient (200), qui reçoit au moins partiellement l'au moins un récipient (100) par insertion depuis un côté proximal en direction distale, où le support de récipient (200) présente un élément de perforation (221) pour sectionner le premier sceau quand le récipient (100) est déplacé en direction distale dans le support de récipient (200) ; et
    un élément d'actionnement (230), lequel est adapté pour coopérer avec le piston (120) à l'intérieur du corps de base (110) du récipient (100), pour distribuer le produit depuis le récipient (100), où l'élément d'actionnement (230) présente au moins un élément de séparation (234), lequel est adapté pour sectionner le deuxième sceau (160).
  2. Dispositif de distribution selon la revendication 1, où le support de récipient présente une ouverture de prélèvement (215) et où l'élément de perforation (221) est creux et forme un canal fluidique (225) pour guider le produit compris dans le récipient vers l'ouverture de distribution (215).
  3. Dispositif de distribution selon la revendication 1 ou 2, où une structure de raccordement (214) est formée sur le support de récipient (200) pour raccorder une pièce accessoire (300).
  4. Dispositif de distribution selon l'une des revendications précédentes, où l'élément d'actionnement (230) comprend un coulisseau (231) s'étendant le long d'une direction longitudinale, où le coulisseau présente une extrémité distale, qui est formée pour coopérer avec un revers proximal du piston (120), et où l'élément de séparation (234) comprend un tranchant disposé dans un domaine périphérique extérieur de l'extrémité distale, lequel est formée pour sectionner le deuxième sceau (160) dans un domaine immédiatement adjacent au corps de base.
  5. Dispositif de distribution selon une des revendications précédentes, où le premier sceau (150) et/ou le deuxième sceau (160) présentent au moins une couche conductrice d'électricité et une couche d'adhésif thermoplastique et est scellé de manière inductive sur la surface d'appui respective.
  6. Dispositif de distribution selon une des revendications précédentes, où le premier sceau (150) et/ou le deuxième sceau (160) présentent une épaisseur en direction longitudinale de moins d'un dixième de l'étendue perpendiculaire à la direction longitudinale.
  7. Dispositif de distribution selon une des revendications précédentes, où le premier sceau (150) et/ou le deuxième sceau (160) présentent une épaisseur en direction longitudinale de moins de deux millimètres.
  8. Dispositif de distribution selon une des revendications précédentes, où le premier sceau (150) et/ou le deuxième sceau (160) sont formés comme laminé ayant un support et au moins une couche barrière réduisant la diffusion.
  9. Dispositif de distribution selon la revendication 8, où la couche barrière est constituée de métal.
  10. Dispositif de distribution selon une des revendications précédentes, où le premier sceau (150) et/ou le deuxième sceau (160) présentent un domaine d'atténuation pour faciliter le sectionnement.
EP11716802.1A 2010-05-17 2011-04-18 Dispositif de distribution comprenant un récipient en verre scellé muni d'un piston coulissant Not-in-force EP2571626B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH00764/10A CH703164A1 (de) 2010-05-17 2010-05-17 Versiegelter Glasbehälter mit verschiebbarem Kolben.
PCT/CH2011/000085 WO2011143785A1 (fr) 2010-05-17 2011-04-18 Récipient en verre scellé présentant un piston coulissant

Publications (2)

Publication Number Publication Date
EP2571626A1 EP2571626A1 (fr) 2013-03-27
EP2571626B1 true EP2571626B1 (fr) 2016-10-12

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP11716802.1A Not-in-force EP2571626B1 (fr) 2010-05-17 2011-04-18 Dispositif de distribution comprenant un récipient en verre scellé muni d'un piston coulissant

Country Status (5)

Country Link
US (1) US20130048670A1 (fr)
EP (1) EP2571626B1 (fr)
CN (1) CN102905799A (fr)
CH (1) CH703164A1 (fr)
WO (1) WO2011143785A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2992298A1 (fr) * 2012-06-26 2013-12-27 Pierre Cousseau Cartouche de graisse
JP6416515B2 (ja) * 2014-04-03 2018-10-31 株式会社ダイゾー 吐出容器
CN107107093A (zh) * 2014-09-23 2017-08-29 Sika技术股份公司 顶板装置、存储容器装置、筒装置、分配设备以及它们的用途
ES2906565T3 (es) 2015-01-30 2022-04-19 Emd Millipore Corp Dispositivo, sistema y método de transferencia de fluido
EP3088326A1 (fr) * 2015-04-28 2016-11-02 Afinitica Technologies, S. L. Emballage de présentation pour des compositions de cyanoacrylate primaires et secondaires
US10231846B2 (en) 2016-08-19 2019-03-19 Stryker European Holdings I, Llc Bone graft delivery loading assembly
US11679177B2 (en) * 2017-08-08 2023-06-20 Baxter International Inc. Polymeric compositions, delivery devices, and methods
SG11202003797VA (en) * 2017-11-03 2020-05-28 Baxter Int Polymeric compositions, delivery devices, and methods
US20200278232A1 (en) 2017-11-08 2020-09-03 Noustique Perfumes, S.L. Container and device for dispensing fluid
CN111271023B (zh) * 2020-03-09 2022-03-15 中煤科工集团西安研究院有限公司 一种推动式孔内一体快速封孔装置及方法
DE102021120274A1 (de) * 2021-08-04 2023-02-09 Atlas Copco Ias Gmbh Vorrichtung und Verfahren zum Auftragen eines mindestens zweikomponentigen viskosen Materials auf Werkstücke
CN117326205A (zh) * 2023-09-14 2024-01-02 棒焕实业（上海）有限公司 一种带便捷推杆的注射器包装

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3464412A (en) * 1967-06-12 1969-09-02 Boris Schwartz Intermixing syringe
GB2152590A (en) * 1984-01-09 1985-08-07 Ernest E Murany Dispensing apparatus
US5197618A (en) * 1991-10-15 1993-03-30 Top Seal, Inc. Tamper-evident fusion bonded pull-tab induction foil lining system for container closures
US5918772A (en) 1995-03-13 1999-07-06 Wilhelm A. Keller Bayonet fastening device for the attachment of an accessory to a multiple component cartridge or dispensing device
US5735437A (en) * 1996-01-22 1998-04-07 Minnesota Mining And Manufacturing Lockable, hand-held dispenser and mixing tray for dispensing small quantities of material
US6458095B1 (en) * 1997-10-22 2002-10-01 3M Innovative Properties Company Dispenser for an adhesive tissue sealant having a housing with multiple cavities
US6343718B1 (en) * 1998-10-15 2002-02-05 Loctite Corporation Unit dose dispense package
EP1656309B1 (fr) * 2003-08-14 2014-11-19 3M Deutschland GmbH Capsule pour des materiaux a deux constituants
US8096449B2 (en) 2006-07-17 2012-01-17 Medmix Systems Ag Dispensing appliance for a multiple cartridge
WO2009058343A1 (fr) * 2007-10-31 2009-05-07 Dentsply International Inc. Conditionnement et système de distribution

Also Published As

Publication number Publication date
US20130048670A1 (en) 2013-02-28
EP2571626A1 (fr) 2013-03-27
CH703164A1 (de) 2011-11-30
CN102905799A (zh) 2013-01-30
WO2011143785A1 (fr) 2011-11-24
WO2011143785A8 (fr) 2012-04-12

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